PRODUCT DATA SHEET
CLINICAL CORTISOL DEFENSE†
Size: 60 Capsules | Serving Size: Two (2) Capsules | Servings Per Container: 30
KEY FEATURES
CortiX™ was scientifically formulated to deliver comprehensive and superior quality nutritional
support for healthy cortisol levels. CortiX™’s advanced formula includes Ashwagandha extract
(root), Phosphatidylserine (PS), Bacopa monnieri extract (leaf), Rhodiola rosea extract (root),
L-Theanine and Gamma-aminobutyric acid (GABA). The CortiX™ formula was designed to promote
optimization of cortisol function and homeostasis for effective weight management and stress
defense.†
• Optimal Support for Healthy Cortisol Levels†
• Effective for Weight Management†
• Powerful Stress Defense Modulator†
KEY MESSAGES
Cortisol is a hormone produced by in the human adrenal glands in response to stress.
Intra-abdominal adipocytes (fat cells) also produce cortisol and this hormone directly affects fat
storage and weight gain. Cortisol influences major energy metabolic pathways from carbohydrates,
proteins and fats and also plays a role in regulating electrolyte (salt) balance within the body.
Recent scientific evidence suggests high cortisol levels are associated with disruptive food cues in
response to stress, overeating and abdominal obesity.†
• Science-based formula delivering comprehensive nutritional
support for healthy cortisol hormone function.†
• Designed to promote optimization of cortisol function and
homeostasis for effective weight management and stress
defense.†
• Advanced formula includes Ashwagandha extract (root),
Phosphatidylserine (PS), Bacopa monnieri extract (leaf),
Rhodiola rosea extract (root), L-Theanine and Gammaaminobutyric acid (GABA).
Ashwagandha (Withania somnifera) is a highly revered herb used in Indian Ayurvedic systems.
Ashwagandha, containing bioactive withanolides, functions as an adaptogenic herb and has been
used for centuries providing multi-functional support for promoting general mental and physical
wellness. Bacopa monnieri, a traditional Ayurvedic herb, containing the major bioactive bacosides
has been used for centuries to support the nervous system, manage stress and promote relaxation.
Phosphatidylserine (PS) is a fat-soluble phospholipid and found in all cell membranes of the human
body. Phosphatidylserine is the most abundant phospholipid in the human brain. Phosphatidyserine
plays a vital role in a multitude of processes throughout the body, including the health of the brain
and nervous system, the integrity of cell membranes and the formation of other important
phospholipids. Recently published scientific evidence has shown that PS supplementation
attenuates serum cortisol levels in response to acute stress. Rhodiola rosea contains rosavins that
act to balance cortisol function and modulate the effects of physical and emotional stress.
L-Theanine is a unique amino acid and a natural constituent found in green tea. L-Theanine has
been shown to significantly increase alpha wave production in the brain, an indication of calming
and relaxation. Gamma-aminobutyric Acid (GABA) is a naturally occurring non-essential amino acid
and one of the most important and widespread neurotransmitters in the brain. GABA is the primary
inhibitory neurotransmitter and is the brain’s “natural calming agent”. GABA modulates the effects
of daily stress, cortisol levels and can effectively elevate mood.†
CortiX™ is an advanced and science-based formula from MMSN delivering comprehensive
superior quality nutritional support for healthy cortisol hormone function. CortiX™ was designed to
reset cortisol homeostasis and promote optimization as an effective weight management and
stress defense modulator.†
• Ashwagandha is a highly revered herb used in Indian Ayurvedic
systems. Ashwagandha, containing bioactive withanolides,
functions as an adaptogenic herb and has been used for
centuries providing multi-functional support for promoting
general mental and physical wellness.†
• Bacopa monnieri, a traditional Ayurvedic herb, contains the
major bioactive bacosides and has been used for centuries to
support the nervous system, manage stress and promote
relaxation.†
• Phosphatidylserine (PS) is a fat-soluble phospholipid and is the
most abundant phospholipid in the human brain. Recently
published scientific evidence has shown that PS supplementation attenuates serum cortisol levels in response to acute
stress.
• Rhodiola rosea contains rosavins that act to balance cortisol
function and modulate the effects of physical and emotional
stress.†
• L-Theanine is a unique amino acid and a natural constituent
found in green tea. L-Theanine has been shown to significantly
increase alpha wave production in the brain, an indication of
calming and relaxation.†
(cont’d on p.2)
†
YOUR ASSURANCE OF QUALITY ®
210 W. TAFT AVE • ORANGE, CALIFORNIA 92865 • 714.456.0700 • 714.456.0727 FAX • WWW.MAXMUSCLE.COM
PRODUCT DATA SHEET
Size: 60 Capsules | Serving Size: Two (2) Capsules | Servings Per Container: 30
TARGET MARKET
Primary: Adult athletes and non-athletes seeking a
scientifically-advanced cortisol blocker for effective
weight management and stress modulation.
