Advanced wound healing
and professional
scar management
Switzerland
Patients seeking dermatologic
and plastic surgery interventions
have high expectations
Features of Stratamed and Strataderm –
the ideal material for advanced
wound dressings
Fast wound healing is key to minimize abnormal scar formation.1
There are two key features of Stratamed and Strataderm: their resulting durability
on the skin as a sheet, and their permeability to many molecules (water vapour,
oxygen, drugs, etc.) but their impermeability to water. Stratpharma technologies
provide distinctive properties for innovative health care applications, which can
lead to improved comfort for patients and better patient compliance.2,3
“The main focus for clinicians is to achieve rapid epithelialization
as a first measure of wound care to manage abnormal scar
formation. This is particularly important for wounds subjected
to tension due to motion, body location or loss of tissue.”1
Stratamed and Strataderm features for medical application2,3
Facelift
Body contouring
Features
Benefits
> Inert
− Does not host or allow the proliferation of bacterial growth
− Will not stain or corrode other materials
> No pH value
− Does not affect the protective acid mantle of the skin
> Molecular structure
− Ability to form sheets
− Flexibility and adaptability
> Strong chemical bonds
− Not susceptible to oxidation
− Not susceptible to thermal degradation
> High molecular weight
− Not absorbed through the skin
− Not absorbed into the human gastrointestinal tract
− Excreted without modification
> Low chemical reactivity
− Superior biocompatibility with human tissue and other
body fluids
− Low or non-existing allergenic profile
− Waterproof
> Low surface energy
> Hydrophobicity
Breast augmentation
2
Body contouring
> Film forming
− From transient sheets and thin, superficial coverings,
to more substantive, longer-lasting sheets with self-levelling
or adhesive properties
> Permeability
− Modulates the diffusion of many substances (oxygen,
carbon dioxide, water vapor)
− Avoids tissue maceration
> Pharmacoeconomic
− Used to reduce nursing time but also to improve comfort and
reduce wound complications
3
Strataderm is a self-drying gel for the management
of hypertrophic scars and keloids.
Stratamed is an advanced film forming wound dressing in the form
of a self-drying gel. Stratamed is flexible, adaptable, and creates
a full contact surface.
• Stratamed is a transparent gel for topical application. It dries into
a thin and flexible protective sheet that ensures constant contact
with the wound surface 24 hours a day.
• Stratamed creates an optimal environment for
faster re-epithelialization resulting in reduced downtime.
Convenient and easy to use
• Used to soften and flatten raised
scars4
• Rapidly drying, non-sticky and
waterproof
• Used to relieve itching and
discomfort4
• Can be used on joints and areas
with contours
• Used to reduce redness and
discoloration4
• Transparent, odorless and can be
covered with make-up or sunscreen
• Stratamed creates an optimal environment for the normalization
of the inflammatory response.
• Strataderm is semi-occlusive, which allows the skin to breathe
and remain hydrated. This helps to achieve a softer, smoother and
flatter scar.5,6
• Stratamed is bacteriostatic (protects compromised skin areas
and open wounds from chemical and microbial invasion) and inert
(it does not affect the protective acid mantle of the skin).
• Strataderm forms a durable, flexible and waterproof sheet,
which protects scars from microbial and chemical invasion and helps
normalizing collagen production.6
• Stratamed is compatible with secondary absorbent dressings.
