V
Con8eOats
Volume 2, Part 2,1974
544TH MEETING, LONDON
Colloquium: The Role of Biotransformation in Toxic Action
Reaction producing and reducing toxicity. By R. L. Smith
Mechanisms and effects of the formation of reactive metabolites in the endoplasinic reticulum. By E. Arrhenius
Detoxication of reactive metabolites. By E. Boyland
The interaction of reactive metabolites with components of mammalian cells.
By P. D. Lawley
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167
167
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173
Colloquium: Protein Synthesisin Organelles and Assembly of Energy Conservation
Systems
Structural and regulatory genes for the assembly of photosynthetic membranes.
By D. von Wettstein
176
The biogenesis of chloroplasts : protein synthesis by isolated chloroplasts. By
R. J. Ellis
Mitochondria1 nucleic acids. By P. Borst
Biogenesis of mitochondria1 cytochromes. By H. Weiss
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182
185
Colloquium: Neurochemical Correlatesof Environmental Change and Learning
Specific and non-specific brain events associated with learning. By P. P. G.
Bateson
Possible long-term effects on the human brain of early environmental deprivation. By J. Dobbing
Behavioural effects of blocking macromolecular synthesis in brain. By B. W.
AgranoiY, J. H. Neale & W. M. Schoel
After-effects of drugs o n behaviour, and the concept of ‘state-dependence’.
By H. Steinberg & M. Tomkiewicz
Neuronal protein synthesis and environmental stimulation: state-dependent
and longer-term effects. By S. P. R . Rose
Communications
Configurational changes in isolated turnip (Brussicunupus L.) mitochondria. By
H. Gunawardena & S. B. Wilson
Isolation, purification and characterization of aurovertin B. By M. D. Osselton,
H. Baum & R . B. Beechey
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CONTENTS
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The isolation and properties of venturicidin A. By P. Langcake, R. B. Beechey,
C. R. Lindop, S. G. A. Wickins, D. P. Leworthy, D. E. Wiggins & J. M. Broughall 202
Factors affecting the inhibitor sensitivity of the mitochondrial membrane-bound
adenosine triphosphatase activity. By M. Partis, A. D. Mitchell, J. Whitehead,
205
J. F. Donnellan, P. E. Linnett & R. B. Beechey
The use of a fatty acid desaturase mutant of Saccharomyces cerevisiae to investigate the role of lipids in mitochondrial membrane functions. By J. M. Haslam,
207
G. S. Cobon & A. W. Linnane
A biochemical genetic investigation of oligomycin and related inhibitors. By
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R. L. Houghton, W. E. Lancashire & D. E. Griffiths
Two mitochondrial genes specifying venturicidin resistance in yeast. By W. E.
213
Lancashire, R. L. Houghton & D. E. Griffiths
Is the adenosine diphosphate-adenosine triphosphate translocase system
influenced by mitochondrial genes? By K. Cain, W. E. Lancashire & D. E.
215
Griffiths
Growth of galactose can prevent or delay the induction of petite mutants of
SaccharomycescerevisiaeN.C.Y.C.239 byethidium bromide. By R. C. Hammond,
218
M. Wright & P. A. Whittaker
The effects of prolonged exposure to chloramphenicol on the mitochondrial
system of protein synthesis in yeast. By D. T. Plummer, D. R. Murray & A. W.
221
Linnane
Stable nuclear pleiotropic respiratory-deficient mutants with modified mitochondrial cytochrome a+ u3 and adenosine triphosphatase in a ‘petite-negative’
yeast Schizosaccharornycespombe. By A. Goffeau, A. M. Colson, Y . Landry, F.
223
Foury & M. Briquet
The timing of mitochondrial deoxyribonucleic acid replication during the cell
224
cycle in Saccharomyces cerevisiae. By I. W. Dawes & B. L. A. Carter
Replicative intermediates of Tetrahyrnena pyriforrnis mitochondrial deoxyribonucleic acid. By R. A. Clegg, P. Borst, P. J. Weijers, A. C . Arnberg & E. F. J.
