nadph h nadp h2o 4hphac nh4 h2o2 o2h2o 4hoxpacd paps pap pcreat@mD tymsf TYMSULT creat@mD CK acg5p@mD h AGPRim tyr-L thbpt thbpt4acam co2 o2 glu-L h2o akg PPOR TYRASE DCT phe-L PHETA1 TYRDOPO3 nadh co2 h peamn amet h2o THYPX 42A12BOOX h2o h paps 34DHPLACOXHNADPL h h 3ityr-L dopasf h h2o 3MOXTYROX IDHPOXOX2b B5 pac atp h2o ascb-L o2 DOPABMO paps h triodthy IDHPOXOX3 dhdascb h2o for gthrd mepi pap triodthysuf IDHPOXOX4 2amac SFGTH h2o2 nh4 o2 h2o fald Sfglutth adrnl h2o nadh 41R1H2MAE12BOOX nh4 h 34dhmald 34dhoxpeg 34DHOXPEGOX h2o2 cbp@mD MELATNOX ahcys h h2o h coa accoa amet melatn co2 Nacsertn ACSRTNMT B4 5HTRPDOX o2 SRTNACT srtn AMPTASECG cys-L ind3ac@mD transport mechanism uncharacterized co2 h ala-L h ALDD20xm id3acald@mD ala-L nadp seasmet@nD nformanth h 5HXKYNDCL gthox h GTHRDtr selcyst nh4 hLkynr h2o akg h gthrd@eD ala-L GTHPe adsel ADSELK C3 adp 3padsel h h2o im4act im4act@mD lys-L@xD h2o@xD h2o@mD nad@mD o2@xD h2o2@xD nh4@xD im4ac@mD h2o B2 1PPDCRp forglu h ppi cmpntm2amep MACOXO 5forthf 3mlda crn BBHOX 4tmeabutn TMABADH 4tmeabut GHMT3 3htmelys TMLYSOX tmlys TMLYSter tmlys@rD Ntmelys@rD PLYSPSer amet@nD amet@nD cbp h LYSMTF3n Ndmelys@nD LYSMTF2n Nmelys@nDLYSMTF1n peplys@nD ac thp2c ADSL1 h@mD GHMT3m h@mD coa@mD h2o Nacasp NACASPAH gln-L GLNtm Nacasp@mD NACASPtm dcamp GLUNm succ co2 o2akg PCLYSOX pcollglys h2o nad h2o@mD nad@mD AASAD3m h@mD nadh@mD akg ACGAMK L2aadp@mD 2AMADPTm glu-L accoa@mD pram 3hpcoa@mD ile-L@mD ILEt5m val-L@mD VALt5m val-L ILETA GF6PTA VALTA glu-L ILETAm glu-L@mD h@mD h 3MOPt2im3mop@mD 3mob coa@mD nad@mD OIVD2m OIVD1m co2@mD nadh@mD Valine, Leucine, Isoleucine degradation pyr@xD ibcoa@mD ivcoa@mD AGTix fad@mD fad@mD D2 prpp 4MOPt2im 4mop@mD co2@mD nadh@mD gly@xD ala-L@xD f6p atp dnad h 4mop co2@mD nadh@mD OIVD3m LEUTAm glu-L@mD h@mD h@mD coa@mD nad@mD coa@mD nad@mD pyr@mD akg@mD LEUTA glu-L 3MOBt2im3mob@mD gly@mD AGTim glx@xD akg VALTAm glu-L@mD leu-L@mD LEUt5m leu-L akg@mD akg akg@mD E2 ACOAD10m fadh2@mD h2o fadh2@mD ACOAD9m 2mp2coa@mD 2mb2coa@mD GLUPRT ACOAD8m fad@mD fadh2@mD 3mb2coa@mD h2o@mD cbp pi hglu-L adp hco3 h2oatp glu-L h ASPTAm oaa@mD GLUDym nadp@mD h2o@mD 3hmbcoa@mD akg ASPTA coa@mD h@mD HMGCOASi hmgcoa amp glu-L ASNtm Ala, asp, asn ala-L ALATA_L GLUtrglu-L@rD h pyr DASPO1p accoa h2o nad@mD coa h HMGLm coa@mD asn-L ala-D@lD 3hmp@mD 2maacoa@mD DALAt2rL nadh@mD co2@mD accoa@mD ala-D ppcoa@xD h@lD ppcoa ppcoa@mD co2 h co2@xD oaa@xD DALAxt nadph@mD h@mD nh4@mD ala-D@xD h2o@xD o2@xD h@lD 4abut@lD ABUTt2rL 4ABUTtm4abut@mD 4abut DALAOXx ABTArm sucsal@mD SSALxm h@xD PYRt2p pyr D1 nad@mD coa@mD MMSAD1m nadh@mD MMCDp MMCD glu-L@mD 2mop@mD akg@mD accoa@mD acac@mD 3AIBTm 3AIBtm 3aib@mD coa@mD nad@mD PPCOACm adp@mD h@mD pi@mD succ@mD h@mD nadh@mD succoa@mD MMCDm OCOAT1m MMTSADm h@mD nadh@mD h@mD succ@mD aacoa@mD h mmcoa-S 3aib co2@mD atp@mD hco3@mD h@mD mmcoa-S@xD pyr@xD h nad@mD h2o@mD h@xD h2o2@xD co2 glu-L@mD akg@mD h NH4tp nh4@xD nh4 HIBDm ACACT10m GLUDC akg@mD h2o2@xD nh4@xD hmgcoa@mD aacoa AATAi C1 MGCHrm 3HBCOAHLm HACD9m h@mD nadh@mD glu-L h2o@mD h2o@mD nad@mD GLUt7l glu-L@lD ASNS1 h ppi asp-D@xD ASPDxt asp-D 3mgcoa@mD GLNS oaa asp-L gln-L h2o@xD o2@xD h@mD pi@mD 3hibutcoa@mD nh4 atp h@mD ALAR glu-L@mD MCCCrm adp@mD ECOAH9m glu-L@mD ASPGLUm atp asn-L@mD ECOAH12m pi h2o@mD h2o@mD nad@mD h@mD nadh@mD nh4@mD hco3@mD h2o@mD gln-L h adp akg B1 pyr 2mbcoa@mD co2 asp-L@mD ASNNm h@mD glu-L A1 h nadph prpncoa@mD atpxmp h2o GLUDxm GLUt2m h L2aadp 2oxoadp 3hpcoa@xD GMPS2 nh4@mD AASAD3 h nadh akg@mD glx@mD glu-L ala-L@mD ppi hglu-L amp h2o gmp CBPS L2aadp6sa 3htmelys@mD pcollg5hlys mthgxl h2o@mD h2o@xD h ADSS ASPNATm gln-L@mD h2o@mD L2aadp6sa@mD nh4 h2o nadp PRPNCOAHYDxPRPNCOAHYDm MCDm co2@mD accoa@mD 3mop ASP1DC gtp imp nh4@mD AAPSAS glu-L@mD gly@mD 4tmeabut@mD h2o2 cysam ALR accoa acgam6p gam6p ACGAM6PSi h asp-L SACCD4m CYSAMO atp@mD h h@mD nadph@mD h coa adp h atp ASPCTr cbasp pi h gdp fum h2o Ntmelys@nD NTMELYStner hyptaur o2 h o2 ile-L ppi hglu-L amp h2o THP2Ctp saccrp-L@mD h2o@mD nadp@mD HYPTROX ura ppi glu-L pi aact o2 AACTOOR h DURAD C2 LPCOXp h2o@mD amet@nDahcys@nD 56dura Lpipecol@xD nadp@mD PEPLYStn ahcys@nD ahcys@nD h2o@rD h2o DHPM1 NADS2 amp pepslys@rD h cala nad SACCD3m o2 akg h2o h glu-L@mD akg@mD glu-L peplys@eD succ co2 nh4co2 prpncoa@xD malcoa@mD h@mD h2o 3hpcoa hnadph APAT2rm BALAtmr ala-B msa@mD ala-B@mD GluForTx h nadh EPCTX 3hpp h coa 3HPCOAHYD nadp h@mD nadh@mD ala-B@mD thf h2o2@xD h@xD thp2c@xD h@mD h2o co2 NABTNOm BAMPPALDOXm h h ppi cmp2amep h@mD akg@mD lys-L@mD h 3SALACBOXL E3 h@mD nadh@mD 4aabutn@mD h2o@mD nad@mD h h2o nad nad@xD nadph@mD h LCYSTATm bamppald@mD IZPN h2o2 nh4 2ameph ctp 4abut acgam o2@xD gly SLDxm co2 n4abutn@mD h2o@mD nad@mD NABTNO h nadh 4aabutn h nadh beta-alanine h2o 3mldz CPCTDTX h@xD nadh@xD lys-L LYStm nad h2o LCYSTCBOXL coa h n4abutn h2o nad h2o nad 4izp h nadh h Lcyst@mD glu-L URCN h2o ntm2amep ctp 1pipdn2c@xD 2OXOADOXm 2oxoadp@mD h2o@xD akg akg@mD 3spyr@mD akg urcan h mhista MHISOR ECOAH1x 3hbcoa@xD b2coa@xD o2 h glu-L@mD h@mD nadh@mD nh4 ahcys im4ac PPD2CSPp nadh@mD co2@mDnad@mDcoa@mD aact@mD AACTtm HISD SAMHISTA h nadh 6a2ohxnt@xD Lysine degradation co2@mD 2AMACSULT Lcyst PTRCAT1 UPPN amet IMACTD h@mD nadh@mD his-L HISDC h2o nad IMACTD_m LYSOXp coa@mD succ co2 3spyrLCYSTAT sl-L D3 APRTO2 ABUTD h nadh h hista HISTASE o2 HACD1x SLDx 2amac accoa h2o2 nh4 BAMPPALDOX co2 LYStip akg@mD h@xD nadh@xDnad@xD SLDt pap nadp nadph paps taur@xD h2o nad NBAHH_ir nh4 h2o2 o2h2o h2o@xD pyr thcys AOBUTDsm akg taur h2o2 nh4 h2o2 nh4 bamppald lys-L LYStn 2OXOADPTm aacoa@xD 3SALAOX glu-L hnadh nad TAURtcx PTRCOX1 13DAMPPOX akg A2 cys-L@mD nad na1 4abutn carn lys-L@nD 2aobut@mD h@mD nh4 na1@xD h2o o2 13dampp kynate AMCOXO glutcoa@mD mercppyr@mD PRO1x fad pro-L o2 cmusa nh4 2oxoadp fadh2@mD co2@mD h@mD fad@mD CYSTAm CYSLYSL o2 aprut ptrc h2o o2 h2o o2 nadp h2o@mD PROD2 P5CR so4 urea@mD h2o AM6SAD ECOAH1m b2coa@mDGLUTCOADHm 3hbcoa@mD nadp PROtm ptrc@mD SELNPS h nadh amuco h h2o nadph HACD1m P5CRx nadh h akg@mD h2o PCLAD h@mD nadh@mD nad@mD h fadh2 h nadph h glu-L@mD AGMTm gthox@eD h2o2@eD h2o@eD co2 aacoa Lcystin h2o akg glu-L SULFOX h focytC@mD gly GLYATm coa@mD CYSTA h2o h nadh amet gly@mD 1pyr5c