• Strataderm modulates the level of basic fibroblastic growth factors
(bFGF), which have an influence on the formation of hypertrophic
scar tissue.6,7
Application of
Stratamed/Strataderm
S
EPITHELIALIZATION
2
8
TH
PROLIFERATION
1
4
ON
INFLAMMATION
2
14
M
1
7
KS
EE
2
48
W
1
24
YS
DA
RS
S
TE
COAGULATION
1
60
U
HO
U
IN
Stages of
wound healing
1
M
Time after
wound formation
4
For scars old and new
12
REMODELLING/MATURATION
Delayed epithelialization beyond 10
to 14 days increases
the incidence of hypertrophic scarring
dramatically.8
advanced film-forming
wound dressing
5
Clinical results with Stratamed
Clinical results with Strataderm
Face lift surgery9
Monotherapy
treatment with
Stratamed
Case study #210
Classification: linear hypertrophic scar after nevis
extraction; Location: chest; Dimensions: 1 inch length;
Age of scars before treatment: 14 months
3 months treatment
4
Redness
3.5
3
Elevation
Hardness
2.5
Itchiness
Tenderness
2
1.5
After surgery
1
Day 20
0.5
0
Breast surgery scars
Treatment with
Stratamed in combination with CO2 fractional
laser
Before treatment
9
Before treatment
0
After 2 months treatment
Left scar remained untreated,
right scar treated for 2 months
Case study #310
Classification: linear hypertrophic scar after trauma;
Location: head; Dimensions: 1.75 inch length;
Age of scar before treatment: 2 weeks
Month 5
1
2
3
Months
3 months treatment
4
Redness
3.5
3
Elevation
Hardness
2.5
Itchiness
Tenderness
2
1.5
MOHS surgery
reconstruction10
Monotherapy
treatment with
Stratamed
Before treatment
1
0.5
0
0
Before treatment
Case study #410
Classification: hypertrophic scar after surgery;
Location: knee; Dimensions: 0.2 inch length;
Age of scars before treatment: 13 months
Month 2
1
2
3
Months
After 3 months treatment
Chronic wound
Monotherapy
treatment with
Stratamed, twice daily
11
5 months treatment
Redness
4
Elevation
3.5
Hardness
Itchiness
3
2.5
Tenderness
2
1.5
1
0.5
0
After 1 month treatment
4 months after surgery, before treatment
6
After 5 months treatment
0
1
2
3
4
5Months
Day 7
7
Dry and moist wound healing –
the difference
Dry wound healing12
How the combination of Stratamed
and Strataderm works
Moist wound healing12
Stratamed: Faster re-epithelialization of the wound bed
Protective dressing
Images taken from: Sussman C, Bates-Jensen B.
Wound care. Philadelphia: Wolters Kluwer/Lippincott
Williams & Wilkins Health; 2012
Scab
Zone of secondary injury
from dessication
Moist environment
When wounds are kept exposed to
the air they will dry and form a scab.
The scab protects the wound from
environmental contamination, but has
some disadvantages:
Moist wound conditions allow optimal
cell migration, proliferation, differentiation and neovascularization.13
• Slower healing
• Cells move below the wound bed
to find a moist area
• Delayed proliferation and remodel­
lation phase
The wound will experience delayed
wound healing.
• Stratamed and Strataderm emulate
the epidermal barrier and enhance
the healing of wounds.
• Stratamed and Strataderm prevent
water loss while maintaining the
oxygen transfer rate.
The wound is kept under an optimal
environment for healing.
Appropriate wound dressing should support the natural healing process;
i.e., should provide a moist wound interface, absorb or remove excess exudate,
prevent contamination and provide an environment favorable to the body’s
natural defense mechanisms.
8
Stratamed’s protective and hydrophobic film has a semi-occlusive
effect and therefore improves the tissue hydration of the
injured skin area. This environment allows a faster migration of
keratinocytes across the wound bed and supports a more rapid
re-epithelialization. The faster re-epithelialization decreases the incidence of
abnormal scarring9,11 and gives patients a faster recovery time.
Stratamed: Reduction of inflammatory response
Stratamed forms a flexible, protective sheet that weakly bonds
to the injured skin and protects it from chemical and microbial
invasion, but it does not penetrate into the epidermis or dermis.9
Startamed has no measurable pH value, and therefore does not
affect the protective acid mantle of the skin and does not react with the newly
forming epithelial tissues.9 This environment leads to a reduction in the inflammatory response (redness/discoloration, burning sensation, itching, discomfort,
pain etc), and therefore enhances therapeutic results.9
Strataderm: Scar management
After the re-epithelialization of a wound, the stratum corneum
is immature and still allows abnormally high levels of TransEpidermal Water Loss (TEWL). Dehydration is signaled to keratino­
cytes, which then start to produce cytokines, which activate
dermal fibroblasts to synthesize and release collagen. Excessive
collagen production leads to abnormal scarring.9
At this stage, the Strataderm layer restores the barrier function of the
stratum corneum, reduces TEWL and stops dehydration of the skin, resulting
in a normal mature scar.6
9
Directions for use
How thin to apply?
Ensure that the affected skin or wound is clean.
Apply a very thin layer directly to the affected area.
To achieve the best results, leave the gel in constant
contact with the skin (24 hours a day/7 days a week).
Compatible with secondary dressings. Once dry, the gel
may be covered by sunscreen or cosmetics.
Stratamed
On damaged or broken skin
not requiring a secondary dressing:
•A
pply a very thin layer of Stratamed to
the affected area and allow the gel to dry.
• Stratamed should be applied once daily,
or twice daily to exposed areas or as advised
by your physician.
• Once dry, Stratamed can be covered by
sunscreen, cosmetics, pressure garments
or casts.
Without the usage of a secondary dressing, Stratamed and Strataderm dry
to form a flexible, protective sheet on the affected skin that is gas permeable
but semi-occlusive. The layer weakly bonds to the skin and protects it from
chemical and microbial invasion, but it does not penetrate into the epidermis
or dermis6.
