ARTICLE IN PRESS Social Science & Medicine 63 (2006) 2604–2616 www.elsevier.com/locate/socscimed Urban neighborhoods, chronic stress, gender and depression$ Flora I. Mathesona,b,, Rahim Moineddinc, James R. Dunna,d, Maria Isabella Creatorea, Piotr Gozdyraa, Richard H. Glaziera,c,e a Centre for Research on Inner City Health, St. Michael’s Hospital, Toronto, Ontario, Canada b Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada c Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada d Department of Geography, University of Toronto, Toronto, Ontario, Canada e Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Available online 22 August 2006 Abstract Using multilevel analysis we find that residents of ‘‘stressed’’ neighborhoods have higher levels of depression than residents of less ‘‘stressed’’ neighborhoods. Data for individuals are from two cycles of the Canadian Community Health Survey, a national probability sample of 56,428 adults living in 25 Census Metropolitan Areas in Canada, with linked information about the respondents’ census tracts. Depression is measured with the Center for Epidemiologic StudiesDepression Scale Short Form and is based on a cutoff of 4+ symptoms. Factor analysis of census tract characteristics identified two measures of neighborhood chronic stress—residential mobility and material deprivation—and two measures of population structure—ethnic diversity and dependency. After adjustment for individual-level gender, age, education, marital and visible minority status and neighborhood-level ethnic diversity and dependency, a significant contextual effect of neighborhood chronic stress survives. As such, the daily stress of living in a neighborhood where residential mobility and material deprivation prevail is associated with depression. Since gender frames access to personal and social resources, we explored the possibility that women might be more reactive to chronic stressors manifested in higher risk of depression. However, we did not find random variation in depression by gender across neighborhoods. r 2006 Elsevier Ltd. All rights reserved. Keywords: Canada; Depression; Gender; Neighborhood; Chronic stress Introduction $ This research was made possible through the assistance of the Social Sciences and Humanities Research Council of Canada, Standard Research Grant 410-2005-2306. Corresponding author. Tel.: +1 416 864 6060; fax: +1 416 864 5485. E-mail addresses: [email protected] (F.I. Matheson), [email protected] (R. Moineddin), [email protected] (J.R. Dunn), [email protected] (M.I. Creatore), [email protected] (P. Gozdyra), [email protected] (R.H. Glazier). 0277-9536/$ - see front matter r 2006 Elsevier Ltd. All rights reserved. doi:10.1016/j.socscimed.2006.07.001 The idea that features of the social environment in which we live are important determinants of healthy lives is not new. In one of the earliest studies on environment and mental health, Faris and Dunham (1939) showed that psychiatric admissions in Chicago varied by location within the city with higher rates for those living in the inner-city core than in outlying areas. The ecological approach to the study of health was largely supplanted by ARTICLE IN PRESS F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 individualistic approaches, but more recently the hybrid approach of multilevel modeling has become more popular. Historical and modern writings advocate for population-level studies of health, reasoning that while risk factors originate in individuals (compostional effects), many of these risks propagate and become reinforced within social contexts (contextual effects), especially risks associated with health and health-related behavior. Durkheim (1951) studied the social causes of suicide and found regularities in suicide rates among specific population groups. He argued that social integration and regulation, characteristics of the social environment rather than the individual, contributed to the suicide rate in a particular group thus producing differences from the rate in other groups. According to Dunn, Frohlich, Ross, Curtis, and Sanmartin (2005) social facts may provide details on the uniqueness of specific places and particularly those stressors that influence, enhance and undermine the health of the population. They argue that it is imperative to examine these underlying phenomena to inform a global discussion of population health. Geoffrey Rose (1985) argued that groups of individuals function as a collectivity and these groups are affected by the average functioning of the group. Multilevel modeling allows researchers to simultaneously study individual and contextual effects and to ask questions about the relationship between neighborhood and personal health. The nature of chronic stress in context So what is it about the social environment that might lead to deterioration in the health of individuals? One issue, often identified, is chronic stressors in the local residential environment. In the social science literature contextual features such as crowding (Gillis, 1979a; Gillis, Richard, & Hagan, 1986), density, (Gillis, 1974, 1979b; Gillis & Hagan, 1982; Regoeczi, 2002; Sampson, 1983) and housing (Dunn, 2002; Dunn & Hayes, 2000; Gillis, 1977) have been examined as sources of chronic stress and have been found to be associated with health and well-being and health-related behaviors (Glazier et al., 2004; Hyndman, Holman, & Jamrozik, 1997; Katz, Zemencuk, & Hofer, 2000). Wheaton (1999) defines stressors (chronic, life event and daily hassles) as ‘‘conditions of threat, demands, or structural constraints that, by their very occurrence or existence, call into question the 2605 operating integrity of the organism’’ (Wheaton, 1999, p. 177). Chronic stress is insidious, with a slow and imperceptible onset and an open-ended recurring character; this form of stress is especially important since it can arise from contextual features. Chronic stressors in the local residential environment (ecological) are difficult to avoid (e.g., uncontrollable) and represent ongoing stress that is a part of daily living. Ecological chronic stressors are different from role-related stressors since they originate at a level above the individual and his or her interaction with role partners and peers (Serido, Almeida, & Wethington, 2004; Wheaton, 1999). This form of stress can include reduced or lack of access to opportunity or to the necessary means to achieve ends as well as structural reduction in available alternatives or choices (Wheaton, 1999). Research suggests that these chronic sources of stress or ‘‘quotidian’’ stressors (Pearlin & Skalkidou, 1995; Wheaton, 1999) more strongly affect well-being than the less frequent, but more major class of stressors known as life events which tend to be more transient in nature. Recent research on material deprivation, socioeconomic disadvantage, neighborhood disorder and instability points to the negative impact of chronic stressors on health (Aneshensel & Sucoff, 1996; Boardman, 2004; Boardman, Finch, Ellison, Williams, & Jackson, 2001; Dunn & Hayes, 2000; Feldman & Steptoe, 2004; Linsky, 1969; Ross & Mirowsky, 2001). The ecology of chronic stress is an important area of sociological inquiry (Hill, Ross, & Angel, 2005). The strain created by the chronic nature of neighborhood stressors will not only have an impact on individual health, but can lead to the deterioration of the capacity of the population within a neighborhood to resist the pathological effects of ambient stress. A growing body of research examines the relationship between urban stressors and health outcomes with only a handful of these studies focusing on the life stress paradigm. Boardman and colleagues (2001) found that socio-economically disadvantaged neighborhoods had a significant impact on the likelihood of adult drug use net of individual factors like socioeconomic status (SES) and socio-demographic characteristics (Boardman et al., 2001). Their results show that the effect of neighborhood disadvantage is most pronounced among poorer residents. Elliott (2000), using a composite measure of neighborhood socioeconomic status found that social support was protective of ARTICLE IN PRESS 2606 F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 mental and physical health among residents of higher-SES neighborhoods. He was unable to directly examine neighborhood stressors, but rather assumed that lower-SES neighborhoods are more stressful with less resources than higher-SES neighborhoods. In a more recent paper, Boardman (2004) found that neighborhood residential instability was an important factor in explaining physical health. Residing in relatively unstable neighborhoods had a greater negative impact on health. Silver, Mulvey, and Swanson (2002) examined the impact of neighborhood disadvantage and residential mobility on several mental disorders after controlling for individual-level risk factors. They found that major depression was more prevalent in disadvantaged and residentially mobile neighborhoods. Their findings mirror that of Ross, Reynolds, and Geis (2000) who found that the effect of residential stability on depression depended on the level of poverty in the neighborhood. Under conditions of high poverty, residents of neighborhoods with little residential turnover had higher levels of depression and anxiety than residents of more mobile neighborhoods. Recently, Latkin and Curry (2003) examined the impact of neighborhood stress on depression using a prospective multilevel approach. They found that neighborhood perceptions of social disorder were positively associated with depressive symptoms and argue that social disorganization is an important chronic stressor among inner-city populations. They emphasize that depression should not only be viewed as an individual level phenomenon, but that ecological factors are important for identifying and understanding neighborhoods that are at risk for depression. Using Rose’s (1985) logic we ask, ‘‘Why do some neighborhood populations have more depression.’’ We seek an explanation in sources of chronic stressors that exist at the neighborhood level using the framework of the stress process paradigm. The original stress process paradigm (Lin & Ensel, 1989; Pearlin, 1989) suggests that the pathway to wellbeing is a process that includes individual risk factors (e.g., gender), individual stressors (e.g., life events and chronic strains) and social resources (e.g., supportive friendship networks), but Pearlin (1989) also suggested that stressful experiences do not exist in a vacuum, but can be traced to social structures and the location of individuals within these structures. Stressful experiences are interpreted within a person-environment transactional framework where transactions depend on the impact of the external stressor. This is mediated by the person’s appraisal of the stressor and the social and cultural