From www.bloodjournal.org by guest on June 18, 2017. For personal use only.
A
Study
of
the
by
By
N. A.
A. M.
of
liver
therapy
role
of
According
to
acts
Castle’s
intrinsic
with
an
extrinsic
tion. The nature
known
that the
chloric
acid,
pernicious
the
and
is absent
anemia.
Lasch
stomach
and
investigators,
pure
or minimal
obtained
juice
Smith,
and
G. B. Glass
intrinsic
and
factors
Boyd
enabled
the absorbtion
stomach
may
of
be
B12 by
considered
production
juice
factor
intestine.
as a part
in the
forma-
clear.
It is
and hydro-
third
with
ferment
of
effect
by
the
the
The
Other
administering
intrinsic
nature
factor
the
pancreas,
by Lester
of the
extrinsic
extrinsic
factor
(gastromucoprotein)
which
stomach.
Gastromucoprotein
Thus,
of the
anti-
of individuals
consider
process.
re-
is an
is inactivated.
antianemic
this
special
deposited
of blood
as the
pepsin
factor,
protein
of the
the
gastric
us to evaluate
in
a
the
substance
stomach
as a dual
gland,
bike
secretions.
Studies
conducted
participating
and the intrinsic
one, a special
within
the mucous
membrane
This
The
when
extrinsic
a hormone.
Greenspan
regards
the
with
endocrine
as well
as exocrine
milestones
contains
bloodstream,
in the process
intrinsic
enzyme
without
and
are
factors
is not altogether
distinct
from pepsin
a therapeutic
alone,
food.
in the
the
as a proteolytic
who
gastric
and extrinsic
is thermolabile,
regards
juice
mucosa.
into the
marrow
anemia
formation
gastric
in the
via the gut
by the bone
intrinsic
factor
blood
gastric
the
contained
absorbed
utilized
of the
intrinsic
by
KAKHETELIDZE
pernicious
in
normal
produced
factor
anemic
substance,
liver, and gradually
stomach
hypothesis,
factor,
M. G.
AND
in Addisonian
the
Factor
Methods
NAMYATISIIEVA
elucidation
of the
of modern
hematology.
substance,
Hematopoietic
Hemoculture
FEODOROV,
E SUCCESS
Gastric
the antianemic
general
process
is B12
is formed
secures
function
of digestion.
of
the
This
conception,
however,
cannot
completely
solve
the
problem
of the
participation
of the stomach
in hematopoiesis.
Nobody
disputes
the facts
of
the hematopoietic
activity
of the pure
gastric
juice
or parenterally
introduced
metabolites
and extracts
of the human
stomach.
These
data
were
obtained
by
the
method
gested
that,
of rat-reticulocytic
alongside
hematopoietic
effect
substance
upon
The
by
paper
The
quantitative
(lone as follows:
The
film
is cut
neutralized
From
Submitted
is
capable
quite
of
shallow
Institute
15,
1956;
method).
stomach
exerting
of iire
gastric
he
juice
sug-
another
stimulating
B12.
in man
and
dogs,
i. e., hemoculture.
pieces
of
1 sq.
and
mm.
being
previously
sterilized
by
straining
through
Hematology
and
for
publication
926
Blood
Feb.
factor
a white
in
gastric
cell film
in diameter
latter
of
direct
from
the
accepted
It can
produces
a
independently
a study
technic,
juice,
and
Central
Jan.
with
biologic
into
solution
the
the
determination
of hematopoietic
10 to 15 ml. of blood
are drawn
gastric
Ringer’s
(Singer’s
acting
deals
of a new
reaction
gastromucoprotein,
which
hematopoiesis,
present
means
with
a
Transfusion,
18,
and
diluted
1958.
small
Moscow,
juice
is
is made.
cultured
8 times
porous
USSR.
in
with
filter.
From www.bloodjournal.org by guest on June 18, 2017. For personal use only.
GASTRIC
HEMATOPOIETIC
Cultures
The
of the
927
FACTOR
same
hemocultures
white
are
cell
kept
film
at
in pure
a constant
To determine
the rate of migration
perimental
and control
hemocultures
projected
tracings
of the film. The
culated
by
02
the
the
film.
the
formula
The
of the
percent
and
control
hemopoietic
cultures
factor.
The
sibilities
to quantitate
experimental
ability
for
Numerous
studies
individuals
tion
and
of
shown
(dogs,
from
of
the
juice
that
gastric
and
0
index
the
of migration
between
as
quantitative
the
the
neutralized
provides
into
gastric
as controls.
