1354 Folder Wei (Konvertiert)-1 27.06.2002 12:53 Uhr Seite 6
Roche Molecular Biochemicals
Molecular Weight Markers
for Nucleic Acids
74
421
124, 123
104
89, 80
64, 57, 51,
21, 18, 11, 8
267
234
213
192, 184
458, 434
504
540
587
Cat. No. 1 062 590
100
50
125
Cat. No. 528 552
125
λ DNA • Eco Rl + Hind lll
564
697
8-587 bp
564
831
154
234, 220
298
394
517
453
653
1033
1230
1766
2176
359
492
710
(718*)
992
1164
1515
1482
1953
1882
IX
72
118
281, 271
234
194
310
603
872
1078
1353
X
Cat. No. 1 721 925
2642
2642
3574
150
154, 134,
75
50
100
200
250
750
700
650
600
550
500
450
400
350
300
220, 201
298
396
344
517, 506
1018
1636
2036
3054
3000
2750
100
200
300
400
500
600
700
800
900
1000
1500
1400
1300
1200
1100
2392
appear brighter for
easier analysis
250
500
750
1000
1250
1500
1750
2000
2250
2500
500
1000
1500
2000
2500
3000
3500
4000
Cat. No. 1 721 933
4072
Cat. No. 1 721 615
5000
4500
Cat. No. 1 855 638
5090
12216
11198
10180
9182
8144
7126
6108
48502
38412
32745
29027
26718
24918
22010
20323, 19944
18780
16710
15262, 15258
14183
13282, 12379
11848, 11205
10086, 9688
8113
7801
XVII
XVI
XV
XIV
XIII
Cat. No. 1 855 646
67
37, 34,
26, 19
124
110
147
190
242
320
404
501, 489
692
900
1114
pUC BM 21 • Hpa ll + pUC BM 21 DNA •
Dra l + Hind lll
925
1150
1469
1882
2799
3639
4899
6106
0.019-1.11 kbp
947
1375
1584
2027
1904
2322
2690
3140
4254
0.15-2.1 kbp
2027
2322
3530
4268
5526
VIII
0.072-1.35 kbp
1.000
3530
4361
5148, 4973
λ DNA + pSPTBM 20 DNA •
Sty l + Sau l
4878
8576
7427
0.08-8.57 kbp
5804, 5843
VII
1018 bp DNA fragment
multimers and pBR 322
DNA fragments
7743
VI
0.075-12.21 kbp
6557
0.07-19.3 kbp
19329
V
50 bp ladder
9416
0.12-21.2 kbp
21226
IV
100 bp ladder
7421
0.12-23.1 kbp
23130
III
Expand DNA molecular
weight marker
10.000
3.5-21.2 kbp
21226
II
250 bp ladder
70.000
base pairs
I
Fragment Sizes of DNA Molecular Weight Markers
1354 Folder Wei (Konvertiert)-1 27.06.2002 12:51 Uhr Seite 1
500 bp ladder
Cat. No. 1 498 037
φX 174 • Hae lll
Cat. No. 1 449 460
Cat. No. 1 336 045
SPP l DNA • Eco RI
Cat. No. 1 209 264
pBR 328 DNA • Bgl l + pBR 328 DNA • Hinf l
pBR 322 DNA • Hae lll
Cat. No. 821 705
Cat. No. 1 418 009
λ DNA • Hind lll
Cat. No. 236 250
λ DNA • Eco Rl
Cat. No. 236 233
1354 Folder Wei (Konvertiert)-1 27.06.2002 12:53 Uhr Seite 2
DNA Molecular Weight Markers
DNA Molecular Weight Marker I
(3.5-21.2 kbp)
␭ DNA • Eco Rl
Cat. No. 236 233 • 50 µg (200 µl) • 50 lanes
bp
ng/4 µl
21226
438
7421
5804
5643
4878
3530
153
120
116
100
73
Conc.: 250 µg/ml
6 DNA fragments
Cat. No. 236 250 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml
6 DNA fragments, as determined by computer
analysis for sequenced λ DNA.