PROD2m nad@mD fadh2@mD mlthf@mD accoa@mD gthrd h2o@mD sel SELADT amp pi selnp am6sa cys-L CYSGLTH sl-L@mD h2o2 KYNATESYN CYSO 3sala GNMT SARDHm gthox PROt2rL SPMDOX h2o nad coa 3SPYRSP 3snpyr3SALATAi pyr fad@mD nad ppi h seln o2 sarcsSARCStp h ahcys fad@mD thf@mD E4 nh4 h ficytC@mD PRO1xm sarcs@mDSARCStm so3 h2o2@mDGTHPmh2o@mD atp dttOX h 4aphdob anth h h akg h h@lD atp 3HAO QUILSYN CYSTGL h2o glu-L h gthox@mD h2o ala-L tcynt MCPST mercppyr nadh@mD h@mD h@mD KYNAKGAT glu-L KYN 3hanthrn o2 MCLOR nad@mD 2obut SELCYSLY B3 h2o HKYNH h sl-L@eD GTHOm h selcys dtt Lkynr KYN3OX h cyan pro-L@lD atp h2o 3HXKYNDCL h nadh h2o@xDo2@xD FALDtmfald@mD agm@mD SELCYSTGL o2nadphh 3hxkynam h2o TCYNTtm SELCYSTS h2o h nadp h2o MCLACCYSR mercplaccys mercplac nadph@mD nadp@mD h ser-L for glu-L akg aacoa@mD DMGDHm h@mDso3@mD h2o gthrd@mD 42A3HP24DB h2o dmgly@mD fad@mD h2o@mD fadh2@mD fald@xD h2o2@xD cyst-L h selhcys FKYNH quln asp-L@mD akg@mD asp-L h@mD CYSTS glu5sa adn h2o2 nh4 46dhoxquin nad nad GTHRDt adp pi gthrd@rD SEAHCYSHYD o2 co2 glu-L@mD h2o@mD so3@mD h@mD 3SPYRSPm 3SALATAim 3SALAASPm pyr@mD 3snpyr@mD 3sala@mD atp 5HXKYNOXDA 3HKYNAKGAT ACGSm h h2o pro-L@mD DMGtm 2obut coa@mD h@mD acglu@mD nadp@mD nad@mD GTHP h2o2 h2o co2 5hxkynam Lfmkynr nadh h accoa@mD h@mD fadh2@mD P5CRm P5CRxm pi adp atp seahcys h LFORKYNHYD nad@mD h@mD nadph@mD h@mD nadh@mD nadph GTHO gthrd GTHS glucys SEAHCYStn 5hxkyn TRPO2 h2o h2o o2 hcys-L G5SADs GLUCYS h pi dna5mtc@nD seahcys@nD o2 3HXKYNOXDA tsul@mD dmgly adn AHC ahcys fald D4 h@mDnadh@mD P5CDm h2o nadh@mDh@mD nad@mD h2o@mD nh4 h2o2 fum CYANtm h2o@mD atp h@nD DNAMTSEn trp-L LTDCL trypta nad h2o 48dhoxquin h2o@mD gly adp seasmet SEASMETtn dna@nD h so3@mD so4@mD atp@mD G5SADrm gluala@eD 1pyr5c@mD SELMETAT nh4 h2o2 o2h2o TRYPTAOX glyb ser-L cys-L thbpt id3acald betald met-L glu-L@mD GLU5Km adp@mD GTMLTe pi ppi TRPHYDRO2 o2 nadh GGLUCT cgly@eD h@mD cys-L@eD h@mD nadph@mD glu-L thbpt4acam nmthsrtn f5hoxkyn ALDD20x h2o@eD C4 pi@mD nadp@mD h2o h cholp adp h 5mthf AHCYStn CYANSTmtcynt@mD cyan@mD glu5p@mD G5SDym glu5sa@mD AMPTASECGe h2o 34dhoxmand selmeth atp SRTNMTX SRTN23OX ind3ac mal-L mal-L 5htrp ahcys CHOLK h2o nad METS BHMT h2o dna5mtc@nD ahcys@nD fum o2 amet MELATN23DOX chol h mal-L@mD gly@eD o2 fna5moxam fum@mD MALTSULtm FUMTSULtm FUMSO3tm MALSO3tm FUMSO4tm MALSO4tm ORNTArm o2 h 5HLTDL CHLtm thf h@nD tsul so3 mal-L@mD so4 fum@mD nadph nadh METAT amet DNAMTn 5oxpro OPAHir h h AMETtn dna@nD akg@mD h2o atp cgly 5HOXINOXDA nadphh o2 6hoxmelatn chol@mD CHOLD2m BETALDHx amet@nD adp h pi 5hoxnfkyn h2o2 ser-L@mD h nadh h2o atp h2o nh4 h2o GLYBtm h@mD h2o o2 h@mD succoa@mD co2@mD coa@mD GHMT2rm atp nadp mmcoa-S@mD MMEm E1 5aop@mD fad@mD betald@mD BETALDHxm Methionine and cysteine metabolism citr-L@mD 5HOXINDACTO2OX h nadh@mD h@mD nad@mD h2o@mD fadh2@mD glyb@mD nadh nadph ALASm thf@mD h h h 5hoxindact lpam@mD nadh@mD h@mD hco3@mD 3mox4hoxm 5HOXINDACTOX 5hoxindoa gly@mD h2o@mD GCC2cm nad@mD h@mD h2o ACSOMT h2o2 citr-L OCBTm h2o nad mlthf@mD 2obut OBDHc pi@mD nad h2o nh4 co2 nadh ppcoa nh4@mD CBPSam GLYOp glx@xD h@mD GCC2am ORNt4m 34DHXMANDACOXHNADPL 34DHXMANDACOX h2o GCC2bim coa nad ppi pi o2 h2o 41R2A1H12BOOX nadp nad E5 asp-L atp@mD ala-L@xD h2o@xD o2@xDh2o2@xD nh4@xD h@mD pi@mD h@mD adp@mD co2@mD alpam@mD dhlam@mD MMMm mmcoa-R@mD succoa@mD ala-L@xD sarcs@xD SARCOXp gly@xD SPTx SPTix hpyr@xD GLYtp nh4@mD mlthf@mDthf@mD HCO3Em ACODA h2o ametam MAOLNOR nadh@mDh@mD nad@mD h2o@mD h spmd SPRMS sprm thyox-L 3MOX4HOXPGALDOX 3MOX4HOXPGALDOXHNADPL nadh 5mta MTAP gly GCCam thr-L THRD_L atp co2@mD h2o@mD ser-L@xD pyr@xD gly@xD 5mdr1p MTRI h2o h2o mlthf GLYtm h@mD alpro@mD GCCbim glx@mD ARGSS orn@mD h2o2 nh4 3m4hpga nadh nad h dhlpro@mD pi h amp ORNt3m lpro@mD h2o nh4@mD mlthf@mDthf@mD co2@mD pyr@mD ppi no SERtp ser-L GHMT2r phom glu-L@mD DDPGAm argsuc NOS2 ac normete-L h2o o2 h2o2 nad h 5HOXINDACTOXm 5hoxindoa@mD 5hoxindact@mD 5mdru1p dkmppMDRPD o2 h2o h@mD orn ORNDC h GCCcm EHGLAT2m EHGLATm THRS h mma MAOX FALDH pi h for h ptrc SPMS pi acorn SALMCOM o2 h2o DKMPPD 2kmb h2o co2 ametam h prpp ade ahcys SALMCOM2 h ADPT glu-L gln-L amet h amet h UNK2 UNK3 h amet ahcys ahcys urea h@mD nadh@mD nad@mD akg@mD asp-L@mD SERHL thf 4h2oglt@mD h h2o nadp D5 UREAtm urea@mD ppi o2 h NORANMT coa pheacgln C5 h H2O2syn amp EHGLAT glu-L 4h2oglt o2 ARGNm akg oaa@mD nwharg nadph arg-L@mD met-L nadp nrpphr phaccoa gln-L acac glu-L TRIODTHYSULT PHACCOAGLNAC NOS1 h@mD ARGDCm nadph h2o2 paps NRPPHRSULT nrpphrsf PACCOAL amet co2@mD agm@mD i 35diotyr e4hglu akg h2o nadp ARGN h2o@mD fum h DOPAMT pap ARGSL PGCD pyr@xD pi 2amac 2AMACHYD nadh@mD h@mD e4hglu@mD co2 ametam nad 3pg 3php PSP_L h2o h2o pyr ADMDC o2 34hpp@mD nh4 amet h h 3moxtyr 3mox4hpac 3M4HDXPAC homoval h Glycine, Serine, and Threonine metabolism h h nadph ARGtm glu-L nadh h PSERT h2o nad@mD PHCDm h@mD nadh@mD h@mD Urea cycleArg and Pro 4fumacac hahcys amet nh4 h2o2 o2h2o nadph ahcys h2o TYRTAm glu-L@mD h2o nad akg pser-L h2o@mD 4HGLSDm fum FUMAC nadh h2o@mD nad@mD akg@mD MACACI dopa 1p3h5c@mD PHCHGSm 4mlacac DOPASULT nadp coa accoa@mDACACT1rm h@mD h2o@mD h pap h2o nadph amp ppi ACACT1r HPROxm h@mD nadh@mD 4hglusa@mD arg-L HGNTOR h ahcys nadp ALDD19x ALDD19xHPL accoa 4hpro-LT@mD nad@mD GLYAMDTRc co2 hgentis i IDHPOXOXb o2 h2o2 nh4 34dhpac h A5 iodine o2 34DHPLACOX 34DHPHAMT h2o h2o nad A3 gudac 34HPPOR h2o h2o2h o2 i PEAMNO nadh TYRDOPO co2 nad 34dhpha h2o2 nh4 pacald nadp h2o GACMTRc creat tyr-L@mD o2 3HLYTCL h2o o2 A4 co2@rD succ@rD 4hpro-LT@rD gly amet h PROAKGOX1r h2o2@xD h@xD 1p2cbxl@xD pro-D h PHETA1m h CKc pcreat o2@rD DPROOp PRODt2rL 34hpp TYRTA 34dhphe PHYCBOXL phe-L@mD 5moxact CRTNsyn ahcys atp pro-L@rD akg@rD o2@xD h@lD h collagen degradation pro-D@xD pro-D@lD DARGOp h2o2@xD nh4@xD 5g2oxpt@xD CREATtmdiffir adp glu-L akg tyr-L DOPAQNISO1 pi crtn dopaqn 2c23dh56dhoxin DOPACHRMISO h h h2o@xD o2@xD DORNOp h2o2@xD nh4@xD 5a2opntn@xD atp@mD PCREATtmdiffir TYR3MO2 o2 h2o h h glu-L@mD akg@mD phpyr@mD o2 melanin 56dihindlcrbxltL-dpchrm o2 phpyr TYRCBOX o2 PHETHPTOX2 thbpt nadp@mD pi@mD acg5sa@mD co2 thbpt4acam 2hyoxplac adp@mD h@mD nadph@mD arg-D@xD orn-D@xD h2o@xD o2@xD tym 4HOXPACDOXHNADPL TYROXDAc hpyr@xD nadph h nadp