A Comparison of Procedures for Multiple Comparisons of Means

A Comparison of Procedures for Multiple Comparisons of Means with Unequal Variances
Author(s): Ajit C. Tamhane
Source: Journal of the American Statistical Association, Vol. 74, No. 366 (Jun., 1979), pp. 471480
Published by: American Statistical Association
Stable URL: http://www.jstor.org/stable/2286358
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A Comparisonof Proceduresfor
MultipleComparisons
of Means With
UnequalVariances
AJITC. TAMHANE*
Nine proceduresformultiplecomparisonsof means withunequal cedures based on the correspondingjoint confidence
in someproceduresare provariancesare reviewed.Modifications
or easier im- procedures.
in theirperformance
posed eitherforimprovement
The proceduresincluded in this study fall into two
A MonteCarlosamplingstudyis carriedoutforpairplementation.
and theprocedures groups. One group consistsof procedureshaving resoluas wellas a fewselectedcontrasts
wisedifferences
are comparedbased on the resultsofthisstudy.Recommendations
forthe choiceof the proceduresare given.Robustnessof two pro- tions (Gabriel 1969) forall linearcombinationsof the Ai;
variancesunderviolationofthat the secondgroupconsistsofprocedureshavingresolutions
ceduresdesignedforhomogeneous
is also examinedin theMonteCarlostudy.
assumption
for all pairwise differences
that can be extended to all
KEY WORDS: Multiple comparisons;Unequal variances; One- contrastsamongthe Ai. (Brownand Forsythe'sprocedure
problem.
ANOVA; Behrens-Fisher
wayfixed-effects
also has resolutionfor all contrastsbut it is somewhat
1. INTRODUCTION
model of
Consider the usual one-way fixed-effects
analysis of variance:
Xij = Ai + eij
whereall the eij are independentwitheii - N(0,
j
= 1, 2, ...,
ni; i
=
1, 2, ...,
k. The means
U-2) for
j.i
and
variances o-2are assumed to be unknown.Let xi denote
the sample mean and let Si2 denote an unbiased estimate
of U,2 based on vi degrees of freedom(df) that is independentofXi; forthe mostpart we shall take si2 to be the
usual sample variance based on vi = ni- 1 df.
In recentyearsconsiderableattentionhas been focused
on the problem of multiplecomparisons,among the A
when the ai2 are unequal; for example, see Ury and
Wiggins (1971), Spjotvoll (1972), Brown and Forsythe
(1974), Games and Howell (1976), Hochberg (1976),
Tamhane (1977), and Dalal (1978). The primarypurpose
of the presentarticleis to give a briefreviewof theseprocedures, point out any relationships between them,
propose improvementsin some proceduresand, finally,
make comparisonsbased on an extensive Monte Carlo
(MC) samplingstudy. The criteriaused forcomparison
are (a) the confidencelevel of the joint confidenceintervals (Cl's) of a suitable familyof parametricfunctions
or contrasts)forthe ,uiand (b) the
(pairwisedifferences
widthsof these Cl's. Note that these two quantities respectivelycorrespondto (a) the familywiseType I error
rate and (b) the power of the simultaneoustest pro* AjitC. Tamhaneis AssistantProfessor,
ofIndustrial
Department
University,
and ManagementSciences,Northwestern
Engineering
Evanston,IL 60201. The authoris gratefulto two referees,an
associateeditor,and the Editorforpointingout severalreferences
in theearlierdraft.This workis
manyimprovements
and suggesting
supportedby NSF GrantENG 77-06112.
different
fromthe other proceduresin the second group
as pointedout in Section 2.1.2.) By carryingout the MC
study for pairwiseas well as general contrastswe have
triedto provide "homegrounds"forboth groups of procedures,thus makingthe comparisonfair to the extent
that is possible. It would have been preferableifa simple
modificationof the proceduresin the firstgroup were
available that would reduce their resolution from all
linear combinationsto all contrasts.No such modification seems to exist,however.
The secondarypurpose of this article is to study the
robustness propertiesunder variance heterogeneityof
two generalized-Tukeyprocedures(generalizedto cover
the case of unequal ni's) that are designedforthe homogeneous variances case. These two procedures(Spjotvoll
and Stoline's 1973 Ext-T and Hochberg's 1974 GT2)
were selectedforcomparisonbecause they performquite
well relative to their competitors(see Ury 1976). The
reason forincludingonly the generalizedTukey and not,
for example, the Scheffeprocedure,was because of our
predominantinterestin pairwisecomparisonsforwhich
the Tukey-typeproceduresare knownto be morepowerful.The second reason fornot includingmoreprocedures
was, ofcourse,to keep the size ofthe studyto manageable
proportions. The inclusion of the generalized-Tukey
procedures also serves a subsidiary purpose; namely,
when the ai2 are in fact equal, as is the case for some
configurationsstudied in the sequel, they provide a
standardagainstwhichthe performance
ofthe procedures
designedforunequal o-2 can be compared.
In the remainderof this article,Section 2 reviewsthe
various procedures;Section 3 proposes modificationsof
471
? Journal of the American Statistical Association
June 1979, Volume 74, Number 366
Theory and Methods Section
Journalof the AmericanStatisticalAssociation,June 1979
472
some of the procedureseitherfortheireasierimplementation in practiceor forimprovementin theirperformance.
In part of Section 3 and in Section 4 some preliminary
comparisonsamong the competingproceduresare carried
being eliminatedin the process.
out, a fewnoncontenders
The detailsof the MC studyand the resultsare presented
in Section 5. Finally, the discussionof the results and
recommendationsfor the choice of the proceduresare
given in Section 6.
2. A REVIEWOF THE PROCEDURES
2.1 ProceduresforUnequal aU2
The proceduresin the firstgroup guaranteethe designated joint confidencelevel exactly. Because the contrasts problemis a generalizationof the Behrens-Fisher
problemfor which no exact solution is known to exist,
the proceduresin the second group are inexact; that is,
they are either conservativeor approximate. Now we
describethe proceduresin the two groups.