resources at his or her disposal (Antonovsky & Kats, 1967; Cohen, 1984; Lazarus, 1966) and these appraisals are thought to be influenced by gender roles and gender socialization processes. We use the general framework of the stress process paradigm to examine neighborhood sources of stress and their association with depression. Instead of individual-level stress we construct aggregate measures of neighborhood-level chronic stressors. The evidence that chronic stressors in the local residential environment are associated with physical and mental health is growing (Hill et al., 2005) and is evident in the literature on material deprivation from the UK (Carstairs & Morris, 1989a, b; Jarman, 1983, 1984; Townsend, 1987). More recently, in two separate studies in Canada, Pampalon and Raymond (2000) developed a deprivation index for urban and rural areas in Quebec and Frohlich and Mustard (1996) developed a composite index of neighborhood disadvantage for the province of Manitoba. Like these previous studies we wanted to explore the notions of deprivation and residential instability as potential chronic stressors within the local residential environment. Using similar census measures to those from the UK and Canada on material deprivation and on residential instability (primarily from the US) we sought to define chronic stressors related to deprivation and instability for 25 urban areas in Canada. This paper therefore provides an exploration of the association of neighborhood chronic stressors with individual reports of depression within a national sample of 3619 socially and ethnically diverse neighborhoods. Gender and neighborhood chronic stress The stress process model posits that social status determines one’s position in the social structure, and thus the types and intensity of stressors to which one is exposed. Gender is recognized as a status position that organizes our lives and frames our access to personal and social resources primarily because gender encompasses both biological/genetic and social learning differences. Explanations of gender differences in depression, with women at greater risk, reflect both sex-related biological and social aspects as well as the interplay between these two forces (Verbrugge, 1989). Social explanations of gender ARTICLE IN PRESS F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 differences in health posit that women report higher levels of depression and other health problems because of reduced access to material and social conditions of life that foster health (Arber & Cooper, 1999; Ross & Bird, 1994). In comparison to men, women are less likely to be employed, more likely to work in lower status positions when employed, to have lower incomes and be single parents (Denton & Walters, 1999; Ross & Bird, 1994). While we know from research that living in economically disadvantaged and residentially mobile neighborhoods leads to poor physical and mental health outcomes, we know little of the potential impact of neighborhood chronic stressors on depressive outcomes in men and women. There are grounds to believe that neighborhood stressors may be more detrimental for women’s health. Suicide literature suggests that gender roles veritably weave women more wholly into the social fabric (Danigelis & Pope, 1979; Steffensmeier, 1984) Women know more of their neighbors by name, and talk or visit with them more frequently than do men (Campbell & Lee, 1992; Kessler & McLeod, 1984) suggesting that women have larger social networks than men and are more embedded in their communities. If women are more integrated into their neighborhoods, maintaining more intense and multiplex relations (Campbell & Lee, 1992) we might envision that neighborhood stressors will have greater impact on women’s mental health rather than men’s health; this primarily because residential mobility and material deprivation interfere with maintenance of social bonds and social support both of which are often considered protective for women’s health (Denton & Walters, 1999; Magdol, 2002; Propper et al., 2005). Research questions This paper addresses the four following research questions: (1) Is neighborhood stress correlated with higher risk of depression? (2) To what extent does chronic stress account for neighborhood variation in depression? (3) Does the association of neighborhood chronic stress remain after controlling for individual characteristics, neighborhood ethnic diversity and dependency? (4) Is neighborhood chronic stress associated with gender differences in depression? 2607 Data and methods Data sources Two data sources were used to investigate the association between neighborhood context and depression—the Canadian Community Health Survey (CCHS) and the 2001 census of Canada, both collected by Statistics Canada. The CCHS is a crosssectional nationally representative survey that provides detailed information on health determinants and health outcomes (see Beland, 2002 for detailed methodology). Two cycles of the CCHS (cycle 1.1 and cycle 2.1 collected in 2000–2001 and 2003–2004, respectively) were combined to create a large crossnational dataset of 267,108 respondents. The combined CCHS represents two surveys with the same subject matter and identical populations. There is considerable interest in combining datasets when possible because the combined data provide more efficient estimates by increasing sample size within neighborhoods and by increasing the number of neighborhoods. Statistics