This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.
Research Article: New Research | Development
Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic
Neuronal Circuitry
Abbreviated title: Serotonin regulates serotonergic wiring in adulthood
Marta Pratelli1, Sara Migliarini1, Barbara Pelosi1, Francesco Napolitano2, Alessandro Usiello2 and Massimo
Pasqualetti1,3,4
1
Department of Biology Unit of Cell and Developmental Biology, University of Pisa, Pisa, 56127, Italy
2
Ceinge Biotecnologie Avanzate, Naples, 80145, Italy
3
Center for Neuroscience and Cognitive Systems, Istituto Italiano Di Tecnologia, Rovereto, TN 38068, Italy
4
Neuroscience Institute, National Research Council (CNR), Pisa, 56124, Italy
DOI: 10.1523/ENEURO.0376-16.2017
Received: 19 December 2016
Revised: 14 February 2017
Accepted: 17 February 2017
Published: 3 April 2017
Author contributions: M. Pratelli, S.M., B.P., and M. Pasqualetti designed research; M. Pratelli, S.M., B.P.,
F.N., A.U., and M. Pasqualetti performed research; M. Pratelli, S.M., F.N., A.U., and M. Pasqualetti analyzed
data; M. Pratelli, B.P., and M. Pasqualetti wrote the paper.
Funding: Italian Ministry of Education, University and Research (MIUR)
prin 2008
200894SYW2
Funding: Toscana Life Science Foundation
Orphan_0108 Program
Funding: Norvegian Research Council
Funding: PhD program Pisa University
Funding: Regional Program and European Social Fund
The authors declare no competing financial interests.
This work was supported by Italian Ministry of Education, University and Research (MIUR) (Prin 2008,
200894SYW2), Toscana Life Sciences Foundation (Orphan_0108 program) and Norwegian Research Council
to M. Pasqualetti. B.P. and M. Pratelli were supported by PhD program from University of Pisa. S.M. was
supported by Regional Program and European Social Fund. We thank C. Valente for excellent technical
assistance and members of our laboratory for valuable discussions and comments on the manuscript. We
acknowledge Dr. P. Chambon and Dr. D. Metzger for the CMV-CreERT mouse line.
Corresponding author: Massimo Pasqualetti, University of Pisa, Department of Biology, Unit of Cell and
Developmental Biology, ss 12 Abetone e Brennero, 56127 Pisa, Italy. E-mail: [email protected]
Cite as: eNeuro 2017; 10.1523/ENEURO.0376-16.2017
Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this
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Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading
process.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any
medium provided that the original work is properly attributed.
Copyright © 2017 the authors
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