Louise See Hoe - PhD Candidate
'Mechanisms and clinically relevant actions of sustained ligand-activated preconditioning (SLP)'
I graduated from a Bachelor of Biomedical Science from Griffith
University in 2007. After a few months’ work as a Technical Assistant, I
accepted the role as Senior Research Assistant for the Heart
Foundation Research Centre at Griffith University for Prof.
John Headrick. After working in this position for 3 years, I decided to
undertake my own PhD project to further my career. My project titled
'Mechanisms and clinically relevant actions of sustained ligand-activated
preconditioning (SLP)', aims to uncover the biochemical signalling
pathways of our novel therapy that leads to potent protection against the
injury generated after a heart attack. This novel therapy (SLP) is
important because it protects both older and diseased hearts, which is a
striking difference to the current limited therapies that exist which all
lose their potency in this target population.
Publications:
Peart JN., See Hoe LE., Gross GJ., Headrick JP. Sustained ligand-activated preconditioning via
delta-opioid receptors. J Pharmacol Exp Ther. 2011; 336(1):274-81. (IF: 3.89, citations: 16).
Williams-Pritchard G., Knight M., See Hoe L., Headrick JP., Peart JN. Essential role of EGFR in
cardioprotective and signaling responses to A1 adenosine receptors and ischemic preconditioning.
Am J Physiol Heart Circ Physiol. 2011; 300(6):H2161-8. (IF: 3.63, citations: 14).
Peart JN., See Hoe L., Pepe S., Johnson P., Headrick JP. Opposing Effects of Age and Calorie
Restriction on Molecular Determinants of Myocardial Ischemic Tolerance. Rejuvenation Res. 2012;
15(1): 59-70. (IF: 2.92, citations: 2).
Budiono BP., See Hoe LE., Peart JN., Sabapathy S., Ashton KJ., Haseler LJ., Headrick JP.
Voluntary wheel-running modulates myocardial ischemic tolerance, signaling kinases and gene
expression in mice. Am J Physiol Regul Integr Comp Physiol. 2012; 302(9): R1091-100. (IF: 3.28,
citations: 2).
Ashton KJ., Tupicoff A., Williams-Pritchard G., Keissling CJ., See Hoe LE., Headrick JP, Peart JN.
Unique transcriptional profile of sustained ligand-activated preconditioning in pre- and post-ischemic
myocardium.
PLOS
ONE.
2013
Aug
21;8(8):e72278.
(IF:
3.73,
citations:
0).
Liaw NY., See Hoe LE., Sheeran FL., Peart JN., Headrick JP., Cheung MM., Pepe S. Postnatal
shifts in ischemic tolerance and cell survival signalling in murine myocardium. Am J Physiol Regul
Integr Comp Physiol. 2013 Nov;305(10):R1171-81. (IF:3.28, citations: 0).
Peart JN., Pepe S., Reichelt ME., Beckett N., See Hoe LE., Ozberk O., Niesman IR., Patel HH.,
Headrick JP. Dysfunctional survival-signaling and stress-intolerance in aged murine and human
myocardium. Exp Gerontol. 2014 Feb;50:72-81. (IF: 3.91, citations 0).
Foster SR., Blank K., See Hoe LE., Behrens M., Meyerhof W., Peart JN., Thomas WG. Bitter taste
receptor agonists elicit G-Protein-dependent negative inotropy in the murine heart. FASEB J. 2014
Jul 1. [Epub ahead of print].
See Hoe LE., Schilling JM., Tarbit E., Kiessling CJ., Busija AR., Niesman IR., Du Toit EF., Ashton
KJ., Roth DM., Headrick JP., Patel HH., Peart JN. Sarcolemmal cholesterol and caveolin-3
dependence of cardiac function, ischemic tolerance and opioidergic cardioprotection. Am J Physiol
Heart Circ Physiol. 2014 Jul 25. [Epub ahead of print].