Canada’s data publication guidelines were followed throughout the analysis. All analyses were weighted using the combined sampling weight provided by Statistics Canada. Bootstrapping with 500 replications was used to obtain p values for logistic analysis shown in Table 2. All p values were two-sided. SAS version 9.1 (SAS Institute Inc., Cary, NC, USA) was used for data manipulation and statistical analysis. Ethics approval was obtained from the St. Michael’s Hospital Research Ethics Review Board. Respondents were assigned to census tracts (CTs) using the Postal Code Conversion File Plus (PCCF4F+), an automated system that uses postal codes to assign census geography (Wilkins, 2005). PCCF4F+ is based on the latest Postal Code Conversion File and Postal Code Population Weight File produced by the Geography Division of Statistics Canada. (CMAs) uses weights to allocate postal codes linked to multiple dissemination areas according to the distribution of population using a given postal code. Sample and unit of analysis For practical reasons our focus here is on urban neighborhoods since 80% of Canadians are urban dwellers. The concentration of people in cities makes them the primary locus of neighborhood effects. We included respondents aged 18–74 living ARTICLE IN PRESS 2608 F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 in the 25 Census Metropolitan Areas PCCF4F+ included in the survey (CCHS) representing approximately 40% of the full sample. Respondents who were less than 18 and greater than 74 were excluded due to high rates of proxy interviews. After exclusion of observations with missing data the final sample was 56,428 respondents in 3619 CTs. CTs are small, relatively stable geographic units (populations between 2500 and 8000) constructed similarly with respect to economic status and social conditions. Fig. 1 visually depicts the 25 CMAs included in the CCHS that are the focus of this study. Neighborhood measures The selection of neighborhood characteristics for this analysis was guided by previous neighborhoodbased research and theory linking neighborhood stressors to poor health (Hill et al., 2005; Kornhauser, 1978; Pampalon & Raymond, 2000; Sampson & Groves, 1989; Sampson, Raudenbush, & Earls, 1997; Shaw & McKay, 1969). The literature on deprivation and residential instability was pivotal as a starting point and provided the input variables for factor analysis. In total, 18 CT measures were extracted from the census data, describing the socioeconomic and demographic character of the CT. To avoid the problem of multicollinearity (often associated with census data) that would result from analyzing these measures simultaneously in a regression equation, we followed the recommendation of Land, McCall, and Cohen (1990) and factor analyzed them. Factors were constructed using oblique rotation which allows the factors to co-vary (Kim, 1978a, b). We also estimated an orthogonal factor matrix that yielded substantively identical results. Measures of neighborhood context were constructed from census data available through the Canadian University Data Liberation Initiative. With an eigenvalue of 7.8, the first factor is dominated by moderate to high loadings (460) for percentage living alone, percentage youth 5–15 years (reverse coded), persons per dwelling (reverse coded), percentage living in apartment buildings, percentage married (reverse coded), percentage home ownership (reverse coded), and percentage moving within the last 5 years. This first factor is essentially a measure of residential instability. The second dimension (eigenvalue 2.8) is a measure of material deprivation. The six variables that define this dimension are percentage 20+ without high school graduation, percentage lone parent families, percentage of families receiving government transfer payments, percentage 15+ unemployed, percentage living below the low income cut off (a Statistics Canada defined measure that is adjusted for community size, family size and inflation), and percentage of homes needing major repair. The third dimension, dependency (eigenvalue 2.5) includes high factor loadings (480) for percentage Fig. 1. Map of the 25 Canadian census metropolitan areas for which data from the 2001 CCHS was used. Source: Statistics Canada and ESRI Canada. ARTICLE IN PRESS F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 seniors (age 65+), the ratio of the population age 0–14 and 65+ divided by the population aged 15–64, and labor force participation (reverse coded). The final dimension is ethnic diversity (eigenvalue 1.7), which is dominated by high loadings (490) for percentage recent immigrants and percentage visible minorities. The loadings for each factor were used to compute four separate indices for residential instability, material deprivation, dependency, and ethnic diversity from the factor scores generated for each subject (after reverse coding the variables with negative weights). All four indices are standardized scores. In assessing these four factors, residential instability and material deprivation capture the concept of chronic stress to a much larger degree than ethnic diversity and dependency. The latter two measures better reflect demographic characteristics related to ethnicity and population age structure and thus were used as neighborhood-level control variables in the analysis. Depression The CCHS interview incorporated a brief predictive instrument to identify major