h2o 4hphac nh4 h2o2 o2h2o 4hoxpacd paps pap pcreat@mD tymsf TYMSULT creat@mD CK acg5p@mD h AGPRim tyr-L thbpt thbpt4acam co2 o2 glu-L h2o akg PPOR TYRASE DCT phe-L PHETA1 TYRDOPO3 nadh co2 h peamn amet h2o THYPX 42A12BOOX h2o h paps 34DHPLACOXHNADPL h h 3ityr-L dopasf h h2o 3MOXTYROX IDHPOXOX2b B5 pac atp h2o ascb-L o2 DOPABMO paps h triodthy IDHPOXOX3 dhdascb h2o for gthrd mepi pap triodthysuf IDHPOXOX4 2amac SFGTH h2o2 nh4 o2 h2o fald Sfglutth adrnl h2o nadh 41R1H2MAE12BOOX nh4 h 34dhmald 34dhoxpeg 34DHOXPEGOX h2o2 cbp@mD MELATNOX ahcys h h2o h coa accoa amet melatn co2 Nacsertn ACSRTNMT B4 5HTRPDOX o2 SRTNACT srtn AMPTASECG cys-L ind3ac@mD transport mechanism uncharacterized co2 h ala-L h ALDD20xm id3acald@mD ala-L nadp seasmet@nD nformanth h 5HXKYNDCL gthox h GTHRDtr selcyst nh4 hLkynr h2o akg h gthrd@eD ala-L GTHPe adsel ADSELK C3 adp 3padsel h h2o im4act im4act@mD lys-L@xD h2o@xD h2o@mD nad@mD o2@xD h2o2@xD nh4@xD im4ac@mD h2o B2 1PPDCRp forglu h ppi cmpntm2amep MACOXO 5forthf 3mlda crn BBHOX 4tmeabutn TMABADH 4tmeabut GHMT3 3htmelys TMLYSOX tmlys TMLYSter tmlys@rD Ntmelys@rD PLYSPSer amet@nD amet@nD cbp h LYSMTF3n Ndmelys@nD LYSMTF2n Nmelys@nDLYSMTF1n peplys@nD ac thp2c ADSL1 h@mD GHMT3m h@mD coa@mD h2o Nacasp NACASPAH gln-L GLNtm Nacasp@mD NACASPtm dcamp GLUNm succ co2 o2akg PCLYSOX pcollglys h2o nad h2o@mD nad@mD AASAD3m h@mD nadh@mD akg ACGAMK L2aadp@mD 2AMADPTm glu-L accoa@mD pram 3hpcoa@mD ile-L@mD ILEt5m val-L@mD VALt5m val-L ILETA GF6PTA VALTA glu-L ILETAm glu-L@mD h@mD h 3MOPt2im3mop@mD 3mob coa@mD nad@mD OIVD2m OIVD1m co2@mD nadh@mD Valine, Leucine, Isoleucine degradation pyr@xD ibcoa@mD ivcoa@mD AGTix fad@mD fad@mD D2 prpp 4MOPt2im 4mop@mD co2@mD nadh@mD gly@xD ala-L@xD f6p atp dnad h 4mop co2@mD nadh@mD OIVD3m LEUTAm glu-L@mD h@mD h@mD coa@mD nad@mD coa@mD nad@mD pyr@mD akg@mD LEUTA glu-L 3MOBt2im3mob@mD gly@mD AGTim glx@xD akg VALTAm glu-L@mD leu-L@mD LEUt5m leu-L akg@mD akg akg@mD E2 ACOAD10m fadh2@mD h2o fadh2@mD ACOAD9m 2mp2coa@mD 2mb2coa@mD GLUPRT ACOAD8m fad@mD fadh2@mD 3mb2coa@mD h2o@mD cbp pi hglu-L adp hco3 h2oatp glu-L h ASPTAm oaa@mD GLUDym nadp@mD h2o@mD 3hmbcoa@mD akg ASPTA coa@mD h@mD HMGCOASi hmgcoa amp glu-L ASNtm Ala, asp, asn ala-L ALATA_L GLUtrglu-L@rD h pyr DASPO1p accoa h2o nad@mD coa h HMGLm coa@mD asn-L ala-D@lD 3hmp@mD 2maacoa@mD DALAt2rL nadh@mD co2@mD accoa@mD ala-D ppcoa@xD h@lD ppcoa ppcoa@mD co2 h co2@xD oaa@xD DALAxt nadph@mD h@mD nh4@mD ala-D@xD h2o@xD o2@xD h@lD 4abut@lD ABUTt2rL 4ABUTtm4abut@mD 4abut DALAOXx ABTArm sucsal@mD SSALxm h@xD PYRt2p pyr D1 nad@mD coa@mD MMSAD1m nadh@mD MMCDp MMCD glu-L@mD 2mop@mD akg@mD accoa@mD acac@mD 3AIBTm 3AIBtm 3aib@mD coa@mD nad@mD PPCOACm adp@mD h@mD pi@mD succ@mD h@mD nadh@mD succoa@mD MMCDm OCOAT1m MMTSADm h@mD nadh@mD h@mD succ@mD aacoa@mD h mmcoa-S 3aib co2@mD atp@mD hco3@mD h@mD mmcoa-S@xD pyr@xD h nad@mD h2o@mD h@xD h2o2@xD co2 glu-L@mD akg@mD h NH4tp nh4@xD nh4 HIBDm ACACT10m GLUDC akg@mD h2o2@xD nh4@xD hmgcoa@mD aacoa AATAi C1 MGCHrm 3HBCOAHLm HACD9m h@mD nadh@mD glu-L h2o@mD h2o@mD nad@mD GLUt7l glu-L@lD ASNS1 h ppi asp-D@xD ASPDxt asp-D 3mgcoa@mD GLNS oaa asp-L gln-L h2o@xD o2@xD h@mD pi@mD 3hibutcoa@mD nh4 atp h@mD ALAR glu-L@mD MCCCrm adp@mD ECOAH9m glu-L@mD ASPGLUm atp asn-L@mD ECOAH12m pi h2o@mD h2o@mD nad@mD h@mD nadh@mD nh4@mD hco3@mD h2o@mD gln-L h adp akg B1 pyr 2mbcoa@mD co2 asp-L@mD ASNNm h@mD glu-L A1 h nadph prpncoa@mD atpxmp h2o GLUDxm GLUt2m h L2aadp 2oxoadp 3hpcoa@xD GMPS2 nh4@mD AASAD3 h nadh akg@mD glx@mD glu-L ala-L@mD ppi hglu-L amp h2o gmp CBPS L2aadp6sa 3htmelys@mD pcollg5hlys mthgxl h2o@mD h2o@xD h ADSS ASPNATm gln-L@mD h2o@mD L2aadp6sa@mD nh4 h2o nadp PRPNCOAHYDxPRPNCOAHYDm MCDm co2@mD accoa@mD 3mop ASP1DC gtp imp nh4@mD AAPSAS glu-L@mD gly@mD 4tmeabut@mD h2o2 cysam ALR accoa acgam6p gam6p ACGAM6PSi h asp-L SACCD4m CYSAMO atp@mD h h@mD nadph@mD h coa adp h atp ASPCTr cbasp pi h gdp fum h2o Ntmelys@nD NTMELYStner hyptaur o2 h o2 ile-L ppi hglu-L amp h2o THP2Ctp saccrp-L@mD h2o@mD nadp@mD HYPTROX ura ppi glu-L pi aact o2 AACTOOR h DURAD C2 LPCOXp h2o@mD amet@nDahcys@nD 56dura Lpipecol@xD nadp@mD PEPLYStn ahcys@nD ahcys@nD h2o@rD h2o DHPM1 NADS2 amp pepslys@rD h cala nad SACCD3m o2 akg h2o h glu-L@mD akg@mD glu-L peplys@eD succ co2 nh4co2 prpncoa@xD malcoa@mD h@mD h2o 3hpcoa hnadph APAT2rm BALAtmr ala-B msa@mD ala-B@mD GluForTx h nadh EPCTX 3hpp h coa 3HPCOAHYD nadp h@mD nadh@mD ala-B@mD thf h2o2@xD h@xD thp2c@xD h@mD h2o co2 NABTNOm BAMPPALDOXm h h ppi cmp2amep h@mD akg@mD lys-L@mD h 3SALACBOXL E3 h@mD nadh@mD 4aabutn@mD h2o@mD nad@mD h h2o nad nad@xD nadph@mD h LCYSTATm bamppald@mD IZPN h2o2 nh4 2ameph ctp 4abut acgam o2@xD gly SLDxm co2 n4abutn@mD h2o@mD nad@mD NABTNO h nadh 4aabutn h nadh beta-alanine h2o 3mldz CPCTDTX h@xD nadh@xD lys-L LYStm nad h2o LCYSTCBOXL coa h n4abutn h2o nad h2o nad 4izp h nadh h Lcyst@mD glu-L URCN h2o ntm2amep ctp 1pipdn2c@xD 2OXOADOXm 2oxoadp@mD h2o@xD akg akg@mD 3spyr@mD akg urcan h mhista MHISOR ECOAH1x 3hbcoa@xD b2coa@xD o2 h glu-L@mD h@mD nadh@mD nh4 ahcys im4ac PPD2CSPp nadh@mD co2@mDnad@mDcoa@mD aact@mD AACTtm HISD SAMHISTA h nadh 6a2ohxnt@xD Lysine degradation co2@mD 2AMACSULT Lcyst PTRCAT1 UPPN amet IMACTD h@mD nadh@mD his-L HISDC h2o nad IMACTD_m LYSOXp coa@mD succ co2 3spyrLCYSTAT sl-L D3 APRTO2 ABUTD h nadh h hista HISTASE o2 HACD1x SLDx 2amac accoa h2o2 nh4 BAMPPALDOX co2 LYStip akg@mD h@xD nadh@xDnad@xD SLDt pap nadp nadph paps taur@xD h2o nad NBAHH_ir nh4 h2o2 o2h2o h2o@xD pyr thcys AOBUTDsm akg taur h2o2 nh4 h2o2 nh4 bamppald lys-L LYStn 2OXOADPTm aacoa@xD 3SALAOX glu-L hnadh nad TAURtcx PTRCOX1 13DAMPPOX akg A2 cys-L@mD nad na1 4abutn carn lys-L@nD 2aobut@mD h@mD nh4 na1@xD h2o o2 13dampp kynate AMCOXO glutcoa@mD mercppyr@mD PRO1x fad pro-L o2 cmusa nh4 2oxoadp fadh2@mD co2@mD h@mD fad@mD CYSTAm CYSLYSL o2 aprut ptrc h2o o2 h2o o2 nadp h2o@mD PROD2 P5CR so4 urea@mD h2o AM6SAD ECOAH1m b2coa@mDGLUTCOADHm 3hbcoa@mD nadp PROtm ptrc@mD SELNPS h nadh amuco h h2o nadph HACD1m P5CRx nadh h akg@mD h2o PCLAD h@mD nadh@mD nad@mD h fadh2 h nadph h glu-L@mD AGMTm gthox@eD h2o2@eD h2o@eD co2 aacoa Lcystin h2o akg glu-L SULFOX h focytC@mD gly GLYATm coa@mD CYSTA h2o h nadh amet gly@mD 1pyr5c PROD2m