Introducing the Brazilian Network
on Black Fungi
Flávio Queiroz-Telles
MD, PhD
History of Black Fungi in Brazil
Just after graduation Dr Rudolph
came to South America as
“Schiffsartz” (Ship's doctor )
Due to his competence on
board, his was invited by
A rich passenger to work for his
diamond mining company at
Estrela do Sul (South Star), in
Central Brazil
In 1914, Rudolph published the
first cases of what we know as
Chromoblastomycosis today
Max Rudolph
Über Brazilianische Figueira Archiev Schiffs und Tropen-Hygiene
18: 498-9, 1914
Fragments of the Rudolph’s
text
In man it usually beguins as a warty
vegetation on the upper part of the
foot.
And as the years pass, it grows to a
large Cauliflower-like papiloma....
In four of six cases It was possible to
isolate the same blastomycete which
grew in solid media, not as a white but
as dark brown to black hyphae,
resebling the fur of mice...
“Figueira”
Tumoral lesion
Fig tree fruits
(Ficus guapoi)
Demographics
• Population 190.000.000 (year 2,010)
–
–
–
–
22.3 hab/km2
78,4 % in urban areas
55% white, 39% mestizos, 5% black, 0,5% yellow,
02% indians
• 2014 – World Cup of soccer
• 2016 – Olimpic games in the city of Rio de Janeiro
Brazil: Geographic data
•
•
•
•
8.547.403 km2
20% of The Americas
47% of South America
Limits with all countries
– Except Chile and Ecuador
– 7.367 km of ocean coast
Brazilian biomes
Amazon is the largest
biodiversity reserve in the
world and the largest biome
in Brazil, occupying almost
half (49.29%) of the country.
Cerrado is the second
largest biome and covers
22% of the Brazilian territory
The Cerrado holds the
source of three major basins
in South America and holds
more than 6,500 plant
species
Raining Forest is an environmental
complex that includes mountain
ranges, valleys, plateaus and level
lands throughout the east Atlantic
continental range of Brazil
Isolation of Fonsecaea pedrosoi from thorns of Mimosa pudica a
probale natural source of CBMycosis in the State of Pará - Brazil
Sleeping Mary
310 m
Salgado et al. Rev. Inst. Med. trop. S.P 46: 2004
Melanized fungal infections
reported in Brazil
o
o
o
Chromoblastomycosis
Mycetoma
Phaeohyphomycosis
Superficial (tignea nigra)
o Keratites
o Subcutaneous
o Systemic
o
o
Sinusitis
•
•
o
Allergic sinusitis
Invasive sinusitis
Fungemia
Chromoblastomycosis in Brazil
•RS
100/35
4:1
20-80
14
Minotto
Queiroz-Telles; Graybill & McGuinnis Infect. Dis. Clin. N. Am 17: 59-85, 2003
Silva JP, De Souza W, Rozental S. Mycopathologia 1998;143:171–5.
Londero AT, Ramos CD. Na. Bras. Dermatol 1989;64:155–8.
Minoto, ScrofernekerJ et al. J. Am. Acad. Dermatiol, 2001, 44: 585-92
Underlying Diseases in 15 cases of
Fungemia due to Exophiala jeanselmei
Underlying condition
Hematologic malignancies
Systemic lupus erythematous
AIDS
Unstable angina
Breast cancer
Agranulocytosis
Osteomyelitis
Post-operative period
No.
No.deaths
6
1
1
1
1
1
1
3
1
1
1
2
Nucci et al.. J Clin Microbiol, 2001: 39
Infections caused by melanized and hyaline
fungi in renal transplant receptors
•40 episodes of black fungi infections were reported
•30 isolates
•Incidence rate - 5,21 cases/1.000 transplants
•Phaeohyphomycoses – 37 (92,5%)
•Chromoblastomycosis – 03 (7,5%)
Wagner D. Master Degree Thesis- UNIFESP, Sao Paulo 2010
Implantation (subcutaneous) phaeohyphomycosis in
renal transplant receptors
Wagner D. Master Degree Thesis- UNIFESP, Sao Paulo 2010
Pulmonary phaeohyphomycosis in renal transplant
receptors
Wagner D. Master Degree Thesis- UNIFESP, Sao Paulo 2010
The Brazilian Network on Black Fungi
Is borning
We hope you join it
Courtesy Dr Claudio Salgado , UFPA
151 m