research-article2014 AESXXX10.1177/1090820X14535078Aesthetic Surgery JournalAs’adi et al IBUTION TR AL CON ON ERN INT ATI 535078 Rhinoplasty Rib Diced Cartilage–Fascia Grafting in Dorsal Nasal Reconstruction: A Randomized Clinical Trial of Wrapping With Rectus Muscle Fascia vs Deep Temporal Fascia Aesthetic Surgery Journal 2014, Vol. 34(6) NP21–NP31 © 2014 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: http://www.sagepub.com/ journalsPermissions.nav DOI: 10.1177/1090820X14535078 www.aestheticsurgeryjournal.com Kamran As’adi, MD; Seyed Hamid Salehi, MD; and Saeed Shoar, MD Abstract Background: Rib cartilage is an abundant source for cartilage grafts when significant dorsal nasal augmentation or structural support is indicated. Diced cartilage wrapped in fascia was developed to counteract warping, visibility, and displacement of rib cartilage as a dorsal solid graft. The technique for wrapping diced cartilage has evolved during the past several years. Objectives: The authors compared 2 distinct fascial sleeves for wrapping rib diced cartilage in the treatment of patients who required major dorsal nasal augmentation. Methods: Thirty-six patients who planned to undergo major dorsal nasal reconstruction with diced costal rib cartilage were assigned randomly to 1 of 2 groups: the intervention group, which received grafts wrapped with rectus muscle fascia from the rib cartilage harvesting site, or the control group, which received deep temporal fascia harvested separately. Outcomes were compared between the groups. Results: Patients in the intervention group had significantly shorter operating times, significantly higher average satisfaction scores, and significantly shorter postoperative hospital stays than did patients in the control group. Conclusions: Harvesting rectus muscle fascia for wrapping diced rib cartilage is a feasible and reliable technique in dorsal nasal reconstruction surgery. It is associated with favorable outcomes and a high level of patient satisfaction. Level of Evidence: 4 Keywords diced cartilage, wrapping, rectus muscle fascia, deep temporal fascia, nasal augmentation Accepted for publication December 6, 2013. Rib cartilage in the reconstruction of complex rhinoplasty deformities represents an abundant source of autologous cartilage for grafting.1-3 However, solid grafts with autologous costal cartilage have been associated with warping and disfigurement, and the limited availability of long, straight cartilage grafts for major dorsal nasal reconstruction presents a challenge.4,5 Diced cartilage, which has gained popularity in the past decade, provides a dorsal graft option with greater flexibility in shape and size, without the risk of warping or resorption.4,5 Because diced cartilage grafts are prone to palpability, visibility, and uncontrolled dispersion of cartilage fragments, diced cartilage should be enclosed Dr As’adi is an assistant professor in the Department of Plastic and Reconstructive Surgery at St Fatima Hospital, and Dr Salehi is an assistant professor in the Department of Surgery at Motahari Burn Hospital, Iran University of Medical Sciences, Tehran, Iran. Dr Shoar is a research associate in the Department of Surgery at Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Corresponding Author: Dr Kamran As’adi, Department of Plastic and Reconstructive Surgery, St Fatima Hospital, Iran University of Medical Sciences, Suite 2, Afra Tower, Khashayar Park, Africa Blvd, Tehran, 1915683913, Iran. E-mail: [email protected] NP22 Aesthetic Surgery Journal 34(6) Figure 1. (A) A nearly straight 45-mm section of the seventh costal cartilage was harvested from this 28-year-old man through a 3-cm incision. The bruised edges of the incision, caused by traction of instruments, were debrided before closure. (B) A piece of harvested rib cartilage, which was to be used to construct diced cartilage–fascia grafts, was cut into 0.5- to 1-mm cubes on a silicone block with no. 11 blades in preparation for the diced cartilage–fascia construct. The remaining cartilage was used as a structural graft. appropriately. Wrapping the diced cartilage in fascia also improves its efficacy when major augmentation is required.4 Enclosures for diced cartilage in dorsal nasal augmentation have included Surgicel (Ethicon LLC, San Lorenzo, Puerto Rico),6 deep temporal fascia,7,8 and AlloDerm9 (LifeCell Corp, Bridgewater, New Jersey), but each has limitations: Surgicel-related cartilage resorption, the distinct harvesting site of the deep temporal fascia from the cartilage donor, and the cost and