Press release
11 February 2015
Galapagos receives €1.6 million IWT grant for hepatitis B program
Mechelen,
Belgium;
11
February
2015
–
Galapagos
NV
(Euronext:
GLPG) announces that the Flemish Agency for Innovation through Science and
Technology (IWT) has awarded a €1.6 million grant to support the development of new
antiviral therapies against hepatitis B, in a collaboration project with Prof. Johan Neyts
of the Rega Institute of the University of Leuven and Prof. Stephan Urban of the
University Hospital in Heidelberg.
The goal of the project is to identify novel compounds and targets with the potential to cure chronic
hepatitis B infection, allowing patients to come off current life-long therapy. Research will focus
on compounds against viral protein targets and on inhibitors of host cell proteins. Galapagos will
use its proprietary target and drug discovery platform to identify novel modes of action and screen
for candidate drugs. The Rega and Heidelberg sites will contribute to the development of assays,
perform analysis of the mechanism of action of drug candidates, and bring in expertise of the virus
and its life cycle to accelerate the progression of drug development.
“Chronic hepatitis B is a disease area with significant unmet medical need, and where Galapagos
and its academic partners can bring unique expertise to bear on finding new therapies,” said Dr
Piet Wigerinck, Chief Scientific Officer of Galapagos.
“It would be an enormous advance if patients could be cured of their chronic HBV infection” said
Prof. Johan Neyts, virologist at the University of Leuven.
About chronic hepatitis B
Hepatitis B virus (HBV) is a member of the Hepadnavirus family of small DNA viruses, which are
adapted to infect specifically the livers of different species. In adults HBV infections are typically
acute and self-resolving; however in 5-10% of cases they can become chronic. In children and
infants this rate becomes significantly higher (up to 90%). In chronic infection, the virus
establishes itself in the liver of the host and over time leads to progressively more severe
pathology, including eventually cirrhosis, and, in a proportion of cases, hepatocellular carcinoma
(HCC). The proven link between HBV and HCC makes the virus one of the most significant known
carcinogens.
The disease is a significant burden to world health, with approximately 350 million chronic
sufferers worldwide, and around 650,000 deaths per year attributed to the effects of chronic
HBV infection such as HCC. Treatments currently employed for HBV include prophylactics such
as vaccines to prevent infection or therapeutics to treat established chronic infection. However,
so far no therapeutic vaccines have been developed, and drugs such as nucleosides which are
highly effective at reducing viral load in patients do not result in functional cures in the majority
of cases, even after years of therapy. Interferon therapy can give rise to functional cure in a
small proportion of patients, however, the treatment is poorly tolerated. Because of these issues
new treatments are required, and it is likely that combination approaches like those taken with
the hepatitis C virus will be key to establish functional cures in HBV.
About IWT
The agency for Innovation by Science and Technology (abbreviated as IWT) is the government
agency founded in 1991 by the Flemish Government to support technological innovation projects
in Flanders. Each year IWT distributes about €300 million in subsidies for innovation projects to
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companies, organizations, research and educational institutions in Flanders. In addition to financial
support, IWT also assists companies by, for instance helping them find the right information or the
right partners at home or abroad, providing assistance with the preparation of projects for
European programmes and with technology transfer throughout Europe. IWT also has an
important coordination mandate aimed at promoting close cooperation among all the actors
involved in technological innovation in Flanders.
For more information, please visit
http://www.iwt.be or call +32 2 432 42 00.
About Galapagos
Galapagos (Euronext: GLPG; OTC: GLPYY) is a clinical-stage biotechnology company specialized in
the discovery and development of small molecule medicines with novel modes of action, with a
pipeline comprising three Phase 2 programs, two Phase 1 trials, five pre-clinical studies, and 25
discovery small-molecule and antibody programs in cystic fibrosis, inflammation, and other
indications. In the field of inflammation, AbbVie and Galapagos signed a collaboration agreement
for the development and commercialization of GLPG0634. GLPG0634 is an orally-available,
selective inhibitor of JAK1 for the treatment of rheumatoid arthritis and potentially other
inflammatory diseases, currently in Phase 2b studies in RA and in Phase 2 in Crohn’s disease.
GLPG1205, a first-in-class inhibitor of GPR84, is currently being tested in a Phase 2 proof-of-concept
trial in ulcerative colitis patients. GLPG1690 is a compound that targets pulmonary diseases and
is currently in a Phase 1 trial. AbbVie and Galapagos also signed a collaboration agreement in
cystic fibrosis to develop and commercialize molecules that address mutations in the CFTR gene.
Potentiator GLPG1837 is currently in a Phase 1 trial, and corrector GLPG2222 is at the pre-clinical
candidate stage.
The Galapagos Group, including fee-for-service subsidiary Fidelta, has
approximately 400 employees, operating from its Mechelen, Belgium headquarters and facilities in
The Netherlands, France, and Croatia. Further information at: www.glpg.com
CONTACT
Galapagos NV
Elizabeth Goodwin, Head of Corporate Communications & IR
Tel: +31 6 2291 6240
[email protected]
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that may result in differences are the inherent uncertainties associated with competitive developments, clinical
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potential of our product candidates. Given these uncertainties, the reader is advised not to place any undue
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publication of this document. Galapagos expressly disclaims any obligation to update any such forwardlooking statements in this document to reflect any change in its expectations with regard thereto or any
change in events, conditions or circumstances on which any such statement is based, unless required by law
or regulation.
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