depression occurring during the preceding year. The Composite Diagnostic Interview Schedule Short Form for major depression (CIDI-SF MD) is a brief version of a fully structured diagnostic interview for major depression (Kessler, Andrew, Mroczek, Üstün, & Wittchen, 1998) that can be administered by trained lay interviewers in large-scale national health surveys and includes questions covering the symptoms of major depression that are critical to the diagnostic definition within the DSM-IV (American Psychiatric Association, 2000). To construct the individual-level measure of depression we selected a probability of caseness of 0.8125 corresponding to a short form major depression score of 4 or greater. In creating the outcome measure, each respondent was categorized as depressed or not based on a symptom score of 4 or greater. 2609 we include several categorical variables: gender, age of respondent, (age 18–29, age 30–39, age 40–49, age 50–59 with age 60–74 used as the reference category), married, education and visible minority status which includes persons, other than Aboriginal persons, who are not white in race or color. There is considerable debate in the literature on the treatment of individual-level covariates in multilevel modeling. Some investigators include an extensive list of covariates while others are highly selective (see Bingenheimer & Raudenbush, 2004). We began with a relatively extensive list, but found it necessary to cull the list due to a high degree of collinearity among individual-level covariates. In addition to the measures described above, the initial list included low income status, single parenthood status, unemployment, aboriginal status, housing ownership, immigrant status, living alone, and sources of income. We found strong associations between these variables and the five variables that have been retained for multilevel analysis. Other variables often examined within the stress-process model, specifically those related to individual-level personal and social resources, life event and chronic stress, were not collected in all regions of the country and as such could not be included in the analysis. Statistical procedures The analysis begins with a description of the sample followed by standard logistic regression to assess the association of each predictor and control variable with depression. We then conduct multilevel logistic modeling to allow for the hierarchical nature of the data since individuals are nested within neighborhoods. We first determine how much of the variance in the outcome measure of depression can be attributed to the neighborhood level (null model). We follow this with a series of models first introducing individual-level variables then neighborhood-level variables in separate models and finally including the individual and neighborhood level variables together in a final model. Hierarchical logistic regression was performed using the SAS NLMIXED procedure. Individual level measures Results Individual-level variables that reflect socio-demographic characteristics related to depression are included to adjust for their potential impact on individual-level depression when neighborhood stressors are included in the model. From the CCHS Descriptive statistics Correlations among the factors and their components are presented in the third column of Table 1. ARTICLE IN PRESS 2610 F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 Table 1 Factor pattern and correlations for 3619 Canadian neighborhoods Variable Factor loading Correlation with factor 96 95 94 0.95*** 0.91*** 0.87*** Residential instability Living alone Youth (reverse coded) Persons per dwelling (reverse coded) Apartments Married (reverse coded) Owner-occupied house (reverse coded) Residential mobility (5 year) 79 77 71 0.87*** 0.87*** 0.87*** 64 0.67*** Material deprivation No high school graduation Lone parent families Government transfers Unemployment Low income Homes needing major repair 91 84 81 70 67 51 0.88*** 0.87*** 0.86*** 0.79*** 0.77*** 0.52*** 90 88 0.91*** 0.86*** 79 0.82*** 96 95 0.94*** 0.92*** Dependency Seniors Ratio population (age 0–14+65+)/(age 15–64) Labour force participation (reverse coded) Ethnic diversity Recent immigrants Visible minorities Notes: *pp0.05; **pp0.01; ***pp0.001. Correlations among residential instability and its component measures range from 0.67 to 0.95; those for the components of material deprivation range from 0.52 to 0.88; those for the components of dependency range from 0.82 to 0.91; and those between ethnic diversity and its components range from 0.92 to 0.94. As shown in Table 2 the prevalence of depression in the sample was 9% (N ¼ 5497). Approximately 51% of the sample were female, 56% were married, 84% reported having graduated from high school and 22% reported being of visible minority status. Age is shown as a categorical variable: 23% age 18–29, 23% age 30–39, 23% age 40–49, and 16% age 50–59 (age 60–74 was the reference category). The odds of depression by each predictor are shown in the last column of Table 2 (standard logit model). The risk of depression is almost 2 times greater for women than men (OR ¼ 1.79, pp0:001). Those in younger age groups are at greater risk of depression relative to those aged 60–74 (pp0:001). Being married is associated with a 51% decreased risk (OR ¼ 0.49, pp0:001), graduation from high school is associated with a 20% decreased risk (OR ¼ 0.80, pp0:001), and visible minority status is