227
van Bruggen
Interaction and recombination between extranuclear genetic elements of
2,30
Aspergillus nidulans. By R. T. Rowlands & G. Turner
A ferredoxin-polynucleotide complex as a membrane transducer element. By
232
B. R. Thomas
Inhibition of protein synthesis in reticulocytes by 2-(4-methyl-2,6-dinitroanilino)234
N-methylpropionamide. By L. Gedarnu, B. L. M. Hogan & J. E. Kay
The ultrastructure of turnip (Brassicu nupus L.) submitochondrial particles. By
237
H. Gunawardena & S. B. Wilson
Subcellular localization of proteins labelled in visual cortex on first exposure of
2-38
dark-reared rats to light. By A. Jones-Lecointe, S . P. R. Rose & A. K. Sinha
Factors affecting incorporation of [3H]lysine into proteins in neurons and
239
neuropil in uiuo. By S . P. R. Rose & A. K. Sinha
Effects of early visual experience on [14C]lysine incorporation into the chick
241
brain. By J. Haywood, J. Hambley, S. P. R. Rose & P. P. G. Bateson
Developmental changes in the potassium chloride-induced dissociation of rat
243
cerebral free polyribosomes. By J. 0. White, L. Lim & A. N. Davison
Nucleic acid metabolism in the developing rat brain. By W. Berthold, L. Lim
244
& A. N. Davison
The search for the messenger ribonucleic acid of rat brain myelin basic proteins.
245
By L. Lim, J. 0. White, C. Hall, W. Berthold & A. N. Davison
1974
CONTENTS
vii
PAGE
Cellular site of synthesis of myelin protein in the rabbit optic pathway. By P. P.
Giorgi & E. J. Field
Lipid-protein interactions in myelin. By N. L. Banik & A. N. Davison
Incorporation of labelled fucose and glucosamine into glycoproteins in oioo
from cerebellar neuronal perikarya and nerve endings. By G. R. Dutton, J.
Cohen & G. Wilkin
Adult rat brain synaptic vesicles: protein and glycoprotein composition. By
I. G. Morgan, J. P. Zanetta, W. C. Breckenridge, G. Vincendon & G . Gombos
The role of lipid in the structure of central-nervous-system myelin. By D. H.
Adams
Neurochemical evidence for biphasic myelination in the developing central
nervous system of lambs and piglets. By J. A. Foulkes & D. S. P. Patterson
Electrophoretic characterization of A and B isoenzymes of arylsulphatase. By
G. Dubois, J. C. Turpin & N. Baumann
Effect of psychoactive drugs on dopamine(3,4-dihydroxyphenethylamine)-sensitive adenylate cyclase activity in corpus striatum of rat brain. By R. J. Miller &
L. L. Iversen
Cellular localization of phosphoproteins in guinea-pig cerebral-cortex slices
sensitive to noradrenaline, histamine and 5-hydroxytryptamine. By M. Williams,
A. Pavlik & R. Rodnight
The effect of stimulation on 32Pincorporation in uitro into the phospholipids of
subsynaptosomal fractions. By J. E. Bleasdale & J. N. Hawthorne
Accumulation of acetylcholine in ligated cholinergic neurons, traced by subcellular
fractionation and by immunofluorescence. By E. Heilbronn, H. Pettersson &
L. Widlund
Effects of lesions and drugs on tryptamine and 5-hydroxytryptamine in rat brain.
By C. A. Marsden & G. Curzon
y-Aminobutyric acid in the rat peripheral nervous system, pineal and posterior
pituitary. By P. M. Beart, J. S. Kelly & F. Schon
A study ~fy-[~H]aminobutyricacid
and r3H]glycine accumulation by the isolated
pigeon retina utilizing scintillation radioautography. By J. Marshall & M.
Voaden
Biochemical properties of synaptosomes from the optic lobe of squid (Loligo
peal;;). By M. J . Dowdall
Superfused ‘beds’ of neocortical-derived synaptosomal fractions: adenine
nucleotide content and the release of [I4C]adenine derivatives. By I. Pull &
H. McIlwain
Effects of different potassium ion concentrations and of procaine and pentobarbital on [14C]glutamate fluxes in rat brain-cortex slices. By G. B. Weiss &
L. Hertz
Is there a connexion between brain biogenic amines and amnesia in rats? By
H. Rigter, G. van Eys & B. E. Leonard
Cytochrome oxidase and monoamine oxidase activities in mitochondria1
populations isolated from the developing chick brain. By C. Barberis & J. Gayet
Ascorbic acid in developing brain: possible function as an inhibitor of lipid
peroxidation. By B. P. F. Adlard
Amino acids in subcellular brain particles. By G. Brante
Treatment of experimental epilepsy with taurine. By G. H. T. Wheler, R. H.