37 C. for
of
six
hours.
the
on
the
surrounding
of
experimental
index
of
the
up
and
broad
posphysiology.
juice
of healthy
gastric
a marked
cellular
of migration,
circumference
of gastric
juice
opens
studies
on its nature
that
cats)
film
serve
P is the
of migration,
in rate
provisionally
have
action
where
this factor
and
clinical
animals
leukocytes
stimulating
zone
serves
temperature
0201
difference
solution
of cells,
the zones
of migration
of the exare measured
planimetrically
on paperindex
of migration
of the cultures
is cal-
P equals
circumference
Ringer’s
stimulus
for
nutrient
medium.
The
widely
from
migration
varies
the
migra-
5 to 10 to 60 to 80 plus.
We
have
changes
migration.
a speeding
up
with
extruded
nuclei
of
(figs.
Of
absence
including
always
found
also
juice
in marrow
cultures,
in addition
They
are:
increased
mitoses
maturation;
nuclei;
a greater
erythroblasts;
1 and
the
of their
an
an
brings
about
basic
to its stimulatory
of young
cells,
increased
degree
number
on
the
leukocyte
red,
plus
of macronormoblasts
of fragmentation
accelerated
cytophysiobogic
effect
mainly
and
hemoglohinization
swelling
of
the
in
the
cytoplasm
2).
patients
studied,
of hematopoietic
aplastic,
and
only
those
with
Addisonian
factor
in the gastric
also
in polycythemia,
found-sometimes
in elevated
the
amounts.
anemia
In other
forms
hematopoietic
juice.
Our
hemoculture
showed
an
of anemia,
factor
was
method
has
‘4
10
8
6
4
2
0
_____________________
if tez
oDs&vatton
1.D
3as
7i’,#{233}
contzoe
-
FIG.
marrow
1.-Changes
cultures.
in
mitotic
index
under
7e
the
2.V
4.D
test
influence
of
gastric
juice
added
to
bone
From www.bloodjournal.org by guest on June 18, 2017. For personal use only.
928
FEODOROV,
NAMYATISHEVA
AND
KAKHETELIDZE
xx
67
30
lgs
o5snvat.on
ufte
Fic.
2.-The
influence
of
gastric
21
13
juice
on
the
red
cell
43
The contoe
test
7
-
outgrowth
in
the
cultures
bone
of
marrow.
also
to
shown
the
that
the
presence
of
hematopoietic
the
poietic
factor
low temperatures.
is readily
Its
not
its effect
only
loses
With
the hemoculture
site of hematopoietic
utilized
gastric
portions
duced
pyloric
dialyzable
thermolability
on
next
and
factor.
acidity
is the
task
From
of the
the
main
was
with
various
200
occurs
in gastric
cantly
less
food
there
all nutrients,
not the
intimate
factor
We
data
ml.;
juice
substance
at
it
it.
more
For
the
precisely
this study
fundal
(see
stimuli
of
relation
hemato-
a long
time
on boiling
blocks
on
no
The
that
hematopoietic
in the mucosal
of Meulengracht
that
Pavlov
gastric
and
the
we
pyboric
factor
is prosecretions
of the
et al. that
the
table
affecting
1).
the
ml.;
400
the
casein,
Thus,
for
between
the
the
bread,
greatest
by
juice
stimulus
were
also
able
hematopoietic
to demonstrate
depends
upon
pouch
technic
on dogs
secretion:
meat
(raw),
by
bread,
we
factor
obtained
is a corresponding
the strongest
and
next
milk,
showed
is obtained
casein.
relation
of the
substances
600
Our
even
pouches
types
of hematopoietic
employed
the
to stimulate
casein,
bears
secretion.
preserved
for
noteworthy;
but
showed
is absent
opinion
the
juice
of
were
able
to localize
in the dog’s stomach.
isolated
secretor
the stimulus.
We
lowing
substances
ml.;
can be
especially
migration
data
and
the
gastric
amount
experiments
we know
that
the amount,
strength
and
secretion
is dependent
upon
the stimulus
which
evokes
it.
production
(1:1000).
is
also
to clarify
Pavlov’s
gastric
By experimenting
and
cellular
of
or
technic
we
factor
formation
fistulae
portion
Our
that
acidity,
of the stomach.
Our
mainly
by the fundus
portion.
