INSTITUTE FOR PROSPECTIVE TECHNOLOGICAL STUDIES SEVILLE W.T.C., Isla de la Cartuja, s/n, E-41092 Sevilla Modern Biotechnology and the Greening of Industry The Introduction of Process-integrated Biocatalysts in Companies – Effect of Dynamics in Internal and External Networks Final Report Editors: Oliver Wolf, Per Sørup European Commission - Joint Research Center Institute for Prospective Technological Studies IPTS Spain Authors: Dr. Bärbel Hüsing Gerhard Jaeckel Stefan Wörner Andreas Würth Fraunhofer Institute Systems and Innovation Research (ISI) Germany EUR 19582 EN January 2000 ECSC-EEC-EAEC, Brussels • Luxembourg, 2000 The views expressed in this study do not necessarily reflect those of the European Commission (EC). The European Commission retains copyright, but reproduction is authorised, except for commercial purposes, provided the source is acknowledged: neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information. The Fraunhofer Institute Systems and Innovation Research (ISI) in Karlsruhe, Germany has been commissioned by the Institute for Prospective Technological Studies (IPTS), Seville, Spain to carry out the study "The Introduction of Processintegrated Biocatalysts in Companies – Effect of Dynamics in Internal and External Networks" in the period from July 1998 to July 1999. This study is part of the IPTS project "Modern Biotechnology and the Greening of Industry". Authors of the report: Dr. Bärbel Hüsing (Project manager) Dipl.-Phys. Gerhard Jaeckel Dipl.-Wirtsch.Ing. Stefan Wörner Andreas Würth Secretary: Silke Just Other ISI staff involved: Dipl.-Biol. Stefanie Giessler Stephanie Knieriemen Natalie Schumann Dipl.-Agrarbiologin Elke Strauß Contact: Fraunhofer Institute Systems and Innovation Research (ISI) Breslauer Strasse 48 76139 Karlsruhe, Germany phone: +49-721-6809-210, fax: +49-721-6809-176 e-mail: [email protected] Introduction of Process-integrated Biocatalysts in Companies List of contents i page List of tables .............................................................................................................iii List of figures ...........................................................................................................iv Executive Summary.................................................................................................. I 1. Introduction ....................................................................................................... 1 2. Objectives ........................................................................................................... 3 3. Methodology....................................................................................................... 5 4. 5. 3.1 Typology of the sectors and firms .................................................... 5 3.2 Identification and selection of the companies for case studies ............................................................................................... 6 3.3 Performing the case studies .............................................................. 7 3.4 Analysis of the case studies, conclusions for policy purposes ............................................................................................ 7 Typology of industries investigated ................................................................. 9 4.1 Chemical industry............................................................................. 9 4.2 Food industry.................................................................................. 15 4.3 Pulp and paper industry .................................................................. 20 4.4 Textile industry............................................................................... 26 Analysis of case studies ................................................................................... 33 5.1 Comparative description of the case studies................................... 33 5.2 Comparison of the companies' background, their situation at the beginning of the project, and the strategic aspects of the innovation projects.................................................................... 36 5.3 Role of greening in the innovation process .................................... 39 5.4 Challenges and hindrances encountered during the innovation projects in the case studies ........................................... 42 5.5 Supporting factors identified in the case studies ............................ 51 Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies ii .................................................................................................... page 6. Summary .......................................................................................................... 55 6.1 Requirements, prerequisites............................................................ 55 6.2 Hindering and supporting factors ................................................... 56 6.2.1 Awareness – Hindrances ................................................................ 57 6.2.2 Awareness – supporting factors...................................................... 58 6.2.3 Assessing the benefit/cost ratio – Hindrances ................................ 59 6.2.4 Assessing the benefit/cost ratio – Supporting factors..................... 61 7. Conclusions for policy purposes..................................................................... 63 8. Literature ......................................................................................................... 71 Guidance for performing case studies interviews ............................................. 75 1. Information about the interviewee(s) ............................................. 75 2. Information about the company...................................................... 75 3. The innovation process ("case") ..................................................... 76 3.1 Situation of the company before/at the beginning of the innovation process .......................................................................... 76 3.2 How did the innovation project proceed after its successful start? ............................................................................................... 76 3.3 Outcome of the innovation process for the company ..................... 77 4. Relevant frame conditions, supporting and hindering factors ............................................................................................. 78 5. What is specific, what can be generalised? .................................... 78 6. Recommendations .......................................................................... 78 7. Important aspects, not yet discussed?............................................. 79 Annex ....................................................................................................................... 75 Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies iii List of tables ............................................................................................... page Table 3.1: Overview of case study candidates ............................................. 8 Table 4.1: Number of companies in the EU chemical industry by employment size-class in 1992.................................................. 10 Table 4.2: Top chemical companies in the world 1997.............................. 10 Table 4.3: Average shares of chemicals in total manufacturing industry 1987 – 1993................................................................. 13 Table 4.4: Waste production per unit of product in the chemical industry...................................................................................... 14 Table 4.5: Environmental expenditure of the chemical industry as percentage of sales 1990 - 1996 ................................................ 14 Table 4.6: Number of companies in the EU food and drink industry by employment size-class in 1992 .............................. 16 Table 4.7: Top food companies in the EU 1994......................................... 16 Table 4.8: R&D to value-added ratios for various industries in 1989 ........................................................................................... 19 Table 4.9: R&D intensity for pulp, paper and printing (business expenditure on R&D / production in percentages).................... 24 Table 4.10: Recovery rate of used paper in Western Europe 1991 to 1997 ........................................................................................... 25 Table 4.11: Number of companies in the EU textile industry by employment size-class in 1992.................................................. 28 Table 4.12: Top textile companies in the EU 1994 ...................................... 28 Table 4.13: Hourly wage costs (wages + social contributions) in the clothing industry in US$............................................................ 30 Table 5.1: Overview of the six case studies performed.............................. 34 Table 5.2: Overview of difficulties and hindering factors during the innovation projects of case 1 and case 2.............................. 44 Table 5.3: Overview of difficulties and hindering factors during the innovation projects of case 3 and case 4.............................. 46 Table 5.3 continued .................................................................................................. 47 Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies iv .................................................................................................... page Table 5.4: Overview of difficulties and hindering factors during the innovation projects of case 5 and case 6.............................. 48 Table 5.4 continued .................................................................................................. 49 Table 5.5: Overview of difficulties and hindering factors during the innovation projects in the six case studies........................... 50 Table 7.1: Policy measures for a) development of new biotechnology processes for PIEP and b) further diffusion of existing biotechnology processes for PIEP ........... 68 List of figures Figure 4.1: Geographic breakdown of the EU chemical industry production in 1997....................................................................... 9 Figure 4.2: Foreign trade in the chemical industry from 1990 to 1997 ........................................................................................... 11 Figure 4.3: Geographic breakdown of the EU food industry (share of added value) .......................................................................... 15 Figure 4.4: Foreign trade of the European food sector 1985 – 1994 ........... 17 Figure 4.5: Geographic breakdown of the EU paper and board production in 1994..................................................................... 21 Figure 4.6: Foreign trade of the EU in the pulp and paper sector 1985 – 1995 ............................................................................... 22 Figure 4.7: Geographic breakdown of the European textile industry (share of added value) in 1994 .................................................. 27 Figure 4.8: Foreign trade in the textile industry from 1985 to 1995............ 29 Figure 7.1: Supporting schemes for the broader use of biotechnology in production-integrated environmental protection (PIEP) are located at the interface of biotechnology programmes, of environmental programmes and of general industrial innovativeness programmes ......................... 