nad@mD fadh2@mD mlthf@mD accoa@mD gthrd h2o@mD sel SELADT amp pi selnp am6sa cys-L CYSGLTH sl-L@mD h2o2 KYNATESYN CYSO 3sala GNMT SARDHm gthox PROt2rL SPMDOX h2o nad coa 3SPYRSP 3snpyr3SALATAi pyr fad@mD nad ppi h seln o2 sarcsSARCStp h ahcys fad@mD thf@mD E4 nh4 h ficytC@mD PRO1xm sarcs@mDSARCStm so3 h2o2@mDGTHPmh2o@mD atp dttOX h 4aphdob anth h h akg h h@lD atp 3HAO QUILSYN CYSTGL h2o glu-L h gthox@mD h2o ala-L tcynt MCPST mercppyr nadh@mD h@mD h@mD KYNAKGAT glu-L KYN 3hanthrn o2 MCLOR nad@mD 2obut SELCYSLY B3 h2o HKYNH h sl-L@eD GTHOm h selcys dtt Lkynr KYN3OX h cyan pro-L@lD atp h2o 3HXKYNDCL h nadh h2o@xDo2@xD FALDtmfald@mD agm@mD SELCYSTGL o2nadphh 3hxkynam h2o TCYNTtm SELCYSTS h2o h nadp h2o MCLACCYSR mercplaccys mercplac nadph@mD nadp@mD h ser-L for glu-L akg aacoa@mD DMGDHm h@mDso3@mD h2o gthrd@mD 42A3HP24DB h2o dmgly@mD fad@mD h2o@mD fadh2@mD fald@xD h2o2@xD cyst-L h selhcys FKYNH quln asp-L@mD akg@mD asp-L h@mD CYSTS glu5sa adn h2o2 nh4 46dhoxquin nad nad GTHRDt adp pi gthrd@rD SEAHCYSHYD o2 co2 glu-L@mD h2o@mD so3@mD h@mD 3SPYRSPm 3SALATAim 3SALAASPm pyr@mD 3snpyr@mD 3sala@mD atp 5HXKYNOXDA 3HKYNAKGAT ACGSm h h2o pro-L@mD DMGtm 2obut coa@mD h@mD acglu@mD nadp@mD nad@mD GTHP h2o2 h2o co2 5hxkynam Lfmkynr nadh h accoa@mD h@mD fadh2@mD P5CRm P5CRxm pi adp atp seahcys h LFORKYNHYD nad@mD h@mD nadph@mD h@mD nadh@mD nadph GTHO gthrd GTHS glucys SEAHCYStn 5hxkyn TRPO2 h2o h2o o2 hcys-L G5SADs GLUCYS h pi dna5mtc@nD seahcys@nD o2 3HXKYNOXDA tsul@mD dmgly adn AHC ahcys fald D4 h@mDnadh@mD P5CDm h2o nadh@mDh@mD nad@mD h2o@mD nh4 h2o2 fum CYANtm h2o@mD atp h@nD DNAMTSEn trp-L LTDCL trypta nad h2o 48dhoxquin h2o@mD gly adp seasmet SEASMETtn dna@nD h so3@mD so4@mD atp@mD G5SADrm gluala@eD 1pyr5c@mD SELMETAT nh4 h2o2 o2h2o TRYPTAOX glyb ser-L cys-L thbpt id3acald betald met-L glu-L@mD GLU5Km adp@mD GTMLTe pi ppi TRPHYDRO2 o2 nadh GGLUCT cgly@eD h@mD cys-L@eD h@mD nadph@mD glu-L thbpt4acam nmthsrtn f5hoxkyn ALDD20x h2o@eD C4 pi@mD nadp@mD h2o h cholp adp h 5mthf AHCYStn CYANSTmtcynt@mD cyan@mD glu5p@mD G5SDym glu5sa@mD AMPTASECGe h2o 34dhoxmand selmeth atp SRTNMTX SRTN23OX ind3ac mal-L mal-L 5htrp ahcys CHOLK h2o nad METS BHMT h2o dna5mtc@nD ahcys@nD fum o2 amet MELATN23DOX chol h mal-L@mD gly@eD o2 fna5moxam fum@mD MALTSULtm FUMTSULtm FUMSO3tm MALSO3tm FUMSO4tm MALSO4tm ORNTArm o2 h 5HLTDL CHLtm thf h@nD tsul so3 mal-L@mD so4 fum@mD nadph nadh METAT amet DNAMTn 5oxpro OPAHir h h AMETtn dna@nD akg@mD h2o atp cgly 5HOXINOXDA nadphh o2 6hoxmelatn chol@mD CHOLD2m BETALDHx amet@nD adp h pi 5hoxnfkyn h2o2 ser-L@mD h nadh h2o atp h2o nh4 h2o GLYBtm h@mD h2o o2 h@mD succoa@mD co2@mD coa@mD GHMT2rm atp nadp mmcoa-S@mD MMEm E1 5aop@mD fad@mD betald@mD BETALDHxm Methionine and cysteine metabolism citr-L@mD 5HOXINDACTO2OX h nadh@mD h@mD nad@mD h2o@mD fadh2@mD glyb@mD nadh nadph ALASm thf@mD h h h 5hoxindact lpam@mD nadh@mD h@mD hco3@mD 3mox4hoxm 5HOXINDACTOX 5hoxindoa gly@mD h2o@mD GCC2cm nad@mD h@mD h2o ACSOMT h2o2 citr-L OCBTm h2o nad mlthf@mD 2obut OBDHc pi@mD nad h2o nh4 co2 nadh ppcoa nh4@mD CBPSam GLYOp glx@xD h@mD GCC2am ORNt4m 34DHXMANDACOXHNADPL 34DHXMANDACOX h2o GCC2bim coa nad ppi pi o2 h2o 41R2A1H12BOOX nadp nad E5 asp-L atp@mD ala-L@xD h2o@xD o2@xDh2o2@xD nh4@xD h@mD pi@mD h@mD adp@mD co2@mD alpam@mD dhlam@mD MMMm mmcoa-R@mD succoa@mD ala-L@xD sarcs@xD SARCOXp gly@xD SPTx SPTix hpyr@xD GLYtp nh4@mD mlthf@mDthf@mD HCO3Em ACODA h2o ametam MAOLNOR nadh@mDh@mD nad@mD h2o@mD h spmd SPRMS sprm thyox-L 3MOX4HOXPGALDOX 3MOX4HOXPGALDOXHNADPL nadh 5mta MTAP gly GCCam thr-L THRD_L atp co2@mD h2o@mD ser-L@xD pyr@xD gly@xD 5mdr1p MTRI h2o h2o mlthf GLYtm h@mD alpro@mD GCCbim glx@mD ARGSS orn@mD h2o2 nh4 3m4hpga nadh nad h dhlpro@mD pi h amp ORNt3m lpro@mD h2o nh4@mD mlthf@mDthf@mD co2@mD pyr@mD ppi no SERtp ser-L GHMT2r phom glu-L@mD DDPGAm argsuc NOS2 ac normete-L h2o o2 h2o2 nad h 5HOXINDACTOXm 5hoxindoa@mD 5hoxindact@mD 5mdru1p dkmppMDRPD o2 h2o h@mD orn ORNDC h GCCcm EHGLAT2m EHGLATm THRS h mma MAOX FALDH pi h for h ptrc SPMS pi acorn SALMCOM o2 h2o DKMPPD 2kmb h2o co2 ametam h prpp ade ahcys SALMCOM2 h ADPT glu-L gln-L amet h amet h UNK2 UNK3 h amet ahcys ahcys urea h@mD nadh@mD nad@mD akg@mD asp-L@mD SERHL thf 4h2oglt@mD h h2o nadp D5 UREAtm urea@mD ppi o2 h NORANMT coa pheacgln C5 h H2O2syn amp EHGLAT glu-L 4h2oglt o2 ARGNm akg oaa@mD nwharg nadph arg-L@mD met-L nadp nrpphr phaccoa gln-L acac glu-L TRIODTHYSULT PHACCOAGLNAC NOS1 h@mD ARGDCm nadph h2o2 paps NRPPHRSULT nrpphrsf PACCOAL amet co2@mD agm@mD i 35diotyr e4hglu akg h2o nadp ARGN h2o@mD fum h DOPAMT pap ARGSL PGCD pyr@xD pi 2amac 2AMACHYD nadh@mD h@mD e4hglu@mD co2 ametam nad 3pg 3php PSP_L h2o h2o pyr ADMDC o2 34hpp@mD nh4 amet h h 3moxtyr 3mox4hpac 3M4HDXPAC homoval h Glycine, Serine, and Threonine metabolism h h nadph ARGtm glu-L nadh h PSERT h2o nad@mD PHCDm h@mD nadh@mD h@mD Urea cycleArg and Pro 4fumacac hahcys amet nh4 h2o2 o2h2o nadph ahcys h2o TYRTAm glu-L@mD h2o nad akg pser-L h2o@mD 4HGLSDm fum FUMAC nadh h2o@mD nad@mD akg@mD MACACI dopa 1p3h5c@mD PHCHGSm 4mlacac DOPASULT nadp coa accoa@mDACACT1rm h@mD h2o@mD h pap h2o nadph amp ppi ACACT1r HPROxm h@mD nadh@mD 4hglusa@mD arg-L HGNTOR h ahcys nadp ALDD19x ALDD19xHPL accoa 4hpro-LT@mD nad@mD GLYAMDTRc co2 hgentis i IDHPOXOXb o2 h2o2 nh4 34dhpac h A5 iodine o2 34DHPLACOX 34DHPHAMT h2o h2o nad A3 gudac 34HPPOR h2o h2o2h o2 i PEAMNO nadh TYRDOPO co2 nad 34dhpha h2o2 nh4 pacald nadp h2o GACMTRc creat tyr-L@mD o2 3HLYTCL h2o o2 A4 co2@rD succ@rD 4hpro-LT@rD gly amet h PROAKGOX1r h2o2@xD h@xD 1p2cbxl@xD pro-D h PHETA1m h CKc pcreat o2@rD DPROOp PRODt2rL 34hpp TYRTA 34dhphe PHYCBOXL phe-L@mD 5moxact CRTNsyn ahcys atp pro-L@rD akg@rD o2@xD h@lD h collagen degradation pro-D@xD pro-D@lD DARGOp h2o2@xD nh4@xD 5g2oxpt@xD CREATtmdiffir adp glu-L akg tyr-L DOPAQNISO1 pi crtn dopaqn 2c23dh56dhoxin DOPACHRMISO h h h2o@xD o2@xD DORNOp h2o2@xD nh4@xD 5a2opntn@xD atp@mD PCREATtmdiffir TYR3MO2 o2 h2o h h glu-L@mD akg@mD phpyr@mD o2 melanin 56dihindlcrbxltL-dpchrm o2 phpyr TYRCBOX o2 PHETHPTOX2 thbpt nadp@mD pi@mD acg5sa@mD co2 thbpt4acam 2hyoxplac adp@mD h@mD nadph@mD arg-D@xD orn-D@xD h2o@xD o2@xD tym 4HOXPACDOXHNADPL TYROXDAc hpyr@xD nadph h nadp h2o 4hphac nh4 