This
refutes
pyboric
activity
pepsin,
milk,
200
Gm.;
quantity
then
and
the
clearly
nature
histamine,
0.5
of hematopoietic
meat,
and
histamine.
milk
Thus,
serum.
for
each
Signifitype
-
we
were
production
the character
of the stimulus
evoking
turned
to a study
of the hematopoietic
the
able
to
of
gastric
properties
demonstrate
the hematopoietic
secretion
of blood
ml.
factor
of a definite
hematopoietic
strength.
came
from
milk
that
is, the serum
first time,
quantitative
of
and used the fol200 Gm.;
milk,
of
Of
and
the
(fig. 3).
serum.
From www.bloodjournal.org by guest on June 18, 2017. For personal use only.
GASTRIC
HEMATOPOLETIC
1.-
TABLE
929
FACTOR
Contents
Different
of the
Parts
Erythropoietic
of the Stomach
Factor
(After
in the Gastric
Administration
Erythropoietic Factor
Revealed
Place
of
Secretion
of Gastric
Juice
Taken
Juice of Dogs,
of Histamine)
Erythropoietic
Factor
Not
from
Average
Quantity
of Erythropoietic
Factor
Found
Number
of
Dogs
Number
of
Experiments
Stomach
8
37
29
7
19
+34
Fundus
5
32
27
5
16
+29
Pylorus
30
11
9
82
In
one
(log
gastric
juice
meek
Number
of Cases
Number
of Cases
2
ol)taine(l
after
mechanical
Iuad
meat
irritation
of
casen
the
+7.5
stomach.
hy,stamLne
etmc/
J4VJ
intElt
1200
1000
800
.
600
400
200
0
Fic.
the
3.-Contents
influence
of
of
(background)
the
various
section
with
In accordance
with
into the bloodstream
we
could
find
placed
under
femoral
hematopoietic
each
site
of
quantity
view that
carried
were
a clearly
hepatic
of
juice
Isolated
gastric
(after
juice
and
Pavlov
its
changes
under
stomach
on
is absorbed
it seemed
via the gut
probable
that
By
defined
vein
means
was
the
method
of
of hemocultures,
done.
We
much
S.
London)
and
a comparative
found
hematopoietic
contains
E.
veins.
Blood
was withdrawn
vessels-the
portal
and hepatic
that
index.
more
of
the
If the
the
study
blood
serum
animal’s
factor
than
stores
the
or
(table
3).
factor
levels
factor
even
Therefore,
in the
reaching
cuts
off
the
blood.
the
liver
it
via
supply
participates
absorption
factor
According
the
of
stomach
in
substance
the
the
none
brings
of digestive
products
was considerably
higher
to our observation,
the
bloodstream
this
of
from
does
vein.
The
latter
not only has less, but in isolated
cases
contains
2). We concluded,
therefore,
that on an empty
stomach
the liver
a constant
flow of hematopoietic
factor
into the hepatic
vein.
minishes
fundal
produced.
factor
liver,
and hepatic
from three
We also observed
that
postcibally,
during
by the gut, the concentration
of hematopoietic
in the portal
vein than
in the hepatic
vein.
liver
gastric
hematopoietic
thence
to the
used
content
the
the
“Rex.”
blood.
artery.
had
in
named
in the portal
sterile
technic,
factor
is empty,
portal
(table
about
and
dogs
canaliculi
were
simultaneously,
and
the
factor
Dog
count
it in the
Angiotomized
veins
crythropoietic
stimulants.
regulation
and
to
temporarily
the
hepatic
of hematopoietic
diveins
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930
FEODOROV,
2.-Blood-Stimulating
TABLE
Date
Activity
No. of
Dogs
Condition
NAMYATISHEVA
of Blood
Serum
Portal
Vein
Hepatic
Vein
27
AND
of Various
Femoral
Artery
KAKHETELIDZE
Blood
Vessels
Liver
plus,
minus
Intestines
plus,
minus
4.
III
on empty
stomach
1
66
17
plus
39
plus
17.
III
on empty
stomach
2
0
24
21
plus
24
minus
31.
III
on
empty
stomach
3
17
72
56
plus
55
minus
9.
V
on empty
stomach
3
0
0
plus
18
19.
V
on empty
stomach
4
29
108
75
plus
79
minus
13.
V
on
empty
stomach
5
7
32
129
plus
25
minus
122
17.
V
on
empty
stomach
8
plus
34
minus
70
3.-Blood-Stimulating
TABLE
Condition
of Exp.