2.1.1 Proceduresfor all linear combinationsof the ,u,.
Dalal (1978) proposed a familyof proceduresbased on
Holder's inequality.Let p ? 0, q > 0 satisfyi/p + 1/q
= 1, and let dq,a( = dq,a(vi, .. ., Vk) denote the upper a
1
point of the distributionof dq = ( it"=
q)lq wheret,
denotesa Student's t randomvariable (rv) with v df and
the t^,are independont(i = 1, . . ., k). Then the exact
100 (1 - a)% joint CI's for all linear combinations
=1 a.sAare given by
k
k
Z aA C: ai[
i a? dq
i=l
i=l
k
PsiP/np(2)1
I
p
i=
Dalal remarksthat these CI's are competitiveforall q,
although it is possible that for a specificsubclass one
mightdominate the others. In general it is difficultto
compute the distributionof dq and, consequently,to
compute dq,a. For q = x, p = 1 it is easy to see that
doo,a = doo,(a, ..., Vk) is given by the solution in d to
the equation
k
TI{2F,4(d)
i=1
- 1} = 1
-
a
(2.1)
and
a = (1
k
2/b) E
-
i=l
{1v/(vi -
2)}
We shall referto this procedureas the S procedure.
Hochberg (1976) proposed the followingprocedure
based on a generalization of the Tukey method of
multiplecomparisons.Let ha'
ha'(vi, . . ., Vk) denote
theuppera pointoftheaugmentedrangeR' oftv1,..., t;
R' = R'(vi, . . ., Vk) = max { maxi It, I, maxi,j t - t' II.
Then the exact 100(1 - a)%o joint CI's for all linear
are given by
combinationsJk=1 aq,Ai
k
k
E aiAi E
[S aii
where
bk) =
M(b1,
.l.,
?
ha'lM(bi, ...,
k
max(Z bi+,
i=l
bk)],
k
i=l
(2.3)
bi-),
bi+ = max(bt,0), bi- = max(-b,, 0), and bi = aisi/A\n
(i = 1, ..., k). We shall referto this procedureas the
Hi procedure.
in computingha,',HochbergsugBecause of difficulties
gestedinstead using ha, = the upper a point of the range
R of tv, .. ., tvk; R = R(vi, . . ., Vk) = max,jIt,i -t,jI;
he noted that ha' is well approximatedby ha, provided
k > 3 and a < .05. In Section 5.2 we have developed an
integral expressionfor the distributionof R' based on
whichha,' can be easily computedforarbitrarycombinations of the vi. In the MC studies we used Hi in its
exact form.
2.1.2 Proceduresfor all contrastsamongthe jti. In this
group we include the proceduresproposed by Ury and
Wiggins, Brown and Forsythe, Games and Howell,
Hochberg, and Tamhane. All these procedures except
that of Brown and Forsythe involve firstconstructing
joint CI's forall pairwisedifferencesi - Aj(i, j = 1, . . ..
k; i < j) and then extendingthem to all contrastsby
using Lemma 3.1 of Hochberg (1975). (This extensionis
not in the originalarticlesof Uryand Wigginsand Games
and Howell.) Thus, if wij denotes the width of the
100(1 - a)%0 joint CI forpi - j(i, j =1, . . ., k; i < j),
then the correspondingjoint CI's for all contrasts
i=1 csiA,where i=1 ci = 0, are given by
whereF,(.) denotes the distributionfunctionof a t, rv.
We shall referto this procedureas the D procedure.
For the special case q = 2, the above Cl's were proCi(-Cj)WijE
E
k
k (c)
(c)
posed by Spjotvoll (1972). He approximated the disjeO
ki ?
(2 4)
Ci,i E = c
tributionof d22 = Ek=1 t,i2by a scaled F distributionand
by using the methodof momentsgave the followingapwhere c = (cl, ..., ck)', @(c) = {i: ci > 0}, and nI(c)
proximationto d2,a = d2, a (vl, . . ., Vk)
= {j: cj < 01. On the otherhand, Brown and Forsythe
(2.2)
d2, .2
aF(c(k,b),
obtain joint Cl's forall contrastsdirectlyusing Scheff6's
where F, (m, n) denotes the upper a point of an F dis- projection method. Also the previous procedurestypitributionwithm and n df,
cally involve bounding the probability of the joint
statement related to the Cl's for (2) differences
k
k
i j=1,
,k; i < j) by a functionof the
, ItV,2(V, -1)/ (vi-2)2(vi-4) )
Ai(k-2)[ L Itvi/(vi-2)I]2+4ki=l
i=l1
probabilities of individual statements by means of a
k
k
inequality.All the proceduresare based
Bonferroni-type
i=l
on some solutionto the Behrens-Fisherproblem,usually
i=l
E=
J
,
Procedures
forUnequalVariances
Tamhane:MultipleComparison
Welch's (1938) approximatesolution.Thus, most of the
procedures described in the followingparagraphs are
approximate-conservative(approximate because of the
Welch solution; conservativebecause of the Bonferronitypeinequalityused). The validityof the Welch solution
in the case of the two-sampleproblemhas been demonstrated by Wang (1971). Wang recommends that it
should be true that ni > 6 foreach sample.
Ury and Wiggins (1971) proposed a procedurebased
on the Welch approximate solution and the Bonferroni
inequality.Accordingto this procedurethe approximateconservative 100(1 - a)% joint Cl's for all pairwise
differences,ui- Auj(i,j = 1 ..., k; i < j) are given by
473
given by
(t,i ,,sillni+ t4i"2sj2/nlj)
where y = {1 - (1 - a)l/'k
We shall refer to this
procedureas the TI procedure.The second procedurewas
based on the Welch solution and the gidak inequality.