associated with a 37% decreased risk (OR ¼ 0.63, pp0:001) of depression. Table 2 also provides the odds of depression by each of the neighborhood characteristics. Both measures of neighborhood chronic stress are associated with increased odds of depression, with residential instability associated with an 11% and deprivation with a 6% increased risk (pp0:001 and p0:01, respectively). Dependency (OR ¼ 0.94, pp0:01) and ethnic diversity (OR ¼ 0.92, pp0:001) are associated with decreased risk of depression. These results provide an affirmative response to the first research question: Is neighborhood stress correlated with the risk of depression? Multilevel logistic regression We begin by considering a fully unconditional ordered logit model of the dichotomous outcome of depression (not shown) in order to decompose variance in the dependent variable across levels of analysis. The intraclass correlation (ICC) for logistic regression can be calculated as r ¼ ðs2u =s2u þ s2e Þ, where s2e ¼ p2 =3 (Guo & Zhao, 2000).The estimate of the intercept variance (0.089, OR ¼ 1.09, pp0:001) yields an intra-class correlation (ICC) of 0.026, suggesting that, on average, 2.6% of the variance in the dependent variable can be attributed to the neighborhood level. In interpreting the value of the ICC it is important to keep the following points in mind: while most of the variability in depression is at the individual level, the magnitude of the ICC is within the typical range since ICCs rarely exceed 0.20 (Snijders & Bosker, 1999); the size of the ICC does not rule out relatively large effects of neighborhood level measures (Duncan & Raudenbush, 1999); and, to the extent that the final model includes significant cross-level interactions, ICCs will vary across level two units. Table 3 reports the results of a series of hierarchical ordered logit models predicting depression. Model 1 reports the results of a regression predicting depression based on demographic background variables. The unadjusted odds ratios for women remained relatively unchanged from results ARTICLE IN PRESS F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 2611 Table 2 Descriptive statistics (N ¼ 56; 428) Variables Percent N Bivariate odds of depression Individual characteristics Depression (4+ symptoms) Female Age 18–29* Age 30–39 Age 40–49 Age 50–59 Married High school graduation Visible minority 9% 51% 23% 23% 23% 16% 56% 84% 22% 5497 30,414 11,688 12,768 12,433 9499 28,126 47,038 8578 — 1.79*** 2.41*** 2.01*** 1.97*** 1.59*** 0.49*** 0.80*** 0.63*** Neighborhood characteristicsa Residential instability Material deprivation Dependency Ethnic diversity — — — — — — — — 1.11*** 1.06** 0.94** 0.92*** Notes: Weighted means and odds ratios and non-weighted N’s are presented.*pp0.05; **pp0.01; ***pp0.001. a Factor scores are standardized with a mean of 0 and standard deviation of 1. Table 3 Multilevel logistic regression odds ratios of depression by individual and neighborhood characteristics (N ¼ 56; 428) Depression (4+ symptoms) Variables Model 1 Individual level Female Age 18–29 Age 30–39 Age 40–49 Age 50–59 Married High school graduation Visible minority 1.87*** 2.46*** 2.84*** 2.78*** 2.20*** 0.49*** 0.73*** 0.65*** Model 2 Model 3 1.87*** 2.44*** 2.81*** 2.76*** 2.19*** 0.51*** 0.74*** 0.66*** Neighborhood level Residential instability Material deprivation Dependency Ethnic diversity 1.12*** 1.12*** 0.92*** 0.90*** 1.04* 1.05** 0.97 0.97 Intercept 0.06*** Intercept Variance Component 1.07*** 0.11*** 1.05*** 0.06*** 1.06*** Notes: *pp0.05; **pp0.01; ***pp0.001. reported in Table 2 after adjusting for age, marital status, high school graduation and visible minority status. The odds ratios for all demographic background variables were similar in size and effect to those presented in Table 2. Despite the inclusion of individual-level characteristics, the variance of the random intercept remains significant indicating that there is still unexplained variance at the neighborhood-level (pp0:001) net of individual-level variables. Model 2 reports results for depression regressed on neighborhood characteristics including the two measures of chronic stress—residential instability and material deprivation. The two neighborhood stressors—residential instability (OR ¼ 1.12, pp0:001) and material deprivation (OR ¼ 1.12, pp0:001)—are each significantly and independently associated with a 12% increased risk of depression in Model 2. The positive effect of both measures of neighborhood stress is consistent with our conceptualization of the stress process model suggesting that neighborhood stressors account for some of the variation in depression after controlling for neighborhood population structure (dependency) and ethnic diversity. Both dependency (OR ¼ 0.92, pp0:001) and ethnic diversity (OR ¼ 0.90, pp 0:001) are negatively associated with depression. Model 3 includes neighborhood characteristics as well as demographic background characteristics. Tracking changes in neighborhood stressors (our primary interest) across models 2 and 3 indicate that neighborhood stressors contribute independently to depression, so although the social composition (individual-level) of urban Canadian neighborhood matters, context matters as well. While there is a reduction in the size of the odds ratios for material deprivation (OR ¼ 1.05, pp0:01) and residential instability (OR ¼ 1.04, pp0:05) (see model 3 as ARTICLE IN PRESS 2612 F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 