Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 1. Basic Human Pathology Lecture #1 Cellular Adaptations to Dis... 2. Definitions OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 1 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 3. Definitions (cont’d) 4. Review: Tissue, Cellular, and Plasma Membrane Anatomy and Te... OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 2 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 5. Definitions 6. Parenchyma and Stroma OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 3 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 7. Plasma Membrane 8. Reaction of Cells to Stimuli OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 4 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 9. Hypertrophy - Masseter Muscle 10. Hypertrophy OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 5 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 11. Hypertrophy – Skeletal Muscle 12. Left Ventricular Wall Hypertrophy of Cardiac Muscle –... OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 6 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 13. Hypertrophy – Cardiac Muscle 14. Nodular Hyperplasia – Prostate OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 7 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 15. Nodular Hyperplasia – Prostate 16. Hypertrophy and Hyperplasia OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 8 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 17. Hypertrophy and Hyperplasia During Pregnancy 18. Physiological Hyperplasia – OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 9 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 19. Physiological Hyperplasia – Endometrium of Uterus 20. Developmental causes of reduced cell mass OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 10 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 21. Adaptation to Environmental Stress (cont’d) – <b... 22. Adaptation to Environmental Stress (cont’d) – OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 11 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 23. Adaptation to Environmental Stress (cont’d) 24. Autophagy and Cell Atrophy OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 12 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 25. Adaptation to Environmental Stress (cont’d) 26. Adaptation to Environmental Stress OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 13 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 27. Local Atrophy - Disuse 28. Atrophy - Endocrine OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 14 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 29. Atrophy 30. Hemifacial Atrophy OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 15 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 31. Adaptation to Environmental Stress (cont’d) 32. Involution – Thymus Gland OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 16 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 33. Adaptation to Environmental Stress (cont’d) 34. Adaptation to Environmental Stress (cont’d) OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 17 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 35. Cellular Adaptations to Disease/Cell Injury and Death I: Sli... 36. Respiratory Epithelium Prior to Metaplasia OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 18 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 37. Cellular Adaptations to Disease/Cell Injury and Death I: Sli... 38. Esophageal Mucosa Metaplastic to Stratified Squamous Epithel... OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 19 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 39. Ductal – Squamous Metaplasia 40. Squamous Metaplasia OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 20 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 41. Summary of Adaptation to Environmental Stress 42. Summary OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 21 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 43. Cell Adaptation Key Facts 44. Reaction of Cells to Injury OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 22 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 45. Reaction of Cells to Injury on a Biochemical Level 46. Reaction of Cells to Injury on a Biochemical Level OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 23 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 47. Function of Ubiquitin in Cell Stress 48. Protein Kinesis OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 24 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 49. Reaction of Cells to Injury on a Biochemical Level 50. Reaction of Cells to Injury on a Biochemical Level OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 25 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 51. Free Calcium’s Role as a Destructive Agent 52. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 26 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 53. Hydropic Change 54. Hydropic Change - Leukoedema OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 27 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 55. Hydropic Degeneration - Leukoedema 56. Reversible Change – Cell Degeneration OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 28 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 57. Reversible Cellular Changes and Accumulations 58. Fatty Change OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 29 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 59. Fatty Change 60. Fatty Change - Liver OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 30 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 61. Fatty Change - Liver 62. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 31 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 63. Reversible Cellular Changes and Accumulations 64. Hyaline Change – Liver Cell OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 32 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 65. Reversible Cellular Changes and Accumulations 66. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 33 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 67. Labial Melanotic Macule – Focal Melanosis 68. Melanin Pigmentation – Labial Melanotic Macule OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 34 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 69. Reversible Cellular Changes and Accumulations 70. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 35 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 71. Hemosiderin in Liver Cells 72. Hemosiderin – Lung Alveoli OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 36 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 73. Reversible Cellular Changes and Accumulations 74. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 37 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 75. Reversible Cellular Changes and Accumulations 76. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 38 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 77. Hemochromatosis - Pancreas 78. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 39 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 79. Lipofuscin – Striated Muscle and Liver 80. Reversible Cellular Changes and Accumulations OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 40 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 81. Pathologic Calcifications 82. Metastatic Calcification Hypercalcemia - Lung OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 41 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 83. Pathologic Calcifications 84. Calcific Stenosis of Aortic Valve OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 42 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 85. Dystrophic Calcification – Medial Sclerosis 86. Dystrophic Calcification – Medial Sclerosis OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 43 Tufts OpenCourseWare © 2008 Tufts University Cellular Adaptations to Disease/Cell Injury and Death I 87. Dystrophic Calcification – Stomach Injury 88. Dystrophic Calcification – Periapical and Pulpal Patho... OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 44
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