h2o2 o2h2o 4hoxpacd paps pap pcreat@mD tymsf TYMSULT creat@mD CK acg5p@mD h AGPRim tyr-L thbpt thbpt4acam co2 o2 glu-L h2o akg PPOR TYRASE DCT phe-L PHETA1 TYRDOPO3 nadh co2 h peamn amet h2o THYPX 42A12BOOX h2o h paps 34DHPLACOXHNADPL h h 3ityr-L dopasf h h2o 3MOXTYROX IDHPOXOX2b B5 pac atp h2o ascb-L o2 DOPABMO paps h triodthy IDHPOXOX3 dhdascb h2o for gthrd mepi pap triodthysuf IDHPOXOX4 2amac SFGTH h2o2 nh4 o2 h2o fald Sfglutth adrnl h2o nadh 41R1H2MAE12BOOX nh4 h 34dhmald 34dhoxpeg 34DHOXPEGOX h2o2 cbp@mD MELATNOX ahcys h h2o h coa accoa amet melatn co2 Nacsertn ACSRTNMT B4 5HTRPDOX o2 SRTNACT srtn AMPTASECG cys-L ind3ac@mD transport mechanism uncharacterized co2 h ala-L h ALDD20xm id3acald@mD ala-L nadp seasmet@nD nformanth h 5HXKYNDCL gthox h GTHRDtr selcyst nh4 hLkynr h2o akg h gthrd@eD ala-L GTHPe adsel ADSELK C3 adp 3padsel h h2o im4act im4act@mD lys-L@xD h2o@xD h2o@mD nad@mD o2@xD h2o2@xD nh4@xD im4ac@mD h2o B2 1PPDCRp forglu h ppi cmpntm2amep MACOXO 5forthf 3mlda crn BBHOX 4tmeabutn TMABADH 4tmeabut GHMT3 3htmelys TMLYSOX tmlys TMLYSter tmlys@rD Ntmelys@rD PLYSPSer amet@nD amet@nD cbp h LYSMTF3n Ndmelys@nD LYSMTF2n Nmelys@nDLYSMTF1n peplys@nD ac thp2c ADSL1 h@mD GHMT3m h@mD coa@mD h2o Nacasp NACASPAH gln-L GLNtm Nacasp@mD NACASPtm dcamp GLUNm succ co2 o2akg PCLYSOX pcollglys h2o nad h2o@mD nad@mD AASAD3m h@mD nadh@mD akg ACGAMK L2aadp@mD 2AMADPTm glu-L accoa@mD pram 3hpcoa@mD ile-L@mD ILEt5m val-L@mD VALt5m val-L ILETA GF6PTA VALTA glu-L ILETAm glu-L@mD h@mD h 3MOPt2im3mop@mD 3mob coa@mD nad@mD OIVD2m OIVD1m co2@mD nadh@mD Valine, Leucine, Isoleucine degradation pyr@xD ibcoa@mD ivcoa@mD AGTix fad@mD fad@mD D2 prpp 4MOPt2im 4mop@mD co2@mD nadh@mD gly@xD ala-L@xD f6p atp dnad h 4mop co2@mD nadh@mD OIVD3m LEUTAm glu-L@mD h@mD h@mD coa@mD nad@mD coa@mD nad@mD pyr@mD akg@mD LEUTA glu-L 3MOBt2im3mob@mD gly@mD AGTim glx@xD akg VALTAm glu-L@mD leu-L@mD LEUt5m leu-L akg@mD akg akg@mD E2 ACOAD10m fadh2@mD h2o fadh2@mD ACOAD9m 2mp2coa@mD 2mb2coa@mD GLUPRT ACOAD8m fad@mD fadh2@mD 3mb2coa@mD h2o@mD cbp pi hglu-L adp hco3 h2oatp glu-L h ASPTAm oaa@mD GLUDym nadp@mD h2o@mD 3hmbcoa@mD akg ASPTA coa@mD h@mD HMGCOASi hmgcoa amp glu-L ASNtm Ala, asp, asn ala-L ALATA_L GLUtrglu-L@rD h pyr DASPO1p accoa h2o nad@mD coa h HMGLm coa@mD asn-L ala-D@lD 3hmp@mD 2maacoa@mD DALAt2rL nadh@mD co2@mD accoa@mD ala-D ppcoa@xD h@lD ppcoa ppcoa@mD co2 h co2@xD oaa@xD DALAxt nadph@mD h@mD nh4@mD ala-D@xD h2o@xD o2@xD h@lD 4abut@lD ABUTt2rL 4ABUTtm4abut@mD 4abut DALAOXx ABTArm sucsal@mD SSALxm h@xD PYRt2p pyr D1 nad@mD coa@mD MMSAD1m nadh@mD MMCDp MMCD glu-L@mD 2mop@mD akg@mD accoa@mD acac@mD 3AIBTm 3AIBtm 3aib@mD coa@mD nad@mD PPCOACm adp@mD h@mD pi@mD succ@mD h@mD nadh@mD succoa@mD MMCDm OCOAT1m MMTSADm h@mD nadh@mD h@mD succ@mD aacoa@mD h mmcoa-S 3aib co2@mD atp@mD hco3@mD h@mD mmcoa-S@xD pyr@xD h nad@mD h2o@mD h@xD h2o2@xD co2 glu-L@mD akg@mD h NH4tp nh4@xD nh4 HIBDm ACACT10m GLUDC akg@mD h2o2@xD nh4@xD hmgcoa@mD aacoa AATAi C1 MGCHrm 3HBCOAHLm HACD9m h@mD nadh@mD glu-L h2o@mD h2o@mD nad@mD GLUt7l glu-L@lD ASNS1 h ppi asp-D@xD ASPDxt asp-D 3mgcoa@mD GLNS oaa asp-L gln-L h2o@xD o2@xD h@mD pi@mD 3hibutcoa@mD nh4 atp h@mD ALAR glu-L@mD MCCCrm adp@mD ECOAH9m glu-L@mD ASPGLUm atp asn-L@mD ECOAH12m pi h2o@mD h2o@mD nad@mD h@mD nadh@mD nh4@mD hco3@mD h2o@mD gln-L h adp akg B1 pyr 2mbcoa@mD co2 asp-L@mD ASNNm h@mD glu-L A1 h nadph prpncoa@mD atpxmp h2o GLUDxm GLUt2m h L2aadp 2oxoadp 3hpcoa@xD GMPS2 nh4@mD AASAD3 h nadh akg@mD glx@mD glu-L ala-L@mD ppi hglu-L amp h2o gmp CBPS L2aadp6sa 3htmelys@mD pcollg5hlys mthgxl h2o@mD h2o@xD h ADSS ASPNATm gln-L@mD h2o@mD L2aadp6sa@mD nh4 h2o nadp PRPNCOAHYDxPRPNCOAHYDm MCDm co2@mD accoa@mD 3mop ASP1DC gtp imp nh4@mD AAPSAS glu-L@mD gly@mD 4tmeabut@mD h2o2 cysam ALR accoa acgam6p gam6p ACGAM6PSi h asp-L SACCD4m CYSAMO atp@mD h h@mD nadph@mD h coa adp h atp ASPCTr cbasp pi h gdp fum h2o Ntmelys@nD NTMELYStner hyptaur o2 h o2 ile-L ppi hglu-L amp h2o THP2Ctp saccrp-L@mD h2o@mD nadp@mD HYPTROX ura ppi glu-L pi aact o2 AACTOOR h DURAD C2 LPCOXp h2o@mD amet@nDahcys@nD 56dura Lpipecol@xD nadp@mD PEPLYStn ahcys@nD ahcys@nD h2o@rD h2o DHPM1 NADS2 amp pepslys@rD h cala nad SACCD3m o2 akg h2o h glu-L@mD akg@mD glu-L peplys@eD succ co2 nh4co2 prpncoa@xD malcoa@mD h@mD h2o 3hpcoa hnadph APAT2rm BALAtmr ala-B msa@mD ala-B@mD GluForTx h nadh EPCTX 3hpp h coa 3HPCOAHYD nadp h@mD nadh@mD ala-B@mD thf h2o2@xD h@xD thp2c@xD h@mD h2o co2 NABTNOm BAMPPALDOXm h h ppi cmp2amep h@mD akg@mD lys-L@mD h 3SALACBOXL E3 h@mD nadh@mD 4aabutn@mD h2o@mD nad@mD h h2o nad nad@xD nadph@mD h LCYSTATm bamppald@mD IZPN h2o2 nh4 2ameph ctp 4abut acgam o2@xD gly SLDxm co2 n4abutn@mD h2o@mD nad@mD NABTNO h nadh 4aabutn h nadh beta-alanine h2o 3mldz CPCTDTX h@xD nadh@xD lys-L LYStm nad h2o LCYSTCBOXL coa h n4abutn h2o nad h2o nad 4izp h nadh h Lcyst@mD glu-L URCN h2o ntm2amep ctp 1pipdn2c@xD 2OXOADOXm 2oxoadp@mD h2o@xD akg akg@mD 3spyr@mD akg urcan h mhista MHISOR ECOAH1x 3hbcoa@xD b2coa@xD o2 h glu-L@mD h@mD nadh@mD nh4 ahcys im4ac PPD2CSPp nadh@mD co2@mDnad@mDcoa@mD aact@mD AACTtm HISD SAMHISTA h nadh 6a2ohxnt@xD Lysine degradation co2@mD 2AMACSULT Lcyst PTRCAT1 UPPN amet IMACTD h@mD nadh@mD his-L HISDC h2o nad IMACTD_m LYSOXp coa@mD succ co2 3spyrLCYSTAT sl-L D3 APRTO2 ABUTD h nadh h hista HISTASE o2 HACD1x SLDx 2amac accoa h2o2 nh4 BAMPPALDOX co2 LYStip akg@mD h@xD nadh@xDnad@xD SLDt pap nadp nadph paps taur@xD h2o nad NBAHH_ir nh4 h2o2 o2h2o h2o@xD pyr thcys AOBUTDsm akg taur h2o2 nh4 h2o2 nh4 bamppald lys-L LYStn 2OXOADPTm aacoa@xD 3SALAOX glu-L hnadh nad TAURtcx PTRCOX1 13DAMPPOX akg A2 cys-L@mD nad na1 4abutn carn lys-L@nD 2aobut@mD h@mD nh4 na1@xD h2o o2 13dampp kynate AMCOXO glutcoa@mD mercppyr@mD PRO1x fad pro-L o2 cmusa nh4 2oxoadp fadh2@mD co2@mD h@mD fad@mD CYSTAm CYSLYSL o2 aprut ptrc h2o o2 h2o o2 nadp h2o@mD PROD2 P5CR so4 urea@mD h2o AM6SAD ECOAH1m b2coa@mDGLUTCOADHm 3hbcoa@mD nadp PROtm ptrc@mD SELNPS h nadh amuco h h2o nadph HACD1m P5CRx nadh h akg@mD h2o PCLAD h@mD nadh@mD nad@mD h fadh2 h nadph h glu-L@mD AGMTm gthox@eD h2o2@eD h2o@eD co2 aacoa Lcystin h2o akg glu-L SULFOX h focytC@mD gly GLYATm coa@mD CYSTA h2o h nadh amet gly@mD 1pyr5c PROD2m nad@mD fadh2@mD