According to the second procedure approximate-conservative 100(1- a)% joint Cl's forall pairwisedifferj E[xt
-
Ai
encesi
-
j(ij
t-p
=
tj :4
,
1, .. .,
pi-yj E [Xi-Xj
k; i < j) are given by
i t^ij, (s2/n +
12/nj)1]
where Pij is given by (2.5). We shall referto this latter
procedureas the T2 procedure.In the MC studiescarried
out in Tamhane (1977) it was demonstratedthat Ti is
+ sP2/nj)f]l
-.iUj E [E-i j
t^i>t(si11ni
highly conservativerelative to T2 and hence we shall
drop TI fromfurtherconsideration.It is reviewedhere
where4,0 denotesthe upper : point of a t, rv, 3
/2k',
for
the sake of completeness.
ki'= (k),and
Finally, we describeBrownand Forsythe's(1974) pro(s82/ni + sj2/nj)2
cedure. According to this procedure approximate
A.j
=(2.5)
where
100(1 - a)% joint Cl's forall contrasts '= ci,Ai,
+ sj4/nj2(nj - 1)}
{ si4/n-2 (ni-1)
J=,ci = 0, are given by
We shall referto this procedureas the UW procedure. k
L k
of (2.5), E, Ciipi E E, CiXti
Uryand Wigginsadvocated a slightmodification
i=1
i1=1
but we shall take up this modificationin Section 3.2.
k Ci2Si2]
Hochberg
was
by
given
procedure
A closely related
i{(k -1) F,(k-1p)8
ni
i=l
(1976). According to this procedure the approximateconservative 100(1 - a) % joint CI's for all pairwise where vcis the Welch df given by
differencesAi- A(ij j = 1, ..., Ik; i < j) are given by
'-1
2
k
4
k
A- ij
E E
-Xi
t4
g(S2/ni
Sj2/nj)']
+
wherega solves the equation
k
E
-
ic
Ci2Si2\
E
i_=1~ni
-
C,4 i
i.,
n2(i;n-3
i
(2.6)
We shall referto this procedureas the BF procedure.
Note that BF gives the followingapproximate-conservative 100(1 - ax)% joint Cl's forall pairwisedifferences
k
E Pt ltvjii> g) = a
= 1 j=i+1
HAi-
A(j
j
=1,
... I k;
< j):
in g, and v is given by (2.5). We shall referto this Ai -'j
E[ti - Xj
procedureas the H2 procedure.
A: (k - 1)Fa(k - 1, vii) (2/ni + s2/nj)]
Games and Howell (1976) proposed the followingapproximate100(1- a)% joint Cl's forall pairwisediffer- where Pij is given by (2.5). Closely related procedures
have been describedin Naik (1967).
1 ...,kk;i < j)
encesli - (jj(iJj
Ai -
E
X
xi
j
1
v/2
(si2/ni
+
gj1/nj)1
forEqual -,2
2.2 Procedures
Spj0tvoll and Stoline (1973) extendedTukey's multiple
comparison
procedureto take into account the case of
whereqV,k,adenotesthe upper a point of the studentized
unequal
ni's.
According to their procedure the exact
rangedistribution(see Miller1966,Ch. 2, fora definition)
the
variances assumption holds)
(if
homogeneous
with parametersk and v and Pij is given by (2.5). We
- a)%
for all linear combinations
Cl's
100(1
joint
shall referto this procedureas the GH procedure.The
;
are
given
by
,
ailAi
use ofthe studentizedrangestatisticin the GH procedure
k
k
does not seem to have been adequately justified;in fact
A: qk,, _sM(b,.,
_
b)]
E aigi GE [
it turnsout in the MC studiesthat in some instancesGH
i=l
i=1
procedureyields familywiseType I error rate greater
whereqk,v,a' denotesthe upper a pointof the studentized
than the specifiedlevel a, that is, it is radical.
In Tamhane (1977) we proposed two procedures,the augmented range distributionwith parametersk and v
firstof whichis based on Banerjee's (1961) conservative (see Miller 1966, Ch. 2, fora definition);82 iS the usual
solution to the Behrens-Fisherproblem and gidAk's "within" estimate of the common variance with
lcX- df; bt a1/VnX and M is as definedin
(1967) multiplicativeinequality. Accordingto this pro- 3/= -=
cedure conservative100(1 -a) %0joint CI's forall pair- (2.3). If a is a contrastvectorand the miare equal, then
kc;i < j) are qk,v,at can be replacedby qk,w, (See Theorem2.3 of
jst
h(i, j = 1, ..
wise differences
3
-
.,
474
Journalof the AmericanStatisticalAssociation,June 1979
Hochberg 1975), thus yielding Tukey's original pro- wheredoo,a and tvz,(i = 1, . . ., k) satisfy
cedure.For thisreason we shall referto this procedureas
-=
a P I Itv,I doo,,, i= 1, ... ,1k}
the TSS procedure.
Hochberg (1975) proposedthe followingprocedurefor
= PI ItvI < tvtb i = 1, ..., k}
the case of unequal ni's that he referredto as the GT2
procedure;we shall use the same nomenclaturebecause Therefore,there exists a number v* E (minivi,maxivi)
of its widespread familiarity.According to GT2, the such that if Vi,vj > v*then (3.1) is violated; if vP,vj < v*
conservative(if the homogeneousvariances assumption then (3.1) is satisfied;in all othercases (3.1) is satisfied
from
is highlydifferent
holds) 100(1- a)o joint Cl's forall pairwisedifferences (with high probability)if oq2/rn,
than
D'
for
D
to
do
better
we
should
expect
Thus
oaj2/nj.
j
=
1,
...,
k; i < j) are given by
Al Aj(i,
those pairwisecomparisonsinvolvinghighlyunbalanced
, - Ai E [-Ti
-fi +4 IM k',v,aS(1/n1i + 1/n,) 2]
(< 2/i)-values. In spite of this one advantage of D over
D'
we drop D fromfurtherconsiderationbecause of the
where Imik' ,,a denotes the upper a point of the stuin favor of D' cited earlierand because, on
advantages
dentizedmaximummodulusdistributionwithparameters
of D and D' are similar. (The
the
performances
average,
k' and v (see Miller 1966, Ch. 2, for a definition).One
D
fromthe author.)
for
are
available
MC
results
can extend the aforementionedpairwiseintervalsto all
H2
similar
manner.The modified
modified
in
a
can
be
contrastsusing (2.4).
