chromosomes separate, and meiosis continues.
In some cases, the Xs or the X chromosome and
Y chromosome fail to pair and fail to exchange
genetic material. Occasionally, this results in
their moving independently to the same cell,
producing either an egg with two Xs, or a sperm
having both an X and a Y chromosome. When a
sperm having both an X and a Y chromosome
fertilizes an egg having a single X chromosome,
or a normal Y- bearing sperm fertilizes an egg
having two X chromosomes, an XXY male is
conceived.
MW 8 AM - 9:30 AM
ained that cells destined to
eggs undergo a process
s. In this process, the 46
the cell separate, ultimately
http://www.nichd.nih.gov/publications/pubs/klinef
w cells having 23
elter.cfm
ch. Before meiosis is
ver, chromosomes pair with
ng chromosomes and
genetic material. In women, X
ir; in men, the X and Y
. After the exchange, the
Symptoms
Symptoms of Klinefelter's Syndrome - XXY or X-X-Y
Sjogren's Syndrome
Klinefelter's Syndrome is a genetic disorder that happens in •Low Energy
1 in every 500 to 1000 male births. Instead of the normal XY •Developmental Delays
Difficulty with Motor Skills
chromosomes, these individuals have and extra X
chromosome making them XXY. The normal human genetic
Impaired Language / Speech Skills (especially with
up is 46XY. Males usually have one X and one Y
expressive language)
chromosome, i.e. make the chromosome constitution 46,XY. •Learning Disabilities
Males with Klinefelter's syndrome have two X chromosomes •Normal or High IQ
(47-XXY), in rare cases three (48-XXXY) or four (49-XXXXY) •Social Interaction Difficulties
X-chromosomes. The X-chromosomes carry genes in terms •ADHD (Attention Deficient Hyperactivity Disorder)
•Impulse Control Disorder
of development of testicles, sex hormone production and
physical sex development in general as well as to a certain •Depression
extent also height growth. The extra chromosome(s) results in •Low Self Esteem
a series of issues:
Testosterone Treatment often results in:
•Increased muscle mass
Klinefelter's Syndrome Symptoms
•Small Firm Testicles
•Increased strength
•Male distribution body hair
•Low Testosterone
Infertility
•Improved mood and self esteem
Incomplete Masculinization
•Increased energy and sex drive
•Does not treat infertility

Female Body Hair Distribution
(Sparse facial, armpit, and pubic •Testicles remain small
•Improved concentration
hair)
•Stabilization of breast growth (often does not decrease size)
Decreased Libido
•Body Shape Patterns:
Pear Shaped
Tall
Testing for Klinefelter's Syndrome
Abnormal Proportions (Short Trunk, Long Legs, Long
Karyotyping Chromosome
Arms, Lower Body Larger Than Upper)
47 XXY
•Teeth Abnormality - (Taurodontism - Enlarged Pulp and Thin
Mapping
Tooth Surface)
Semen Count
Low
•Varicose Veins, Spider Veins, and Clots
Serum Testosterone
Low
•Gynecomastia Male Breast Deformity
•Autoimmune Disorders
Serum LH (Leuteinizing
High
Lupus
Hormone)
Rheumatoid Arthritis
Serum FSH (Follicle
High
Stimulating Hormone
Serum Estradiol (Estrogen)
High
Testicle Size Measurement
<10cc
www.plasticsurgery4u.com/kinefelters_xxy/index.html
www.medscape.com/.../art-sm490130.fig1b.jpg
This is a graph describing the testosterone
treatment of an individual with Klinefelter’s
syndrome. Andro Gel is a clear, colorless,
hydroalcholic gel containing 1percent
testosterone..The first side effect is acne.
The second side effect is aloepecia. The
third side effect is depression. The fourth
side effect is a headache. The last is
nervousness.
www.theodora.com/drugs/images/693.jpg
http://images.google.com/imgres?imgurl=http://www.andrologyaustralia.or
g/images/pageContentImages/KlinefeltersIMG.jpg&imgrefurl=http://www.a
ndrologyaustralia.org/pageContent.asp%3FpageCode%3DFSKLINE&h=4
69&w=268&sz=21&hl=en&start=3&tbnid=1DMcYHu8fg_M4M:&tbnh=128
&tbnw=73&prev=/images%3Fq%3Dklinefelter%2527s%2Bsyndrome%26g
bv%3D2%26hl%3Den%26sa%3DG
This is apicture depicting an individual with klinefelter’s syndrome . This picture
also describes the symptoms this individual has. The first symptom of kline felter’s
syndrome he had was his height. The second symptom this man had was
reduced facial hair. The third symptom this man had was reduced body hair. The
fourth symptom this man had was breast development. The f ifth symptom this man
had was feminine hair distribution. The last symptom this man had was small
testicles.
This is a picture
illustrating the side
effects of the
testosterone therapy of a
person with Klinefelter’s
Syndrome.This person had
ulcers in his right leg
for a year due to the
testosterone treatment.
The right leg did not
respond to various topical
treatments, accompanied by
lymphenada of the right
leg.
Klinefelter’s Syndrome
Angela Sanborn
Biology 1408-5
http://find.galegroup.com/itx/retrieve.do?contentSet=IACDocuments&qrySerId=&inPS=true&tabID=T002&prodId=EAIM&searchId=R2&retrie
veFormat=PDF&currentPosition=16&userGroupName=txshracd2503&resultListType
=RESULT_LIST&sort=DateDescend&docId=A163478673&callistoContentSet=NPD
F&workId=5CWX_198-12-1-55_10120055-p.pdf
This is a picture of the bone density
of an individual with Klinefelter’s
syndrome.Klinefelter’s syndrome is a
chromosal disorder associated with a
shortage of androgen and osteoporosis.
Bone mineral density and no
quantitative ultrasound data can be
accessable to those patients after
longterm testosterone replacement
therapy.
http://content.revolutionhealth.com/contentimages/imagesimage_popup-m7_glands.jpg
This is a picture of the
pituatary gland and
hypothalamus gland.
Klinefelter’s syndrome is one of the
most common chromosmal
abnormalities. This disease only
occurs in males and it is caused by
an extra X chromosome. Instead of
the normal 46XY, their genetic
makeup is 47, XXY. Egg and sperm
cells only have 23 chromosomes.
One inherited from the dad, and the
other from the mother.
http://www.antenataltesting.info/images/karyotype_klinef.jpg
DNA
CAUSES
hat puts a couple at risk for
Y child. Advanced maternal
e risk for the XXY chromosome
ghtly. Furthermore, recent
d by NICHD grantee Terry
cist at Case Western Reserve
eland, OH, show that half the
romosome comes from the
KLEINFELTER’S SYNDROME
ANGELA SANBORN
BIOLOGY1408
www.nlm.nih.gov/medlineplus/images/dna.jpg
this is a picture illustrating the DNA and
chromosomes of an indiviual with
Klinefelter’s syndrome.