mlthf@mD accoa@mD gthrd h2o@mD sel SELADT amp pi selnp am6sa cys-L CYSGLTH sl-L@mD h2o2 KYNATESYN CYSO 3sala GNMT SARDHm gthox PROt2rL SPMDOX h2o nad coa 3SPYRSP 3snpyr3SALATAi pyr fad@mD nad ppi h seln o2 sarcsSARCStp h ahcys fad@mD thf@mD E4 nh4 h ficytC@mD PRO1xm sarcs@mDSARCStm so3 h2o2@mDGTHPmh2o@mD atp dttOX h 4aphdob anth h h akg h h@lD atp 3HAO QUILSYN CYSTGL h2o glu-L h gthox@mD h2o ala-L tcynt MCPST mercppyr nadh@mD h@mD h@mD KYNAKGAT glu-L KYN 3hanthrn o2 MCLOR nad@mD 2obut SELCYSLY B3 h2o HKYNH h sl-L@eD GTHOm h selcys dtt Lkynr KYN3OX h cyan pro-L@lD atp h2o 3HXKYNDCL h nadh h2o@xDo2@xD FALDtmfald@mD agm@mD SELCYSTGL o2nadphh 3hxkynam h2o TCYNTtm SELCYSTS h2o h nadp h2o MCLACCYSR mercplaccys mercplac nadph@mD nadp@mD h ser-L for glu-L akg aacoa@mD DMGDHm h@mDso3@mD h2o gthrd@mD 42A3HP24DB h2o dmgly@mD fad@mD h2o@mD fadh2@mD fald@xD h2o2@xD cyst-L h selhcys FKYNH quln asp-L@mD akg@mD asp-L h@mD CYSTS glu5sa adn h2o2 nh4 46dhoxquin nad nad GTHRDt adp pi gthrd@rD SEAHCYSHYD o2 co2 glu-L@mD h2o@mD so3@mD h@mD 3SPYRSPm 3SALATAim 3SALAASPm pyr@mD 3snpyr@mD 3sala@mD atp 5HXKYNOXDA 3HKYNAKGAT ACGSm h h2o pro-L@mD DMGtm 2obut coa@mD h@mD acglu@mD nadp@mD nad@mD GTHP h2o2 h2o co2 5hxkynam Lfmkynr nadh h accoa@mD h@mD fadh2@mD P5CRm P5CRxm pi adp atp seahcys h LFORKYNHYD nad@mD h@mD nadph@mD h@mD nadh@mD nadph GTHO gthrd GTHS glucys SEAHCYStn 5hxkyn TRPO2 h2o h2o o2 hcys-L G5SADs GLUCYS h pi dna5mtc@nD seahcys@nD o2 3HXKYNOXDA tsul@mD dmgly adn AHC ahcys fald D4 h@mDnadh@mD P5CDm h2o nadh@mDh@mD nad@mD h2o@mD nh4 h2o2 fum CYANtm h2o@mD atp h@nD DNAMTSEn trp-L LTDCL trypta nad h2o 48dhoxquin h2o@mD gly adp seasmet SEASMETtn dna@nD h so3@mD so4@mD atp@mD G5SADrm gluala@eD 1pyr5c@mD SELMETAT nh4 h2o2 o2h2o TRYPTAOX glyb ser-L cys-L thbpt id3acald betald met-L glu-L@mD GLU5Km adp@mD GTMLTe pi ppi TRPHYDRO2 o2 nadh GGLUCT cgly@eD h@mD cys-L@eD h@mD nadph@mD glu-L thbpt4acam nmthsrtn f5hoxkyn ALDD20x h2o@eD C4 pi@mD nadp@mD h2o h cholp adp h 5mthf AHCYStn CYANSTmtcynt@mD cyan@mD glu5p@mD G5SDym glu5sa@mD AMPTASECGe h2o 34dhoxmand selmeth atp SRTNMTX SRTN23OX ind3ac mal-L mal-L 5htrp ahcys CHOLK h2o nad METS BHMT h2o dna5mtc@nD ahcys@nD fum o2 amet MELATN23DOX chol h mal-L@mD gly@eD o2 fna5moxam fum@mD MALTSULtm FUMTSULtm FUMSO3tm MALSO3tm FUMSO4tm MALSO4tm ORNTArm o2 h 5HLTDL CHLtm thf h@nD tsul so3 mal-L@mD so4 fum@mD nadph nadh METAT amet DNAMTn 5oxpro OPAHir h h AMETtn dna@nD akg@mD h2o atp cgly 5HOXINOXDA nadphh o2 6hoxmelatn chol@mD CHOLD2m BETALDHx amet@nD adp h pi 5hoxnfkyn h2o2 ser-L@mD h nadh h2o atp h2o nh4 h2o GLYBtm h@mD h2o o2 h@mD succoa@mD co2@mD coa@mD GHMT2rm atp nadp mmcoa-S@mD MMEm E1 5aop@mD fad@mD betald@mD BETALDHxm Methionine and cysteine metabolism citr-L@mD 5HOXINDACTO2OX h nadh@mD h@mD nad@mD h2o@mD fadh2@mD glyb@mD nadh nadph ALASm thf@mD h h h 5hoxindact lpam@mD nadh@mD h@mD hco3@mD 3mox4hoxm 5HOXINDACTOX 5hoxindoa gly@mD h2o@mD GCC2cm nad@mD h@mD h2o ACSOMT h2o2 citr-L OCBTm h2o nad mlthf@mD 2obut OBDHc pi@mD nad h2o nh4 co2 nadh ppcoa nh4@mD CBPSam GLYOp glx@xD h@mD GCC2am ORNt4m 34DHXMANDACOXHNADPL 34DHXMANDACOX h2o GCC2bim coa nad ppi pi o2 h2o 41R2A1H12BOOX nadp nad E5 asp-L atp@mD ala-L@xD h2o@xD o2@xDh2o2@xD nh4@xD h@mD pi@mD h@mD adp@mD co2@mD alpam@mD dhlam@mD MMMm mmcoa-R@mD succoa@mD ala-L@xD sarcs@xD SARCOXp gly@xD SPTx SPTix hpyr@xD GLYtp nh4@mD mlthf@mDthf@mD HCO3Em ACODA h2o ametam MAOLNOR nadh@mDh@mD nad@mD h2o@mD h spmd SPRMS sprm thyox-L 3MOX4HOXPGALDOX 3MOX4HOXPGALDOXHNADPL nadh 5mta MTAP gly GCCam thr-L THRD_L atp co2@mD h2o@mD ser-L@xD pyr@xD gly@xD 5mdr1p MTRI h2o h2o mlthf GLYtm h@mD alpro@mD GCCbim glx@mD ARGSS orn@mD h2o2 nh4 3m4hpga nadh nad h dhlpro@mD pi h amp ORNt3m lpro@mD h2o nh4@mD mlthf@mDthf@mD co2@mD pyr@mD ppi no SERtp ser-L GHMT2r phom glu-L@mD DDPGAm argsuc NOS2 ac normete-L h2o o2 h2o2 nad h 5HOXINDACTOXm 5hoxindoa@mD 5hoxindact@mD 5mdru1p dkmppMDRPD o2 h2o h@mD orn ORNDC h GCCcm EHGLAT2m EHGLATm THRS h mma MAOX FALDH pi h for h ptrc SPMS pi acorn SALMCOM o2 h2o DKMPPD 2kmb h2o co2 ametam h prpp ade ahcys SALMCOM2 h ADPT glu-L gln-L amet h amet h UNK2 UNK3 h amet ahcys ahcys urea h@mD nadh@mD nad@mD akg@mD asp-L@mD SERHL thf 4h2oglt@mD h h2o nadp D5 UREAtm urea@mD ppi o2 h NORANMT coa pheacgln C5 h H2O2syn amp EHGLAT glu-L 4h2oglt o2 ARGNm akg oaa@mD nwharg nadph arg-L@mD met-L nadp nrpphr phaccoa gln-L acac glu-L TRIODTHYSULT PHACCOAGLNAC NOS1 h@mD ARGDCm nadph h2o2 paps NRPPHRSULT nrpphrsf PACCOAL amet co2@mD agm@mD i 35diotyr e4hglu akg h2o nadp ARGN h2o@mD fum h DOPAMT pap ARGSL PGCD pyr@xD pi 2amac 2AMACHYD nadh@mD h@mD e4hglu@mD co2 ametam nad 3pg 3php PSP_L h2o h2o pyr ADMDC o2 34hpp@mD nh4 amet h h 3moxtyr 3mox4hpac 3M4HDXPAC homoval h Glycine, Serine, and Threonine metabolism h h nadph ARGtm glu-L nadh h PSERT h2o nad@mD PHCDm h@mD nadh@mD h@mD Urea cycleArg and Pro 4fumacac hahcys amet nh4 h2o2 o2h2o nadph ahcys h2o TYRTAm glu-L@mD h2o nad akg pser-L h2o@mD 4HGLSDm fum FUMAC nadh h2o@mD nad@mD akg@mD MACACI dopa 1p3h5c@mD PHCHGSm 4mlacac DOPASULT nadp coa accoa@mDACACT1rm h@mD h2o@mD h pap h2o nadph amp ppi ACACT1r HPROxm h@mD nadh@mD 4hglusa@mD arg-L HGNTOR h ahcys nadp ALDD19x ALDD19xHPL accoa 4hpro-LT@mD nad@mD GLYAMDTRc co2 hgentis i IDHPOXOXb o2 h2o2 nh4 34dhpac h A5 iodine o2 34DHPLACOX 34DHPHAMT h2o h2o nad A3 gudac 34HPPOR h2o h2o2h o2 i PEAMNO nadh TYRDOPO co2 nad 34dhpha h2o2 nh4 pacald nadp h2o GACMTRc creat tyr-L@mD o2 3HLYTCL h2o o2 A4 co2@rD succ@rD 4hpro-LT@rD gly amet h PROAKGOX1r h2o2@xD h@xD 1p2cbxl@xD pro-D h PHETA1m h CKc pcreat o2@rD DPROOp PRODt2rL 34hpp TYRTA 34dhphe PHYCBOXL phe-L@mD 5moxact CRTNsyn ahcys atp pro-L@rD akg@rD o2@xD h@lD h collagen degradation pro-D@xD pro-D@lD DARGOp h2o2@xD nh4@xD 5g2oxpt@xD CREATtmdiffir adp glu-L akg tyr-L DOPAQNISO1 pi crtn dopaqn 2c23dh56dhoxin DOPACHRMISO h h h2o@xD o2@xD DORNOp h2o2@xD nh4@xD 5a2opntn@xD atp@mD PCREATtmdiffir TYR3MO2 o2 h2o h h glu-L@mD akg@mD phpyr@mD o2 melanin 56dihindlcrbxltL-dpchrm o2 phpyr TYRCBOX o2 PHETHPTOX2 thbpt nadp@mD pi@mD acg5sa@mD co2 thbpt4acam 2hyoxplac adp@mD h@mD nadph@mD arg-D@xD orn-D@xD h2o@xD o2@xD tym 4HOXPACDOXHNADPL TYROXDAc hpyr@xD nadph h nadp h2o 4hphac nh4 h2o2 o2h2o 