63 Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies I Executive Summary Within the concept of production-integrated environmental protection (PIEP), biotechnical processes have an important role, and therefore an increased uptake of this technology can be observed in industry. The question is if the implementation of this technology follows an optimal integration path, or if there exist obstacles which hinder an accelerated development. In order to identify the decisive factors for the adoption of biotechnology for pollution prevention, six case studies were performed in nine companies from the chemical industry, the food industry, the textile industry and the pulp and paper industry in Germany, Austria and the Netherlands which already apply process-integrated biotechnical processes with an environmental benefit. The decision-making and implementation processes which led to the introduction of process-integrated biocatalysts into these companies were investigated. From the analysis of the case studies, from literature and from expert interviews hindering and supporting factors were identified. Biotechnology for pollution prevention requires extensive expertise in biotechnology, environmental management, market requirements and customers' needs. In most cases, this comprehensive know-how is not and cannot be present within one company, but can only be acquired via cooperations and participation in appropriate networks. Especially in the food, pulp and paper and textile sector, this is hampered by structural and economic factors, such as small and medium-sized companies, low research intensity, difficult economic situation, and conservativetraditional attitudes. Environmental benefits are not sufficient incentives for the adoption of biotechnology for pollution prevention by companies. Decisions are much more influenced by economic considerations, company strategy, and product quality. Participation of companies in appropriate networks, active dissemination of the concept of pollution prevention by biotechnology instead of pollution remediation, further implementation of environmental management procedures in companies, and providing practically oriented tools for company-specific assessments whether certain biotechnical processes will be advantageous for them could support the further adoption of biotechnology for pollution prevention. Institute for Prospective Technlogical Studies 1. Introduction At present, environmental biotechnology is dominated by end-of-pipe processes, e. g. biological waste water treatment or bioremediation of contaminated sites. Closer to sustainability than cleaning up pollution after it has occurred should be the design of industrial production processes in a way that consumption of energy and resources and release of harmful substances and waste are minimised from the onset. Biotechnical processes definitely have an important role within such a concept of production-integrated environmental protection (PIEP). They can significantly contribute to the reduction of environmental pollution and to the increase of companies' economic efficiency. Despite this potential and a broad knowledge base in Europe (Enzing et al. 1998), process-integrated biotechnical processes are not yet widely used in industry. The European Commission aims at actively supporting the broader use of biotechnical processes for the prevention of environmental pollution. As a step towards this aim, the IPTS project "Modern Biotechnology and the Greening of Industry" has been launched, in order to identify the main barriers to the introduction of process-integrated biocatalysts into companies and to derive policy recommendations how the broader application of biotechnology could be triggered for greening purposes. Within the IPTS project "Modern Biotechnology and the Greening of Industry" the following questions will be addressed: • What is the present status of process-integrated biocatalysts (European level)? • Are there any gaps between the available knowledge of biocatalysis and its industrial application in process-integrated biotechnology? • What are the barriers to the introduction of process-integrated biocatalysts at the company level? • What incentives are needed to encourage the introduction of process-integrated biocatalysts? • How does European competitiveness compare with that of the USA and Japan (international level)? As a part of the IPTS project "Modern Biotechnology and the Greening of Industry" the Fraunhofer Institute Systems and Innovation Research (ISI) has been commissioned to carry out the sub-project "The Introduction of Process-integrated Biocatalysts in Companies - Effect of Dynamics in Internal and External Networks". It addresses the question what the barriers to the introduction of process-integrated biocatalysts at the company level are. By performing case studies in companies which already apply process-integrated biocatalysts it is analysed how these biotechnical processes have been adopted and implemented. Widening the Commission's understanding of the decision-making and implementation processes Introduction of Process-integrated Biocatalysts in Companies 2 which lead to the introduction of process-integrated biocatalysts into companies, should enable the Commission to take targeted and effective measures in order to promote the introduction of process-integrated biocatalysts into companies. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 2. 3 Objectives Based on case studies in the four industrial sectors chemistry, pulp and paper, textiles and food, this study aims at elucidating the dynamics in company-internal and company-external networks which lead to successful introduction of processintegrated biocatalysts. The technologies under investigation are modern processintegrated biotechnologies, which have been designed for greening purposes or have a greening effect. Altogether, the project pursues the following aims: • To identify the dynamics influencing the introduction of process-integrated modern biocatalysts in company-internal or -external networks. • To draw conclusions from these dynamics and make recommendations for shaping biotechnology policy. • To show to what extent these conclusions and recommendations can be applied to technology policy in general and to other research on technology policy. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies Institute for Prospective Technlogical Studies 4 Introduction of Process-integrated Biocatalysts in Companies 3. 5 Methodology The study consists of three parts: (1) Empirical Part. In the empirical part six case studies were carried out in companies from different industrial branches which have successfully developed and/or implemented process-integrated biotechnical processes or process steps. The circumstances which provide encouragement or form barriers to the (finally) successful process integration are of special interest (chapter 5). (2) Analytical Part. Generalising from the individual case studies, the analytical part investigates how companies manage complex innovation processes in biocatalysis, to which extent the selected case studies are typical for e. g. the sector, the company size, its position in the biotechnological production chain, for biotechnology or other technologies which evolve in highly dynamic and strategy areas, etc. and to which extent the environmental effect of the innovation influences the innovation process as compared to other factors. As six case studies are a rather limited information base for farreaching conclusions, the findings from the case studies must be compared with findings from other studies in order to find out to which extent the results from this subfield of biotechnology are in line with other research on innovation dynamics (chapter 6). (3) Policy Implications. From the conclusions of the analytical part, suggestions for biotechnology policy are derived (chapter 7). 3.1 Typology of the sectors and firms In order to be able to select both "typical" case studies and to analyse whether findings in the case studies are of general or special nature, a typology of the sectors investigated is required. The four sectors investigated, chemical industry, pulp and paper industry, textile industry, and food industry, were characterised with respect to indicators such as number and size distribution of companies, economic situation of the sector, its international competitiveness, its investment in R&D, existing R&D infrastructure and networks, environmental awareness, tradition in the application of biotechnology, relevant framework conditions. Relevant information was compiled from various sources, especially literature including sector specific studies, international statistics, and publications of and telephone interviews with industrial associations. The collected information was verified in the interviews with the case study companies (see chapter 3.3) and is documented in chapter 4 of this report. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 3.2 6 Identification and selection of the companies for case studies In order to identify companies which actually use or develop process-integrated biocatalysts, literature and database searches were carried out. Moreover, experts from industry, research institutions and industrial associations were contacted by mail or phone and asked for relevant information. The following difficulties were encountered during this identification process: • The concept of production-integrated environmental protection is not yet widely known. Many experts gave us information on biotechnology companies in general, or on companies using or selling biotechnical end-of-pipe processes. • The information we tried to obtain is often confidential. Some experts were unwilling to disclose names of companies which apply such processes, or were only willing to disclose the company names if their (the informant's) name, was kept confidential. Once identified, more information of the respective companies were gathered from literature, company directories and internet sources in order to characterise the companies with respect to the following selection criteria: • Coverage of the industrial sectors chemical industry, food industry, textile industry, pulp and paper industry, • Coverage of several European countries, • Application or development of process-integrated biocatalysts (rather than endof-pipe technology), • Environmental benefit of the bioprocess, • Companies representative for the sector investigated, • Inclusion of companies of different sizes, • Inclusion of enzyme producers, enzyme producers and -users, enzyme users only. Due to the difficulties which were expected in recruiting companies for case studies a preliminary list of 13 promising candidates for a case study was compiled in order to be able to finally gain access to six companies. The list and ranking of case study candidates was approved by IPTS. Table 3.1 gives an overview of the 13 companies. After the approval by IPTS, ISI approached the companies one after the other in autumn and late 1998 in order to find out whether they were willing to participate in a case study. The companies received a brief description of the project and the Fraunhofer ISI. Confidentiality was guaranteed. As had been expected, gaining access to the "first-choice companies" proved to be difficult, timeconsuming, lengthy, and in 3 cases unsuccessful. The main reasons for the unwillingness of companies to take part in the study appeared to be Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 7 • Managers‘ lack of time for such a study, • Secrecy reasons, • No sufficient benefits for the company were perceived to justify the devotion of resources to such a study. All in all, 9 of the 13 preselected case study candidates were contacted until 6 cases could be recruited. 3 contacted candidates refrained from participation in the study. 4 companies were not contacted at all (table 3.1). 