Figure S1
A
SEA LAMPREY (PETROMYZON MARINUS)
LpClic1
LpClic6?
LpRunxA
LpClic5
LpRunxB
LpRcan
LOST?
Gene
Duplication
ancClic
ancRunx
ancClic’
ancRunx’
ancRcan
ancRcan’
LOST
1R-WGD
~738.95 ±
74.84 Mya
ancRcan
ancRunx
ancClic
Ancestral vertebrates
(before split of
agnathans and
gnathostomes)
INVERTEBRATES (CEPHALOCORDATES and UROCHORDATES)
B
SEA LAMPREY (PETROMYZON MARINUS)
LOST?
LpRcan1
LpClic6?
LpRunxA Separation of
the clusters?
LOST
LpClic3
LpClic1
LpClic6?
One of
them
LOST?
LOST
2R-WGD
~532.54 ±
57.84 Mya
Clic2’
ACD Cluster
formation
ACD
clustering
Clic2 precursor
Clic1/3
LOST?
LpRcan2
LpClic5
LpRunxB
Rcan1/2/3
Clic4/5/6
Runx1/2/3
Ancestral vertebrates
(before split of
agnathans and
gnathostomes)
ancClic’’
Gene
Duplication
ancClic
ancClic’
ancRunx
ancRunx’
ancClic
ancRcan’
LOST
LOST
1R-WGD
~738.95 ±
74.84 Mya
ancRcan
ancRunx
ancRcan
INVERTEBRATES (CEPHALOCORDATES and UROCHORDATES)