cartilage resorption of AlloDerm (respectively). Due to the high morbidity and complication rates associated with these limitations,7-9 the utility of these materials as graft enclosures has been challenged. We conducted a randomized clinical trial to determine whether rectus muscle fascia, a potential option because of its close proximity to the harvest site for rib cartilage, can serve as a fascial sleeve to enclose diced rib cartilage during major dorsal nasal augmentation. Outcomes for dorsal nasal augmentation with diced cartilage wrapped in deep temporal fascia (conventional technique) were compared with outcomes for diced cartilage wrapped in rectus muscle fascia. Methods Study Design A prospective randomized clinical trial was designed to evaluate the outcome of dorsal nasal reconstruction with diced rib cartilage wrapped in 2 types of autologous fascia. Two groups were compared: the intervention group, which was treated with diced rib cartilage wrapped in rectus muscle fascia obtained from the site of harvested rib cartilage, and the control group, which received diced rib cartilage wrapped in deep temporal fascia. The study was approved by the institutional review board of St Fatima Hospital in Tehran, Iran. All surgical procedures were performed by the senior author (K.A.). Patients Between September 2010 and October 2012, 36 consecutive rhinoplasty patients who required rib cartilage grafting for dorsal nasal reconstruction were enrolled in this study. Eligible participants were required to have insufficient septal cartilage, thus requiring an abundant source of cartilage for dorsal augmentation. Patients older than 55 years and those with radiologic evidence of cartilaginous rib ossification were excluded from the study. Patients were informed of the advantages and risks of the procedure and the necessity for grafting with fascial-wrapped rib cartilage. Written informed consent was provided by each patient. Information gathered preoperatively included demographic data, medical conditions, and precise measurements of nasal dorsum defects. Standard photographs also were obtained, from which anthropometric analysis was performed. Randomization and Blinding Before surgery, patients were randomly assigned to 1 of 2 equally sized groups via a computer-generated randomization system. The patients and nurses who later evaluated postoperative outcomes were blinded to study group assignment (double-blind design). However, because all procedures were performed by the same surgeon (K.A.), it was not possible to blind the surgeon to study group assignment. Surgical Techniques Harvesting of Rib Cartilage After assessing the grafting requirement, the surgeon determined the harvest site; the fifth, sixth, and seventh cartilaginous ribs were most frequently selected. The ribharvesting technique was similar to that described by Cochran and Gunter3 (Figure 1). Through a 3- to 4-cm As’adi et alNP23 Figure 2. (A) Harvesting of rectus muscle fascia from a 28-year-old woman was performed as a second surgical step through the same incision made for harvesting costal cartilage. (B) The quadrangular strip of rectus muscle fascia graft harvested from the patient. incision just above the inframammary fold in women and directly over the selected rib in men, the skin, subcutaneous, fascial, and muscle layers were transected until the selected rib was exposed. A central longitudinal perichondrial incision was made along the length of the cartilaginous rib, and 2 vertical cuts were made at the most lateral and medial parts of the rib. Two perichondrial flaps, based on the superior and inferior rib borders, were elevated to the deep surface of the rib. After adequate release and transection of the lateral and medial ends, a 3- to 5-cm segment of rib cartilage was harvested, depending on the need for augmentation and/or structural support. The wound was irrigated, and pleural integrity was verified. After harvesting of the rib cartilage only (control group) or the rib cartilage plus rectus muscle fascia (intervention group), the perichondrium and muscles were reapproximated and the wound was closed layer by layer. Similar to the technique described by Daniel and Calvert,8 the harvested cartilage was placed in antibiotic saline solution, diced into 0.5- to 1-mm cubes on a silicone block with no. 11 blades, and packed into the cylinder of a 1-mL syringe. Harvesting of Rectus Muscle Fascia (Intervention Group) The skin, subcutaneous, and superficial fascia were incised down to the rectus muscle fascia through the same incision