Cat. No. 821 705 • 50 µg (200 µl) • 50 lanes
Separation conditions:
4 % Agarose MP gel, 1 µg DNA/lane
21226, 7421, 5804, 5643, 4878, 3530 bp as determined by computer
analysis of sequenced λ DNA. The 21226 and 3530 bp DNA fragments
contain the 12-base sticky ends (cos-side) of the λ DNA. These DNA
fragments are visible after the appropriate incubation procedure acc. to
pack insert.
␭ DNA • Hind lll
pBR 322 DNA • Hae III
Conc.: 250 µg/ml
22 DNA fragments, as determined by computer
analysis for sequenced pBR 322 DNA.
Separation conditions: 1 % Agarose MP gel, 1 µg DNA/lane
DNA Molecular Weight Marker II
(0.12-23.1 kbp)
DNA Molecular Weight Marker V
(8-587 bp)
bp
The DNA fragments smaller than 64 bp cannot
be separated clearly due to their small size.
ng/4 µl
23130
477
9416
6557
194
135
4361
89
2322
2027
48
42
DNA Molecular Weight Marker VI
(0.15-2.1 kbp)
pBR 328 DNA • Bgl l +pBR 328 DNA • Hinf lll
Cat. No. 1 062 590 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml
15 DNA fragments, as determined by computer
analysis for sequenced pBR 328 DNA.
Separation conditions:
2 % Agarose MP gel, 1 µg DNA/lane
Separation conditions:
1 % Agarose MP gel, 1 µg DNA/lane
The 23130 and 4361 bp DNA fragments contain
564
the 12-base sticky ends (cos-side) of the λ DNA.
These DNA fragments are visible after the appropriate incubation
procedure acc. to pack insert. The 125 bp DNA fragment cannot be
detected due to its small size.
12
The DNA fragment mixture shows a pattern
with 11 bands after agarose gel electrophoresis.
DNA Molecular Weight Marker VII
(0.08-8.57 kbp)
SPP I DNA • Eco RI
DNA Molecular Weight Marker III
(0.12-21.2 kbp)
␭ DNA • Eco Rl + Hind lll
Cat. No. 528 552 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml
13 DNA fragments, as determined by computer
analysis for sequenced λ DNA.
Separation conditions:
1 % Agarose MP gel, 1 µg DNA/lane
bp
ng/4 µl
21226
438
5148
4973
4268
3530
106
103
88
73
2027
1904
42
39
1584
1375
33
28
925
831
19
17
The 21226 and 3530 bp DNA fragments contain
564
the 12-base sticky ends (cos-side) of the λ DNA.
These DNA fragments are visible after the incubation procedure acc.
to pack insert. The 125 bp DNA fragment cannot be detected due to its
small size.
DNA Molecular Weight Marker IV
(0.07-19.3 kbp)
␭ DNA + pSPTBM 20 DNA • Sty l + Sau l
Cat. No. 1 418 009 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml
14 DNA fragments, as determined by
computer analysis for sequenced λ DNA and
pSPTBM 20 DNA.
bp
12
Cat. No. 1 209 264 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml
17 DNA fragments, as determined by computer
analysis of the SPP 1 sequence.
Separation conditions:
1 % Agarose MP gel, 1 µg DNA/lane
ng/4 µl
bp
587
540
504
458
434
135
124
116
105
99
267
234
213
192
184
61
54
49
44
42
124/123
104
89/80
28/28
24
20/18
64/75/51/
21/18/11/
8
15/13/
12/5/
4/3/2
bp
ng/4 µl
2176
222
1766
179
1230
125
1033
105
653
67
517
453
394
53
46
40
30.5/
30.5
24/
24/22
15.5/
15.5
298/298
234/234/220
154/154
bp
ng/4 µl
8576
7427
6106
4899
3639
189
167
141
113
82
2799
64
1953
1882
45
44
1515
1482
1164
992
35
33
27
24
710 (718*)
16
492
12
The DNA fragment 718 bp is not present in
359
9
stoichiometric amount due to circular permutation of the genome. The 718 bp and 710 bp DNA fragments run as one
band. In agarose gels where the 710 bp and the 718 bp DNA fragment
can be resolved, the 718 bp DNA fragment with approx. 20% the intensity
of the 710 bp DNA fragment, can be distinguished.* The 81 bp DNA fragment is only visible on overloaded gels. The DNA fragment mixture shows
the typical pattern with 15 bands after agarose gel electrophoresis.