H2 (denoted by H2') has the same advantages over H2
that D' has over D. For this reason we drop H2 from
3. MODIFICATIONS OF SOME PROCEDURES
furtherconsideration.Now note that the modifiedproAND COMPARISONS
cedure H2' is identical to UW and, therefore,H2' will
3.1 A Modificationof the D Procedure
not be consideredseparately.
We note that forsolving (2.1) one must use a tedious
trial-and-errormethod with a hand calculator or use a 3.2 Modificationof (2.5) and ProceduresAffectedby It
digital computer,except possibly for the case ni
Ury and Wiggins (1971) pointedout that P', given by
a with
= nk = 'u (say). For thiscase we have do,a = tn_(2.5)
ranges between min(rni- 1, nj - 1) and ?--+ nm
which
can
interbe
obtained
2{1(1
by
a)l/k},
2=
polating in the t tables. This suggests the following - 2, but usually tends to be on the conservativeside.
of the D procedurethat can be implemented Based on the workof Pratt (1964), they advocated that
modification
with the help of the t tables alone even for the case of V,jbe taken to be equal to its upper limit mp+ nj - 2
holds:
unequal nr's. Accordingto the modifiedprocedurethe when at least one of the followingfourconditioins
exact 100(1 - a)%o joint Cl's forall linear combinations
< 10/9;
1. 9/10 < nli/?1T
i=1aiA,are givenby
2.
k
E
i=l1=
k
k
a,uj
E
[E
a,1
i
E
i=l
tvi,bIaiIsN/Vn1]
We shall refer to this modifiedprocedure as the D'
procedure.It has the followingadvantages over D:
1. D' is easier to implementin practice.
2. In D' the CI fora linear combinationEiEE
where E C {1, 2, ...,
ajAi1
k} depends only on the vi
fori E E. In D, however,this CI depends on all
the vi that is unappealingforobvious reasons.
The performanceof D' should be on the average (over
(2) pairwisecomparisons)equivalentto that of D; in fact
if the v, are equal then D and D' are identical. In the
unequal v, case, if all the vi -c
or, equivalently, if all
the ai2 are known,then do,a and all the t, a tend to zb
wherezbdenotesthe upper6 pointofthe standardnormal
distribution.Thus D and D' are again equivalent. If the
vi are unequal but small then it mightbe noted that if
using D
Wii,D denotes the width of the CI for Ai - ,j,
and Wii,D', that using D' then (a.s.) we have
+ t^3,asj/V/n,)
(ti,asi/V/n1
, (3.1)
(s/n +sV3
9/10 <
1)/ (Sj2/nl,) < 10/9;
(S,2/nt1
3. 4/5 < n,/n,< 5/4 and 1/2 < (s,2/n1)/(sj2/n)
< 2;
4. 2/3 < ni/n, < 3/2 and 3/4 < (s,2/ni)/(sj2/llj)
< 4/3.
This modificationessentiallymeans that if the sample
sizes of the two groupsare approximatelybalanced or the
standard errorsof the correspondingsample means are
approximatelybalanced thenone should use the "usual"
df ni + ij - 2.
This modifiedvalue of vi,can be used in UW, T2, GH,
and BF (for pairwise comparisons) procedures; denote
the modifiedproceduresby UW', T2', GH', and BF',
respectively.(For generalcontrastswe shall use (2.6) for
the df vCfor BF withoutany modificationalthough we
shall still referto that procedureas BF'.) Because UW,
T2, and BF (forpairwisecomparisons)are approximateconservative,one can anticipate that this modification
will make UW', T2', and BF' sharper without making
them radical; this is indeed so and we drop originalprocedures UW, T2, and BF from furtherconsideration.
The same statementcannotbe made about GH', however.
In fact,in our MC studies GH' was triedbut turnedout
to be substantiallyradical. Therefore,we retainledGH,
which itselfis somewhatradical. For the convenienceof
Tamhane: MultipleComparisonProceduresfor Unequal Variances
475
5. MONTE CARLO STUDY
the reader we provide a glossary of all the procedures
consideredso far.
5.1 Choice of (2.2, n)-Configurations
and OtherParameters
The sampling experimentswere conducted for all
pairwise differencesof the i, for k = 4 and 8 and for
Procedure
Mlnemoiic
selected contrastsfor k = 8. The values of a used were
Dalal's (1978) procedureand its modified .05 and .10 althoughhere we reportthe resultsonly for
D, D'
a = .05; the patternsin the resultsfora = .10 are quite
version,respectively
similar.
For each combinationof k and a, eight (a2, n)S
Spjotvoll's (1972) procedure
were studied. Our concernis mainlywith
configurations
Hochberg's (1976) two procedures
Hi, H2
the
small-samplebehavior of the procedures,and this
Ury and Wiggins's (1971) procedureand
UW, UW'
guided our choice of the n,'s in the range 7 to 13. These
its modifiedversion,respectively
were orderedin termsof a measureof unGames and Howell's (1976) procedureand configurations
GH, GH'
balance in the values of
its modifiedversion,respectively
Ti, T2, T2' Tamhane's (1977) two proceduresand the
var(,) =
a2.2, n(i-1,
. .
h;)
modifiedversionof his latter procedure,
respectively
This measure p(r) is given by
Brown and Forsythe's (1974) procedure
BF, BF'
k
and its modifiedversion,respectively
E (T, - T)2
9(s
TSS
Spjotvoll and Stoline's (1973) procedure
i=l
Hochberg's (1974) procedure
GT2
where T = Ek=, Ti/k. The same measure was used by
Keselman and Rogan (1978) although they used it for
4. SOME FURTHERCOMPARISONS
measuring
unbalanceof J,2'S; we believethatT is a more
First note that while UW' is based on the Bonferroni relevantparameterin the presentproblemthan a-2. The
inequality,T2' is based on the multiplicativeSidak in- configuirationsin their "natural" order (primed serial
equality; thus : < yand t,, > t, . Therefore,T2' uni- numbers)are listed in Table 1. The sovalues associated
formlydominates UW' in terms of the CI widths and with the configurations
and theirorderaccordingto the
hence we drop UW' fromfurtherconsideration.