In order to ensure the optimal function of Stratamed and Strataderm, the
applied layer should be less than the thickness of this piece of paper or as if
you stretch a piece of household clingfilm over your skin.
Strataderm
On damaged skin or wounds
requiring a secondary dressing:
3–4 min
1 Ensure that the scar is clean and dry.
2 Apply a very thin layer of Strataderm to the
scar and allow to dry. When applied correctly,
Strataderm should be dry in 3–4 minutes.
3 If it takes longer to dry you have probably
applied too much. Gently remove the excess
with a tissue and allow the drying process
to continue.
4 Once dry, Strataderm can be covered by sunscreen, cosmetics, pressure garments
or casts.
• Apply a thin layer of Stratamed then cover
with the secondary dressing. Drying is not
necessary.
• Stratamed should be reapplied when changing
the dressing or checking wound progress, or
as advised by your physician.
Stratamed is available in 0.17 oz, 0.35 oz, 0.7 oz and 1.75 oz tubes.
e
onc y
dail
Strataderm is available in 0.17 oz, 0.35 oz, 0.7 oz and 1.75 oz tubes.
0.17 oz (5g)
Enough to treat a 1–2 inch (2–4 cm) linear incision twice per day
for over 90 days.
0.17 oz (5g)
Enough to treat a 1–2 inch (2–3 cm) linear scar for over 90 days.
0.35 oz (10 g)
Enough to treat a 2–3 inch (5–8 cm) linear incision twice per day
for over 90 days.
0.35 oz (10 g)
Enough to treat a 2–3 inch (5–7 cm) linear scar for over 90 days.
0.7 oz (20 g)
Enough to treat a 4–5 inch (10–12 cm) linear incision twice per day for over
90 days or an area of 2.5 × 5 inch (6 × 12 cm) twice per day for over 60 days.
0.7 oz (20 g)
Enough to treat a 4–6 inch (10–14 cm) linear scar for over 90 days.
1.75 oz (50 g)
Enough to treat an area of 5 × 6 inch (12 × 15 cm) twice per day for over 60 days.
1.75 oz (50 g)
Enough to treat an area of 2.5 × 5 inch (6×12 cm) for over 90 days.
10
11
us.stratamed.com
The usage of Stratamed does not require
changes in any existing wound care
protocol. It is a simple addition to your
usual process – but with great effects.
• C an be applied immediately after interventions
• Bacteriostatic, gas permeable and inert9,11
• C reates optimal environment for faster
re-epithelialization resulting in reduced downtime9
• C reates an optimal environment for normalization
of the inflammatory response9
•H
ydrates and protects superficial wounds and
compromised skin9
• Improves the visible outcome of the treatment9
• P rovides symptomatic relief (redness/discoloration,
itching, discomfort, pain)9
•A
llows management of abnormal scarring to begin
earlier than ever before9
us.strataderm.com
Strataderm – for the management of
hypertrophic scars and keloids.
• For old and new scars
• Once per day application
• Used to soften and flatten raised scars4
•U
sed to relieve the itching and discomfort
associated with scars4
• Used to reduce redness and discoloration4
Manufactured by:
Stratpharma AG
Centralbahnplatz 8
CH-4051 Basel
Switzerland
7. Hanasono MM et al. Facial Plast Surg 2004;6:88–93
8. Gauglitz GG et al. Mol Med 2011;17(1–2):113–125
9. Sandhofer M, Schauer P. Skinmed 2012; 10(6):1–7
10. Data on file. Stratpharma AG
11. Monk EC et al. Dermatol Surg 2014; 40:76–79
12. S ussman C, Bates-Jensen B. Wound care. Philadelphia: Wolters Kluwer/Lippincott
Williams & Wilkins Health; 2012
13. Jones K, Fennie K, Lenihan A. Advances in Skin & Wound Care. 2007;20:591–600
To contact a Stratpharma
representative in USA please call
(877) 226-7525
Switzerland
SM-SD-US-050-2-0116
References
1. Upton Z et al. Wounds Int 2011; 2(1):7–8
2. Curtis JM, Colas A. Biomaterials Science, 2nd Edition; Ratner, B. D., Ed.;
Elsevier: London, UK, 2004, 80
3. Thomas X. Dow Corning technical paper, Form No. 52-1057–01
4. Tobola J. Dermat Estetyczna 2004;35(6):323–328
5. Monstrey S et al. JPRAS 2014;1–9
6. Mustoe TA. Aesth Plast Surg 2008;32:82–92