3.3 Performing the case studies In late 1998 and early 1999, the six case studies were carried out. In each case, on average two to four personal in-depth interviews were performed with high-ranking, experienced staff with intimate knowledge of the respective innovation process, e. g. the project co-ordinator, the head of the biotechnology R&D department, a member of the executive board responsible for R&D and/or marketing. The interviews were led according to an interview guide (questionnaire) which was specifically adapted to each company and each interview partner (see annex). The interviews each lasted several hours, and the information were taken down in interview minutes. The information from the interviews were complemented by information from written material, such as project reports, company brochures and business reports, and scientific-technical publications. The findings were documented in a separate, confidential report for each case study. In order to obtain a feedback from the investigated companies, the separate confidential report was sent to the company investigated for comments. If necessary, the report was modified according to the comments received from the respective company. 3.4 Analysis of the case studies, conclusions for policy purposes One of the goals of the proposed study is to derive generalised findings from the individual case studies. Therefore, the case studies were analysed in a comparative and generalising way. For this purpose, findings from the typology of the sectors investigated (chapter 4) and results from the literature and other relevant studies were included. Based on the findings of the case studies and their comparative analysis (chapters 5 and 6), conclusions for policy purposes were drawn (chapter 7). Institute for Prospective Technlogical Studies 8 Introduction of Process-integrated Biocatalysts in Companies Overview of case study candidates D 3 x NL 4 x D x D SME, large multinational companies 6 7 8 9 10 11 x x DK NL DK D D BEL SME large joint venture SME SME large large multinational research daughter of large multinational SME 12 13 x x x x x x D x A Institute for Prospective Technlogical Studies x x x 1 2 x x x x x x x x x x x 3 x x 4 x x 5 x x (1 partner) x 8 5 x Not contacted x x Refrained from participation 2 SME, young technology-based company large multinational joint venture of two large multinationals large multinational Typology of company Participation in IPTS project Case study no. UK Country Enzyme user + producer x Pulp and paper 1 Textile Chemical Food/feed Case No. Enzyme user Enzyme know-how within company Industrial sector Enzyme producer Table 3.1: 6 9 Introduction of Process-integrated Biocatalysts in Companies 4. Typology of industries investigated 4.1 Chemical industry The chemical industry produces a wide range of intermediate and finished goods. Most important product classes are basic chemicals, pharmaceuticals, cosmetics, and other household products, paints and chemical fibres. One third of the products are reprocessed within the chemical industry itself. The other production is destined for other industries like textile industry, paper industry or agriculture and directly for consumers. The European Union is the world's leading producer of chemicals. According to the European Chemical Industry Council (CEFIC 1999), the EU accounted for 383 billion ECU (31 %) of a total chemicals production of 1,223 billion ECU in 1997. The US came second with a share of 28 %, followed by Japan with 15 %. Within the EU, Germany, France, the UK, and Italy were in descending order the largest chemicals producers (figure 4.1). Figure 4.1: Geographic breakdown of the EU chemical industry production in 1997 UK 12% I 12% B 9% F 18% E 7% NL 7% OTHER 11% D 24% Source: CEFIC 1999 In 1996 the chemical industry accounted for 416 billion ECU (11 %) of all sales in the EU manufacturing sector, second only to the food industry. Institute for Prospective Technlogical Studies 10 Introduction of Process-integrated Biocatalysts in Companies 1.67 million employees in 38,440 companies generated a gross value added at market prices of nearly 132 billion ECU, the highest in the European manufacturing industry, followed by the machinery and equipment sector with about 130.4 billion ECU (CEFIC 1999). Industry Structure Most firms by number are small and medium-sized enterprises (SMEs). Although only 6.8 % of all companies have more than 100 employees, they employ 81 % of the workforce in the chemical industry and generate 86.4 % of all sales (table 4.1). Table 4.1: Number of companies in the EU chemical industry by employment size-class in 1992 Number of employees <20 20-99 >100 Number of companies 31,560 4,644 2,636 Percentage of all companies 81.0 12.0 6.8 Percentage of employment 7.0 10.9 81.9 Percentage of sales 5.0 8.3 86.4 Source: European Commission 1997 Europe claims the leading position in the chemical industry. Six of the ten biggest companies have their headquarters in Europe. The first three in terms of worldwide sales are located in Germany (table 4.2). Table 4.2: Rank 1 2 3 4 5 6 7 8 9 10 Top chemical companies in the world 1997 Company BASF Bayer Hoechst* DuPont Merck Novartis Dow ICI Rhône-Poulenc* Mitsubishi Chem *Merger announced. Source: CEFIC 1999 Institute for Prospective Technlogical Studies Country Germany Germany Germany USA USA Switzerland USA United Kingdom France Japan Sales in million ECU 28,360 27,966 26,489 21,237 20,838 18,957 17,648 15,961 13,587 12,630 11 Introduction of Process-integrated Biocatalysts in Companies International Orientation Not surprisingly, Europe is also the leading exporter of chemicals. In 1997, extraregional exports of the EU reached 25 % of sales, compared with 18 % and 15 % of the United States and Japan, respectively (CEFIC 1999). The steep rise of the trade balance surplus seen in 1993 and 1994 resulted primarily from the depreciation of the ECU and the recession in the domestic markets in 1993. After two years of consolidation on a high level, the surplus surged again in 1997 (figure 4.2). The most exported products are fine chemicals, whereas basic chemicals account for most of the imports. The main regions for exports are Asia (including Japan), North America, and Eastern Europe. These regions are in turn importing most into the European Union. Trade surplus in millions of ECU Figure 4.2: Foreign trade in the chemical industry from 1990 to 1997 45.000 40.000 35.000 30.000 25.000 20.000 15.000 10.000 5.000 0 -5.000 EU USA Japan 1990 1991 1992 1993 1994 1995 1996 1997 Year Source: CEFIC 1999 Trends and Perspectives According to the European Chemical Industry Council, growth rate in terms of volume reached an annual average of 2.9 % between 1985 and 1997. This was well behind those of the USA (3.2 %) and Japan (4.2 %). Nevertheless, the chemical industry achieved a so-called growth premium, i. e. growth in chemicals outmatched that in overall European industry by 1.0 % and that of GDP by 0.4 % (CEFIC 1999). The by far most expanding sector were pharmaceuticals with an annual growth of 4.3 % between 1990 and 1997. Below average was growth of agrochemicals, paints and cosmetics. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 12 In the future competition is expected to intensify, especially because of new competitors from Asia. Due to much lower labour costs, these firms are expected to push into the markets, primarily in areas of mass production like chemical and pharmaceutical standard products, intermediate goods, paints and vitamins. This trend requires an increase in competitiveness of the European chemical industry. The companies try to restructure, reduce costs and, after concentrating on their core competencies, they more and more tend to merge (e. g. Rhône-Poulenc and Hoechst). The main incentives for mergers are hopes for increased productivity and profitability, economies of scale in R&D and access to new markets. This restructuring process contributed to a loss of 250,000 jobs in Europe since 1990. Beginning with 1996, the job losses stopped, however. The number of strategic partnerships, mainly with few big and international logistic firms, and joint ventures has increased dramatically in recent years. While in 1989, a company had an average of two partnerships, this figure rose to about six in 1994 and is expected to reach 14 in 1999 (European Commission 1997). The main advantages of the partnerships are reduced time for procurement, lower costs and better service for the customers. Innovation and Biotechnology Innovation plays an important role in maintaining the competitiveness of the chemical industry, in reducing production costs and in searching for new products with a higher added value. This applies especially for the pharmaceutical industry. Most companies maintain R&D departments and use various forms of cooperation with external institutions like universities and other research establishments. Expenses for R&D reached 5.2 % of sales in 1997. This ratio differs from sector to sector. In 1992, it varied from 2.2 % for man-made fibres to 5.6 % for pharmaceuticals (CEFIC 1997). The targets of R&D depend on the particular sector: producers of basic chemicals focus their R&D efforts on cost reduction. In the industrial and fine chemicals sector, R&D is aimed at both product and process innovation, whereas the speciality chemicals industry concentrates on developing new products (EIMS 1996a). Until 1992, expenses for R&D increased in the EU, similar to the development in the United States and Japan. The downward trend between 1993 and 1995 resulted from a slowdown in R&D spending growth combined with a recovery of sales (CEFIC 1997). The European chemical industry is R&D intensive, as it accounted for 23 % of total R&D expenditure in the manufacturing sector, whereas its share of turnover is 12 % (table 4.3). Institute for Prospective Technlogical Studies 13 Introduction of Process-integrated Biocatalysts in Companies Table 4.3: EU USA Japan Average shares of chemicals in total manufacturing industry 1987 – 1993 Chemical industry in total R&D manufacturing 23 % 17 % 12 % Chemical industry in total manufacturing turnover 12 % 10 % 8% Share of EU R&D cumulated spending 100 % 90 % 39 % Source: CEFIC 1997 Factors hampering the innovation process are financial risks like lack of funds, high costs and the long pay-off period, internal resistance to changes mainly in case of process innovation and competitive risks, as for example standards, regulations and lack of customer responsiveness to new products (CEFIC 1997). The companies try to minimise the financial risks by cooperations and R&D joint ventures, particularly in the pharmaceuticals industry, where R&D expenses are highest. Biotechnology is regarded as one of the most promising areas for R&D in the future. For pharmaceuticals it has become a key technology. According to experts, virtually all innovative products will be based directly or indirectly on biotechnology (Mc Coy 1999). Biotechnically produced proteins for therapeutical use like insulin are for example one major sector, in which biotechnology will play a substantial role. An even greater importance of biotechnical processes can be forecasted for the innovation process of the pharmaceutical industry. Instead of time-consuming and more or less incidental conventional screening methods, new highly efficient methods are developed with the help of whole genome sequencing activities (Lohner et al. 1998). For the chemical industry, biotechnology is more a tool for organic synthesis. The main areas, in which biotechnical processes will be used, are seen in synthesis of high value special and fine chemicals and for asymmetric synthesis of chiral substances (Liese and Villela Filho 1999, Schulze and Wubbolts 1999, von Schriltz 1998, Pantaleone 1999). Here the often high costs of biotechnical processes are more likely to be compensated by higher prices than in areas like basic chemicals, where cost reduction is the main task for the producers. Factors impeding a broader use of biotechnical methods in chemical