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Muscles and Movement
07
The goal of this lecture is to discuss
the basic physiology of skeletal and
smooth muscle (cardiac muscle will be
cover in the cardiovascular section).
This lecture will also introduce issues
linked to the control of movement.
The sections for this lecture are:
Life is a series of chemical reactions
occurring in compartmentalized
Introduction
environments. Skeletal muscule, structure & contraction
Muscle energy metabolism and fiber types The main purpose of life is to keep itself alive
Smooth muscule structure & contraction Physiology, the study of how life works, is
based on the simultaneous occurrence of the
Control of body movement
following three concepts:
levels of organization
structure / function relationship
homeostatic regulation
Introduction
Skeletal muscle structure and
contraction mechanisms
Smooth muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Smooth muscle structure and
contraction
Molecular mechanism of contraction
Excitation - contraction coupling Inputs influencing smooth
muscle contraction
Mechanics of single fiber contraction Types of smooth muscles
Skeletal muscle, energy metabolism,
fiber types and muscle contraction
Control of body movement
Sources of ATP for contraction
Motor control hierarchy
Fiber types in skeletal muscles Whole muscle contraction
Local control of motor neurons
Brain motor centers and the
descending pathways controlled
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Introduction
…the “slap in the face” example
from the neuro lecture…
2
how is info
moving from
touching or
grabing to the
slap in the
face???
1
3
4
6
5
???
Introduction
S
E
2
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Introduction
Skeletal Smooth and Cardiac Muscles Neuro - muscular junction Introduction
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
4
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
5
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
6
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Functions of ATP in
Skeletal Muscle Contraction
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
how to get
from here…
…to here
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
summary
answer
8
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
(link between neuron and muscle)
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
(link between neuron and muscle)
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Skeletal muscle
Myasthenia gravis
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
curare (link between neuron and muscle)
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
(link between neuron and muscle)
10
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
(link between neuron and muscle)
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
(link between neuron and muscle)
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
(link between neuron and muscle)
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Sequence of Events from
Neuron to Muscle
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
(link between neuron and muscle)
12
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
13
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Skeletal muscle
Skeletal muscle structure and
contraction mechanisms
Muscle structure to sarcomere
Molecular mechanism of
contraction
Excitation - contraction coupling Mechanics of single fiber
contraction
Muscle and energy
Skeletal muscle, energy
metabolism, fiber types and
muscle contraction
Sources of ATP for contraction
Fiber types in skeletal muscles Whole muscle contraction
(who “pays the bill” for each muscle fiber type)
14
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Muscle and energy
Skeletal muscle, energy
metabolism, fiber types and
muscle contraction
Sources of ATP for contraction
Fiber types in skeletal muscles Whole muscle contraction
energy
tetanus
fatigue
(who “pays the bill” for each muscle fiber type)
Muscle and energy
Skeletal muscle, energy
metabolism, fiber types and
muscle contraction
Sources of ATP for contraction
Fiber types in skeletal muscles Whole muscle contraction
(who “pays the bill” for each muscle fiber type)
15
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Muscle and energy
Skeletal muscle, energy
metabolism, fiber types and
muscle contraction
Characteristics of the three
Skeletal Muscle Fiber Types
Sources of ATP for contraction
Fiber types in skeletal muscles Whole muscle contraction
(who “pays the bill” for each muscle fiber type)
Muscle and energy
Skeletal muscle, energy
metabolism, fiber types and
muscle contraction
Sources of ATP for contraction
Fiber types in skeletal muscles Whole muscle contraction
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Muscle and energy
Skeletal muscle, energy
metabolism, fiber types and
muscle contraction
Factors Determining
Skeletal Muscle Tension
Sources of ATP for contraction
Fiber types in skeletal muscles Whole muscle contraction
Smooth muscle
Smooth muscle
structure and
contraction
mechanism
Smooth muscle
structure and
contraction
Inputs influencing
smooth muscle
contraction
Types of smooth
muscles
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Smooth muscle
Smooth muscle
structure and
contraction
mechanism
Smooth muscle
structure and
contraction
Inputs influencing
smooth muscle
contraction
Types of smooth
muscles
Smooth muscle
Smooth muscle
structure and
contraction
mechanism
Smooth muscle
structure and
contraction
Inputs influencing
smooth muscle
contraction
Types of smooth
muscles
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Smooth muscle
Smooth muscle
structure and
contraction
mechanism
Smooth muscle
structure and
contraction
Ach
NE
Epi
Inputs influencing
smooth muscle
contraction
Types of smooth
muscles
Smooth muscle
Smooth muscle
structure and
contraction
mechanism
Smooth muscle
structure and
contraction
Inputs influencing
smooth muscle
contraction
Types of smooth
muscles
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Smooth muscle
Smooth muscle
structure and
contraction
mechanism
Smooth muscle
structure and
contraction
Inputs influencing
smooth muscle
contraction
Types of smooth
muscles
(compare Single-Unit and Multi-Unit Smooth Muscles) Smooth muscle
Smooth muscle
structure and
contraction
mechanism
“Inputs influencing Smooth
Muscle Contractile Activity:”
Smooth muscle
structure and
contraction
Inputs influencing
smooth muscle
contraction
Types of smooth
muscles
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Muscle fiber summary
Characteristics of Muscle Fibers
Movement control
Control of body movement
Motor control hierarchy
Local control of motor neurons
Brain motor centers and the
descending pathways they
control
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Movement control
Control of body movement
Motor control hierarchy
Local control of motor neurons
spindle = stretch Golgi = tension Brain motor centers and the
descending pathways they
control
Movement control
Control of body movement
Motor control hierarchy
Local control of motor neurons
Brain motor centers and the
descending pathways they
control
The
Knee Jerk
Reflex
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Movement control
Control of body movement
Motor control hierarchy
Local control of motor neurons
Brain motor centers and the
descending pathways they
control
The
Withdrawal
Reflex
Movement control
Control of body movement
Motor control hierarchy
Local control of motor neurons
Brain motor centers and the
descending pathways they
control
23