*Alonso, J.C. & Trautner, T.A.; personal communication of unpublished results.
ng/4 µl
19329
7743
5526
4254
3140
2690
2322
1882
1489
1150
925
697
374
150
107
82
61
52
45
36
29
22
18
14
421
8
Separation conditions: 1 % Agarose MP gel, 1 µg DNA/lane
The 19329 and 4254 bp DNA fragments contain the 12-base sticky ends
(cos-side) of the λ DNA. These DNA fragments are visible after the
appropriate incubation procedure acc. to pack insert. The 74 bp DNA
fragment cannot be detected due to its small size.
DNA Molecular Weight Marker VIII
(0.019-1.11 kbp)
pUC BM 21 DNA • Hpa ll +
pUC BM 21 DNA • Dra l + Hind lll
Cat. No. 1 336 045 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml
18 DNA fragments, as determined by computer
analysis for sequenced pUC BM 21 DNA.
Separation conditions:
2 % Agarose MP gel, 1 µg DNA/lane
bp
ng/4 µl
1114
102
900
83
692
63
501
489
404
138
135
111
320
88
242
67
190
52
147
124
110
40
34
30
67
37/34/34/
26/19
18
10/9.5/
9.5/7/2
The DNA fragment mixture shows a pattern
with 15 bands after agarose gel electrophoresis. The 501 bp and 489 bp
DNA fragments as well as the DNA fragments 37-19 bp run as one band.
1354 Folder Wei (Konvertiert)-1 27.06.2002 12:53 Uhr Seite 3
DNA Molecular Weight Marker IX
(0.072-1.35 kbp)
⌽X 174 • Hae lll
Cat. No. 1 449 460 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml
11 DNA fragments, as determined by computer
analysis for sequenced ΦX 174 DNA.
Separation conditions:
1 % Agarose MP gel, 1 µg DNA/lane
bp
ng/4 µl
1353
250
Mixture of 1018 bp DNA fragment with its
multimers and pBR 322 DNA fragments
Cat. No. 1 498 037 • 100 µg (400 µl) • 50 lanes
Conc.: 250 µg/ml
23 DNA fragments, as determined by computer
analysis of sequenced pBR 322 DNA.
Separation conditions:
2 % Agarose MP gel, 2 µg DNA/lane
200
872
160
603
110
Conc.: 100 µg/ml · 24 DNA fragments
57
52/50
Separation conditions:
0.4 % Agarose MP gel, 300-500 ng DNA/lane
310
281/271
234
194
43
36
118
72
22
13
bp
12216
11198
10180
9162
8144
7126
6108
5090
4072
3054
2036
1636
50 bp ladder
Cat. No. 1 721 925 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml · 16 DNA fragments
Separation conditions:
2 % Agarose MP gel, 1 µg DNA/lane
Cat. No. 1 855 638 • 50 µg (200 µl) • 50 lanes
517/506
396
344
298
220/201
154/134
Conc.: 250 µg/ml · 12 DNA fragments
bp
ng/4 µl
2642
638
750
700
650
600
550
500
450
400
350
300
250
200
150
16
15
14
13
11
95
19
17
15
13
53
21
22
100 bp ladder
Cat. No. 1 721 933 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml · 16 DNA fragments
Separation conditions:
2 % Agarose MP gel, 1 µg DNA/lane
bp
ng/4 µl
2642
1500
1400
1300
1200
1100
1000
900
800
700
600
500
400
300
468
24
23
21
19
18
113
29
26
23
19
105
39
29
The DNA fragment mixture shows a ladder with
200
15 DNA fragments and one DNA fragment of
100
2642 bp. The 500 and 1000 bp DNA fragment
are two to three times brighter, facilitating analysis of DNA fragments
generated by PCR or restriction digest and separated on agarose gels.