synthesis are (Hüsing et al. 1998): • Inherent disadvantages of biocatalysts, • Unfavourable ratio of R&D expenditure to potential sales, • Lack of market knowledge and orientation in technology-prone companies, • Difficult integration of biotechnical processes into existing processes, • In some cases regulations and standards, • Competition with other technologies. Institute for Prospective Technlogical Studies 14 Introduction of Process-integrated Biocatalysts in Companies The development of biotechnology is realised in form of building up know-how within the companies or by cooperations and joint ventures. Environment The most severe environmental problems the chemical industry encounters are the emission of pollutants during production, as well as consumption and disposal of their products. Moreover, energy consumption is high, especially in the basic chemicals sector. The amount of waste produced per unit of product differs widely between the different product groups of the chemical industry: as can be seen from table 4.4, the ratio of waste per unit of product is much more favourable for basic chemicals than for specialty chemicals. This is mainly due to the fact that specialty chemicals require very waste-intensive purification procedures, and that the market price is high enough to allow such a costly waste of resources. Table 4.4: Waste production per unit of product in the chemical industry Product unit Basic chemicals Commodities Specialty chemicals 1 ton 100 kg 1 kg Waste per product unit 0,5 tons 100 kg 10 kg Ratio Waste units per product units 50 % 100 % 1000 % Environmental expenditure (operating costs and capital spending) varied between nearly 5 % of sales in 1990 and about 4 % in 1996 (table 4.5). Table 4.5: Environmental expenditure of the chemical industry as percentage of sales 1990 - 1996 Capital spending Operating costs Total 1990 1.0 3.9 4.9 1991 1.0 3.9 4.9 1992 1.0 4.0 5.0 1993 0.8 3.8 4.6 1994 0.6 3.5 4.1 1995 0.5 3.4 3.9 1996 0.6 3.5 4.1 Source: CEFIC 1999 As integrated environmental investments substitute the traditional end-of-pipe investments to an increasing degree (CEFIC 1999), these figures tend to underestimate the actual expenditure. The environmental share of integrated investments is difficult to assess and therefore often not reported at all. Institute for Prospective Technlogical Studies 15 Introduction of Process-integrated Biocatalysts in Companies The chemical industry managed to separate growth of energy consumption and CO2 emissions from growth of production. According to CEFIC (1999), energy consumption increased by 8.4 % between 1985 and 1996, while production was expanded by 34.7 %. As growth of CO2 emissions in the same period was only 1.9 %, emissions per unit of production was decreased by more than 24 %. 4.2 Food industry Besides a broad range of end products, the food industry produces a line of intermediate goods, which are used in other branches. The main product groups are meat and fish, fruits and vegetables, frozen food, dairy products, sugar confectionery, and beverage. Figure 4.3: Geographic breakdown of the EU food industry (share of added value) UK 20% D 22% F 17% OTHER 11% NL 7% E 13% I 10% Source: European Commission 1997 Over the last decade, Europe has become the biggest producer of food in the world, changing position with the United States. Between 1985 and 1994, production was increased from 338 billion ECU to 477 billion ECU and expected to reach nearly 5901 billion ECU in 1998 (European Commission 1997). In 1996 production reached 503 billion ECU, while the US and Japan recorded a production worth 374 billion ECU and 220 billion ECU (CIAA 1999). Meat, dairy products and tobacco are the main products in terms of production and consumption. In 1996 the food and beverage industry sold products worth 547.6 billion ECU (15 % of all 1 EU15 including Sweden, Finland and Austria. Institute for Prospective Technlogical Studies 16 Introduction of Process-integrated Biocatalysts in Companies sales in the European manufacturing industry), making the food industry the most important sector of the manufacturing industry. Over 272,000 companies employed about 2.6 million persons or 11 % of the workforce in the manufacturing industry. They generated a gross value added at market prices of 129.4 billion ECU. The countries with the greatest share of the added value were Germany, the United Kingdom and France (figure 4.3). Industry Structure The food industry is dominated by a relatively small number of companies, despite the fact that some 92 % of all firms have less than 20 employees. Nearly 70 % of the sales are made by companies with more than 100 employees (table 4.6). Table 4.6: Number of employees <20 20-99 >100 Number of companies in the EU food and drink industry by employment size-class in 1992 Number of companies 256,063 16,545 4,588 Percentage of all companies 92.4 6.0 1.7 Percentage of employment 30.1 18.1 51.8 Percentage of sales 14.7 15.8 69.4 Source: European Commission 1997 Table 4.7: Rank 1 2 3 4 5 6 7 8 9 10 Top food companies in the EU 1994 Company Unilever B.A.T. Industries Hanson Ferruzzi Finanziaria Group Danone Montedison Grand Metropolitan Eridania Beghin-Say Associated British Food Hillsdown Holdings Country Netherlands – UK UK UK Italy France Italy UK France UK UK Sales in million ECU 38,299 15,062 14,069 11,955 11,679 10,723 9,054 7,721 5,859 5,499 Source: European Commission 1997 Big companies are primarily common in the United Kingdom. Nine out of the 15 leading companies in the EU have their headquarters in Great Britain. The top firms Institute for Prospective Technlogical Studies 17 Introduction of Process-integrated Biocatalysts in Companies are for example Unilever (NL-UK), B.A.T. Industries (UK) and Hanson (UK) (table 4.7). One of the leading firms in Europe is also Nestlé from Switzerland with sales of 35.1 billion ECU in 1994. International Orientation The European Union is in general autarkic, as far as the food sector is concerned. The volume of exports exceeds that of imports by far, leading to a surplus in the trade balance despite fluctuating trade flows. Between 1985 and 1994, the EU exported on average a mere 7 % of production. The export to production ratio varied in 1996 from 1.3 % in Portugal to 23.1 % in France. The Netherlands (13.4 %), Germany (13.3 %) and Italy (10.1 %) also exported more than 10 % of production (CIAA 1999). However, in recent years, both exports and imports tend to rise (figure 4.4), despite various trade restrictions and restraints. Yet trade within the European Union still dominates, as here these obstacles do not exist any longer. Meat, dairy products and sugar are the most exported products. In 1994 the main trade partners were the members of the EFTA, Brazil and the United States (European Commission 1997). Figure 4.4: Foreign trade of the European food sector 1985 – 1994 35000 30000 25000 million ECU 20000 15000 10000 Trade balance Source: European Commission 1997 Institute for Prospective Technlogical Studies Year 1994 1993 1992 1991 1990 1989 1988 1987 Imports 0 1986 Exports 1985 5000 Introduction of Process-integrated Biocatalysts in Companies 18 Trends and Perspectives The European food industry grew with an average of 2.7 % in the years 1986 to 1991, 1 % below the average growth of the overall manufacturing sector. Since 1990, however, the food industry enjoyed an above average growth. Real production (adjusted for exchange rate fluctuations) expanded in Europe by 25.2 % between 1985 and 1994, in the United States by 19.1 % and in Japan by 15.6 % (European Commission 1997). As in nearly all sectors of economy, competition increases in the food industry as well, primarily in form of trade brands and brandless products. Companies, especially the large ones, react in form of cost reductions, mergers and acquisitions. This concentration process is part of the efforts to gain more purchasing and marketing power. Due to the low growth before 1992 and the rationalisation processes, 100,000 jobs were lost in the European food industry between 1990 and 1995. The decrease in employment was nevertheless not as distinctive as in other sectors of the manufacturing industry, because intensity of labour remains high. Since 1995 the job losses slowed down (European Commission 1997). Employment is generated by the SMEs, whereas the large companies tend to reduce employment. As a result of technological innovation, more jobs are created in higher added value service sectors (Walker et al. 1998a). Furthermore, the food industry has to respond to a change in demand. Trends are in favour to cheap products on the one hand and high quality, high price products on the other hand, to the detriment of products with medium quality and price. This results from two main types of consumers, which are beginning to emerge: one group is aged between 18 and 45 with unconventional habits of eating and high relevance of the value of the products in consideration of their price. The other group are people aged over 45, who regard quality as the most important criterion for their buying decisions. This group represents about 40 % of the demand (European Commission 1997). The main trends in the food and drink sector for the next 20 years are (Walker et al. 1998a): • Consumers will buy food to meet their individual nutritional needs, • Smart cooking equipment will be commonplace in many homes, • Packaging will provide detailed information on the food contents, • Advanced food processes designed by computers will further enhance food quality and hygiene, • Food raw materials will be designed to meet consumer needs for improved quality. Institute for Prospective Technlogical Studies 19 Introduction of Process-integrated Biocatalysts in Companies Innovation and Biotechnology Product innovations become more and more important as competition intensifies, consumer needs diversify and demand for healthful products increases. Even so, expenditure for R&D remains low. According to Galizzi and Venturini (1996), the food industry "is characterised by a low R&D intensity, radical innovations are absolutely rare and R&D is only a minor component of expenditures for implementing non-price strategies." The food industry has one of the lowest R&D to added value ratios of any industrial sector (table 4.8). In 1994 R&D expenses amounted to 1,180 million ECU or about 0.23 % of production2. But the number of minor or incremental innovations observed in recent years is all but neglectible. Table 4.8: R&D to value-added ratios for various industries in 1989 Denmark France Germany Japan Sweden United Kingdom Food and drink 1.2 1.6 1.2 2.0 1.8 1.0 Drugs 18.0 31.7 16.0 13.0 41.2 22.6 Electronics 12.7 ? 15.6 18.4 33.2 22.9 Source: Traill and Grunert 1997 Low R&D intensity in the food industry is often claimed to result from imports of technological innovations from other high-tech industries like machine tools, advanced materials or biotechnology. Recent surveys (Traill and Grunert 1997) however show that "food industry presents a relatively balanced picture between product and process innovation and between the use of innovations from within and from outside the industry." As the roots of biotechnology can be found in the manufacturing of food and drink biotechnical approaches are broadly and traditionally used in this industrial branch. Despite this tradition in biotechnology, new biotechnology (e. g. genetic engineering, analytical methods based on biotechnology) plays until now only a rather small role in SMEs of the food industry, while large multinationals have broadly adopted these techniques. Application in SMEs is hindered by a still prevailing negative perception and a fundamental lack of knowledge of the technology (Walker et al. 1998a). Suitably qualified staff is rare, although there are considerable differences between the EU member states. Based on their studies, 2 altogether for Denmark, Finland, France, Germany, Ireland, Italy, the Netherlands, Spain, Sweden and the United Kingdom (OECD 1996). Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 20 Walker et al. (1998a) therefore call for a campaign to raise awareness of the benefits of biotechnology for companies, and for continual training to reach high level skills. Environment In the food industry several environmental problems exist which have not yet been solved satisfactorily. Among them are the production of large amounts of sludges, by-products or organic waste from food processing, which could be converted to valuable substances but are presently discarded, the emission of bad odours and dust, as well as a high water and energy consumption in some processes. Moreover, a substantial problem arises from the waste of packaging (Boudouropoulos and Arvanitoyannis 1999). Many countries introduced special laws for recycling of food packaging. Due to small profit marges and a low research intensity in the food industry new application areas for biotechnical processes are innovative products and reduction of production costs. Innovations which only reduce the environmental load do not offer sufficient incentives for an alteration of production procedures. Although there are established biotechnical processes in food industry which resulted in a processintegrated reduction of the environmental load, these effects have been more or less "desired side effects" while the driving forces for the adoption of the respective processes by industry were more efficient processes or novel products. Future potentials of biotechnical processes lie in innovations where the reduction of environmental load can be coupled to product quality improvement. This should especially be the case with the optimisation of already established processes. Further potentials lie in the conversion of polluting side products and waste which are presently discarded into valuable substances (Hüsing et al. 1998). 4.3 Pulp and paper industry The pulp and paper industry in Europe generates many products. The main product groups are wood pulp and chemical pulp, which serve foremost as intermediate goods, all sorts of paper for various areas of application and board in many variations. The intermediate and the finished goods are destined for other industry sectors and consumers. The pulp industry has to be distinguished in some ways from the paper industry, as pulp is a standardised product sold mainly (about 80 % of production) to integrated customers, making the pulp industry more dependent and less flexible than the paper industry. Institute for Prospective Technlogical Studies 21 Introduction of Process-integrated Biocatalysts in Companies In 1996, the pulp and paper industry reported sales of 114.6 billion ECU, a share of 3 % of the European manufacturing industry. About 620,000 employees created a gross value added at market prices of 39.8 billion ECU, ranking 13th in the manufacturing sector3 (CEFIC 1999). In 1994, Western Europe, including the Nordic countries, produced 27 % of global paper and board production (269 million tons). North America accounted for 37 % and Asia for 26 %. Of global virgin pulp production (171 million tons), Western Europe produced 20 %, in the area of mechanical pulps 34 % (CEPI 1999a). In Europe, Germany together with Finland, Sweden and France are the main producers of paper and board (figure 4.5). Figure 4.5: Geographic breakdown of the EU paper and board production in 1994 FIN 16% SWED 14% F 13% D 20% OTHER 4% NL AUS 4% 5% I 10% E 5% UK 9% Source: European Commission 1997 Sweden and Finland produced in 1994 about 65 % of all pulp in the European Union, reflecting the distribution of the European forests. Industry Structure Similar to virtual all other industry sectors, companies in the pulp and paper industry tend to mergers and acquisitions, leading to an increasing market concentration. According to CEPI (1999b), the twenty largest European companies owned about 55 % of regional paper making capacity in 1994, compared with more than 60 % in North America. The rate of concentration varies widely from one sector to another, however. In Scandinavia new big conglomerates emerged after Sweden and Finland joined the European Union. In 1994 64 of the 150 leading companies in the world were located in the EU, 21 of them in the Nordic countries. 3 Note: These figures include the pulp, paper and paper products industry. Institute for Prospective Technlogical Studies 22 Introduction of Process-integrated Biocatalysts in Companies In recent years the concentration process was going on without intermission, permanently reshaping the industry's structure. For example the Swedish SCA acquired a 60 % stake in PWA, Repola from Finland merged with Kymmene and Enso-Gutzeit with Veitsluoto (European Commission 1997). International Orientation Although the paper industry's production exceeded demand by 7 % in 1995, trade reaches a high proportion of overall production. Before the Nordic states joined the EU, Europe ran a substantial trade deficit. Now in the paper and board sector, the EU can record a trade balance surplus, whereas in the pulp sector it runs a deficit, approximately compensating each other to an equilibrium in the trade balance (figure 4.6). Figure 4.6: Foreign trade of the EU in the pulp and paper sector 1985 – 1995 20000 15000 million ECU 10000 5000 0 -5000 Exports Imports Trade balance 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 -15000 1985 -10000 Year Source: European Commission 1997 The United States are the main host country for paper exports. Pulp is imported primarily from Canada and the United States. Trends and Perspectives Between 1980 and 1993 average annual growth rate of the paper industry was 3.3 % for Western Europe. Corresponding figures for North America and Japan were 2.4 % and 3.4 %, respectively (CEPI 1999b). This growth is well above that of GDP Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 23 in this period. The future long term growth rate is expected to be somewhat lower, although in 1994 growth in the European industry was as high as 8.2 % (CEPI 1999a). This rapid expansion resulted from a strong increase in demand, which is in general correlated to the overall economic cycle. The European paper industry has to meet competition from at least three different directions (CEPI 1999a): • Electronic media challenge the printing and writing paper industry, • The packaging industry meets competition from alternative packaging materials, • The whole industry is under pressure from low cost producing, raw material rich areas like East Asia and, from time to time, depending on currency exchange rates, from North America. As the pulp and paper industry is comparatively cyclical, the companies were forced to restructure during the weak economic climate at the beginning of the 90s. They tried to increase volume of sales and productivity by concentrating on core competencies, afterwards on mergers and acquisitions. By extending operation to European levels, the industry tried to realise economies of scale. As recycling becomes more and more important, locations near large metropolitan areas are preferred for production to reduce transportation costs. These transformations were linked with extensive job losses. From 1984 to 1995 18.5 % of all jobs were lost. This trend is expected to continue in the nearer future, though not to that extent (European Commission 1997). After these restructuring processes, which are to some degree still going on, the European paper industry is considered to be competitive, e. g. in labour productivity. Due to the fast changing market conditions, investments were concentrated on the introduction of flexible production technologies instead on extensions of production capacity. Investment activities of the European paper industry focus on two areas at the moment (European Commission 1997): On the one hand, ecological investments in order to reduce harmful emissions and waste water and on the other hand investments in recycling processes. According to CEPI (1999a), in order to retain its market position, the pulp and paper industry has to concentrate on: • Higher value products, • Cost effective and environmentally acceptable production (efficient and sustainable use of raw materials and innovative technologies), • An increase in the knowledge base, where R&D as well as training of the skills at all levels. Institute for Prospective Technlogical Studies 24 Introduction of Process-integrated Biocatalysts in Companies Innovation and Biotechnology The pulp and paper industry traditionally belongs to the low-tech industries with low R&D intensity. Pulp, paper and printing is ranked among the four most lowtech of 22 industries based on average R&D intensities in the OECD area (Laestadius 1998). The commitment to R&D differs however widely from country to country. As can be seen in table 4.9, Sweden, Finland and Japan deviate from the rest of the world. Similar to the food industry, the pulp and paper business can be regarded as a carrier industry, importing new technologies originating in other sectors and using them in developing of new products. In order to defend its market position, the paper companies need to raise level of R&D significantly. As most knowledge is imported from other sectors, it is crucial for the companies to establish effective information channels with its external suppliers of technologies, equipment and materials (EIMS 1996b). Table 4.9: R&D intensity for pulp, paper and printing (business expenditure on R&D / production in percentages) Canada Finland France Japan United Kingdom Sweden Germany USA OECD-12 1973 1992 0.3 0.4 0.2 0.4 0.2 0.5 0.1 0.3 0.3 0.3 0.8 0.1 0.3 0.1 0.8 0.1 0.5 0.3 Increase (+) or decrease (-) = + + = + = Source: Laestadius 1998 Biotechnical processes that perhaps can be used in the pulp and paper industry are for example (Barker et al. 1997, Hüsing et al. 1998, Bajpai et al. 1999): • Biopulping: enhances the mechanical wood disruption, lignin can be removed more easily in cooking, and energy can be saved to a significant extent (Messner und Srebotnik 1994, Scott et al. 1998a, b). • Biobleaching: The so-called laccase-mediator system, allowing to oxidatively degrade lignin, could become interesting for delignification and bleaching. Institute for Prospective Technlogical Studies 25 Introduction of Process-integrated Biocatalysts in Companies • Enzymatic pitch removal: already in large scale use in Japan. • Enzymatic waste paper preparation and modification: Two approaches are pursued (enzymatic improvement of dewatering properties and enzymatic deinking). In the pulp and paper industry, the used technologies have a long history. The basic processes are pretty the same since their introduction at the end of the 19th and in the first half of the 20th century. Improvements were and are still made of course, but often by simply adding ever more process steps, resulting in an increasing complexity of the production system. Radical new technologies often do not fit in the current technological regime, explaining to some extent the reluctant use of biotechnical processes in the paper industry. As most innovations are imported from other sectors, the way in which these sectors, especially the chemical industry, take up biotechnology could become a factor in the adoption process (Tils 1997). It has been argued that another hindrance for the use of biotechnical processes could be regulation. At the moment, environmental regulation is focused on recycling technology. If it were possible that the environmental burden of the paper production process becomes smaller than that of recycling by adopting biotechnology regulation could become a barrier, hampering the introduction of new technologies (e. g. biotechnology) (Tils 1997). Environment The main environmental problems arising for the pulp and paper industry are the increasing consumption of paper, emissions of pollutants and waste water. Moreover, the industrial branch is criticised for the exploitation of forest resources in a way not compatible with sustainability. This led to the adoption of extensive forest regeneration programmes (CEPI 1998b). Moreover the recycling of used paper was increased (table 4.10). Table 4.10: Paper collected in 1000 tons Recovery rate4 Recovery rate of used paper in Western Europe 1991 to 1997 1991 23,606 1992 24,913 1993 26,531 1994 29,390 1995 30,791 1996 32,224 1997 34,437 39.3 40.0 42.1 43.5 46.3 48.7 48.9 in % Source: CEPI 1998a 4 Ratio between recovered paper collection and total paper and board consumption. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 26 With a recovery rate of 48.9 % in 1997, Europe was well ahead of the world average (37 %), ranking among the leading developed countries like USA, Canada (both 45 %) and Japan (53.1 %). The pulp and paper industry furthermore claims to have made substantial progress in the consumption of water. According to CEPI (1998b), the amount of water needed to manufacture a ton of chemical pulp has fallen by 75 % in the last 20 years. About 95 % of the water used during the pulp and papermaking process is nowadays purified and returned to the waterways. Consumption of elemental chlorine in the paper industry was reduced from some 340,000 metric tonnes in 1990 to about 30,000 in 1996. Discharges of organo-chlorine compounds was reduced by more than 90 %. Investments in improved environmental control represents about 20 % of the costs for a new mill. In the last ten years, the European pulp and paper industry has invested between 6 and 8 billion ECU in environmental improvements (CEPI 1998b). Measures integrated into the production process are applied increasingly. The era of end-of-pipe palliatives is regarded more and more as gone in the paper industry (Landis Gabel et al. 1996). Landis Gabel et al. (1996) identified the following technologies which could reduce the environmental impacts of pulp production: • Genetically engineered low-lignin tree species, reducing the need for active pulping chemicals, • Enzyme bleaching systems, • Co-generation systems for energy recovery from organic wastes. As already mentioned above, concentration on recycling may in the long term prove to be short-sighted, as new biotechnical processes reduce the environmental impacts on pulp and paper production. Policies to promote recycling should therefore not mandate secondary fibre components uniformly across all paper grades (Landis Gabel et al. 1996). 4.4 Textile industry Production processes of the textile industry range from fibre preparation, knitting, weaving and spinning to finishing of textiles. As well as in the other industries analysed before the intermediate goods are sold to other sectors, whereas the finished products are destined for both industrial or private customers. The main sectors receiving products from the textile sector are the clothing industry, car Institute for Prospective Technlogical Studies 27 Introduction of Process-integrated Biocatalysts in Companies manufacturers, the furniture industry, the construction industry and service sectors like hotel and retail industry. With sales of 91.7 billion ECU in 1996 the textile industry ranked 15th within the European manufacturing sector. About 950,000 people were employed in the textile companies in 1996, creating a gross added value of 34.1 billion ECU or 2.6 % of the added value in the European manufacturing industry (CEFIC 1999). The European textiles production exceeded that of the United States and of Japan (all calculated in ECU) by 40 % and 67 %, respectively. Corresponding figures for apparent consumption are 25 % and 60 % (European Commission 1997). Within Europe, the leading countries are Italy, Germany, France and the United Kingdom (figure 4.7). These countries account for about 78 % of added value generated in the EU. Figure 4.7: Geographic breakdown of the European textile industry (share of added value) in 1994 UK 15% E 7% B 5% P 4% F 16% OTHER 6% D 22% I 25% Source: European Commission 1997 Industry Structure Rate of concentration is relatively low in the textile industry. Of the approximately 60,000 companies in 1994, 75 % had less than 20 employees. These small firms accounted for 19 % of employment and 15 % of sales. Compared with the corresponding figures of 1992 (table 4.11), however, concentration has increased significantly. The ten leading companies accounted for 11 % of all sales of the EU textile industry, whereby the top five companies alone created 7.7 % of the overall sales. The leading firms are located in the UK, France, Germany and Italy (table 4.12). Institute for Prospective Technlogical Studies 28 Introduction of Process-integrated Biocatalysts in Companies Although Italy is the leading European country in textiles, only one Italian firm appears in the top ten list, indicating that concentration is lower in Italy than in other countries. Mölnlycke from Sweden ranks third since the Nordic States joined the EU in 1995. Table 4.11: Number of employees <20 20-99 >100 Number of companies in the EU textile industry by employment size-class in 1992 Number of companies 83,274 7,513 2,356 Percentage of all companies 89.4 8.1 2.5 Percentage of employment 24.2 23.4 52.4 Percentage of sales 25.6 23.6 50.8 Source: European Commission 1997 Table 4.12: Rank 1 2 3 4 5 6 7 8 9 10 Top textile companies in the EU 1994 Company Coats Viyella Chargeurs DMC-Dollfus-Mieg & Cie DLW Akzo Nobel Faser Scapa Group Bremer Woll-Kämmerei Dawson International Pfersee-Kolbermoor Zucchi Vincenzo Country UK France France Germany Germany UK Germany UK Germany Italy Sales in million ECU 2,818 1,494 1,212 794 756 571 458 429 308 308 Source: European Commission 1997 International Orientation Since 1985 both exports and imports have grown continuously, but as the increase in exports (42 %) lagged behind that of imports (77 %), the trade balance was running a higher deficit from year to year. Since 1992 this trend reversed to some degree and the deficit began to fall slightly (figure 4.8). The main reason for the deficits are imports of basic materials like wool, cotton and silk, while the EU has a surplus in the area of textile products. Most exports go to the United States, Switzerland, Poland, Japan, Tunisia and Morocco. Most imports come from China, Turkey, India and the USA. Both exports and imports were transacted to about Institute for Prospective Technlogical Studies 29 Introduction of Process-integrated Biocatalysts in Companies 60 % with only ten countries in 1994 (European Commission 1997). In 1995, the main exporting countries in Europe were Germany with a share of 9 % of world exports and Italy with a share of 8 %. Although its share has fallen from 11 % in 1980, Germany was still the worldwide leading exporting nation in the textile industry, slightly ahead of China (Cahill and Ducatel 1997). Figure 4.8: Foreign trade in the textile industry from 1985 to 1995 25000 million ECU 20000 15000 10000 5000 0 -5000 1985 Exports Imports 1990 1991 Trade balance 1992 1993 1994 1995 Year Source: European Commission 1997 Trends and Perspectives In the last decade the European textile industry has undergone a dramatic restructuring process. Consumption of textiles has stagnated due to a decreasing share of textiles in private expenditure (which is in fact typical for a mature and saturated market), strong competition by foreign producers and a weak economic climate. Reacting to the demand, production fell since 1990 with an average annual rate of 2.3 % (European Commission 1997). Hand in hand with the restructuring processes employment shrunk significantly. Between 1985 and 1995 more than 500,000 jobs were lost. In 1992 and 1993 alone, more than 6 % of the jobs were cut. The main reason for the adverse developments is the increased competition from low-wage countries, which are pushing into the markets aggressively with cheap products. According to Cahill and Ducatel (1997), the European producers are facing one major disadvantage: labour costs. Wages in the clothing industry are between ten and fifty times higher than that in some emerging markets like China, India and Pakistan. Even when compared to relatively developed nations in Eastern Institute for Prospective Technlogical Studies 30 Introduction of Process-integrated Biocatalysts in Companies Europe, South East Asia and America, labour costs in Europe are quite high (table 4.13). Table 4.13: Germany France Italy Poland Bulgaria Japan China India Thailand USA Hourly wage costs (wages + social contributions) in the clothing industry in US$ 1991 14.81 12.41 13.50 0.42 0.25 7.44 0.24 0.25 0.59 6.77 1993 17.22 14.84 12.31 0.44 0.26 10.64 0.25 0.27 0.71 8.13 Change in % 16.2 19.5 -8.8 4.7 4.0 43.0 4.1 8.0 20.3 20.0 Source: Cahill and Ducatel 1997 In the commodity production area Europe may retain some residual manufacturing capacity, but the scope for growth is negligible due to the uncompetitive high labour costs. As the wage differences will not change substantially in the near future, Europe's textile industry has to specialise on areas where other issues than wages are more important such as (Cahill and Ducatel 1997): • Textiles and clothings which meet specialised requirements, either where new high technology materials are used or where the final product has to meet high levels of technical performance, e. g. high performance products for use in certain leisure activities, the automobile industry and the hospitality trade, • High skill/technology processes, where handling the materials or the final assembly requires special technologies, environments or skills, • Customisation and service: satisfying differentiated consumer tastes and fashion awareness, where the variability of specifications combined with exact requirements favour production locations with high quality and technical mastery near final demand. One of the most important specialist markets can be seen in the area of so-called technical textiles, used as intermediates in sectors like transportation, geotextiles, technical garments, health care and construction. In 1993 this market had a volume of some 30 billion ECU, making it worth pursuing, whereas it cannot be regarded as saviour to all European textile producers (Cahill and Ducatel 1997). Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 31 Innovation and Biotechnology The textile industry can be regarded as a low-tech industry with only small expenditure for R&D (374 million ECU or 0.21 % of production in 19945). After years of continuous growth, investments were reduced between 1990 and 1993 by about 6 % per annum. In 1994, investments were expanded by 6 %, but development varied widely among the member states of the EU (European Commission 1997). Despite the lower investments and decreasing employment, productivity of labour could be raised by more than 40 % in constant prices between 1985 and 1994. Still more important for competitiveness are permanent exploration of new markets, improvement of product quality and development of new products to meet specific needs of customers. Application of biotechnical processes is low in the textile industry, but the influence of biotechnology is growing. Use of biotechnical processes is already or in the near future possible in the following areas (Hüsing et al. 1998): • Prewashing: enzymatic processes are developed for simultaneous cotton prewashing and desizing. • Silk treatment: natural fibrin is removed from the silk fibres with the help of proteases. • Desizing: desizing of starch sizes by amylases. • Bleaching: biobleaching with the laccase-mediator system. • Enzymatic removal of bleaching agent residues. • Dyeing: use of enzymatically modified fibres and substitution of chemical dyes with biosynthetic dyes and pigments. • Biostoning: pumice stones are replaced by cellulases. • Felt-free wool: use of lipoprotein lipases is tested. • Structural modifications of wool. • Biopolishing: application of cellulases for the processing of cotton fabrics and viscose. Based on a survey among small and medium- sized companies in four European regions, also Walker et al. (1998b) come to the conclusion that the level of 5 Altogether for Denmark, Finland, France, Germany, Ireland, Italy, the Netherlands, Spain, Sweden and the United Kingdom (OECD 1996). Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 32 biotechnical application is low. Main reasons for this are a lack of expertise and to some degree insufficient recognition of the importance of biotechnology to the future development of the textile industry. Other obstacles to a broader use of biotechnical processes are (Hüsing et al. 1998): • Requirements for large and expensive serial trials in order to scale up the process from laboratory to practical scale, • Long pay-off periods of investments in R&D, which are often beyond the planning horizons of the companies, • Some new biotechnical processes cannot be integrated in existing processes and would therefore require a change in the complete production process, • Possible loss of production and/or quality while transforming the production processes. All these obstacles have to be appreciated against the background of a difficult economic situation for the textile industry. Many companies find it very difficult to invest large sums in the development and application of new production processes while severe competition endangers their existence. Environment The textile industry is an industrial branch with high energy and resources consumption. In order to finish 1 kg of textiles (including washing, dyeing, bleaching and material improvements by finishing) 15 to 20 kWh of energy and 80 to 100 litres of water are consumed (Staeck 1993). The largest loads are emitted via the waste water stream since most textile processes are based on wet chemistry. The waste water from textile finishing companies is characterised by a large variety of pollutants ranging from inorganic and organic compounds, tensides, dispersing aids to complexing substances. As reaction to the increasing regulation of emissions and waste both on a national and European level the textile industry more and more realises voluntary ecological audit systems with the goal of reducing the environmental impacts of production below the mandatory limits (European Commission 1997). In future, environmental improvements, especially reduced consumption of water, chemicals and energy are expected from the application of new biotechnical processes in areas like bleaching and dyeing as mentioned in the preceding section. During the last decade however, the environment in Europe seems to have profited most from the overall reduction in level of production and the relocation of production facilities to low-wage countries, primarily in Asia. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 5. 33 Analysis of case studies The following analysis is based on six case studies of companies which have – more or less successfully (see below) – introduced biocatalytic approaches into their production processes. To investigate successful cases and to identify success factors is a more recent approach which has not yet been used very often – in literature, studies on hindering factors predominate. As it was outlined in chapter 3.2, the cases were selected in such a way that they covered a large number of variables (e. g. industrial sector, size of company, country, experience with biotechnology etc.). This made it possible to investigated a rather broad spectrum of influencing factors with a limited number of case studies. The disadvantage, however, is that the individual cases are not representative of e. g. an industrial sector so that results and conclusions cannot simply be generalised. In order to make generalisations possible to a certain extent, the findings from the case studies were compared to the scientific literature in order to distinguish special from general findings. 5.1 Comparative description of the case studies Table 5.1 gives an overview of the six case studies performed. Four of the six companies investigated have their headquarters in Germany, one company is located in the Netherlands, and one company is in Austria. The bias towards Germany is due to the fact that companies in other countries (e. g. UK, Denmark) which were also contacted as case study candidates, refrained from participation (cf. chapter 3.2). It is remarkable that neither the performed case studies nor the list of case study candidates from which they were chosen comprised companies from Southern Europe. Due to the lack of coverage of Southern European countries in this study, it should be carefully checked within other work packages of the overall project "Biotechnology and the Greening of Industry" whether the derived findings and recommendations also hold true for the south of Europe. Institute for Prospective Technlogical Studies 35 Introduction of Process-integrated Biocatalysts in Companies 2 Industrial sector Chemical industry NL Chemical industry D Food industry, engineering 4 D Textile industry 5 D 6 A Chemical industry (pulp and paper industry) Pulp and paper industry Large multinational Joint venture of two large multinationals Two large multinational companies, one SME7* SME x x x* x Development and introduction of an enzymatic degumming step in physical seed oil refining x Adoption of enzymatic desizing and enzymatic textile finishing (biopolishing, biostoning) by the company x x 6 D: Germany, NL: The Netherlands, A: Austria 7* The SME involved in the innovation process refrained from participating in the case study. Institute for Prospective Technlogical Studies Substitution of the chemical synthesis of a vitamin by a fermentative process Substitution of chemical synthesis steps by enzymatic steps in the synthesis of an antibiotic x Research daughter of a large multinational SME Innovation project Development of an enzymatic pulp bleaching process Development of a biotechnical pulping process using white-rot fungi 35 3 Size of company Enzyme user and producer D Enzyme know-how within company Enzyme user Country6 1 Overview of the six case studies performed Enzyme producer Case study no. Table 5.1: Introduction of Process-integrated Biocatalysts in Companies 37 Three companies belong to the chemical industry, but one of them (case no. 5) develops a process for the pulp and paper industry. One company belongs to the food sector, one to the textile industry and one to the pulp and paper industry. This coverage of the industrial sectors by case studies reflects that at present most biotechnical processes with a greening effect are performed within the chemical industry. It also reflects the fact that innovations in the food, textile and pulp and paper sector often have not been generated in the respective sector itself, but are generated in "supply sectors" such as the chemical industry or engineering/machinery companies (e. g. case 3, 5). All in all, nine companies were involved in the six case studies. Five of them are large multinational companies, three are small and medium-sized companies, and one company is a (small to medium-sized) research daughter of a large multinational. Two companies are enzyme producers, five are enzyme users only, and two are enzyme user and producer. In two cases (no. 2 and 3), an enzyme user and an enzyme producer explicitly joined forces in order to carry out the innovation project. In case 4, the textile company was more loosely connected to an enzyme producer; the enzyme producer was more a supplier than an equal partner in the project. In case 6, a university institute was chosen as a partner with competencies in biotechnology. All innovation projects aimed at replacing a conventional process or conventional process steps by biotechnical processes or process steps. Two of the six projects (cases no. 1 and 6) relate to fermentation processes, the other cases involve the introduction of enzymatic steps into the production process. All cases investigated have a significant greening effect which is described in more detail in chapter 5.3. The innovation projects covered in the case studies cover a broad spectrum, from ambitious and complex projects where a novel process was developed from scratch (e. g. case 2) or from developing a licensed principle into a viable marketable process (case 5) which both required a substantial amount of basic R&D, to projects which comprise the adaptation of – in principle established bio-processes – to the requirements and special needs of the company (e. g. case 4). The duration of the projects ranges from 2 years up to 10-15 years, with R&D capacities involved of only very few man-years up to dozens or even a hundred of man-years. All investigated six cases are clear process innovations, with four cases (cases 1, 3, 4 and 5) comprising also aspects of product innovation. In case 1, the product, a vitamin, had already been produced by chemical synthesis and marketed before the fermentative process was introduced. However, as the fermentative process yielded a less pure product than the chemical synthesis, the product was better suited for the animal feed sector than for the food or pharmaceutical sector, and the additional adoption of the fermentative process enabled the company to gain substantial market shares in the animal feed market. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 38 In case 3, the physical oil refining process innovation required also an enzyme which was not available in sufficient amounts and at cost-efficient prices at the beginning of the innovation project. Therefore, an enzyme (= product) innovation formed a significant milestone in the overall process innovation8. The situation is similar in case 5: in order to develop a new process for pulp bleaching, two innovative products, an enzyme and a chemical redox mediator, are required. Both product and process innovation are carried out within the same company. In case 4, an innovative process has been introduced into the textile company which makes it possible to achieve unique textile finishing effects which can only be realised with the enzymatic, but not with conventional chemical processes. Therefore, textiles can be produced with the new process which have unique properties and thus, also represent a certain product innovation. 5.2 Comparison of the companies' background, their situation at the beginning of the project, and the strategic aspects of the innovation projects In the following section, the companies' background and their situation at the beginning of the innovation project will be outlined. It will be analysed how the project fits into the company strategy, what the expectations were, what the outcomes of the projects were and what the future prospects are. In case 1, the market for the respective vitamin was expected to grow. Therefore, it was decided to expand the available production capacities (a purely chemical process) in order to secure a substantial share of the growing vitamin market. However, as the company is a traditional chemical company, it was very controversially discussed whether a biotechnological process should be preferred over a chemical one. Moreover, the company lacked experience and expertise with biotechnology as the vitamin process was the very first fermentative process developed and operated in the company. Finally, it was decided in favour of the biotechnical project because the chemical technology was perceived as mature whereas the fermentation technology seemed to offer further potentials. Biotechnological know-how was built up in-house, and the fermentative process could successfully be developed. A production plant was built (in addition to the existing chemical plant) and both plants were operated in parallel for several years. 