sovalues (unprimedserialnumbers)are listedin the same
It is easy to check that qvk ,/V2 < t, z with equality table. Thus for both k = 4, 8, configuration1' with
holding iffk = 2. Thus GH uniformlydominates T2. yp(r)= 0 is the most balanced while configuration8'
As mentionedearlier,however,GH tends to be radical with =() - 1.479 is the most unbalanced. AInalternaand hencethe comparisonis not exactlyfair.In any case, tive measureof unbalance that can be used is
we use T2' and not T2 and it is not clear whetherGH
1
uniformlydominates T2' because the df of the critical
Q(r) = max n/nmin T,
i<i?k
1<t<k
points used in the two procedurescan now be different.
A directcomparisonbetweenD' and Hi seemsdifficult Note that i1 givesthe same orderingas soexceptthatranks
but one can compareD and Hi as follows.Comparingthe of configurations
3' and 6' are interchanged,that is they
respectiveassociated widthsWi,D and w,H, of the Cl's are 6 and 7 accordingto p while7 and 6 accordingto b.
forA, - ,i(i, j = 1, ..., k; i < j), one has (a.s.)
The MC resultsare presentedin termsof the unprimed
serial numbersof the configurations,
thus enabling the
h'P,
,Pk
>
TVij,H1
Wij,D
reader
to
see
how
the
react to indifferent
procedures
. . .,
dho a'(P1,
creasingunbalance in the r,'s.
(si/Vn/i+ s\/Vn/i) (4.1)
The class of general contrasts of practical interest
involvescomparingthe average of one subset of
typically
max(sj/&\/nj,sj-\4.nj)
the
the average of anothersubsetof the ,us.We
against
,
It is easy to verifythat the leftside of (4.1) is greaterthan
selected
three
representativecontrastsfromthis class for
and a values
one and forthe (pi, ..., vk)-combinations
in
Thus fork = 8, we selected
the
MC
study
experiments.
studied in this article we verifiedthat it is in the range
one
:4
and two middlecontrast
high-order
(4
comparison)
1.35 to 1.5 by computingha' and d:,a; the values of ha'
are
order
:2
contrasts
(2
comparisons).
They
are given in Table 2. The rightside of (4.1) is greater
than one (a.s.), and it would be close to one with large Contrast 1: ( 1 + A 2 + A/3 + it4)
Thus
probabilityif o-i2/niand ojl2/njare highlydifferent.
51
-4(A5 + J6 + 117 + A8);
(5.1)
(au//ni)exceptforcomparisonsinvolvinghighlyunequal
7 + 1L8)
values, it is likelythat Hi would dominateD (and there- Contrast2: 2(Al + 42)- (results.
the
MC
foreD'); this is supportedby
Contrast 3: 2(I( + 4) - (O5 + L6)
Based on these considerationswe finallykeep eight
proceduresin our MC study: D', 5, Hi, T2', GH, BF', The pairwisecomparisonsare, of course,the lowest-order
contrasts.
TSS, and GT2.
GLOSSARY OF THE PROCEDURES
IIlk)
CONSIDERED
476
Journalof the AmericanStatisticalAssociation,June 1979
1.
Configuration
No.
k
4
8
o-
2,U2
n)-Configurations
(j-2
n, n2,
.k
7,7,7,7
7,7,7,7
7,7,7,7
7,9,11,13
7,9,11,13
13,11,9,7
7,9,11,13
13,11,9,7
0
1
4
6
2
3
7
5
8
1'
2'
3'
4'
5'
6'
7'
8'
1,1,1,1,1,1,1,1
1,1,2,2,3,3,4,4
1,1,4,4,7,7,10,10
1,1,1,1,1,1,1,1
1,1,2,2,3,3,4,4,
1,1,2,2,3,3,4,4
1,1,4,4,7,7,10,10
1,1,4,4,7,7,10,10
7,7,7,7,7,7,7,7
7,7,7,7,7,7,7,7
7,7,7,7,7,7,7,7
7,7,7,7,7,7,7,7
7,7,9,9,11,11,13,13
13,13,11,11,9,9,7,7
7,7,9,9,11,11,13,13
13,13,11,11,9,9,7,7
0
1
4
6
2
3
7
5
8
.
= PI max (Ti)-Tj
? h' forall jI
k
E
i=O
P{Ti > Tj
for all j
Ti -h'
k
k
=
j=1
7)
1,1,1,1
1,2,3,4
1,4,7,10
1,1,1,1
1,2,3,4
1,2,3,4
1,4,7,10
1,4,7,10
In this section we describehow the criticalpoints for
the various proceduresincluded in the MC study were
obtained. The actual details of the MC study are given
in the followingsection.
Unusual t values needed forD' and T2' wereobtained
by using the IMSL subroutineMDSTI. Similarly,the
critical point d2,a, for S and the F values for BF' were
obtained by using the IMSL subroutineMDFI. Note
that both MDSTI and MDFI give exact resultseven in
the case of fractionaldf. The q and q' values needed for
GH and TSS wereobtainedby interpolationin the tables
given by Harter (1960) and Stoline (1978), respectively.
The ImI values needed for GT2 were obtained by
interpolationin the tables given by Stoline and Ury
(1978). Linear harmonic interpolationwith respect to
the df was used in all threecases.
Tables of values of ha' needed forHi are not available
in the literature.To computeha' we develop an integral
expressionforthe distributionfunctionof R' that seems
to be new and hence is given here. Represent
R' = maxo<i<j<k IT, - Tj where To - 0, Ti is distributedas a t4 rv (denotedby TM 4
t), and T1, ... Tk
To obtain ha' ha'(,,v ...
are independent.
