Chapter 1 Introduction Obesity is simply defined as a condition in which excess body fat is accumulated. The definition of obesity is based on the Body Mass Index (BMI; weight (kg)/height (m2). It is generally agreed that a BMI of greater than 30 is indicative of obesity, while a BMI of 25.0-29.9 is suggestive of overweight in an individual. BMI ranging between 18.5- 24.99 is considered as normal weight range BMI (Centers for Disease Control and Prevention, 2009). Obesity is increasing at an alarming rate throughout the world and has become a global problem. The World Health Organization (WHO, 2002) has declared that due to overweight many health risks may occur. According to recent estimates, there are more than one billion overweight people worldwide, and approximately 250 million of people to be clinically obese (WHO, 1998a). World health organized presented the data and standards based on reports from different countries. Reports from 79 developing countries including a number of industrialized countries suggest that about 22 million children five years old are overweight worldwide (WHO, 1998b). Once considered a problem related to affluence, obesity is now fast growing in many developing countries and also in the poor neighbourhoods of the developed countries (WHO, 2003; WHO, IASO, & IOTF, 2000). Obese people suffer from guilt, depression, anxiety and low self-esteem. In addition to this there is increased incidence of high blood pressure, increased level of cholesterol and other lipids in the blood, increased diabetes and colon cancer, liver ailments, mechanical difficulties particularly back and foot problems in obese and 1 overweight subjects (Lew and Garfinkel, 1979; Larsson et al, 1981; Hubert et al, 1983; Dyer and Elliott, 1989; Chute et al, 1991; Stampfer et al, 1992; Lipton et al, 1993; Young et al, 1993; Hochberg et al, 1995; Tchernof et al, 1996; Ford et al, 1997; Rexrode et al, 1997). In the field of public health, obesity constitutes one of the important medical and public health problems (Berke and Morden, 2000). Modernisation has led to excess foods those rich in fats along with decrease in physical activity of people leading to conditions that favour obesity. By definition, obesity refers to a condition of building up of body fat beyond that deemed normal for the age, sex, body type of a given individual. Obesity is not only related with a number of health problems but with psychological problems also (Wadden and Foster, 1992; NIH, 1992; Bray et al, 1996; Food and Drug Administration, 1996; Centers for Disease Control and Prevention, 1997; Connolly et al, 1997). In scientific terms, obesity occurs when a person consumes more calories than he or she burns. What causes this imbalance between calories in and calories out may differ from one person to another? Genetically speaking obesity tends to run in families. This is caused both by genes and shared by diet and lifestyle habits, environmental factor - the most important environmental factor is lifestyle. The eating habits and activity level are partly learnt from the people around the person. Overeating and sedentary habits (inactivity) are the most important risk factors for obesity, psychological factor - in some people, anxiety, worry, depression, love failures divorce, loneliness, unmarried, married too late due to financial and other causes, unsuccessful in business, non-cooperation from office colleagues or higher officials leads to emotional excitement, alcoholism, inactivity or moody mentality and causes over eating mostly unnatural and tasty food to satisfy their moods and other factors may all play a part. Excess body weight, especially when it is 2 located in the abdominal region, has a strong association with blood glucose levels, insulin resistance and the development of diabetes. This has been a consistent finding across a range of prospective studies (Despres et al. 2001; Boyko et al. 2000; Njolstad et al. 1998; Chan et al. 1994; Haffner et al. 1991; Charles et al. 1991; Colditz et al. 1990), crosssectional studies (Janssen et al, 2002; Schmidt et al, 1992; Dowse et al, 1991; Skarfors et al, 1991) and recent reviews (Despres et al, 1990; Hodge et al, 1996; Kuller, 1999; WHO, 2000; WHO, 2003). A large number of studies support that central adiposity is the dominant risk factor for the development of Type 2 diabetes, although there are some exceptions. Perry et al. (1995) and Skarfors et al. (1991) found BMI was the dominant risk factor over other measures of central adiposity for risk of developing Type 2 diabetes. A review by Hodge et al (2001) concluded that both overall adiposity and central fat distribution were important independent risk factors for Type 2 diabetes. Some illnesses can also lead to obesity or a tendency to gain weight. These include hypothyroidism, Cushing's syndrome, depression, and certain neurological problems that can lead to overeating. Also, drugs such as steroids and some antidepressants may cause weight gain. A medical person can tell whether there are underlying medical conditions that are causing weight gain or making weight loss difficult. Obesity is of two types: localized and generalized, localized mainly in the abdomen it is called as android obesity as male pattern and when localized in hip region it is called gynoid obesity or female pattern (Pear Shaped). In generalized fat is distributed all over the body without localized condition. Numerous methods are used for weight reduction e.g. physical activity, dieting, surgery, yoga and weight reduction pills and Electrical Muscle Stimulation (EMS). 