The marker can be used in combination with the 50 bp ladder, 250 bp
ladder and 500 bp ladder for precise size determination.
19
ng/4 µl
46
73
62
55
51
47
146
39/38
36
16710
15262/15258
14183
13282
12379
11848
11205
32
29/29
27
88
24
23
21
The 19944 bp and 20323 bp DNA fragments as
well as the 15258 bp and 15262 bp fragments
10086
19
9688
64
run as one band. The DNA fragments 9688 bp,
13282 bp and 22010 bp appear brighter.
8113
15
The 48502, 38412, 32745, 29027, 26718, 20323,
7601
14
19944, 15262, 15258, 14183, 12379, 11848, 11205,
10086, 9688 and 8113 bp DNA fragments contain the 12-base sticky ends
(cos-side) of the λ DNA. 22 DNA fragments are visible after the appropriate incubation procedure acc. to pack insert. DNA Molecular Weight
Marker XV allows accurate sizing of DNA fragmnets generated by long
PCR or restriction digest of high molecular weight DNA cleaved with rare
cutting restriction endonucleases and seperated on agarose gels.
250 bp ladder
The DNA fragment mixture shows a ladder with
15 DNA fragments and one DNA fragment of
100
19
2642 bp. The 250 and 500 bp DNA fragment are
50
21
two to three times brighter, facilitating analysis
of DNA fragments generated by PCR or restriction digest and seperated
on agarose gels. The marker can be used in combination with the 100 bp
ladder for precise size determination.
DNA Molecular Weight Marker XIV
Cat. No. 1 721 615 • 50 µg (500 µl) • 50 lanes
bp
48502
38412
32745
29027
26718
24918
22010
20323/19944
18780
DNA Molecular Weight Marker XVI
1018
The DNA fragment mixture shows a pattern of
19 bands after agarose gel electrophoresis.
The 517 bp and 506 bp, the 220 and 201 bp and the 154 and 134 bp
DNA fragment run as one band. These DNA fragments are visible after
the incubation procedure acc. to pack insert, the 1018 bp DNA fragment
and its multimers contain sticky ends. The 75 bp DNA fragment cannot
be detected due to its small size.
DNA Molecular Weight Marker XIII
Expand DNA molecular weight marker
1078
The DNA fragment mixture shows the typical pattern with 10 bands. The
281 bp and 271 bp DNA fragments run as one band.
DNA Molecular Weight Marker X
(0.075-12.21 kbp)
DNA Molecular Weight Marker XV
Separation conditions:
0.7 % Agarose MP gel, 1 µg DNA/lane
bp
ng/4 µl
3090
2750
2500
2250
2000
1750
1500
60
60
60
60
200
60
60
1250
60
1000
200
750
60
bp
ng/4 µl
5000
4500
4000
3500
3000
70
70
220
70
70
The DNA fragment mixture shows a ladder with
500
60
12 DNA fragments. The 1000 and 2000 bp DNA
fragment are two to three times brighter, facili250
60
tating analysis of DNA fragments separated on
agarose gels. The 250 bp ladder allows accurate sizing of DNA fragments
generated by PCR or restriction digests separated on agarose gels. This
marker can be used in combination with DNA Molecular Weight Marker
Xlll (50 bp ladder), DNA Molecular Weight Marker XIV (100 bp ladder)
and DNA Molecular Weight Marker XVlI (500 bp ladder) for precise size
determination.