4hoxpacd paps pap pcreat@mD tymsf TYMSULT creat@mD CK acg5p@mD h AGPRim tyr-L thbpt thbpt4acam co2 o2 glu-L h2o akg PPOR TYRASE DCT phe-L PHETA1 TYRDOPO3 nadh co2 h peamn amet h2o THYPX 42A12BOOX h2o h paps 34DHPLACOXHNADPL h h 3ityr-L dopasf h h2o 3MOXTYROX IDHPOXOX2b B5 pac atp h2o ascb-L o2 DOPABMO paps h triodthy IDHPOXOX3 dhdascb h2o for gthrd mepi pap triodthysuf IDHPOXOX4 2amac SFGTH h2o2 nh4 o2 h2o fald Sfglutth adrnl h2o nadh 41R1H2MAE12BOOX nh4 h 34dhmald 34dhoxpeg 34DHOXPEGOX h2o2 cbp@mD MELATNOX ahcys h h2o h coa accoa amet melatn co2 Nacsertn ACSRTNMT B4 5HTRPDOX o2 SRTNACT srtn AMPTASECG cys-L ind3ac@mD transport mechanism uncharacterized co2 h ala-L h ALDD20xm id3acald@mD ala-L nadp seasmet@nD nformanth h 5HXKYNDCL gthox h GTHRDtr selcyst nh4 hLkynr h2o akg h gthrd@eD ala-L GTHPe adsel ADSELK C3 adp 3padsel h h2o im4act im4act@mD lys-L@xD h2o@xD h2o@mD nad@mD o2@xD h2o2@xD nh4@xD im4ac@mD h2o B2 1PPDCRp forglu h ppi cmpntm2amep MACOXO 5forthf 3mlda crn BBHOX 4tmeabutn TMABADH 4tmeabut GHMT3 3htmelys TMLYSOX tmlys TMLYSter tmlys@rD Ntmelys@rD PLYSPSer amet@nD amet@nD cbp h LYSMTF3n Ndmelys@nD LYSMTF2n Nmelys@nDLYSMTF1n peplys@nD ac thp2c ADSL1 h@mD GHMT3m h@mD coa@mD h2o Nacasp NACASPAH gln-L GLNtm Nacasp@mD NACASPtm dcamp GLUNm succ co2 o2akg PCLYSOX pcollglys h2o nad h2o@mD nad@mD AASAD3m h@mD nadh@mD akg ACGAMK L2aadp@mD 2AMADPTm glu-L accoa@mD pram 3hpcoa@mD ile-L@mD ILEt5m val-L@mD VALt5m val-L ILETA GF6PTA VALTA glu-L ILETAm glu-L@mD h@mD h 3MOPt2im3mop@mD 3mob coa@mD nad@mD OIVD2m OIVD1m co2@mD nadh@mD Valine, Leucine, Isoleucine degradation pyr@xD ibcoa@mD ivcoa@mD AGTix fad@mD fad@mD D2 prpp 4MOPt2im 4mop@mD co2@mD nadh@mD gly@xD ala-L@xD f6p atp dnad h 4mop co2@mD nadh@mD OIVD3m LEUTAm glu-L@mD h@mD h@mD coa@mD nad@mD coa@mD nad@mD pyr@mD akg@mD LEUTA glu-L 3MOBt2im3mob@mD gly@mD AGTim glx@xD akg VALTAm glu-L@mD leu-L@mD LEUt5m leu-L akg@mD akg akg@mD E2 ACOAD10m fadh2@mD h2o fadh2@mD ACOAD9m 2mp2coa@mD 2mb2coa@mD GLUPRT ACOAD8m fad@mD fadh2@mD 3mb2coa@mD h2o@mD cbp pi hglu-L adp hco3 h2oatp glu-L h ASPTAm oaa@mD GLUDym nadp@mD h2o@mD 3hmbcoa@mD akg ASPTA coa@mD h@mD HMGCOASi hmgcoa amp glu-L ASNtm Ala, asp, asn ala-L ALATA_L GLUtrglu-L@rD h pyr DASPO1p accoa h2o nad@mD coa h HMGLm coa@mD asn-L ala-D@lD 3hmp@mD 2maacoa@mD DALAt2rL nadh@mD co2@mD accoa@mD ala-D ppcoa@xD h@lD ppcoa ppcoa@mD co2 h co2@xD oaa@xD DALAxt nadph@mD h@mD nh4@mD ala-D@xD h2o@xD o2@xD h@lD 4abut@lD ABUTt2rL 4ABUTtm4abut@mD 4abut DALAOXx ABTArm sucsal@mD SSALxm h@xD PYRt2p pyr D1 nad@mD coa@mD MMSAD1m nadh@mD MMCDp MMCD glu-L@mD 2mop@mD akg@mD accoa@mD acac@mD 3AIBTm 3AIBtm 3aib@mD coa@mD nad@mD PPCOACm adp@mD h@mD pi@mD succ@mD h@mD nadh@mD succoa@mD MMCDm OCOAT1m MMTSADm h@mD nadh@mD h@mD succ@mD aacoa@mD h mmcoa-S 3aib co2@mD atp@mD hco3@mD h@mD mmcoa-S@xD pyr@xD h nad@mD h2o@mD h@xD h2o2@xD co2 glu-L@mD akg@mD h NH4tp nh4@xD nh4 HIBDm ACACT10m GLUDC akg@mD h2o2@xD nh4@xD hmgcoa@mD aacoa AATAi C1 MGCHrm 3HBCOAHLm HACD9m h@mD nadh@mD glu-L h2o@mD h2o@mD nad@mD GLUt7l glu-L@lD ASNS1 h ppi asp-D@xD ASPDxt asp-D 3mgcoa@mD GLNS oaa asp-L gln-L h2o@xD o2@xD h@mD pi@mD 3hibutcoa@mD nh4 atp h@mD ALAR glu-L@mD MCCCrm adp@mD ECOAH9m glu-L@mD ASPGLUm atp asn-L@mD ECOAH12m pi h2o@mD h2o@mD nad@mD h@mD nadh@mD nh4@mD hco3@mD h2o@mD gln-L h adp akg B1 pyr 2mbcoa@mD co2 asp-L@mD ASNNm h@mD glu-L A1 h nadph prpncoa@mD atpxmp h2o GLUDxm GLUt2m h L2aadp 2oxoadp 3hpcoa@xD GMPS2 nh4@mD AASAD3 h nadh akg@mD glx@mD glu-L ala-L@mD ppi hglu-L amp h2o gmp CBPS L2aadp6sa 3htmelys@mD pcollg5hlys mthgxl h2o@mD h2o@xD h ADSS ASPNATm gln-L@mD h2o@mD L2aadp6sa@mD nh4 h2o nadp PRPNCOAHYDxPRPNCOAHYDm MCDm co2@mD accoa@mD 3mop ASP1DC gtp imp nh4@mD AAPSAS glu-L@mD gly@mD 4tmeabut@mD h2o2 cysam ALR accoa acgam6p gam6p ACGAM6PSi h asp-L SACCD4m CYSAMO atp@mD h h@mD nadph@mD h coa adp h atp ASPCTr cbasp pi h gdp fum h2o Ntmelys@nD NTMELYStner hyptaur o2 h o2 ile-L ppi hglu-L amp h2o THP2Ctp saccrp-L@mD h2o@mD nadp@mD HYPTROX ura ppi glu-L pi aact o2 AACTOOR h DURAD C2 LPCOXp h2o@mD amet@nDahcys@nD 56dura Lpipecol@xD nadp@mD PEPLYStn ahcys@nD ahcys@nD h2o@rD h2o DHPM1 NADS2 amp pepslys@rD h cala nad SACCD3m o2 akg h2o h glu-L@mD akg@mD glu-L peplys@eD succ co2 nh4co2 prpncoa@xD malcoa@mD h@mD h2o 3hpcoa hnadph APAT2rm BALAtmr ala-B msa@mD ala-B@mD GluForTx h nadh EPCTX 3hpp h coa 3HPCOAHYD nadp h@mD nadh@mD ala-B@mD thf h2o2@xD h@xD thp2c@xD h@mD h2o co2 NABTNOm BAMPPALDOXm h h ppi cmp2amep h@mD akg@mD lys-L@mD h 3SALACBOXL E3 h@mD nadh@mD 4aabutn@mD h2o@mD nad@mD h h2o nad nad@xD nadph@mD h LCYSTATm bamppald@mD IZPN h2o2 nh4 2ameph ctp 4abut acgam o2@xD gly SLDxm co2 n4abutn@mD h2o@mD nad@mD NABTNO h nadh 4aabutn h nadh beta-alanine h2o 3mldz CPCTDTX h@xD nadh@xD lys-L LYStm nad h2o LCYSTCBOXL coa h n4abutn h2o nad h2o nad 4izp h nadh h Lcyst@mD glu-L URCN h2o ntm2amep ctp 1pipdn2c@xD 2OXOADOXm 2oxoadp@mD h2o@xD akg akg@mD 3spyr@mD akg urcan h mhista MHISOR ECOAH1x 3hbcoa@xD b2coa@xD o2 h glu-L@mD h@mD nadh@mD nh4 ahcys im4ac PPD2CSPp nadh@mD co2@mDnad@mDcoa@mD aact@mD AACTtm HISD SAMHISTA h nadh 6a2ohxnt@xD Lysine degradation co2@mD 2AMACSULT Lcyst PTRCAT1 UPPN amet IMACTD h@mD nadh@mD his-L HISDC h2o nad IMACTD_m LYSOXp coa@mD succ co2 3spyrLCYSTAT sl-L D3 APRTO2 ABUTD h nadh h hista HISTASE o2 HACD1x SLDx 2amac accoa h2o2 nh4 BAMPPALDOX co2 LYStip akg@mD h@xD nadh@xDnad@xD SLDt pap nadp nadph paps taur@xD h2o nad NBAHH_ir nh4 h2o2 o2h2o h2o@xD pyr thcys AOBUTDsm akg taur h2o2 nh4 h2o2 nh4 bamppald lys-L LYStn 2OXOADPTm aacoa@xD 3SALAOX glu-L hnadh nad TAURtcx PTRCOX1 13DAMPPOX akg A2 cys-L@mD nad na1 4abutn carn lys-L@nD 2aobut@mD h@mD nh4 na1@xD h2o o2 13dampp kynate AMCOXO glutcoa@mD mercppyr@mD PRO1x fad pro-L o2 cmusa nh4 2oxoadp fadh2@mD co2@mD h@mD fad@mD CYSTAm CYSLYSL o2 aprut ptrc h2o o2 h2o o2 nadp h2o@mD PROD2 P5CR so4 urea@mD h2o AM6SAD ECOAH1m b2coa@mDGLUTCOADHm 3hbcoa@mD nadp PROtm ptrc@mD SELNPS h nadh amuco h h2o nadph HACD1m P5CRx nadh h akg@mD h2o PCLAD h@mD nadh@mD nad@mD h fadh2 h nadph h glu-L@mD AGMTm gthox@eD h2o2@eD h2o@eD co2 aacoa Lcystin h2o akg glu-L SULFOX h focytC@mD gly GLYATm coa@mD CYSTA h2o h nadh amet gly@mD 1pyr5c PROD2m nad@mD fadh2@mD mlthf@mD