3 Physical activity is important for physical health, emotional well-being, and achieving a healthy weight. Physical activity may help control the weight by using excess calories that would otherwise be stored as fat. Most foods and many beverages one eats and drink contain calories, and everything one does uses calories. This includes sleeping, breathing, digesting food, and of course, moving around. Balancing the calories a person ingests with the calories he use through physical activity may help maintain him current weight. It may help in the control of body weight and prevent obesity, a major risk factor for many diseases and it makes the person physically fit. Physical fitness is the ability of the human body to function with vigor and alertness, without undue fatigue, and with ample energy to engage in leisure activities, and to meet physical stresses. Muscular strength and endurance, cardio respiratory integrity, and general alertness are the overt signs of physical fitness. Physical fitness is usually measured in relation to functional expectations-that is, typically, by periodic tests measuring strength, endurance, agility, coordination, and flexibility. In addition, stress testing, which ascertains the body's accommodation to powerful, sustained physical stimuli, is used to analyze fitness. If individuals are able to accommodate to the stressors, they are assumed to be fit. Obesity is the number one nutritional disorder in the developed world. According to the most recent National Health and Nutrition Examination Survey (NHANES III, 19881994), between one-third and one-half of US men and women 20 years and older are overweight, and nearly one-fourth are clinically obese. It is often a lifelong problem that preferentially affects women (Dickerson, 2001). The information about the extent of obesity in developing countries is needed in order to assist policy makers and health planners with setting priorities, and for mobilizing and allocating resources to programs 4 (World Health Organization, 1998). Much of the developing world still suffers from nutritional deficiencies such as protein energy malnutrition, iron deficiency anemia, vitamin A and iodine deficiencies (Administrative Committee on Coordination=SubCommittee on Nutrition, 1997). A number of factors have been linked to obesity, including age, gender and socioeconomic status. Patterns of prevalence of overweight and obesity have emerged across different socio-economic groups. In developed countries levels of obesity are higher in the lower socio-economic groups. In developing countries this relationship is reversed Sobal and Stunkard (1989) after reviewing 144 published papers dealing with socioeconomic status (SES) and obesity Found that in developed societies there was an inverse Relationship between SES and obesity among women, i.e., the poor were more likely to be obese. The relationship, however, was inconsistent among men and children of both sexes. A different situation was observed in developing societies (which included data from three native American populations – Apache, Kiowa/Comanche, and Navajo), where the relationship was direct, i.e., the wealthy were more likely to be obese. This applied to men, women and children. In India it has been found that women from lower socioeconomic groups are also significantly more likely to have a low BMI (Griffiths and Bentley, 2001). Clear gender differences are seen in most countries with more women than men being obese (James et. al., 2000; Zargar et. al., 2000 Filozof et. al., 2001; Mokhtar et. al., 2001;Ismail et. al., 2002). In contrast, the proportion of men who are overweight tends to be greater than women. Research on obesity in India has found prevalence to be higher among women (Misra et. al., 2001), and among economically better off persons (Singh et. 5 al., 2000; Griffiths and Bentley, 2001) Higher socio-economic status has been consistently associated with greater risk of obesity and diabetes, but the relationship with educational status appears to be inconsistent (Gupta, 1994; al-Mannai et. al., 1996). In a study of obesity among north Indian women it was found that women working as professional/technical/managers were more prone to be overweight and obese than those working in other fields (Agrawal, 2002). Age wise, a significant increase has also been noticed for obesity. In developed countries it