SUPPORT GUIDE
First Morning Void vs.
24-Hour Collection
Options for Urine Hormone Collection
Introduction
Urine hormone testing is well established as a valid and accurate form of hormone testing. This sample type also
provides a “time-average”, which integrates multiple spikes that may occur in some hormones throughout the day.
There are two options for urine specimen collection:
First Morning Void (FMV)
24-Hour Collection
The FMV is a single urine collection upon waking.
It provides a time-average for hormone spikes that may
occur during the hours of sleep (approximately 8-hours),
and includes the early morning peak excretion expected
in a number of hormones. As a result, the time-average
of the overnight collection paired with capturing the
peak excretion provides an estimate of both the Total
Output and Peak Output of measured hormones.
The 24-Hour Collection captures all urine over a 24-hour
time period. It provides a time-average for hormone
spikes that may occur throughout a complete circadian
rhythm (24 hours). As a result, the 24-Hour provides the
highest level of sensitivity to assess very low levels of
hormones by providing a direct measurement of the
Total Output of each hormone.
Specimen collection comparison:
First Morning Void (FMV)
• Single collection convenience
• Includes early morning hormone peaks
• Excellent measure of Peak Output
• Convenient estimate of Total Output
24-Hour Collection
• Multiple collections
• Includes entire circadian rhythm
• Direct measure of Total Output
• Best measure for low total hormone levels
Both specimen collection options provide the following advantages:
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Time-average of hormone spikes that may occur
Measures parent hormones and metabolites
Measures the free, bio-available fraction of each hormone
Simple, at-home specimen collection
Both collection options can be used effectively for prescribing and monitoring hormone replacement therapy (HRT).
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Asheville, NC 28801
800 522.4762
www.GenovaDX.com
This information is for the sole use of a licensed health care practitioner and is for
educational purposes only. It is not meant for use as diagnostic information. All claims
submitted to Medicare/Medicaid for Genova Diagnostics laboratory services must be
for tests that are medically necessary. “Medically necessary” is defined as a test or
procedure that is reasonable and necessary for the diagnosis or treatment of illness or
injury or to improve the functioning of a malformed body member. Consequently, tests
performed for screening purposes will not be reimbursed by the Medicare program.
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