compared to model 2), each continues to contribute independently to depression. When individual characteristics are controlled, neighborhood ethnic diversity and dependency exert no independent effects on depression. The variance estimate of the random intercept remains statistically significant indicating that neighborhood chronic stress continues to explain some of the variation in depression when individual and other contextual factors are included in the model. In separate analyses, we specified a model with random slopes for gender in order to determine whether these effects vary across neighborhoods. The fixed effect of gender was significant in the models reported in Table 3; however, allowing the slope of gender effect to vary revealed no significant variance component suggesting that the gender difference in depression is constant across CTs of 25 of Canada’s CMAs. This finding means that we have a negative response to our research question: Is neighborhood chronic stress associated with gender differences in depression? Neighborhood chronic stress does not seem to differentially affect risk of depression for men and women. Taken together, the analyses indicate that neighborhood stressors—residential instability and material deprivation—exert significant effects on depression, even after controlling for individual demographic variables and relevant neighborhood level processes (ethnic diversity and dependency). Discussion Rose (1985) argues that we should shift some of our focus from treatment and prevention at the individual level to prevention for ‘‘sick populations’’. In this study we asked: ‘‘Why do some neighborhoods have more depression than others’’? We argued that at least part of the answer might lie in the existence of chronic stressors in the local residential environment. Identification of chronic stressors that may be uncontrollable at the individual-level, but which are embedded in the social and political structure of the community, may lead to population-based initiatives and policies that reduce the impact of these chronic stressors on the population. To investigate this possibility, we selected neighborhood characteristics from the census that were identified in the literature on material deprivation and residential instability. Our focus on neighborhood material deprivation and residential instability was based on the fact that these concepts seem to possess inherent qualities of chronic stressors. When present, deprivation and residential instability are uncontrollable, especially at the individual level, and tend to be persistent features of a neighborhood. Uncontrollable stressors are documented to undermine health more so than controllable ones (Friis, Wittchen, Pfister, & Lieb, 2002; Perkins, 1982; Zautra & Reich, 1983). Factor analysis of the selected census characteristics produced two chronic stress indices, neighborhood material deprivation and residential instability. Two other dimensions emerged from the data which reflect ethnic diversity and what we called dependency, which essentially reflects the age structure of the population. Several features of our study are particularly noteworthy: (1) we develop a model that embodies research on neighborhood context using knowledge from literature on the stress process which has guided the majority of the micro-level research on social antecedents of health; (2) we define and operationalize two sources of chronic stress at the neighborhood level as multi-item composite indicators of residential instability and material deprivation; (3) we examine the impact of neighborhood chronic stress at a national level using a large general population sample of over 50,000 respondents located in 25 large urban centers which comprise over 3000 neighborhoods. Our results indicate that neighborhood residential instability and material deprivation contribute significantly to the likelihood of depression above and beyond the influence of individual-level sociodemographic factors. Moreover, although the estimated net effects of residential instability and material deprivation are relatively small in magnitude, such effects may be especially important because even modest shifts in neighborhood instability and deprivation have the ability to impact thousands of individuals. Gender has long been recognized as a status position that frames our access to personal and social resources. In this study we examined whether gender framed one’s response to neighborhood chronic stressors thinking that women might be more reactive to such stress, however we did not find random variation in depression by gender across neighborhoods. So, while women were at greater risk of depression the gender difference in depression was relatively constant across our neighborhood units of CTs. The null findings for depression do not mean that this will be the case for ARTICLE IN PRESS F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 other health outcomes. We believe that it is important to seek those contextual features that might differentially impact the genders in an effort to discover the mechanisms that differentially affect the health of men and women. Limitations Census variables are commonly used to characterize neighborhoods, but they tend to be relatively non-specific. Better measures are required to elucidate pathways and provide opportunities for intervention. A shortcoming of this research is that our exploration of