has been found that there occurs an increase in the body weight with ageing, at least up to 50-60 years old (both in men and women). The relationship between obesity and age is similar in developing countries, but the maximum rates of obesity tend to be reached at an earlier age (e.g. 40 years old). The decline in prevalence after this peak is thought to be partly attributed to lower survival rates of obese individuals. In India, it has been found that older women were relatively more overweight and obese than younger women (Agrawal, 2002). There is substantial evidence that body weight is regulated by complex signaling systems that provide afferent signals, including glucostatic, lipostatic, and aminostatic signals to the CNS about the nutritional state of the organism, which are translated into efferent signals that affect energy intake and expenditure (Rosenbaum & Liebel, 1998). Benefits of Physical Activity/ Exercise The benefits to physical activities are simply countless. The list overflows with benefits that affect overall health and fitness, not only of the body but also of the mind. Regular exercises help keep the body healthy, keeps mood relaxed, and protect from chronic diseases. On the whole, exercise can improve performance in anything one does and, in the long run, actually prolong the life. But one of the reasons that have got majority 6 of exercise buffs dashing to the gym or to other exercise sessions is weight loss. Many variables may influence eating behavior and therefore may also influence obesity, including depression, anxiety, stress, social support, race, ethnicity, education and income (Allen et al,2001; Goodman et al, 2002; Haas et al, 2003; Kaplan et al, 2003; Sammel et al, 2003). While the national media and federal websites emphasize the importance of physical activity in controlling body weight, exercise alone is not effective for this purpose. In fact, some research shows no relationship between exercise and body weight in community samples (Goodman et al, 2002). Belly fat reduction is the direct consequence of physical exercises, dieting and lifestyle improvements. It results from changes in eating habits, and it has a direct connection with emotional balance and positive thinking. A large number of people suffer from overweight because of their personal dissatisfaction, disappointments or failure in various aspects of their life. Obesity has been thought to be a behavioral disorder that results from eating too much and exercising less, these factors are associated with weight gain. Changes in the lifestyle including the increased consumption of high fat foods, as well as increasingly sedentary work and leisure habits, undoubtedly contribute to the marked rise in obesity. Studies suggest that the body weight is under substantial genetic control, accounting for approximately one third of the variation in BMI (Bouchard, 1997). Genetic influences appear to contribute to differences among individuals in resting metabolic rate (Rice et al, 1996) as well as body fat distribution (Bouchard, 1998) and weight gain in response to overfeeding (Bouchard et al, 1990). Some people appear to come into the world with a predisposition to obesity, which is readily nourished by a high fat, low activity lifestyle. 7 Energy Expenditure For every physical activity, the body requires energy and the amount depends on the duration and type of activity. Energy is measured in calories and is obtained from the body stores or the food we eat (Davis, 1999). The measurement of the energy expenditure of man depends on the following principle. All the energy used by the body in carrying out either external work or internal work (such as the movements of the heart and respiratory muscles, etc.), or in chemical synthesis (such as the production of enzymes in the digestive juices or of hormones in the endocrine glands), or in maintaining the ionic gradients between the fluids inside and outside the tissue cells, is ultimately degraded into heat (Mccargar, et al, 1992, 1993; Robert, 1996). When measurements of total energy expenditure are needed there are two requirements - first, an accurate account of all of the time spent on each and every activity of the day by the subject. Second, it is necessary to assess the metabolic cost of each activity. The energy expenditure is then calculated by multiplying the time spent in each activity (min) by the metabolic cost of activity (Melby, 1989). Role of Aerobic Exercises In Obesity & Benefits Aerobic means "with oxygen" and aerobic exercise is defined as any long duration exercise of low to moderate intensity using the large muscle groups of the body such as the legs, back, gluteals, arms, etc. By long duration it is meant that in order to achieve the many benefits of aerobic exercise, one must usually sustain this activity for 20 minutes or longer. Activities that are very difficult or "intense" and can only be sustained for brief periods of time (seconds to minutes), are usually anaerobic, or are carried out without oxygen, and do not necessarily produce the same benefits as aerobic exercise. 