Vk) one
solves the followingequation in h':
=
nk
1'
2'
3'
4'
5'
6'
7'
8'
5.2 CriticalPointsforthe VariousProcedures
1-a
Configuration
No. in
Terms of
I{F,2(0)
-
F,(-h')}
-
t=1
F;
h'
k
j=81
-FPY
-
i=
j
1}
I {Fvj(t)
si
(t - h') }dF, (t)
k
k
i==1 J, 1
+
{F,j(h')
k
hl
+ E |
4
(t -h') } f, (t)]dt ,
j|l
[Z
{FP,(t)
(5.2)
.447
.610
.235
.262
.639
.500
1.479
.447
.610
.235
.262
.639
.550
1.479
where f4(.) denotes the densityfunctionof a t, rv. The
IMSL (1978) subroutinieMDTD was used to evaluate
F,(.) and ZSYSTM was used to solve (5.2); Romberg
quadrature methodwas used to evaluate the integral.
ifthen, are equal), ImIk',Y,a,
The valuesofqk,,,a'(qk,v,,
11
and
... I >k)
ha'(i.
vk)used in the MC study
d2,aci
(
are given in Table 2.
2. CriticalPointsforthe VariousProcedures
(1 - a
k
P-'I,
I
'2
.,
Vk
V
h'
=
.95)
d2,
qk.v,a
q,V
I
m
kv,
4
6,6,6,6
6,8,10,12
24
36
4.747
4.374
4.156
3.812
3.901
-
3.810
2.851
2.775
8
6,6,6,6,6,6,6,6
48
6,6,8,8,10,10,12,12 72
5.903
5.359
5.396
4.906
4.481
-
4.415
3.286
3.228
5.3 Details of the MC Study
For each combinationof k and the (q2, n)-configuration
1,000 experimentswere run. For studyingthe CI's we
can take all the , equal to zero withoutloss ofgenerality.
Therefore,in each experiment,k independentpairs of
_
rv'ss i -~ N(0, ot2/n1) and s82 cr-2X"-/V,
weregenerated.
For generatingnormal rv's, the Box-MVilleralgorithm
was used; the chi-squaredrv's were generatedby using
the relation (for v even) xv2 - ' i=2 loge Ui wherethe
Ui are independentuniform[0, 1] rv's. The FORTRAN
libraryfunctionRANF was used to generatethe uniform
rv's.
We carriedout separate runs forpairwisecomparisons
and contrasts.For pairwise comparisons,for each procedure we obtained the estimates of (a) the achieved
of the
joint confidencelevel, (b) the expectedhalf-widths
and (c) the average
CI's forall (2) pairwisedifferences,
of the (") expected half-widths.For a given procedure,
the estimate of the joinitconfidencelevel was obtained
by keepinga count of the numberof runs in which zero
Tamhane: MultipleComparisonProceduresfor Unequal Variances
477
3. EstimatedConfidenceLevels forAll PairwiseComparisons
(1
O.95)a
-
No.
(~2n)-Configuration
k
Procedure
1
2
3
4
5
6
7
8
D'
S
Hi1
~~.999
.994
.985
.955
.946
.998
.993
.984
.956
.944
.995
.990
.975
.953
.941
.998
.993
.983
.954
.942
.996
.991
.989
.963
.950
.993
.987
.979
.947
.940
.998
.992
.986
.968
.957
.988
.982
.975
.948
.936*
.950
.951
.960
.955
.968
.963
.938*
.950
.970
.967
.998
.997
.985
.965
.935*
.990
.962
.962
.992
.992
.981
.942
.916*
.975
.927*
.942
~~T2'
4
GH
BF'
TSS
GT2
D'
S
Hi
~~T2'
8
8
~~~~GH
BF'
TSS
GT2
.957
.964
~~.999
~~~~
~~.997
.992
.966
.941
.990
.960
.965
~
.996
.995
.980
.963
.943
.985
.959
.960
.964
~
.962
.973
.953
.975
I
.9551
.992
.993
.984
.966
.948
.987
.965
.962
.993
.993
.983
.963
.949
.977
.914*
.938*
.998
.996
.986
.966
.946
.990
.922*
.916*
.993-i
.994
.984
.973
.949
.988
.897*
.882*
.930*
.940*
.945
.928*
.909*
.891~
Asterisk
indicatesthattheachievedconfidencetevelis less thanthe designatedconfidencelevel =95 at 10 percentsignificance.
The standarderrorofanyentry
P is given
by(P(l - P)/1,000)21.
was included in all
(2) Cl's for the differences unless the unbalance in the ri values is extreme.Keep in
k; i < j). The results regarding mind that both TSS and GT2 are conservativefor the
estimatedconfidencelevels are presentedin Table 3. For problem of pairwise comparisons (if the homogeineous
lack of space we have not reportedhere the estimatesof variances assumption holds) except when the ni are
the expected half-widthsforthe individual (k) compari- equal when TSS is exact. Thus the apparent robust
sons, but in Table 4 we have given the average (over (t) behavior of these procedures might be due to their
of the Cl's forpairwisediffer- inherentconservativenature.
Cl's) expectedhalf-widths
ences produced by each procedure.The half-widthsof
Amongthe proceduresdesignedforunequal variances
the Cl's produced by each procedurefor selected con- we findthat only GH tends to be liberal but theredoes
trastsare given in Table 5. Note that the resultsforTSS not seem to be any specificpatternof configurations
for
and GT2 are not included,in an effortto keep the table whichGH is liberal.This liberalnatureof GH was noted
small and also because sufficient
informationabout the in Games and Howell (1976), althoughin the MC study
relativeperformanceof these two proceduresis obtained done by Keselman and Rogan (1978) GH is shown to
fromthe pairwisecomparisonsdata. The standarderrors controlthe confidencelevel moreprecisely.We also find
of the estimatesare given as parentheticalentriesin the that BF', HI, S, and D' are increasinglymoreconservasame tables. In arrangingthe tables we have put the tive. This should not come as a surprisebecause BF' is
proceduresof similar type togetherso that their per- designedforall contrasts,whiletheotherthreeprocedures
formancescan be more readilycompared; thus we have are designedforall linear combinations.T2' controlsthe
put D', S, and Hi togetherbecause they possess the confidencelevel fairlywell. One can compare the percommon property of having resolutionsfor all linear formanceof T2' withthat ofT2 (see Table 1 of Tamhane
combinations.The discussion of the resultsis given in 1977; T2 is referredto as the W procedurethere) and
note the reductionin overprotection
the followingsection.
due to the use of the
Ury and Wigginsdf modification.
