FOR EVERY BEAT OF YOUR HEART!
Olive leaf extract
T. Perrinjaquet-Moccetti, Scientific Affairs, Frutarom Health, Switzerland
Food Matters Live
London, 2014 November 19th
Content
• Benolea® : Product information
• Olive leaves: history, botany and traditional usage
• Benolea® : Health effects
• Benolea® : Scientific evidence – Cardiovascular health
Blood lipids
Blood pressure
Safety
• Benolea® : Mechanisms of action
• Summary
Benolea®- Product information
• Olive leaf extract
Typical components:
Type of extract:
Dosage:
(Olea europaea L.)
Oleuropein 16-24 % (m/m)
Polyphenols ≥ 30.0 % (m/m)
powder
500 – 1000 mg / day
• Natural support for cardiovascular health
• Strong antioxidant
• Efficacy and safety confirmed by studies
• High degree of purity thanks to patented EFLA®HyperPure
process
Olive leaves
A traditional remedy & foodstuff
• Broadly cultivated in Mediterranean region
• Traditional usage
 against hypertension, diabetes, atherosclerosis,
inflammation
 against rheumatism, fever
 to topically treat wounds and infections
 as part of daily diet: spices and infusion
Constituents
Oleuropein, the main active component,
several types of flavonoids, flavones and other
polyphenols
Benolea®: Health benefits
Benolea®: Scientific evidence - Cardiovascular health
BLOOD
PRESSURE
Clinical results
Similar blood-pressure reducing effects compared to a standard
antihypertensive drug (Captopril)
Significant dosage-dependent reducing effect on blood pressure
Ref.:
Susalit E, et al. (2011). Phytomedicine; 18(4): 251-8.
Ref.:
Perrinjaquet-Moccetti T, et al. (2008). Phytother Res.; 22(9): 1239-42.
Benolea®: Scientific evidence - Cardiovascular health
Effects on lipid profile of hypertensive human volunteers
BLOOD LIPIDS
Clinical results
(1)
Significant lipid-lowering effect, compared to Captopril
Significant reduction of Triglyceride and Total Cholesterol levels,
slight reduction of LDL-cholesterol
Ref.:
Susalit E, et al. (2011). Phytomedicine; 18(4): 251-8.
Benolea®: Scientific evidence - Cardiovascular health
BLOOD LIPIDS
Clinical results
(2)
Effects on lipid profile of healthy human twins
Significant dosage-dependent reduction of LDL-cholesterol
Ref.:
Perrinjaquet-Moccetti T, et al. (2008). Phytother Res.; 22(9): 1239-42.
Benolea®: Scientific evidence - Safety
Excellent tolerance and safety
SAFETY
Clinical
SAFETY
Tests
Safety parameters within normal range (routine hematology, serum electrolytes,
liver and renal function)
No adverse effects
Acute toxicity study in rats OECD (oral LD50 estimation) **
Test for mutagenic potential (Bacterial Reverse Mutation Assay - Ames-test) *
** in-vivo, * in-vitro
Benolea®: Mechanism of action
Blood pressure decrease:
1. Prevention of constriction of blood vessels due to inhibition of
Angiotensin Converting Enzyme (ACE)
2. Dilation of blood vessels due to an increased production of the
vasodilator nitric oxide (NO)
Blood lipids decrease:
Synergy of multiple components and mechanisms:
•
Inhibition of cholesterol oxidation
•
PPAR modulation
•
ACAT inhibition
•
Reduced intestinal cholesterol absorption
Olive leaf extract for cardiovascular health
Benolea®:
• Lipid-lowering effect
• Blood pressure reducing effect
demonstrated in clinical trials
• Safe and well-tolerated
• Standardized extract
• Suitable for various food applications
FOR EVERY BEAT OF YOUR HEART!
Thank You
www.benolea.com