8 Aerobic exercises have large number of benefits. Aerobic activities strengthen the heart and lungs, making them more efficient and durable, improving quality and quantity of life (Fletcher et al, 1992). These include systemic changes such as reduced cholesterol and blood pressure, improved muscular endurance, reduced body fat, increased metabolism, to name a few (Sarkar et al, 2009). Exercise is known to not only extend the life, but also give more energy to live it to the fullest. Aerobic exercise improves the strength of the bones, ligaments and tendons, allows the body to use fats and sugars more efficiently, burns lots of calories and plays an important role in reducing the onset and symptoms of aging and illness (Sarkar et al, 2009). Aerobic exercise reduces the risk of heart disease, vascular disease and diabetes. Aerobic exercise reduces stress and combats depression as it raises self-esteem and physical awareness. Constant moderate intensity works like bicycling riding, walking etc use up oxygen at a rate in which the cardio respiratory system can replenish oxygen in the working muscles. It is a good activity for fat loss when done in the right amounts but highly catabolic if done in excess. To prevent weight regain after weight loss, it has been recommended that obesity can be treated with a combination of physical exercise and reduced energy intake (Jakicic et al, 2001). Walking is an aerobic exercise that is accessible to many segments of the population because it is convenient, easy and low cost; because exercise intensity during walking is generally below the lactate threshold, walking is considered a typical low-intensity exercise. Aerobic dance, a popular exercise, particularly among women, is representative of moderate- to vigorous-intensity exercise. Okura et al (2002) reported the various positive effects and safety of combining aerobic dance with diet in the treatment of obesity. 9 Leutholtz et al (1995) studied the effects of exercise intensity (40% vs. 60% of heart-rate reserve) on body composition during energy restriction. Because these investigators found that exercising at 60% of the heart-rate reserve was no better at changing the body composition than exercising at 40% of the heart-rate reserve when the total volume of exercise training was controlled, they concluded that exercise intensity did not influence body composition changes. Three prospective studies without weight-loss treatments (Manson et al, 2002; Tanasescu et al, 2002; Kraus et al, 2002) have demonstrated the effects of exercise intensity on plasma lipoproteins, cardiovascular events, CHD, and risk of type 2 diabetes. These studies, reported that exercise intensity was associated with reduced risks (Manson et al, 2002; Tanasescu et al, 2002 ), and a study by Kraus et al (2002) revealed that improvement in plasma lipoproteins were related to the amount of physical activity and not to the exercise intensity. However, few details have been reported on the effects of exercise intensity on improving CHD risk factors and physical fitness during a weight-loss program. Psychological Aspects of Obesity Development of obesity has psychological bearing. Decreasing anxiety and depression by physical exercise has become the most effective treatments to improve mental and physical health. Indeed, the Foundations of Sport and Exercise Psychology text states, “exercise is related to decreases in anxiety and depression as well as increased feelings of general well-being” (Weinberg, 2007). In general research indicates that individuals high in self-efficacy believe they can be successful in an activity, and individuals high in self-esteem are more likely to engage and adhere to an exercise 10 program which may help reduce anxiety and depression (Boyd et. al, 1997). Although the focus of this argument is based on the powerful effects of exercise in improving the mental state. The research reports show a correlation between high self-esteem and the probability of engaging in and maintaining an exercise program (Baxter, 2010). Additionally, as the cognitive processes of children have been categorized by age, the development of selfesteem also seems to be age-dependent and is impacted over time by social interaction and personal experiences. Self-esteem impacts specific factors such as physical self-efficacy, self-confidence, anxiety, and perceived control in both male and female athletes of all ages and across different sports disciplines. An individual’s participation in sports tends to be related to these factors (Boyd et. al, 1997). Additionally, research performed by Gauvin and Spence (1996) indicates that exercise adherers report higher levels of efficacy beliefs about their ability to adhere to exercise as well as their physical proficiency in exercise activities (Gauvin et. al., 1996). This research paired with Boyd’s indicates that not