DNA Molecular Weight Marker XVII
500 bp ladder
Cat. No. 1 855 646 • 50 µg (200 µl) • 50 lanes
Conc.: 250 µg/ml · 10 DNA fragments
2500
70
Separation conditions:
0.7 % Agarose MP gel, 1 µg DNA/lane
2000
220
1500
70
The DNA fragment mixture shows a ladder with
1000
70
10 DNA fragments. The 2000 and 4000 bp DNA
fragment are two to three times brighter, facilitating analysis of DNA fragments seperated
500
70
on agarose gels. The 500 bp ladder allows
accurate sizing of DNA fragments generated by PCR or restriction digest.
This marker can be used in combination with DNA Molecular Weight
Marker Xlll (50 bp ladder), DNA Molecular Weight Marker XIV (100 bp
ladder) and DNA Molecular Weight Marker XVI (250 bp ladder) for
precise size determination.
-Also available as DIG-labeled Molecular Weight Marker.
26
Note: DIG labeled Molecular Weight Markers show a retardation of the
banding pattern compared to the non-labeled DNA Molecular Weight Marker
in high resolution agaroses like agarose MS.
1354 Folder Wei (Konvertiert)-1 27.06.2002 12:53 Uhr Seite 4
RNA Molecular Weight Markers
RNA Molecular Weight Markers consist of a mixture of RNA fragments of defined length for use as size standards in
RNA gel electrophoresis. The fragments are prepared by in vitro transcription of linearized plasmids with either SP6 or
T7 RNA polymerases in separate reactions. The transcripts are then combined in a ratio so that a banding pattern with
even intensty in gel electrophoresis is ensured.
RNA Molecular Weight Marker I
(0.3-6.95 kb)
Cat. No. 1 062 611 • 100 µg (50 µl) • 10 lanes
Conc.: 2 mg/ml
9 RNA bands
RNA Molecular Weight Marker III
(0.3-1.52 kb)
bases
6948
4742
bases
1517
1049
Cat. No. 1 062 638 • 50 µg (50 µl) • 10 lanes
2661
1821
1517
575
483
310
Conc.: 1 mg/ml
5 RNA bands
1049
Separation conditions:
1-2 % Agarose MP in 1 x MOPS and
2 % formaldehyde
Separation conditions:
1-2 % Agarose MP in 1 x MOPS and
2 % formaldehyde
575
483
310
RNA Molecular Weight Marker II
(1.6-6.95 kb)
Cat. No. 1 062 620 • 50 µg (50 µl) • 10 lanes
Conc.: 1 mg/ml
5 RNA bands
-Also available as DIG-labeled Molecular Weight Marker.
bases
6948
4742
2661
1821
1517
Separation conditions:
1-2 % Agarose MP in 1 x MOPS and
2 % formaldehyde
Fragment Sizes of
RNA Molecular Weight Markers
I
II
III
0.3-6.95 kb
Cat. No. 1 062 611
1.6-6.95 kb
Cat. No. 1 062 620
0.3-1.52 kb
Cat. No. 1 062 638
bases
10.000
6948
6948
4742
4742
2661
2661
1821
1821
1517
1517
1517
1049
1049
1.000
100
50
575
575
438
438
310
310
1354 Folder Wei (Konvertiert)-1 27.06.2002 12:53 Uhr Seite 5
Ordering Information
DNA Molecular Weight Markers
DNA Molecular Weight Marker I
DNA Molecular Weight Marker II
DNA Molecular Weight Marker III
DNA Molecular Weight Marker IV
DNA Molecular Weight Marker V
DNA Molecular Weight Marker VI
DNA Molecular Weight Marker VII
DNA Molecular Weight Marker VIII
DNA Molecular Weight Marker IX
DNA Molecular Weight Marker X
DNA Molecular Weight Marker XIII
DNA Molecular Weight Marker XIV
DNA Molecular Weight Marker XV
DNA Molecular Weight Marker XVI
DNA Molecular Weight Marker XVII
Cat. No.