Date
70
Activity
No. of
Dogs
18
104
of Blood
Hepatic
Vein
Femoral
Artery
27
plus
0
15
minus
51
plus
36
0
27
minus
57
plus
30
VI
fed
5
51
X
fed
8
57
of red
cells
by
Bleedings
the
this,
were
once
bleeding,
but
that
that
the
later
tration
lower
consistent
mental
picture
of
anemia.
When
In
than
separate
between
and the
suggest
when
the
pears
entirely
that
call
Conversely,
consistent
red cell
Our
factor
when
on
rise
count
clinical
repeated
able
was
per
swings
blood
by
factor
an
of
after
a drop
to
of
the
bled
the
rise
concentration
each
in concen-
demonstrate
a
course
of experiis totally
absent.
correlation
blood
only
the
indices,
excess
quan-
developing
of factor
balance
direction
parallels
increased
finds
rapidly
amount
transfusions
was deterHemoglobin
leukocytes
were
peripheral
(fig. 4).
one
of
of
juice
a quantitative
is, the
in the
which
of
the
That
pouches.
kilogram
24 hours
by
possible
establish
organism
juice.
rose
replaced
conditions
is great,
gastric
observation
to
normal
of the substance,
(fig. 5).
in polycythemic
the organism
Pavlov
depletion
in the
a peak,
the factor
as manifested
hematopoietic
tinder
organism
isolated
to 25 ml.
content
It
factor
reaches
were
in the
the
with
of 20
was
levels.
hematopoiesis
from
factor.
In the face
over
to an excess
juice.
factor
rise
transitory
factor;
a posthemorrhagic
it.
hematopoietic
we
dogs
rate
this
hematopoietic
the latter
hematopoietic
five
at the
prehemorrhagic
experiments
data
of
anemia
on the
overproduc-
factor
content
of the gastric
24 hours
after
each
blood-letting.
and
differential
counts
of
the degree
of anemia,
amount
of drop
in the
The
tity
bled
a week
body
weight.
The hematopoietic
mined
immediately
before
and
determinations,
red
cell counts
also done.
It was noted
effect
of postheinorrhagic
conditions
of compensatory
16
13
marrow?
we repeatedly
done
Intestine
plus,
minus
minus
9
To determine
Liver
minus
13
0
22
tion
Vessels
11
11
3
what
is the
that
is, under
Blood
49
minus
3
fed
arises:
factor,
plus,
39
0
minus
fed
VI
The question
hematopoietic
of Variaus
21
9
IV
6.
6.
Serum
Portal
Vein
26.
17.
0
10
anemia,
drops
of the
or
disap-
substance
in
heightened
need
animals
produce
in
hemoglobin
of
for
a
and
hematopoietic
patients
agrees
with
this finding.
We must
assume
that
is full-blooded,
there
is less need
to utilize
hematopoietic
of decreased
accumulation
demand
of the
and ample
substance,
supply,
easily
the
found
balance
in the
swings
gastric
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GASTRIC
HEMATOPOIETIC
931
FACTOR
.12
1)09
Y
.i
Fic.
4.-Changes
blood-letting
Ii
in
(Dog
imogeokn
Thcto
-
the
No.
quantity
of
I8ood-#{128}et#{252}ng
and
hemoglobin
erythropoietic
2g
5.-Changes
in
of
erythrocytic
The
role
of the
of vagus
pouch.
Pavlov
pouches,
the
(As
nerve
Pavlov
nervous
‘
of
(l)og
system
determine
from
the
is known,
the
innervation.)
We
pouch,
Two
hundred
pouches
yielded
one-half
quantity
mass
interest.
To
juice
obtained
respectively.
with
tile
Hemoq8oO#{176}tnezithzocytLc
__
and
60
hemoglobin
No.
erythropoietic
in the
formation
mass
factor
of the
a comparative
of the Pavlov
latter,
unlike
studied
after
repeated
the
from
substance
is of con-
study
was made
of the
and Heidenhain
pouches,
former,
29 samples
samples
a complete
lIlt
14).
this,
fundi
grams
of raw
hematopoietic
showed
and
/2
/L
Jcn5fustOn
2zctoz
siderable
gastric
repeated
14
/5
Fic.
after
N)
JJoi
transfusions
factor
12).
is completely
of juice
5 dogs
with
taken
the
devoid
from
9 dogs
Heidenhain
meat
were
used
as a stimulant.
All the
factor
in the juice.
In the denervated
absence
of
the
substance;
the
other
From www.bloodjournal.org by guest on June 18, 2017. For personal use only.