only does participation in exercise activities help to increase self-esteem, but as self-esteem increases the likelihood of continued participation in exercise that provides many health benefits also increases. In contrast, research performed with adolescents who possessed low self-esteem showed tendencies to under-eating and over-eating with less likelihood of adherence to physical activity (Mueller et. al., 1995). These two opposing studies support both lack of participation in physical activity reduces self-esteem while participation in physical activity increases it. Low self-esteem has been implicated in most psychological dysfunctions. However, it appears that low self-esteem is not necessarily the root cause of this dysfunction. It is believed that individuals with high self-esteem who may be predisposed to psychological disorders are better equipped to cope with those disorders, 11 and thus, reduce the negative consequences that may result (Aro, 1994). From this perspective, one could ascertain that if self-esteem can be enhanced, then the psychological consequences of disorders can be reduced. This concept supports the argument that exercise is in the position of being able to contribute to the prevention of illness or the reduction of its effects through the process of improving self-esteem. The study conducted by (Koniak-Griffin, 1994) at UCLA further support this claim. The most unattractive conditions: cellulite, fat and flabby tissue, are without doubt the most common for women over 30 years of age. This result in progressive atrophy of the muscles in the affected area due to the accumulation of fat, which completely encapsulates the muscular abdomen, causing the alterations in the circulation, with an actual hypoxia of the muscles. The muscle shrinks further and further, it deflates, so to speak, leaving room for the fatty capsule, which surrounds it and increases evermore in size and consistency. If obesity is linked with medical conditions, the site of the body, which carries more fat, matters and is associated with diseases. For example, out of two types of obesities, android obesity (more fat deposition in the upper body regions like trunk and abdomen) is more harmful than gynoid obesity (more fat in hip and thighs). Exercise experts and health educationists put more emphasis on increased physical activity in the form of exercise to counter obesity. The major types of exercise programs widely practiced involve aerobics, weight training programs and a combination of aerobics and weight training (Katzel et al, 1995; Pate et al, 1995; NIH, 1996). These exercise programs are usually effective in countering milder forms of obesity and purposive in the sense that improvement or maintenance of physical fitness is an objective. However, weight loss achieved by these techniques is slow and of lower magnitude. 12 Use of Electronic Muscle Stimulation (EMS) In Weight Reduction Electronic Muscle Stimulation (EMS) is a technique of application of externally produced impulses via electrodes, causing the contractions in muscles. This technique finds many uses including weight loss, rehabilitation, and body building, and training technique of athletes. Various electrotherapy modalities e.g. ultrasound, short wave diathermy and interferential therapy are also used by the health and obesity clinics world over to counter obesity (Anderson & Wadden, 1999; Klein, 2000; Jakicic et al, 2001). These clinics are commercially exploiting the people by assuring them fast fat reductions. It is claimed by these professionals that Electrical Muscle Stimulation (EMS) leads to faster and greater weight loss from the fat compartments of the body. The scientific validity of such claims direly needs to be ascertained. Electrical stimulation is effectively used in physiotherapy clinics to provide a situation whereby there is an electrical generation of action potentials; giving rise to therapeutically significant physiological responses e.g. increased muscle strength, stimulated lymph and blood flow, analgesia, kinesthetic awareness and autonomic nervous system responses. It is believed by these clinics that EMS initially breaks the fatty capsule that covers the muscle, improves blood supply to the muscles, and then helps it to gain the lost tone to return to its original size. This return to size and tone gives the abdominal muscles the strength to crumble the fatty capsule from the inside, through their contractions (Bailey, 1976). There are four different types of electrical muscle stimulations. These are regular EMS, transdermal electrical neural stimulation (TENS), interferential (IFT) and Russian muscle stimulation. Out of these, IFT has the ability to stimulate (a) large number of muscle fibers for greater muscular work (b) parasympathetic nerve fibers for causing increased blood flow in the 13 region and (c) deeper tissues at the stimulated sites. According to Gersh (1992); Hayes (2000) and Prentice (2001) neuromuscular electrical