accoa@mD gthrd h2o@mD sel SELADT amp pi selnp am6sa cys-L CYSGLTH sl-L@mD h2o2 KYNATESYN CYSO 3sala GNMT SARDHm gthox PROt2rL SPMDOX h2o nad coa 3SPYRSP 3snpyr3SALATAi pyr fad@mD nad ppi h seln o2 sarcsSARCStp h ahcys fad@mD thf@mD E4 nh4 h ficytC@mD PRO1xm sarcs@mDSARCStm so3 h2o2@mDGTHPmh2o@mD atp dttOX h 4aphdob anth h h akg h h@lD atp 3HAO QUILSYN CYSTGL h2o glu-L h gthox@mD h2o ala-L tcynt MCPST mercppyr nadh@mD h@mD h@mD KYNAKGAT glu-L KYN 3hanthrn o2 MCLOR nad@mD 2obut SELCYSLY B3 h2o HKYNH h sl-L@eD GTHOm h selcys dtt Lkynr KYN3OX h cyan pro-L@lD atp h2o 3HXKYNDCL h nadh h2o@xDo2@xD FALDtmfald@mD agm@mD SELCYSTGL o2nadphh 3hxkynam h2o TCYNTtm SELCYSTS h2o h nadp h2o MCLACCYSR mercplaccys mercplac nadph@mD nadp@mD h ser-L for glu-L akg aacoa@mD DMGDHm h@mDso3@mD h2o gthrd@mD 42A3HP24DB h2o dmgly@mD fad@mD h2o@mD fadh2@mD fald@xD h2o2@xD cyst-L h selhcys FKYNH quln asp-L@mD akg@mD asp-L h@mD CYSTS glu5sa adn h2o2 nh4 46dhoxquin nad nad GTHRDt adp pi gthrd@rD SEAHCYSHYD o2 co2 glu-L@mD h2o@mD so3@mD h@mD 3SPYRSPm 3SALATAim 3SALAASPm pyr@mD 3snpyr@mD 3sala@mD atp 5HXKYNOXDA 3HKYNAKGAT ACGSm h h2o pro-L@mD DMGtm 2obut coa@mD h@mD acglu@mD nadp@mD nad@mD GTHP h2o2 h2o co2 5hxkynam Lfmkynr nadh h accoa@mD h@mD fadh2@mD P5CRm P5CRxm pi adp atp seahcys h LFORKYNHYD nad@mD h@mD nadph@mD h@mD nadh@mD nadph GTHO gthrd GTHS glucys SEAHCYStn 5hxkyn TRPO2 h2o h2o o2 hcys-L G5SADs GLUCYS h pi dna5mtc@nD seahcys@nD o2 3HXKYNOXDA tsul@mD dmgly adn AHC ahcys fald D4 h@mDnadh@mD P5CDm h2o nadh@mDh@mD nad@mD h2o@mD nh4 h2o2 fum CYANtm h2o@mD atp h@nD DNAMTSEn trp-L LTDCL trypta nad h2o 48dhoxquin h2o@mD gly adp seasmet SEASMETtn dna@nD h so3@mD so4@mD atp@mD G5SADrm gluala@eD 1pyr5c@mD SELMETAT nh4 h2o2 o2h2o TRYPTAOX glyb ser-L cys-L thbpt id3acald betald met-L glu-L@mD GLU5Km adp@mD GTMLTe pi ppi TRPHYDRO2 o2 nadh GGLUCT cgly@eD h@mD cys-L@eD h@mD nadph@mD glu-L thbpt4acam nmthsrtn f5hoxkyn ALDD20x h2o@eD C4 pi@mD nadp@mD h2o h cholp adp h 5mthf AHCYStn CYANSTmtcynt@mD cyan@mD glu5p@mD G5SDym glu5sa@mD AMPTASECGe h2o 34dhoxmand selmeth atp SRTNMTX SRTN23OX ind3ac mal-L mal-L 5htrp ahcys CHOLK h2o nad METS BHMT h2o dna5mtc@nD ahcys@nD fum o2 amet MELATN23DOX chol h mal-L@mD gly@eD o2 fna5moxam fum@mD MALTSULtm FUMTSULtm FUMSO3tm MALSO3tm FUMSO4tm MALSO4tm ORNTArm o2 h 5HLTDL CHLtm thf h@nD tsul so3 mal-L@mD so4 fum@mD nadph nadh METAT amet DNAMTn 5oxpro OPAHir h h AMETtn dna@nD akg@mD h2o atp cgly 5HOXINOXDA nadphh o2 6hoxmelatn chol@mD CHOLD2m BETALDHx amet@nD adp h pi 5hoxnfkyn h2o2 ser-L@mD h nadh h2o atp h2o nh4 h2o GLYBtm h@mD h2o o2 h@mD succoa@mD co2@mD coa@mD GHMT2rm atp nadp mmcoa-S@mD MMEm E1 5aop@mD fad@mD betald@mD BETALDHxm Methionine and cysteine metabolism citr-L@mD 5HOXINDACTO2OX h nadh@mD h@mD nad@mD h2o@mD fadh2@mD glyb@mD nadh nadph ALASm thf@mD h h h 5hoxindact lpam@mD nadh@mD h@mD hco3@mD 3mox4hoxm 5HOXINDACTOX 5hoxindoa gly@mD h2o@mD GCC2cm nad@mD h@mD h2o ACSOMT h2o2 citr-L OCBTm h2o nad mlthf@mD 2obut OBDHc pi@mD nad h2o nh4 co2 nadh ppcoa nh4@mD CBPSam GLYOp glx@xD h@mD GCC2am ORNt4m 34DHXMANDACOXHNADPL 34DHXMANDACOX h2o GCC2bim coa nad ppi pi o2 h2o 41R2A1H12BOOX nadp nad E5 asp-L atp@mD ala-L@xD h2o@xD o2@xDh2o2@xD nh4@xD h@mD pi@mD h@mD adp@mD co2@mD alpam@mD dhlam@mD MMMm mmcoa-R@mD succoa@mD ala-L@xD sarcs@xD SARCOXp gly@xD SPTx SPTix hpyr@xD GLYtp nh4@mD mlthf@mDthf@mD HCO3Em ACODA h2o ametam MAOLNOR nadh@mDh@mD nad@mD h2o@mD h spmd SPRMS sprm thyox-L 3MOX4HOXPGALDOX 3MOX4HOXPGALDOXHNADPL nadh 5mta MTAP gly GCCam thr-L THRD_L atp co2@mD h2o@mD ser-L@xD pyr@xD gly@xD 5mdr1p MTRI h2o h2o mlthf GLYtm h@mD alpro@mD GCCbim glx@mD ARGSS orn@mD h2o2 nh4 3m4hpga nadh nad h dhlpro@mD pi h amp ORNt3m lpro@mD h2o nh4@mD mlthf@mDthf@mD co2@mD pyr@mD ppi no SERtp ser-L GHMT2r phom glu-L@mD DDPGAm argsuc NOS2 ac normete-L h2o o2 h2o2 nad h 5HOXINDACTOXm 5hoxindoa@mD 5hoxindact@mD 5mdru1p dkmppMDRPD o2 h2o h@mD orn ORNDC h GCCcm EHGLAT2m EHGLATm THRS h mma MAOX FALDH pi h for h ptrc SPMS pi acorn SALMCOM o2 h2o DKMPPD 2kmb h2o co2 ametam h prpp ade ahcys SALMCOM2 h ADPT glu-L gln-L amet h amet h UNK2 UNK3 h amet ahcys ahcys urea h@mD nadh@mD nad@mD akg@mD asp-L@mD SERHL thf 4h2oglt@mD h h2o nadp D5 UREAtm urea@mD ppi o2 h NORANMT coa pheacgln C5 h H2O2syn amp EHGLAT glu-L 4h2oglt o2 ARGNm akg oaa@mD nwharg nadph arg-L@mD met-L nadp nrpphr phaccoa gln-L acac glu-L TRIODTHYSULT PHACCOAGLNAC NOS1 h@mD ARGDCm nadph h2o2 paps NRPPHRSULT nrpphrsf PACCOAL amet co2@mD agm@mD i 35diotyr e4hglu akg h2o nadp ARGN h2o@mD fum h DOPAMT pap ARGSL PGCD pyr@xD pi 2amac 2AMACHYD nadh@mD h@mD e4hglu@mD co2 ametam nad 3pg 3php PSP_L h2o h2o pyr ADMDC o2 34hpp@mD nh4 amet h h 3moxtyr 3mox4hpac 3M4HDXPAC homoval h Glycine, Serine, and Threonine metabolism h h nadph ARGtm glu-L nadh h PSERT h2o nad@mD PHCDm h@mD nadh@mD h@mD Urea cycleArg and Pro 4fumacac hahcys amet nh4 h2o2 o2h2o nadph ahcys h2o TYRTAm glu-L@mD h2o nad akg pser-L h2o@mD 4HGLSDm fum FUMAC nadh h2o@mD nad@mD akg@mD MACACI dopa 1p3h5c@mD PHCHGSm 4mlacac DOPASULT nadp coa accoa@mDACACT1rm h@mD h2o@mD h pap h2o nadph amp ppi ACACT1r HPROxm h@mD nadh@mD 4hglusa@mD arg-L HGNTOR h ahcys nadp ALDD19x ALDD19xHPL accoa 4hpro-LT@mD nad@mD GLYAMDTRc co2 hgentis i IDHPOXOXb o2 h2o2 nh4 34dhpac h A5 iodine o2 34DHPLACOX 34DHPHAMT h2o h2o nad A3 gudac 34HPPOR h2o h2o2h o2 i PEAMNO nadh TYRDOPO co2 nad 34dhpha h2o2 nh4 pacald nadp h2o GACMTRc creat tyr-L@mD o2 3HLYTCL h2o o2 A4 co2@rD succ@rD 4hpro-LT@rD gly amet h PROAKGOX1r h2o2@xD h@xD 1p2cbxl@xD pro-D h PHETA1m h CKc pcreat o2@rD DPROOp PRODt2rL 34hpp TYRTA 34dhphe PHYCBOXL phe-L@mD 5moxact CRTNsyn ahcys atp pro-L@rD akg@rD o2@xD h@lD h collagen degradation pro-D@xD pro-D@lD DARGOp h2o2@xD nh4@xD 5g2oxpt@xD CREATtmdiffir adp glu-L akg tyr-L DOPAQNISO1 pi crtn dopaqn 2c23dh56dhoxin DOPACHRMISO h h h2o@xD o2@xD DORNOp h2o2@xD nh4@xD 5a2opntn@xD atp@mD PCREATtmdiffir TYR3MO2 o2 h2o h h glu-L@mD akg@mD phpyr@mD o2 melanin 56dihindlcrbxltL-dpchrm o2 phpyr TYRCBOX o2 PHETHPTOX2 thbpt nadp@mD pi@mD acg5sa@mD co2 thbpt4acam 2hyoxplac adp@mD h@mD nadph@mD arg-D@xD orn-D@xD h2o@xD o2@xD tym 4HOXPACDOXHNADPL TYROXDAc hpyr@xD
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