used to harvest the rib cartilage. A quadrangular strip of rectus muscle fascia was marked to an appropriate graft size (4 × 2-3 cm). An incision was made with a no. 15 blade to beneath the rectus muscle fascia. With meticulous dissection over the rectus muscle and countertraction on elevated fascia, the fascia was easily separated from the muscle through a bloodless dissection. The harvested fascia was placed in saline- and antibiotic-soaked gauze (Figure 2). Harvesting of Deep Temporal Fascia (Control Group) A curved 3-cm temporal incision was made above the root of the helix and 2 to 3 cm behind the anterior hairline. The incision was placed parallel to hair follicles to avoid the risk of alopecia. The superficial temporal fascia was incised down to the glistening white surface of deep temporal fascia. A 4-cm × 2- to 3-cm strip of deep temporal fascia was harvested and placed in saline- and antibiotic-soaked gauze. Fascial-Wrapped Diced Cartilage: Construction and Placement Over Dorsum The nasal dorsum was accessed through an open rhinoplasty approach and transcolumellar incision. The extent of the defect area over the nasal dorsum was precisely determined as the recipient site of the graft. As described by Daniel and Calvert,8 harvested fascia (rectus muscle fascia and deep temporal fascia) was wrapped around a 1-mL syringe filled with diced cartilage micrografts and secured with a running 5-0 Monocryl suture (Ethicon Endo-Surgery, Inc, Cincinnati, Ohio). The fascial-wrapped diced cartilage was constructed on the back table, without the injection technique (Figure 3). The constructed graft was placed in the defect area, and overcorrection was avoided. Fixation was achieved at the cephalic end by transcutaneous pullout nasofrontal sutures and at the caudal end to the anterior septal angle. As a final step, digital manipulation allowed further refinement to obtain a desirable shape and dorsal height (Figure 4). Outcome Assessments Dorsal nasal augmentation was assessed with dimensional measurements from soft-tissue surface landmarks (nasion and rhinion soft tissue), and anthropometric measurements were obtained from standardized preoperative and NP24 Aesthetic Surgery Journal 34(6) Figure 3. (A) Diced rib cartilage was packed into the cylinder of a 1-mL syringe. Harvested rectus muscle fascia was wrapped around the syringe and secured with a running suture of Monocryl 5-0. (B) Length and (C) height of the construct of diced rib cartilage and rectus muscle fascia. Figure 4. Intraoperative view shows the placement of a diced cartilage–fascia construct over the previously determined defect of nasal dorsum in a 21-year-old woman. A nasofrontal pullout suture was used as a guide and a cranial point of fixation of the construct. The caudal end of the construct was fixed to the anterior septal angle. postoperative photographs of the patient’s profile (Image J 1.41 image processing software; US National Institutes of Health, Bethesda, Maryland). Preoperative radix height and dorsal nasal height were measured using soft-tissue landmarks and compared with net postoperative changes. Radix height was defined as the measurement from the medial canthus to the nasion. Dorsal nasal height was defined as the height of the nasal dorsum at the rhinion level and was measured from the point at which the medial canthus intersected the alar facial crease.10 A comparative review of pre- and postoperative photographs was performed by 2 independent plastic surgeons. For both the intervention group and the control group, outcomes of dorsal augmentation were scored on a Likert scale from 0 (least desirable) to 10 (most desirable). Patient satisfaction with surgical outcome was assessed at the 1-month postoperative visit. Patients were asked to score their satisfaction on a visual analog scale from 0 (least satisfied) to 10 (most satisfied). Statistical Analysis Data were analyzed with SPSS statistical software (SPSS, Inc, an IBM Company, Chicago, Illinois). Continuous and categorical data were analyzed by t test and χ2 test, respectively. In addition, the Mann-Whitney test was applied to compare anthropometric indices between the study groups. Statistical significance was defined as P < .05. As’adi et alNP25 Table 1. Patient Demographics, Indication for Surgery, and Graft Size Intervention Group (n = 18) Age, mean ± SD, y 35.4 ± 2.6 Control Group (n = 18) 34.8 ± 3 Sex, No. (%) P Value .80 NS Male Female 7 (38.9) 6 (33.3) 11 (61.1) 12 (66.7) Indication for surgery, No. (%) NS Cleft lip/nose 2 (11.1) 1 (5.5) Posttraumatic 5 (27.7) 7 (38.8) 11 (61.1) 10 (55.5) Length 19 ± 3.6 20.2 ± 3 .60 Width 7.2 ± 2.4 7.6 ± 2.1 .70 Height 6 ± 1.4 5.8 ± 0.9 .50 Intervention Group (n = 18) Control Group (n = 18) P Value 1 (5.5) 0 NS Intraoperative bleeding, No. (%) 0 0 NS Operating time, mean ± SD, min 15.6 ± 3.5 30 ± 4.6 <.0001 Cosmetic Size of diced cartilage–fascia graft, mean ± SD, mm Abbreviations: NS, difference not statistically significant; SD, standard deviation. Table 2. Intraoperative Events and Operating Time Pleural tears/pneumothorax, No. (%) Abbreviations: NS, difference not statistically significant; SD, standard deviation. Results Eighteen patients (the intervention group) were treated with diced cartilage wrapped in rectus muscle fascia, and 18 (the control group) were treated with diced cartilage wrapped in deep temporal fascia. No patient was lost to follow-up, and the median follow-up time was 12 months (range, 10-20 months). Patient demographics, indication for surgery, and graft size did not differ significantly between the study groups (P > .05). Twenty-three patients (63.9%) were women, and 13 (36.1%) were men. The mean age was 35.2 ± 2.7 years (range, 19-42 years). Cosmetic rhinoplasty was the most common indication (58.3%) for surgery (Table 1). Intraoperative events and operating times are listed in Table 2. Operating time (± standard deviation) for harvesting rib cartilage and fascia was significantly lower for the intervention group (15.6 ± 3.5 minutes vs 30 ± 4.6 minutes for the control group; P < .0001). Pneumothorax occurred in 1 patient in the intervention group, during harvesting of rib cartilage. No other significant differences in intraoperative adverse events were observed between the groups (P > .05). Aesthetic outcomes are listed in Table 3. Asymmetry occurred in 1 patient (5.5%) in the intervention group. The 2 major anthropometric indices—net alterations of radix height and dorsal nasal height—did not differ significantly between the groups (P > .05). Rates of other aestheticrelated events, such as visibility and step-off, were similar for the groups (Table 3). One case (5.5%) of surgical site infection occurred in the control group and resolved with appropriate antibiotic treatment. One patient from each group (5.5% of each group) required revision surgery. A case of mild junctional step-off at the radix occurred in the intervention group, which was easily managed with injection of Juvéderm (Allergan, Inc, Irvine, California) performed as an outpatient procedure. One case of pleural tear and air leak during rib harvesting, also in the intervention group, was managed by intraoperative lung expansion and water-tight closure of the chest wall incision. One patient in the intervention group and 2 patients in the control group had palpable dorsal grafts, without any visibility or contour deformity. No cases of resorption were noted. NP26 Aesthetic Surgery Journal 34(6) Table 3. Postoperative Aesthetic Outcomes Intervention Group (n = 18) Control Group (n = 18) 10.2 ± 1.7 9.6 ± 1.9 3.6 ± 0.9 3.3 ± 1.1 16.7 ± 2.4 17.3 ± 2.1 Postoperative net change 6.8 ± 1.3 7.4 ± 1.6 Visibility/palpability, No. (%) 1 (5.5) 2 (11.1) Dorsal asymmetry, No. (%) 1 (5.5) 0 1 (5.5) 0 0 1 (5.5) Radix height, mean ± SD, mm Preoperative Postoperative net change Dorsal nasal height, mean ± SD, mm Preoperative Step-off, No. (%) Radix Supratip Abbreviation: SD, standard deviation. Table 4. Postoperative Clinical Outcomes Intervention Group (n = 18) Control Group (n = 18) P Value 0 1 (5.5) NS Revision surgery, No. (%) 1 (5.5) 1 (5.5) NS Patient satisfaction score, mean ± SD 8.4 ± 3.1 5.3 ± 2.7 <.0001 Surgical team evaluation score, mean ± SD 6.2 ± 3.6 4.7 ± 2.4 .025 Postoperative hospital stay, mean ± SD, h 16.2 ± 5.8 25.6 ± 6.4 <.0001 Infection, No. (%) Patient satisfaction was scored on a scale of 0 (least satisfied) to 10 (most satisfied). Surgical outcomes were scored on a scale of 0 (least desirable) to 10 (most desirable). Postoperative hospital stay was defined as the time from patient entry to the surgical ward until hospital discharge. Abbreviations: NS, difference not statistically significant; SD, standard deviation. Mean patient satisfaction rates were significantly higher for the intervention group (8.4 ± 3.1 vs 5.3 ± 2.7 for the control group; P < .0001), likely due to the single surgical site, lower level of pain, and diminished donor-site morbidity. The mean postoperative hospital stay (time from patient entry into the surgical ward until hospital discharge) was significantly shorter for the intervention group (16.2 ± 5.8 hours vs 25.6 ± 6.4 hours for the control group; P < .0001). Postoperative clinical outcomes are summarized in Table 4. Representative pre- and postoperative photographs from patients in the intervention group are shown in Figures 5 and 6. Discussion The ideal reconstructive technique for nasal dorsum defects is still evolving. Rib cartilage continues to be the preferred grafting material for complex rhinoplasty deformities when a considerable amount of cartilage is required for dorsal augmentation and/or robust structural integrity. Despite improvements in harvesting and processing of rib cartilage (such as internal stabilization and central and balanced cross-sectional carving), the primary challenges of solid rib cartilage remain: visibility, abnormal contouring, and warping.3,4,11 Wrapping diced rib cartilage in Surgicel,6 autologous fascia,7,8,12 or Alloderm9 addresses these limitations by providing a pliable dorsal graft with minimal visibility and a smooth transition between dorsum and lateral nasal subunits, without the risk of warping. With the increased popularity of diced cartilage for dorsal nasal augmentation, there has been greater focus on wrapping methods that enclose the cartilaginous fragments and homogenously stabilize them inside the area of defect.13,14 Erol6 reported successful outcomes with Surgicel as a sleeve for diced cartilage grafts for rhinoplasty, which obviated an additional harvest site for autologous tissue, increased collagen content, and suppressed the generation capacity of cartilage cells without affecting viability.15,16 However, due to the high rate of cartilage resorption, the As’adi et alNP27 Figure 5. (A, C, E, G) This 18-year-old woman presented with a low-set dorsum, wide middle vault, and a poorly defined nasal tip with thick skin. She had nasal trauma during childhood, which resulted in deficient septal support. (B, D, F, H) Twenty-six months after dorsal nasal augmentation with diced rib cartilage wrapped in rectus muscle fascia and placement of additional structural grafts derived from the harvested sixth costal cartilage (columellar strut graft, lateral crural strut graft, and tip graft). Nasal base stabilization and improved tip definition were achieved. NP28 Aesthetic Surgery Journal 34(6) Figure 5. (continued) (A, C, E, G) This 18-year-old woman presented with a low-set dorsum, wide middle vault, and a poorly defined nasal tip with thick skin. She had nasal trauma during childhood, which resulted in deficient septal support. (B, D, F, H) Twenty-six months after dorsal nasal augmentation with diced rib cartilage wrapped in rectus muscle fascia and placement of additional structural grafts derived from the harvested sixth costal cartilage (columellar strut graft, lateral crural strut graft, and tip graft). Nasal base stabilization and improved tip definition were achieved. As’adi et alNP29 Figure 6. (A, C, E) This 32-year-old woman, who had undergone 2 previous rhinoplasty procedures, presented with a foreshortened nose from overresection of the nasal dorsum and a rotated nasal tip. (B, D, F) Sixteen months after corrective rhinoplasty, which included harvest of the sixth costal cartilage for dorsal augmentation with a construct of diced rib cartilage and rectus muscle fascia plus additional structural grafts (septal extension, extended spreader graft, and shield graft for structural support and lengthening of the nose). NP30 Aesthetic Surgery Journal 34(6) Figure 6. (continued) (A, C, E) This 32-year-old woman, who had undergone 2 previous rhinoplasty procedures, presented with a foreshortened nose from overresection of the nasal dorsum and a rotated nasal tip. (B, D, F) Sixteen months after corrective rhinoplasty, which included harvest of the sixth costal cartilage for dorsal augmentation with a construct of diced rib cartilage and rectus muscle fascia plus additional structural grafts (septal extension, extended spreader graft, and shield graft for structural support and lengthening of the nose). longevity of results attained with Surgicel-wrapped cartilage has been questioned.8 Autologous fascia, which has optimal tensile strength and good tissue integration, became a preferred material for enclosing diced cartilage.7,8,17 Daniel4 used deep temporal fascia to wrap cartilage for major dorsal nasal augmentation; this construct provided a stable dorsal nasal graft with no evidence of cartilage absorption. Guerrerosantos et al14 reported excellent long-lasting aesthetic results in augmentation rhinoplasty with fascial-wrapped multifragmented