Table E1 Definitions of Septic Shock and Shock reversal
Study
Definition of Septic Shock
Santhanam
(13)
Upadhyay (14)
de Oliveira
(15)
Definition of Shock Reversal
Blood pressure
Urine output
(ml/kg/hr)
Capillary Refill
Time (secs)
Other
Tachycardia and poor perfusion defined as decreased peripheral pulses
compared to central pulses, altered alertness, CRT >2 secs, mottled
extremities and decreased urine output (7)
Sepsis and hypotension OR Sepsis and 3 out of decreased pulse volume,
CRT ≥ 3secs, tachycardia and urine output < 1ml/k/hr (5)
Normal BP for age
>1
<2
Warm peripheries
BP > 5th percentile
>1
<3
CVP > 10cmH2O,
normal HR for age
Severe sepsis (evidence of infection and 2 of hypo-/hyperthermia, tachy/bradycardia, tachypnoea, WBC count >12000cells/ml3 or < 4000cells/ml3
and at least 1 indicator of organ hypoperfusion: altered mental state,
hypoxaemia, lactataemia, bounding pulses, oliguria or hypotension OR fluid
refractory septic shock (>40ml/Kg of fluid) or Vasoactive agents (4)
Normal BP for age
>1
<2
Normal pulses