neighborhood chronic stressors and their impact on depression was restricted to urban centers. Much of rural Canada is not tracted so census characteristics cannot be ascribed to these areas at the same geographic level. Census information is available for smaller geographic areas (i.e., dissemination and enumeration areas), but using such areas would lead to sparse data at the individual level and this would affect estimation of logistic models for low-prevalent outcomes. In a recent study Weich, Twigg, and Lewis (2006) found that people living in rural areas experience better mental health than those living in urban areas. Rural areas differ from urban areas in availability of health services, access to transport, social support and social networks and potentially in exposure to life event and chronic stressors. Development of models to investigate the impact of context on mental health in rural areas is relatively understudied and needs attention. A further limitation of the data is the lack of individual information on mediating variables like personal (e.g., mastery and self-esteem) and social resources (e.g., social support and social networks), life events (e.g., divorce) and chronic stress (e.g., long-term illness). Questions that would capture this information were part of the optional content of the CCHS and administered only to a few health regions across Canada. This is disappointing because while knowing that neighborhood chronic stressors affect the health of individuals is important, it is also important to understand how microlevel resources and stressors either exacerbate or attenuate the impact of neighborhood chronic stressors on mental health. In addition, data that capture neighborhood resources that may attenuate the negative impact of neighborhood chronic stressors on health should also be included in future research. 2613 The Achilles heel in cross-sectional studies of neighborhood and individual-level mental health is that it is not possible to get a clear picture of the extent to which neighborhood accounts for depression. This problem applies not only to research conducted at the individual level, but inevitably to approaches that combine the individual and the ecological. Without longitudinal data it is impossible to state unequivocally that chronic stress at the level of the neighborhood ‘‘causes’’ depression; neither can we say that onset and perseverance of depression leads to downward drift and migration of those with poor mental health to less economically viable areas; obviously, not everyone in these neighborhoods migrates in because of downward drift. The present state of any neighborhood reflects broader socioeconomic transformations which in turn influence migration patterns: healthy, economically advantaged individuals may migrate to more affluent areas of the city from neighborhoods laden with chronic stress; healthy and economically disadvantaged individuals may be unable to move despite desire to escape the neighborhood; and, unhealthy and economically disadvantaged individuals may migrate in. The point to emphasize here is that both neighborhoods and individuals are dynamic with a constant interplay between the neighborhood and its residents. Conclusions Rose (1985) and Weich (1997) emphasize that approaches to prevention and treatment need to go beyond the individual to the level of the population and have suggested that prevention and treatment within the community or neighborhood should be considered, not as an alternative to clinical practice, but as an approach to improve the general health of a large network of people. Studies that employ multilevel methods will assist in this endeavor through identification of communities and neighborhoods that have higher burden of chronic stressors and a concomitant high number of people reporting depression or other common mental disorders. Rose (1993) asks us to reflect on what might be the ‘‘psychiatric counterpart’’ to the reduction of cholera through the control of water pollution. He calls for research that can bridge clinical skills, epidemiology and the social sciences and prevention techniques that bridge medicine, social policy and politics. This approach suggests several layers, including identifying communities or ARTICLE IN PRESS 2614 F.I. Matheson et al. / Social Science & Medicine 63 (2006) 2604–2616 neighborhoods in need, public and political partners that can come to the table with concrete strategies to address the problem, find solutions and to build sustainability. The stigma associated with the common mental disorders such as depression means that these damaging illnesses often go largely undetected and untreated. Environmental and contextual factors like chronic stress in the neighborhood are modifiable. The findings linking social context to mental health that are derived from the foregoing analysis are important because they may help to provide information that will better help guide policies specifically aimed at ameliorating persistent health inequalities. The findings presented above are important for health-related policy makers because they suggest where mental health resources might be better located to provide interventions that reduce neighborhood chronic stress which may improve the health of at-risk populations. Such information could improve the effectiveness of existing community-based mental health care agencies. 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