Next turnto Table 4. Amongthe proceduresdesigned
6. DISCUSSIONAND RECOMMENDATIONS
for unequal variances we note that GH produces the
Let us study Table 3 first.To identifythe liberal pro- shortestCI's for all the eight configurationswhile T2'
cedureswe have markedwithan asteriskthoseconfidence and BF' come next; HI, S, and D' produceincreasingly
levels that fall in the critical region for the one-sided wider Cl's. Althoughit seems that GH gives the best
hypothesis-testingproblem Ho: 1 - a = .95 vs. H1: performance
forpairwisecomparisons,one musttake into
1 - a < .95 at 10 percentlevel of significance(i.e., con- account the factthat GH is also somewhatliberal.If one
fidencelevels < .942). Thus we note that TSS and GT2 does not want to run the risk of frequentlyliberal CI's
tend to be liberalforconfigurations
6, 7, and 8; forother producedby GH, thenT2' seems to offerthe best choice
configurations
they seem to controlthe designatedcon- for pairwise comparisonsbecause it controls the confidencelevel fairlywell. One can thus conclude that for fidencelevel more preciselyand produces the Cl's that
pairwise comparisonsTSS and GT2 are fairly robust are only slightlywider.
-
i
j
=
1,
...,
478
Journalof the AmericanStatisticalAssociation,June 1979
4. Average Estimated Cl Half-Widthsfor Pairwise Comparisons
(1 - a
0.95)
(2,
k
1
2
3
4
5
6
7
8
D'
2.541
(.017)a
1.987
(.011)
2.930
(.016)
3.924
(.027)
4.109
(.022)
5.532
(.039)
3.212
(.021)
4.633
(.032)
S
2.173
(.014)
2.000
(.014)
1.643
(.010)
1.586
(.010)
1.692
(.011)
1.457
(.007)
1.506
(.007)
1.713
(.009)
1.580
(.010)
1.376
(.008)
1.309
(.007)
1.424
(.008)
1.323
(.005)
1.260
(.005)
2.576
(.014)
2.370
(.015)
2.022
(.011)
1.933
(.010)
2.103
(.011)
2.205
(.009)
2.100
(.009)
3.418
(.024)
3.285
(.027)
2.583
(.018)
2.535
(.018)
2.661
(.018)
2.335
(.012)
2.393
(.012)
3.720
(.020)
3.594
(.022)
2.930
(.016)
2.797
(.016)
3.045
(.017)
3.339
(.014)
3.181
(.014)
4.930
(.037)
4.901
(.042)
3.727
(.028)
3.722
(.030)
3.839
(.029)
3.371
(.018)
3.485
(.018)
2.809
(.019)
2.774
(.023)
2.368
(.018)
2.227
(.017)
2.426
(.018)
1.983
(.008)
1.889
(.008)
4.129
(.031)
4.201
(.034)
3.560
(.030)
3.330
(.027)
3.628
(.030)
2.840
(.013)
2.705
(.013)
D'
2.976
(.020)
3.341
(.018)
6.524
(.046)
3.708
(.024)
5.359
(.037)
2.830
(.018)
2.498
(.018)
2.086
3.305
(.018)
2.910
(.017)
2.500
4.534
(.036)
4.374
(.030)
3.994
(.037)
3.225
4.672
(.025)
S
2.284
(.014)
2.207
(.013)
1.934
(.013)
1.721
4.750
(.026)
4.325
(.027)
3.607
6.423
(.048)
6.050
(.051)
4.736
3.612
(.024)
3.362
(.027)
2.993
5.297
(.038)
5.070
(.043)
4.526
(.014)
1.947
(.013)
2.367
(.015)
1.687
(.005)
1.750
(.006)
(.010)
1.590
(.009)
1.973
(.011)
1.522
(.004)
1.471
(.004)
(.014)
2.332
(.013)
2.894
(.016)
2.530
(.006)
2.445
(.007)
(.022)
3.057
(.022)
3.658
(.024)
2.641
(.009)
2.739
(.009)
(.020)
3.357
(.018)
4.169
(.023)
3.817
(.011)
3.689
(.011)
(.035)
4.572
(.034)
5.372
(.038)
3.932
(.015)
4.077
(.016)
(.024)
2.705
(.022)
3.365
(.027)
2.291
(.007)
2.215
(.007)
(.039)
4.044
(.033)
5.035
(.041)
3.281
(.010)
3.171
(.010)
Procedure
H1
T2'
4
GH
BF'
TSS
GT2
Hi
T2'
8
n)-Configuration
No.
GH
BF'
TSS
GT2
The entries in parentheses are the standard errors of the corresponding estimates.
8 whereTr = 1/13 and Tk = 10/7. It is not
It is not the purpose of this article to carry out an configuration
such detailed comparisonshere because
give
to
possible
note
we
GT2.
But
and
extensivecomparisonbetweenTSS
of
space.
of
lack
uninvolving
in passing that for all the configurations
Finally, we turn to Table 5. In this table we have
numbers2, 3, 5, 7, and 8)
equal ni's (i.e., configuration
listed
the estimatedhalf-widthsof the Cl's forselected
while
for
the
other
GT2 producesshorterCl's than TSS,
for all the procedures designed for unequal
contrasts
Cl's.
shorter
produces
TSS
cases, as one would expect,
(i.e., excludingTSS and GT2). Here we find
that
variances
T2'
with
and
GH
of
widths
CI
By comparingthe
BF'
the best performancein all the cases. For
gives
that
re1
and
numbers
2,
of TSS and GT2 forconfiguration
second-best
performance,the contendersare S and
the
variances
the
for
which
configurations
spectively(i.e., the
betterthan GH forthehigh-order
seems
to
perform
GH.
