PRODUCT SPECIFICATIONS
CONTROLLED SUBSTANCES
CAS REGISTRY NO.
912-60-7
Noscapine Hydrochloride EP Purified
FORMULA
C22H23NO7·HCl·H2O
ITEM CODE 6250
MOLECULAR WEIGHT
467.9
APPEARANCE
Colorless crystals or fine white crystalline
powder, may clump with age
SOLUBILITY
Clear, colorless solution
IDENTIFICATION
(C) IR (EP): Matches standard
(E) Chlorides (EP): Curdled, white precipitate
Silver Nitrate: White curdy precipitate
UV: A310/A290 ≈ ~1.2
Melting Point: 174 – 177oC
APPEARANCE OF SOLUTION (EP)
Degree of Clarity: Clear solution
Degree of Coloration: Not more intensely
colored than Y6 or BY6
pH (EP)
3.0 Min
SPECIFIC OPTICAL ROTATION
(DRIED BASIS) (EP)
+38.5o to +44.0o
RELATED SUBSTANCES (HPLC) (EP)
Papaverine: 0.5% area Max
Other Impurities: 0.2% area Max
Total Other Impurities: 0.5% area Max
LOSS ON DRYING (EP)
2.5 - 6.5%
SULPHATED ASH (EP)
0.1% Max
ASSAY (C22H23NO7·HCl)
(DRIED BASIS) (EQUAL TO EP)
99.0 – 101.0%
ASSAY (HPLC) (ANHYDROUS BASIS)
98.0 – 102.0% w/w
RELATED SUBSTANCES
Narcotoline: 0.15% w/w Max
Codeine Hydrochloride: 0.15% w/w Max
Papaverine Hydrochloride: 0.50% w/w Max
Nor-noscapine: 0.15% w/w Max
Noscapine Analog A: 0.15% w/w Max
Noscapine Analog B: 0.15% w/w Max
Thebaine Hydrochloride: 0.15% w/w Max
Unknown rel. subs. (each): 0.10% w/w Max
Total rel. subs.: 0.50% w/w Max:
RESIDUAL SOLVENTS (GC)
Methanol: 0.30% w/w Max
Ethanol: 6.0% w/w Max
Isopopanol: 0.50% w/w Max
CLARITY OF SOLUTION
Clear to very slight opalescent
COLOR OF SOLUTION
APHA 40 Max
SULFATE
0.15% Max
NOSCAPINE was once considered a narcotic
and was initially known as narcotine because of
its derivation from the opium poppy. However, in
1957, after evidence accumulated that it was
neither chemically nor pharmacologically related
to the opiate alkaloids, it became known officially as
noscapine. Noscapine is not a controlled substance.
Noscapine is used primarily as an antitussive.
Doses of 5 to 15 milligrams are as effective as
30 milligrams of codeine. It is used for temporary
relief of cough or conditions such as bronchial
asthma, allergies, colds or bronchitis.
The major markets for noscapine-based cough
medications are Japan and Europe. The
hydrochloride salt is often formulated into tablets.
SIEVE TESTS
No. 40: Report % retained
No. 100: Report % retained
No. 140: Report % retained
No. 200: Report % retained
No. 200: Report % through
The information printed herein is derived from our own laboratories and other sources, and is believed to
be accurate. However, it may be modified by later findings and should be used with this understanding.
Nothing herein shall be construed as a recommendation to use any product in violation of any patent
rights. The user shall have sole responsibility for determination of whether this product is suitable for any
particular purpose. Prior to use, refer to the Material Safety Data Sheet for assistance in determining
safe handling, storage, and use procedures.
Effective 3/2014