Pack Size
236 233
236 250
528 552
1 418 009
821 705
1062 590
1 209 264
1 336 045
50 µg
50 µg
50 µg
50 µg
50 µg
50 µg
50 µg
50 µg
200 µl
200 µl
200 µl
200 µl
200 µl
200 µl
200 µl
200 µl
1 449 460
1 498 037
50 µg
100 µg
200 µl
400 µl
1 721 925
1 721 933
1 721 615
1 855 638
1 855 646
50 µg
50 µg
50 µg
50 µg
50 µg
200 µl
200 µl
500 µl
200 µl
200 µl
Cat. No.
Pack Size
1 062 611
1 062 620
1 062 638
100 µg
50 µg
50 µg
RNA Molecular Weight Markers
RNA Molecular Weight Marker I
RNA Molecular Weight Marker II
RNA Molecular Weight Marker III
µl
Size range + Specification
(3.5-21.2 kbp) λ DNA • Eco Rl
(0.12-23.1 kbp) λ DNA • Hind lll
(0.12-21.2 kbp) λ DNA • Eco Rl + Hind lll
(0.07-19.3 kbp) λ DNA • + pSPTBM 20 DNA • Sty l + Sau l
(8-587 bp) pBR 322 DNA • Hae III
(0.15-2.1 kbp) pBR 328 DNA • Bgll +pBR 328 DNA • Hinf lll
(0.08-8.57 kbp) SPP I DNA • Eco Rl
(0.019-1.11 kbp) pUC BM 21 DNA • Hpa ll
+ pUC BM 21 DNA • Dra l + Hind lll
(0.072-1.35 kbp) ΦX 174 • Hae lll
(0.075-12.21 kbp) 1018 bp DNA fragment
multimers and pBR 322 DNA fragments
50 bp ladder
100 bp ladder
Expand DNA molecular weight marker
250 bp ladder
500 bp ladder
(0.3-6.95 kb)
(1.6-6.95 kb)
(0.3-1.52 kb)
µl
50 µl
50 µl
50 µl
DNA Molecular Weight Markers, DIG labeled
Cat. No.
Pack Size
DNA Molecular Weight Marker II, DIG labeled
DNA Molecular Weight Marker III, DIG labeled
DNA Molecular Weight Marker V, DIG labeled
DNA Molecular Weight Marker VI, DIG labeled
DNA Molecular Weight Marker VII, DIG labeled
DNA Molecular Weight Marker VIII, DIG labeled
1 218 590
1 218 603
1 669 931
1 218 611
1669 940
1 449 451
5 µg
5 µg
5 µg
5 µg
5 µg
5 µg
RNA Molecular Weight Markers, DIG labeled
Cat. No.
Pack Size
RNA Molecular Weight Marker I, DIG labeled
RNA Molecular Weight Marker II, DIG labeled
RNA Molecular Weight Marker III, DIG labeled
1 526 529
1 526 537
1 373 099
4 µg
2 µg
2 µg
µl
500 µl
500 µl
500 µl
500 µl
500 µl
500 µl
µl
200 µl
200 µl
200 µl
Related Products
Product
Agarose Gel DNA Extraction Kit
Agarose MP (multi purpose agarose)
Agarose LM-MP (low melting point multi purpose agarose)
Agarose MS
Agarose LE (low electroendosmosis)
Agarase from Pseudomonas atlantiva
Premixed TAE Buffer, 10 x
Premixed TBE Buffer, 10 x
SYBR Green l Nucleic Acid Gel Stain
SYBR Green ll RNA Gel Stain
Cat. No.
Pack Size
1 696 505
1 388 983
1388 991
1 441 345
1 441 353
1 816 586
1 816 594
1 685 660
1 685 678
1 417 215
1 417 223
1666 690
1666 703
1 988 131
1 988 123
1 988 158
1 988 140
1 kit (max. 100 extr.)
100 g
500 g
50 g
100 g
100 g
500 g
100 g
500 g
100 units
500 units
4L
4L
500 µl
2 x 500 µl
500 µl
2 x 500 µl
To place an order or for more information, contact your Roche
Molecular Biochemicals worldwide representative or contact us
on the Internet at http://biochem.roche.com.
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Roche Molecular Biochemicals
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Germany