stimulation improves increases metabolic demand through activating the muscle pump around the circulation network. They recommend that a low frequency of 20-30 pps with 10- 30% of maximal effort up to 10- 30 minutes duration is most effective. Interference current, utilized as interferential current therapy (IFC), is based on the summation of two alternating-current signals of slightly different frequencies. This results in current having a recurring modulation of amplitude, based on the difference in frequency between the two signals. When these signals are in phase, they sum to amplitude sufficient to stimulate; when the signals are out of phase, no stimulation occurs. Interferential current therapy can deliver high currents compared to other stimulators, and can use 2, 4, or 6 applicators, arranged in either the same plane for use on regions such as the back or in different planes in complex regions such as the shoulder (Gersh,1992; eMedicine Clinical Knowledge Base, 1996). Electrical stimulation affects each phase of wound healing differently, by increasing blood flow that can help in the removal of debris by way of phagocytosis; in addition, by increasing blood flow, electrical stimulation enhances tissue oxygenation. Neuromuscular electrical stimulation (NMES) has been commonly used in physical therapy and rehabilitation to help patients facilitate peripheral circulation, increase muscle power and endurance, and re-educate motor function (Lake et al, 1992; Alon et al, 2008). At the point of health promotion it is gaining significant attention, NMES is introduced to increase physical fitness and reduce the risk of heart disease. Clinically, NMES is provided as an alternative to more conventional forms of exercise to encourage increases in physical activity. This is especially true in the case of those who are unable to engage in physical exercise or have 14 barriers to participation, such as individuals with stroke or spinal cord injury (SCI). NMES has been used to help individuals with SCI exercise or passively move their extremities and is found to significantly improve their aerobic capacity (Raymond et al, 1997; Griffin et al, 2009). Other identified health benefits of using NMES in promoting exercise have been reported and includes improvement in muscle strength/endurance, enhanced peripheral circulation, attenuated bone mineral density loss, improved body composition, more efficient and safer cardiac function, and cardiovascular, and pulmonary training adaptations ( Lai et al, 2010; Sabut et al, 2010). In addition to helping in promoting exercise, another common application of NMES is associated with burning fat in that NMES is given on unloaded muscles, i.e., without loading limbs or joints when an individual is at rest. Commercially, it is claimed to be able to facilitate fat burning and has been used to serve as part of weight loss/control programs. It is assumed that NMES can enhance energy consuming, considering that NMES induces muscle contraction and increase fat utilization. It is thus pertinent to explore the EMS through interferential currents to counter the problem of overweight in the people. In this context the present study has been undertaken on females ranging in age from 20– 40 years to explore the impact of EMS-Interferential program on weight loss as well as the shedding of fat from the abdominal region, so as to reduce the health risks. Objectives Of The Study 1. To study the effect of four weeks of electrical muscle stimulation by Interferential mode on the abdominal region on the thickness of abdominal skinfold. 15 2. To study whether the application of hot water on the abdominal area affects the ability of EMS (IFT) to reduce fat. 3. To compare the effects of aerobic exercise program with the effects observed by electrically stimulating the muscles through Interferential electrical muscle stimulation. Hypothesis The present study endeavours to test the affectivity of electrical muscle stimulation in reducing fat from the specific body sites. The study is based on the hypothesis that Interferential current stimulation (EMS) because of its known ability to (a) stimulate large number of muscle fibers for greater muscular work (b) cause increased blood flow through parasympathetic nerve fibers in the region and (c) stimulate deeper tissues will be effective in loss of fat from the stimulated sites. In addition, the study is also likely to reveal the supportive effect of increasing blood circulation (through hot water bottle application) on the ability of fat reduction by EMS (IFT). If the EMS is found to be effective in reducing fat; then the potential can be exploited to reduce the obesity related disease burden in the society. Inclusion Criteria Only the females in the age range of 20-40 years having BMI > 27 was included in Study Exclusion Criteria The female who are wearing any metallic device in the abdomen was excluded from the study 16
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