932
FEODOROV,
half
yielded
(table
In
4).
a second
quantities
Pavlov
and
significantly
series
each,
one stimulant,
we could
isolated
portions
of the
lants
were
used:
administered,
pouch
at the
denervated
We
tion
obtain
fundus,
meat,
same
time
bread,
factor
it fell
AND
those
studied
from
of
3 dogs
their
simultaneous
one of which
milk,
that
than
we
derived
hematopoietic
the
Pavlov
with
gastric
histamines.
After
reached
from
juice
from
two
Various
stimuof these
peak
or disappeared
pouches,
Hence,
most
a high
pouches
double
fundi.
samples
of gastric
was denervated.
level
sharply
KAKHETELIDZE
were
in the
altogether
Pavlov
from
the
pouch.
concluded,
hematopoietic
of
stimulant
therefore,
factor
which
milk
was
raw
the
lower
of experiments,
Heidenhain,
NAMYATISHEVA
and
action-via
that
by
produced
milk
serum.
sympathetic
the
the
vagus
mucosa
a high
level
It may
be
mediation,
gastric
mucosa.
In a third
series
of experiments,
vation
on hematopoietic
factor
or
nerve
plays
a role in the producof the gastric
fundus.
The
sole
of the
that
factor
milk
in the
has
directly
on
denervated
a different
the
pouch
mechanism
of
apparatus
of
glandular
the
of this substance
denervation
was
ance
were
carried
we investigated
production.
Two
studied
by means
out, we observed
of hematopoietic
factor
(fig.
Observations
ing this time,
on these
animals
the substance
was
it did
especially
fore
appear,
that
under
after
normal
by
way
These
splenic
studies
denervation
Zhukova,
noted
of
the
an
week
after
operation,
row erythropoiesis.
cats,
following
fall
a
the
of milk.
spleen
the
of bone
by
Kan
of their
After
splenic
disappear-
has
and
concluded
there-
effect
on
of the
the
secretion.
data
on the influence
such
as Rozanova
hematopoiesis
marrow
splenic
acidity
published
observers,
a sharp
observed
We
a neurotropic
temporarily
injure
intrinsic
factor
other
aspects
of gastric
secretory’
amount
our previously
the blood.
Other
followed
Likewise,
pouches.
temporary
made
over a period
of six months.
Durlacking
from
the gastric
juice;
at times,
effect
may
also affects
in both
activation
ablation
of Pavlov
a complete,
administration
conditions
confirm
on
effects
of splenic
denerwith
normal
production
6).
were
often
gastric
mucosa.
Ablation
of this
production.
Splenic
denervation
function
the
dogs
in
cats
and long-lasting
depression
persistent
hypochromic
of
and
the
first
of maranemia
in
innervation.
CONCLUSIONS
1. A new
hemoculture
method
has
of quantitating
been
4.-Contents
of Erythropoietic
and Heidenhain
Pouches
TABLE
gastric
hematopoietic
Factor
of Dogs:
in the Gastric
Test Meal 200
The
gastric
of
of
Juice
by
means
Juice
Obtained
from
Gm. of Raw Meat
Eryth
Factor
Place
Secretion
Gastric
factor
Number
of
Dogs
Number
of
Experiments
Erythropoietic Factor
Revealed
Pavlov
ropoietic
Not
Found
Average
Quantity
Erythropoie.
tic Factor
Number
of Cases
pouch
of Pavlov
The gastric
pouch
of Heidenhain
of
developed.
9
29
29
0
5
60
30
30
-
+60
50
+27
of
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GASTRIC
HEMATOPOLETIC
933
FACTOR
50
BuLon
1309
ko
30
0
zrnta,
Fic.
the
6.-Change
spleen.
of
meal
Test
2. The
sistently
neutralized
surrounding
3. In marrow
red
dogs,
the
an
the
the
in
gastric
named
bread
and
development
gastric
formation
come
system
to
poietic
48
after
52
denervation
and
a white
juice
evokes
of
animals
cell
increased
and
con-
film
into
mitotic
a speeded-up
portion
a
activity
hemoglobini-
level
factor,
both
of the
gastric
being
obtained
juice
depends
the
subcutaneous
administration
of posthemorrhagic
anemia,
drops
of
shows
that
fundal
sharply;
with
from
part
leads
from
in
on
the
and
levels
nerve
type
raw
meat,
transfusions,
in
influences
to a complete,
gastric
juice.
accounting
that
the stomach
control
over
red
producing
plays
milk
blood
factor
vagus
though
Pavlov
and
hematopoietic
of the
fulfills
blood
gastromucoprotein,
a definite
and
transitory,
hematopoietic
with
in
data
functions
Besides
stomach,
part
method
factor
this problem.
