UTI-Stat
™
UTI-Stat
™
The Power of 544 Pounds
of Cranberries
in a Single Serving.
Natural, gentle, effective
A single 30 ml serving of UTI-Stat ™ with PROANTINOX ™
provides as much protection from urinary tract infections
as 16 eight ounce glasses of cranberry juice cocktail
or 544 pounds of cranberries.
Medical Nutrition USA, Inc.
Positive Clinical Outcomes Through Evidence-Based Research
Urinary tract infections (UTIs)
• Annually affect over 7 million men and women at a cost of over one billion dollars.1
• Up to 40% of nursing home residents contract urinary tract infections leading to significant morbidity.2
• Severe UTI can cause hospitalization, sepsis, and even mortality.
• E. Coli bacteria cause 90% of UTI.
• Prevention methods rely primarily on hydration and hygiene.
• Primary treatment is antibiotic therapy, contributing to excessive antimicrobial usage.
• The National Center for Complementary Medicine reported that cranberry proanthocyanidins (PAC)
help reduce the adhesion of certain E. Coli bacteria to the urinary tract walls.3
• 14 separate studies have shown that cranberry PAC can prevent the adhesion of E. Coli to urinary
tract walls.4
UTI-Stat™ is a natural urinary tract cleansing complex containing PROANTINOX™ - a proprietary
blend of concentrated Cranberry Proanthocyanidins, Ascorbic Acid, D-Mannose, FOS and Bromelain to inhibit adhesion of infection causing E-coli bacteria to urinary tract walls, increase urinary acidity to
create a less tolerable environment for E. Coli, and stimulate the growth of probiotic bacteria in the
small and large intestines.
UTI-Stat™ has been shown effective in reducing symptomatic UTI, including urgency and frequency
of urination, when used in conjunction with hydration and a hygiene program.
Each one ounce (30 ml) serving of UTI-Stat™ with PROANTINOX™ provides as much cranberry
proanthocyanidins as 16 eight oz glasses of cranberry juice cocktail or 544 pounds of cranberries to
support urinary tract health and help prevent recurrence of infection.
16 eight oz glasses of cranberry juice
cocktailor one ounce of
UTI-Stat™
www.clinicaltrials.gov
www.adam.about.com
3
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html
4
http://www.cranberryinstitute.org/news/MayIssue04.pdf
1
2
Medical Nutrition USA, Inc. Positive Clinical Outcomes Through Evidence-Based Research
Clinically proven
Use of a cranberry concentrate complex liquid (PROANTINOX TM ) combined
with increased hydration to prevent recurrence of UTI symptoms in residents
of long-term care facilities
ABSTRACT
Objective:
To assess the efficacy of a cranberry concentrate cleansing complex (PROANTINOXTM) combined with
increased hydration in preventing recurrence of UTI symptoms in LTC residents with a history of Urinary
Tract Infections.
Design:
A multi-state, multi-center interventional prospective trial.
Setting: 10 LTC facilities in 5 states.
Subjects: 124 residents of LTC facilities.
Methods:
A convenience sample of male and female subjects from 10 LTC sites received 30 ml (1 oz.) of a
cranberry concentrate complex (PROANTINOXTM) administered twice daily combined with a goal of
1500 – 1600 cc of fluid intake for 90 days. The primary outcome was prevention of symptoms of UTI.
Secondary outcomes were quality of life indicators (an umbrella of survey requirements), compliance
to increased fluid intake, and overall UTI recurrence rate.
Results:
A total of 88 residents completed the three-month study; 81/88 (92%) remained symptom-free.
A total of 2 of residents had mild urinary pain for up to 5 weeks; 2 had mild urinary burning for up to 6
weeks; 2 had mild urinary odor for 4 weeks; and 1 had dark urine for 6 weeks. A total of 72/88 (80%)
exceeded the fluid intake target of >1500 cc/d.
Conclusion:
This study supports the efficacy of a cranberry concentrate complex liquid (PROANTINOXTM)
combined with increased hydration in preventing recurrence of UTI symptoms in residents of LTC
facilities. Additional studies are needed to determine the minimum dose of liquid cranberry concentrate
complex needed to prevent or improve UTI symptoms and reduce recurrence.
UTI Symptom Incidence
2% Urinary odor
2% Urinary pain
2% Urinary burning
1% Dark urine
92% No symptoms
Medical Nutrition USA, Inc. Positive Clinical Outcomes Through Evidence-Based Research
UTI-Stat
TM
With PROANTINOX ™, a natural urinary tract cleansing complex that includes:
• Cranberry Extract Concentrate
• Cranberry proanthocyanidins disable the cell structure of E. Coli inhibiting their ability to adhere
to the wall of the urinary tract.
• Vitamin C (Ascorbic Acid)
• Helps maintain adequate urine acidity creating a less tolerable environment for E. Coli bacteria.
• D-Mannose
• Increases bacterial anti-adherence effect. D-Mannose adheres to E-Coli bacteria forming a complex
compound that is expelled with urine.
• FOS (Inulin)
• A “prebiotic” that stimulates the growth of bifidobacteria in the colon and acidifies the colon
creating an unfavorable environment for E. Coli bacteria growth.
• Bromelain
•
1
Bromelain has been used effectively with UTI to enhance antibiotic effectiveness. In a double-blind
trial, subjects with UTI received antibiotics plus bromelain in combination or antibiotics with a placebo.
100% of those who received the bromelain had a resolution of their infection, compared
with only 46 % of those given the placebo. The mechanism of action is anti-inflammatory activity.1
http://findarticales.com/p/articles/mi_mOISW/is_2003_June/ai_102372155/pg_2
Nutrition Facts
UTI-Stat™ Features and Benefits
Serving Size: 30 ml (2 tablespoons)
Servings per Container: 30
■
Natural, gentle, effective
■
Aids in reducing symptomatic UTIs including
urgency and frequency of urination
when used in conjunction with hydration and
a hygiene program.
■
Helps reduce adhesion of infection causing bacteria
■
Contains FOS to stimulate the growth of
Bifidobacteria and reduce
the number of E-Coli 1
■
Helps maintain adequate urine acidity
■
Natural Cranberry taste
■
Available in 887 ml bottles and 30 ml packets
Amount Per Serving
1
http://findarticles.com/p/articles/mi_m0ISW/is_2003_June/ai_
102372155/pg_2
% Daily Value*
Calories
Calories from Fat
Total Carbohydrate
Total Sugar
Protein
PROANTINOX™
(4:1 Cranberry Extract Concentrate,
Ascorbic Acid, D-Mannose,
FOS [Inulin], and Bromelain)
Sodium
Potassium
Phosphorus
1
0
250 mg
250 mg
0g
3875 mg
39.3 mg
3.9 mg
5.9 mg
<1%
<1%
0%
<1%
<1%
<1%
*Percent Daily Values are based on a 2,000-calorie diet.
Size
Item
Flavor
Case Pack
NDC #
HCPCS #
Bottles (887 ml - 30 oz.)
Packets (30 ml - one oz)
60001
60001-U
Cranberry
Cranberry
4/30 oz.
96 x one oz
26974-0410-66
26974-0410-67
B4104
B4104
Call 1.800.221.0308 for sampling and information.
Medical Nutrition USA, Inc., Englewood, NJ 07631 www.uti-stat.info
Copyright ©2008 Medical Nutrition USA, Inc.
MNI-28