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
RECOMMENDED STACK
Amount Per Serving % DV*
Magnesium (as citrate)
P.2
• MTX
50 mg 12.5%
870 g
Proprietary CortiX Blend:
Ashwagandha extract (root), Phosphatidylserine, Bacopa
monnieri extract (leaf), Rhodiola rosea extract (root),
L-Theanine, Gamma-aminobutyric acid (GABA)
™
• 2TX
• LTox
**
• CNS Black
KEY REFERENCES
*Percent Daily Values are based on a 2000 calorie diet.
**Daily value not established.
1. Findling JW, Aron DC, Tyrrell JB. Glucocorticoids & Adrenal
Androgens. 5th ed. In: Greenspan FS, Strewler GJ, ed. Basic &
Clinical Endocrinology. Stamford, CT: Lange Medical Boods,
1997:317-58.
DIRECTIONS: As a dietary supplement, take two (2) capsules daily with or without food.
2. Tchernof A, Despres JP. Pathophysiology of human visceral
obesity: an update. Physiol Rev. 2013;93:359-404.
OTHER INGREDIENTS: Magnesium Stearate, Rice Powder, Silicon Dioxide, Gelatin Capsule.
3. Kaur P, Mathur S, Sharma M, et al. A biologically active
constituent of withania somnifera (ashwagandha) with antistress
activity. Indian J Clin Biochem. 2001;16:195-8.
CONTAINS: Soy
Manufactured in a cGMP facility that processes milk, egg, fish, Crustacean shellfish, tree nuts, wheat and
soybeans.
4. Singh N, Bhalla M, de Jager P, Gilca M. An overview of
ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit
Complement Altern Med. 2011;8:208-13.
WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR
NURSING. Consult a physician before starting any diet and exercise program and before using this product. Do
not take this product if you have a medical condition. Discontinue use and call a physician or licensed health care
professional immediately if you experience unexpected side effects. If taking prescription medications, consult a
licensed health care professional prior to use.
5. Panossian A, Wikman G. Evidence-based efficacy of adaptogens
in fatigue, and molecular mechanisms related to their
stress-protective activity. Curr Clin Pharmacol. 2009;4:198-219.
6. Panossian A, Wagner H. Stimulating effect of adaptogens: an
overview with particular reference to their efficacy following
single dose administration. Phytother Res. 2005;19:819-38.
7. Wagner H, Norr H, Winterhoff H. Plant adaptogens. Phytomedicine. 1994;1:63-76.
KEEP OUT OF REACH OF CHILDREN.
STORE IN A COOL, DRY PLACE AWAY FROM MOISTURE, SUNLIGHT AND EXCESS HEAT. ALWAYS KEEP
TIGHTLY SEALED.
8. Lee TK, Clarke IJ, St John J, et al. High cortisol responses identify
propensity for obesity that is linked to thermogenesis in skeletal
muscle. FASEB J. 2013 Sep 12.
9. Bjorntorp P, Rosmond R. Obesity and cortisol. Nutrition.
2000;16:924-36.
KEY MESSAGES
10.Pavlatou MG, Vickers KC, Varma S, et al. Circulating cortisolassociated signature of glucocorticoid-related gene expression in
subcutaneous fat of obese subjects. Obesity. 2013;21:960-7.
(cont’d from p.1)
• Gamma-aminobutyric Acid (GABA) is a naturally occurring non-essential amino acid and one of the most important and widespread
neurotransmitters in the brain. GABA is the primary inhibitory neurotransmitter and is the brain’s “natural calming agent”. GABA
modulates the effects of daily stress, cortisol levels and can effectively elevate mood.†
11.Starks MA, Starks SL, Kingsley M, et al. The effects of
phosphatidylserine on endocrine response to moderate intensity
exercise. J Int Soc Sports Nutr. 2008;5:11.
• Convenient and easy-to-swallow capsules.
12.Tryon MS, Carter CS, Decant R, Laugero KD. Chronic stress
exposure may affect the brain’s response to high calorie food
cues and predispose to obesogenic eating habits. Physiol Behav.
2013;120C:233-242.
13.Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea):
traditional use, chemical composition, pharmacology and clinical
efficacy. Phytomedicine 2010;17:481-93.
14.Hung SK, Perry R, Ernst E. The effectiveness and efficacy of
Rhodiola rosea L.: a systematic review of randomized clinical
trials. Phytomedicine. 2011;15:235-44.
15.Russo A, Borrelli F. Bacopa monniera, a reputed nootropic plant:
an overview. Phytomedicine. 2005;12:305-17.
16.Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces
psychological and physiological stress responses. Biol Psychol.
2007;74(1):39-45.
17.McCann SM, Rettori V. Gamma aminobutyric acid (GABA) controls
anterior pituitary hormone secretion. Adv Biochem Psycholpharmacol. 1986;42:173-89.
†
YOUR ASSURANCE OF QUALITY ®
210 W. TAFT AVE • ORANGE, CALIFORNIA 92865 • 714.456.0700 • 714.456.0727 FAX • WWW.MAXMUSCLE.COM