experimental
manifold
production.
the
independent
disapsubstances
is more
exact
than
the
study
of the hemopoetic
and also for other
problems
connected
basing
ourselves
on the above
mentioned
center,
in
mucosa.
spleen
factor
of quantitative
the conclusion
of neurohumoral
and
of histamine.
the hematopoietic
multiple
hematopoietic
the
in man
stomach.
highest
it rises.
study
the
of the
the
juice
by
method
important
juice
from
of gastric
juice
which
has been
worked
out
Singer
and opens
broad
perspectives
for the
stomach,
10. Thus,
46
individuals
of hematopoietic
fundic
8. Denervation
of the
pearance
of hematopoietic
the
40
“Buian.”
healthy
maturation,
factor
pouches
9. The
factor
leukocytes
gastric
of formation
be
in polycythemia,
7. A comparative
factor
36
l)og
of
of
healthy
administered,
Heidenhain
juice
accelerated
hematopoietic
of
meat.
3
medium.
site
to
lowest
from
6. With
the
factor
and
raw
is
cytoplasm.
appears
of stimulant
erythropoietic
of
migration
cultures,
main
5. The
of
gastric
cells,
of the
4. The
i#{225}a’,
16
Ciii.
the
nutrient
in young
i’
contents
of 200
stimulates
zation
8
,
as
of
of
we
in the
a very
an
erythro-
regulating
hemato-
poiesis.
SUMMARIO
1. Esseva
intrinsec
gastric
disveloppate
per
medios
un
IN
nove
hematocultural.
INTERLINGUA
methodo
pro
le
quantitation
de
factor
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934
FEODOROV,
2.
Le
neutralisate
uniformemente
verso
succo
le ambiente
3.
gastric
le migration
In
de
medio
culturas
de
medulla,
rapide
hemoglobinisation
sito
major
del
formation
basse
que
del
Le
de
pan
le hepate
ha
del
e
le portion
de
stimula
cellulas
rob
active
evoca
del
blanc
in succo
resulta
del
gastric
lacte
de
in
in
depende
e came
de
canes
del
humanos
del
crude,
typo
de
le plus
histamina.
angiotonhisate
in be regulation
del
maturante,
stomacho.
subcutanee
chronic
auginentos
processo
intrinsec-tanto
fundic
administration
anemia
gastric
del cytoplasma.
de factor
esser
con
tin
KAKHETELIDZE
e animales
pellicula
acceleration
factor
intrinsec
plus
alte nivello
Experimentos
tin
succo
erythrocytos,
in canes-pare
resulta
6.
in juvene
nivello
usate.
humanos
ab
normal
e tin plus
4. Le
5. Le
stimulante
normal
AND
nutritive.
mitotic
etiam
de
leucocytos
activitate
como
NAMYATISHEVA
ha
nivelbo
de
monstrate
factor
intrinsec
in le sanguine.
7.
Con
le disveloppamento
de factor
mentate
8.
intrinsec
per multiple
Un
Pavlov
studio
in
de
de
parition
10.
Le
gastric
factor
pro
es
pro
problemas
pro
de
plus
be
quantitation
de
Singer
be qtiantitation
exacte
del
genere
intrinsec
in
es
augde
saccos
exerce
tin
influentia
super
(ben
que
transiente)
de
factor
dis-
e aperi
vaste
intrinsec
perspectivas
campo.
pro
le sttidio
Illo
gastric.
be methodo
elaborate
gastric
perspectivas
le succo
in iste
methodo
Ic succo
altere
que
concentration
fundal.
in le complete
hematocultural
accurate
additional
Le
ab
le
factor
vage
le mucosa
restilta
intrinsec
methodo
studios
11.
in
factor
de
Ic nervo
per
splen
posthemorrhagic,
es acutemente
reducite.
sanguine
e in polycythemia.
nivelbos
que
intrinsec
del
es pltis
del
demonstra
9. Disnervation
anemia
gastric
de
comparative
e Heidenhain
be formation
de
le succo
transfusiones
qtie
factor
del
substantias
be methodo
de
hematopoietic
hematopoietic
Singer
del
e aperi
stomacho
vaste
e etiam
de
affin.
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1958 13: 926-935
A Study of the Gastric Hematopoietic Factor by Hemoculture Methods
N. A. FEODOROV, A. M. NAMYATISHEVA and M. G. KAKHETELIDZE
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