F
FORM
FORM 7 Evaluation of university study programmes of undergraduate, graduate and
integrated undergraduate and graduate studies, and vocational studies
DESCRIPTION OF CHANGES AND ADDITIONS TO UNDERGRADUATE, GRADUATE AND INTEGRATED
UNDERGRADUATE AND GRADUATE STUDY PROGRAMMES
Table 2. Description of the new course or the course to which changes and additions are made
* Copy the table for each proposed new course, or course to which changes and additions are made
1. COURSE DECRIPTION – GENERAL INFORMATION
1.1. Course teacher
Dr. Dijana Škorić, Associate Professor
1.2. Name of the course
Subviral Infectious Molecules
1.3. Associate teachers
1.4. Study programme (undergraduate,
graduate, integrated)
graduate
facultative
1.5. Status of the course
1.6. Year of study
1.7. Credit value (ECTS)
1.8. Type of instruction (number of hours
L+S+E+e-learning)
1.9. Expected enrolment in the course
1.10. Level of use of e-learning (1, 2, 3
level), percentage of instruction in the
course on line (20% maximum)
2nd
4
2+0+1+0
8-10
1
2. COURSE DESCRIPTION
2.1. Course objectives
2.2. Enrolment requirements and
required entry competences for the
course
2.3. Learning outcomes at the level of
the study programme to which the
course contributes
2.4. Expected learning outcomes at the
level of the course (4-10 learning
outcomes)
Introduce students to the types of subviral pathogens and concepts related to them, noncoding genomes and prions as
pathogenic proteins encoding information, diseases of subviral aetiology and importance of subviral and RNA world for the
development of evolution and general biological concepts.
Complete understanding of advanced concepts in bacteriology, virology, biochemistry of nucleic acids and proteins, molecular
genetics and evolution.
Developing critical thinking and reading skills, recognizing the breakthrough findings in molecular biology research, learning
new laboratory techniques in molecular virology. Perfecting general laboratory skills and dexterity. Developing competencies in
planning, organizing, execution and presentation of research project.
Acquiring basic molecular concepts on biological entities smaller and simpler than viruses, new technical skills on research
methods in molecular biology, biology of small RNA molecules and subviral pathogens (viroid cultures, satellite RNA cultures,
methods for characterization of RNA structure, size and sequence, viroid-plant interactions).
1. Definition of subviral infectious molecules, the concept of satellitism, satellites A and B.
2. Satellites C and D (virusoids).
2.5. Course content broken down in
detail by weekly class schedule
(syllabus)
3. Lethal necrosis of tomatoes-a case study of satellite influence on the disease expression in plants.
4. Viroids – agents of plant diseases and noncoding genomes.
5. Molecular mechanisms of viroid diseases-RNA silencing.
6. Hammerhead ribozymes, viroids as relics of the RNA world.
1
F
FORM
FORM 7 Evaluation of university study programmes of undergraduate, graduate and
integrated undergraduate and graduate studies, and vocational studies
DESCRIPTION OF CHANGES AND ADDITIONS TO UNDERGRADUATE, GRADUATE AND INTEGRATED
UNDERGRADUATE AND GRADUATE STUDY PROGRAMMES
7. Ribozymes and ribozyme drugs – student’s project.
8. RNA quasispecies and evolution of RNA.
9. Molecular biology of hepatitis delta agent.
10. Pathology of hepatitis D.
11. Evolution and RNA-mosaics.
12. Prion discovery and prion hypothesis.
13. Human and animal prion diseases-biology of TSE.
14. Breakthroughs in prion and prion disease research.
15. Prevention and tests for prion diseases.
Practical exercises (research project):
1. Development of research project proposal (different variants are possible depending on the research object) for
purification, detection and characterization of viroids or satellite RNAs.
2. Research project preparation and organization.
3.- 13. Research project execution (subviral pathogen purification, RT-PCR, amplicon analyses) in small groups (up to 4
students).
14-15. Analyses of the results and research report writing (individually).
a. Type of instruction
c.
Student responsibilities
d. Screening of student’s
work (specify the
proportion of ECTS
lectures
seminars and workshops
exercises
online in entirety
mixed e-learning
field work
b. Comments:
independent study
multimedia and the internet
laboratory
work with the mentor
Practical exercises in the laboratory are
prepared, organized and executed as a
small research project by small groups
of students (up to 4) due to the nature of
(other)
experiments and laboratory spatial
limitations.
Regular attendance of lectures and practical exercises. Preparation, organization and execution of a small practical research
project. Reporting the project results in a form of small research paper or laboratory report. Taking the final oral exam.
Class attendance
1
Research
0,5
Practical training
1
Experimental work
1
Report
Essay
Seminar essay
(Other--describe)
2
F
FORM
FORM 7 Evaluation of university study programmes of undergraduate, graduate and
integrated undergraduate and graduate studies, and vocational studies
DESCRIPTION OF CHANGES AND ADDITIONS TO UNDERGRADUATE, GRADUATE AND INTEGRATED
UNDERGRADUATE AND GRADUATE STUDY PROGRAMMES
credits for each activity
so that the total number
of CTS credits is equal
to the credit value of the
course)):
2.1. Grading and evaluation of student
work over the course of instruction
and at a final exam
Tests
Oral exam
Written exam
Project
0,5
2.12. Optional literature (at the time of
the submission of the study
programme proposal)
2.13. Methods of monitoring quality that
ensure acquisition of exit
competences
(Other—describe)
Evaluation of final laboratory report (written individually by each student from a group) in the form of a small research paper
(50% of the grade), final oral exam (50% of the grade).
Title
2.2. Required literature (available at the
library and via other media)
(Other—describe)
Viroids. Eds: A. Hadidi, R. Flores, J. Randles, J. S. Semancik, Science Publishers Inc.,
2003.
Prion Diseases. Eds: J. Collinge & M. S. Palmer, Oxford
University Press, 1997.
Review articles (open access) selected by the lecturer.
Pdf version of lecturer's presentations (available to the students enrolled into this
course).
Number of
copies at the
library
1
Origin and Evolution of Viruses. Ed. E. Domingo, R. Webster, J. Holland, Academic Press, 1999.
Journal articles (open access) selected and recommended by the lecturer.
Anonymous students' review of the course contents and teachers.
3
1
0
0
Availability via
other media
yes
yes
yes
yes