S
in
loss
efficiency
idea
of
the
are homogeneous),one getsan
1
in
the
case of middle-ordercontrasts2
of
and,
case
in
the
contrast
comparisons,
for
pairwise
ifgood procedures
7 and 8 correspondingto unconfigurations
and
for
3,
when
used
unequal variances such as GH and T2', are
performsbetterin the other
GH
while
values
balanced
seem
that
ri
the underlyingvariances are equal. It would
comparisons,T2' proof
pairwise
case
the
cases.
As
in
in
be
kept
must
it
the loss is not substantial,although
wider than those proare
slightly
only
duces
CI's
that
sample
the
when
pertains
only
mindthat this conclusion
D'
very wide Cl's, Hl
produce
Hl
and
by
GH.
duced
sizes are not too different.
D'.
than
better
compariperforming
previous
the
all
out
that
It shouldbe pointed
Perhaps a verysurprisingresult (at least to us) of the
sons pertainto average CI widths. If the widthsof the
compared,
MC
study for contrastswas the performanceof S. Alare
differences
pairwise
(2)
for
individualCl's
we anticipatedthat BF' would performverywell
T2'.
D'
though
beats
there are few instances in which even
we did not quite anticipatethat S would be
highly
for
contrasts,
are
values
the
two
when
Typically this occurs
Ti
of D' and Hl even
The poor performance
the
second
best.
=
for
8)
hk(k
for
CI
different,
4,
namely, for the
Al
Tamhane: MultipleComparisonProceduresfor Unequal Variances
479
5. Estimated Cl Half-Widthsfor Contrasts
(1 - a= 0.95)
Contrast
No.
(CT2,
Procedure
1
2
3
4
5
6
7
8
1.436
(.004)
2.316
2.285
(.007)
1.120
(.003)
1.858
3.351
(.009)
1.681
(.004)
2.828
4.586
(.015)
2.281
(.008)
4.020
4.658
(.012)
2.431
(.006)
4.377
6.527
(.022)
3.349
(.012)
6.210
3.686
(.012)
1.868
(.007)
3.469
5.361
(.019)
2.797
(.011)
5.350
(.008)
2.085
(.006)
(.007)
1.740
(.006)
(.008)
2.511
(.006)
(.018)
3.292
(.012)
(.014)
3.648
(.010)
(.028)
4.820
(.017)
(.016)
3.130
(.014)
(.024)
4.841
(.022)
GH
1.945
(.006)
1.599
(.005)
2.339
(.006)
3.149
(.012)
3.387
(.009)
4.725
(.019)
2.788
(.011)
4.252
(.018)
BF'
1.022
(.003)
0.867
(.003)
1.286
(.003)
1.658
(.006)
1.863
(.005)
2.477
(.010)
1.499
(.006)
2.284
(.011)
D'
2.969
(.013)
2.016
(.009)
2.383
(.011)
2.081
(.009)
1.941
(.008)
1.571
(.007)
2.383
(.010)
1.612
(.007)
1.979
(.011)
1.842
(.010)
1.671
(.008)
1.365
(.007)
3.272
(.012)
2.310
(.008)
2.918
(.012)
2.449
(.009)
2.280
(.008)
1.847
(.007)
4.489
(.022)
3.211
(.017)
4.325
(.028)
3.300
(.018)
3.230
(.019)
2.590
(.015)
4.292
(.016)
3.270
(.013)
4.581
(.021)
3.516
(.015)
3.256
(.013)
2.662
(.011)
6.136
(.031)
4.668
(.027)
6.721
(.043)
4.787
(.027)
4.901
(.031)
3.872
(.024)
3.891
(.020)
2.771
(.016)
3.928
(.026)
3.663
(.025)
3.146
(.020)
2.501
(.015)
5.578
(.031)
4.173
(.026)
6.126
(.040)
5.852
(.041)
4.907
(.033)
3.866
(.025)
D'
2.980
(.013)
5.023
(.018)
6.917
(.031)
3.481
(.014)
5.143
(.021)
2.025
(.009)
2.401
(.011)
2.090
(.009)
1.951
(.009)
1.578
(.007)
3.429
(.013)
2.428
(.009)
2.855
(.012)
2.568
(.009)
2.398
(.009)
1.942
(.007)
4.684
(.022)
S
2.187
(.008)
1.544
(.006)
1.820
(.008)
1.642
(.007)
1.532
(.006)
1.245
(.005)
3.199
(.015)
3.847
(.021)
3.299
(.016)
3.094
(.015)
2.502
(.012)
3.574
(.013)
4.270
(.018)
3.785
(.013)
3.530
(.012)
2.862
(.010)
4.743
(.021)
5.821
(.032)
4.892
(.022)
4.609
(.022)
3.721
(.017)
2.473
(.010)
3.050
(.017)
2.683
(.012)
2.487
(.011)
2.031
(.009)
3.670
(.015)
4.600
(.025)
4.008
(.018)
3.705
(.016)
3.033
(.014)
D'
2.975
(.009)a
S
Hi
T2'
S
H1
2
n)-Configuration
T2'
GH
BF'
Hi
T2'
GH
BE'
"The entries in parentheses are the standard errors of the corresponding estimates.
for contrastswould seem to rule out their use in most
practicalapplications.It shouldbe mentionedthat Hi is
less conservativeforpairwisecomparisonsthan S, while
D' always seems to be the most conservative.
On the whole, we would recommendGH and T2' for
pairwisecomparisons,GH givingslightlynarrowerCl's
than T2' at the riskof not attainingthe designatedconfidencelevel by a small amountin some cases. For general
contrastcomparisonswe recommendthe BF' procedure.
[ReceivedOctober1977. RevisedDecember1978.]
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