cartilage obtained from ear concha. However, additional donor-site morbidity remained a potential drawback. Despite newer techniques with autologous fascia as an enclosure for diced cartilage, harvesting fascia from a location other than the costal cartilage donor site (eg, the temporal area) is a demanding technique that may increase morbidity. Regardless of the type of autologous fascia, all patients in our study had optimal long-term outcomes with no significant change from the initial postoperative degree of dorsal augmentation. The diced rib cartilage fascia construct provided a stable dorsal nasal graft and durable outcomes. To our knowledge, this is the first comparative analysis of outcomes for fascial grafting with diced rib cartilage vs rectus muscle in dorsal nasal reconstruction. Our results showed that rectus muscle fascia is a feasible option for enclosing diced cartilage. Although the rates of intraoperative events and postoperative complications were similar for the 2 types of fascial grafts, rectus muscle fascia grafts were associated with reduced operating time and shorter hospital stays (vs traditional grafts), and they eliminated the need for an additional autologous donor site for the fascial sleeve. In addition, patients were significantly more satisfied with the newer technique, likely because of the single donor site (minimizing morbidity and scarring) and the potential for a less painful recovery. As autologous tissues, the rectus muscle fascia and deep temporal fascia share similar histologic characteristics; they are comparable in tensile strength, tissue incorporation As’adi et alNP31 capability, and scaffolding effects. Deep temporal fascia is more elastic than rectus muscle fascia, but we experienced no technical difficulty when wrapping with rectus muscle fascia (Figure 3). The poor dimensional stability of deep temporal fascia as a free graft and its tendency to shrink more than the fascia lata have been reported.18 Because of the gross similarity of the rectus muscle fascia and the fascia lata, rectus muscle fascia grafts may undergo less contraction and shrinkage than deep temporal fascia grafts. With respect to dorsal nasal and radix augmentation, there was no significant difference in long-term absorption of the diced cartilage–fascia constructs between our study groups. Further investigation of the dimensional stability and contraction of the rectus muscle fascia as a free graft is recommended. Relative to the traditional approach, the benefits of the newer technique include reductions in operating time and hospital stay. The advantages of temporal fascia are maintained while donor-site morbidity is reduced. Moreover, surgical outcomes are more favorable, patient satisfaction is greater, and the risk of alopecia (which may occur when harvesting deep temporal fascia) is eliminated. Revision surgery was needed for only 2 of our patients (1 in each study group.) The patient in the intervention group experienced a supratip step-off deformity that required revision surgery for placement of a cartilage graft. The patient in the control group had nasal asymmetry; during revision surgery, lateral displacement of the diced cartilage–fascia construct was observed. Our small randomized controlled trial will pave the way for additional studies of the utility of rectus muscle fascia for wrapping diced cartilage. Future research in larger study populations is warranted to permit thorough investigation of the pros and cons of this technique. Moreover, it will be important to evaluate clinical and aesthetic outcomes in a more quantitative manner. A head-to-head comparison of our technique with the Surgicel technique also may provide valuable information. Conclusions Harvesting rectus muscle fascia is a feasible and reliable technique for dorsal nasal reconstruction surgery that requires wrapped diced rib cartilage. Using the same donor site for harvesting and augmentation is associated with favorable clinical and aesthetic outcomes. Disclosures The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article. Funding The authors received no financial support for the research, authorship, and publication of this article. References 1.Yilmaz M, Vayvada H, Menderes A, Mola F, Atabey A. Dorsal nasal augmentation with rib cartilage graft: longterm results and patient satisfaction. J Craniofac Surg. 2007;18(6):1457-1462. 2. Cervelli V, Bottini DJ, Gentile P, et al. Reconstruction of the nasal dorsum with autologous rib cartilage. 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