Osborne, H. F. Bradford & A. N. Davison
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Changes in amino acid and enzyme amounts during the development of cobaltinduced epilepsy in the rat. By M. H. Joseph & P. C. Emson
Mechanisms of Addisonian central-nervous-system degeneration : identity and
possible role of cerebrospinal folate derivatives. By N. G. L. Harding
Fatty acid composition of cholesterol esters in congenital disorders of lambs
and piglets. By D. Sweasey & D. S. P. Patterson
Comparative biosynthesis of ceramides in brain microsomal fractions of normal
and quaking mice. By B. Zalc & N. Baumann
Fatty acid biosynthesis in mouse brain microsomal fractions. By S. Pollett,
J. M. Bourre & N. Baumann
The kinetics of glucose influx into the mouse brain in uiuo and the effects of
pentobarbitone anaesthesia and hypothermia. By R. W. Horton
Sodium-independent uptake of sugars by brain-cortex slices. By H. LundAndersen & H. E. Brmdsted
The uses of unfixed isolated mammalian nerve cells. By H. Hillman
Dietary carbohydrate and intellectual performance. By G. G. Birch
New aflatoxins from cultures of Aspergillusflauus. By J. G. Heathcote & J. R.
Hibbert
Monophenyl phosphate, anew conjugate of phenol in the cat. By I. D. Capel, P.
Millburn & R. T. Williams
Studies on the conjugation of 4’-hydroxyamphetamine in uitro. By J. V . Dingell,
J. Caldwell, J. R. Moffat, R. L. Smith & R. T. Williams
Acrolein as a possible metabolite of cyclophosphamide in man. By C. M. Kaye
& L. Young
Studies on the metabolism and hepatotoxicity of coumarin in the baboon. By
S. D. Gangolli, W. H. Shilling, P. Grasso & I. F. Gaunt
Effects of prolactin upon CI9steroid metabolism by rat mammary carcinoma.
By W. R. Miller, R. Buchan & A. P. M. Forrest
Glutathione metaboiism in sheep erythrocytes with high and low concentrations
of reduced glutathione. By J. D. Young, I. A. Nimmo & J. G. Hall
Increased hepatotoxicity of paracetamol in rats on low-protein diets of phenobarbital, and protection by selenate. By A. E. M. McLean & P. Day
The neurotoxicity and conversion of N-hydroxymethylacrylamide in viuo. By
P. M. Edwards
The use of mega quantities of ascorbic acid or ascorbate for therapeutic and
prophylactic purposes in relation to biochemical individuality. By S. Lewin
Studies on the effects of the oral administration of di-(2-ethylhexyl)phthalate
on some hepatic enzymes in the rat. By B. G. Lake, S. D. Gangolli, M. G. Wright,
P. Grasso & A. G. Lloyd
The uptake of glucose by human skin fibroblasts. By J. C. Marsden
Indirect assessment of the sodium-plus-potassium ion-stimulated adenosine
triphosphatase in cystic-fibrosis skin fibroblasts. By J. C. Marsden
The physicochemical factor required for the biliary excretion of organic cations
and anions. By P. C. Hirom, R. D. Hughes & P. Millburn
Growth inhibition of Escherichia coli by Acridine Orange and its dependence on
pH. By G . R. Barker & N. Hardman
Attempts to obtain small functional subunits of the haemocyanins from
Buccinum undatum and Neptunea antiqua. By J. S. Pearson & E. J. Wood
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CONTENTS
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The isolation and properties of a lipoprotein fraction possessing tyrosinase
activity from the haemolymph of the larva of the fleshfly, Sarcophaga barbata.
By L. Hughes & G. M. Price
Studies on phosphoglycollate phosphatase isolated from pea leaves. By M. W.
Kerr & C. F. Gear
Curvilinear kinetics of dihydrofolate reductase. By F. A. M. Fennel1 & N. G. L.
Harding
Fluorescence study of the interaction of 3,4-benzopyrene with microsomal
membranes. By A. L. Ibbetson & R. B. Freedman
Studies on the messenger ribonucleic acid fraction of rat ventral prostate gland.
By W. I. P. Mainwaring
Absence of ri bosomal specificity in livers from fed and starved mice. By P. Drew &
N. Maclean
BOOK REVIEWS
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