8 However, the original project partner did not succeed in providing this enzyme, and the innovation was at last carried out by a competitor. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 39 Meanwhile, the fermentative process has completely substituted the chemical process. The company has achieved its expected market goals. Moreover, the division in which the vitamin innovation took place is considered as one of the most promising growth sectors within the company. As biotechnology contributes substantially to progress in this sector, the former resistance towards non-chemical processes begins to erode, and the company has now explicitly committed itself to exploiting the potentials of biotechnology in R&D. In case 2, the company had a good market position with its chemically produced antibiotic. However, it faced growing competition from companies in newly industrialising countries, such as India or China, which had recently adopted the conventional, mature chemical production technology. The company wanted to defend its leading position in an attractively large, growing market and wanted to achieve this goal by making use of innovative, leading-edge technology which gave them a competitive advantage. In contrast to the chemical company in case 1, this chemical company had been monitoring the emerging technology of enzymes in organic synthesis for some time, and was eager to adopt this innovative tool. However, the company had only profound experience in the manufacturing of intermediates for the pharmaceutical industry but lacked the required biotechnological know-how. This know-how was incorporated by forming a joint venture with another company with core competencies in microbiology, genetics, biochemistry and fermentation. In the following years, the chemical synthesis of the antibiotic was replaced by an improved synthetic process which involved several enzymatic steps. The company has achieved its market goals. The new process was so cost-effective that even falling prices of the antibiotic could be compensated. Meanwhile, the combination of biotechnology, bio- and chemocatalysis, fermentation and chemistry has become a core competence of the life science sector of the company which is expected to expand. Moreover, the mother companies which formed the antibiotics joint venture have now merged so that the joint venture can be seen as smoothing the way for the recent merger. In case 3, a general trend towards physical instead of chemical refining of seed oil could be observed. The engineering company already had competencies in degumming techniques required for the physical refining. It was therefore a logical consequence for the company to aim at designing a superior degumming process in terms of cost and efficiency. It belongs to its core competencies (and is a competitive advantage over other engineering companies) that the company develops new technologies itself. It also had previous experience with biotechnological processes and had good cooperations with an enzyme producing company which agreed to develop the enzyme required for the degumming process. As the enzyme company had difficulties in developing the enzyme, it took nine years until a pilot plant could be operated at the involved food company. Although the process was technically mature, it took another two years until the cost targets could be met and the process proved successful both in terms of technology, quality Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 40 and costs. The new degumming process has now also been implemented in several other seed oil companies in other countries. The textile finisher in case 4 is a rather innovative company in comparison to other finishers. However, the company also suffered heavily from the worsening economic situation of the European textile industry (see chapter 4.4). On the one hand, the company reacted as many others with a retrenchment programme, which e. g. comprised the shift of part of its production to a low-wage-country. On the other hand, it reacted rather exceptional by investing relatively large sums into innovative production technology in order to stay competitive in the long run. The strategic goal was to broaden the product base, to increase flexibility to changing market needs, to increase the share of high-tech finishing and the share of higher prices goods where quality is more important than price, and to offer goods and services which are not easy to imitate by competitors. Although the technical goals, the implementation of several enzymatic textile finishing processes in the company, were successfully met as scheduled after two years, the company has not reached its economic goals yet. Nevertheless, it plans to keep to its strategy, and it has already started a new biotechnical research project in order to broaden its product base further and gain more flexibility. The company in case 5 was granted the exclusive license to develop the enzymatic pulp bleaching process to market maturity because both biotechnology and chemistry are its core competencies. The lack of expertise in pulp production within the company was compensated by building strategic cooperations with pulp producers and by gradually building up in-house expertise also in this field. The main driving force for the company to develop the process is the exceptionally large market potential of the process. This justifies the relatively large investments in R&D of this process and may also explain why the project has not been abandoned although the required time to market turned out to be much longer than anticipated. Moreover, the project fits perfectly into the company's business strategy as it requires core competencies of the company both in biotechnology and chemistry which also puts the company at an advantage over competitors who only have expertise in one of both fields. During the innovation project, technical trends in pulp bleaching changed and required a considerable strategic adjustment of the innovation project which led to a substantial prolongation of the time required for developing the process to market maturity. At the time when the case studies were performed, a large-scale trial in an industrial production plant was being prepared. At the beginning of the 1990s, when the innovation project was started, the SME in case 6 had been a rather progressive company: It had been a leader in environmental protection, and R&D played a relatively important role. The main emphasis of its R&D – chlorine-free bleach, modern bleaching sequences and biological wastewater processing plants evidence the particular importance of the fields of environmental protection and biotechnology within the enterprise. By employing Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 41 research staff trained in biotechnology, by establishing cooperations with a university institute specialised in wood biotechnology, and by joining a US-based consortium on biopulping, the company managed to do internationally competitive research on the biopulping process. However, the company is also a typical example of the economic trends in the European pulp and paper industry in the 1990s: an increasing market concentration, the need to restructure by increasing volumes of sales and productivity by concentrating on core competencies, afterwards by mergers and acquisitions (see chapter 4.3). Due to economic problems, the company in case 6 was subsequently taken over by two larger pulp and paper companies. By concentrating on its competence of high-quality woodfree papers it realised economies of scale. Its staff was reduced. Despite competitive results in the biopulping project, the research project was abandoned at the laboratory stage due to economic difficulties of the company and due to the fact that the responsibility for R&D has been transferred to the mother company outside Europe during the restructuring process. As a consequence, the biopulping process has successfully been developed to industrial scale in the USA, but has not yet been introduced in Europe. 5.3 Role of greening in the innovation process All cases investigated have a significant greening effect: In the cases 1 and 2, the number of synthesis steps can be substantially reduced which is linked to a significant reduction of the amount of waste or side-products. Moreover, ecologically harmful substrates and processing aids can be replaced by less toxic substances to a large extent. A substantial reduction of the waste stream by a factor of 8 to 10 and savings in toxic processing aids were also the effects in case 3. In case 4, the environmental benefit is a substantial reduction of pumice stone sludge, and a significantly lower water and energy consumption. Moreover, production losses by damage of machines and fabric are also considerably reduced (Kothuis and Schelleman 1996). In case 5, the quantity of bleaching agent (chlorine or chlorine dioxide) required in pulp production can be significantly reduced. In addition, the enzymatic process fits well into paper mill concepts with a closecircuit water cycle, thus minimising the environmental impact even further. In case 6, environmental advantages of the bioprocess lie in savings in term of raw materials, chemicals used as processing aids, and energy, as well as in a lower wastewater toxicity (Messner und Srebotnik 1994). The ecological effects of biotechnological processes as compared to conventional chemical processes (such as mild conditions (pH, temperature, pressure), aqueous media, high selectivity and specificity, less toxic and recalcitrant chemicals, biodegradable waste) were qualitatively known to the management staff at the time when the decision whether to start the project was made. The ecological benefits Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 42 definitely played a certain role in this decision-making: they were relevant in the sense that the new process should be less harmful to the environment than the conventional process. The innovation projects had not been pursued it the bioprocess had been environmentally problematic. On the other hand, the environmental benefits alone were not sufficient to give the bio-process a clear competitive advantage over other, competing options. This may also be due to the fact that none of the companies had difficulties to comply with environmental standards at the time of decision-making so that there was no immediate need for the company to improve its environmental performance. This is also in line with findings from a study on the use of life cycle assessment (LCA) methods in companies. In none of the cases was response to regulation a driving force for the use of LCA (Verschoor and Reijnders 1999). As outlined in chapter 5.2, strategic aspects such as gaining or maintaining flexibility in reacting to changes in the market or as maintaining a long-term economic advantage proved to be more important in the decision-making than environmental aspects alone. However, being among the leaders in environmental technologies may also contribute to a company's flexibility: as the company prospectively anticipates future developments in environmental protection and standards, it has a larger time frame and can select a suitable situation in which to react to these requirements than companies who only become active "in the last minute" when they cannot keep up their polluting production processes any longer. Case 5 is a very good example that the environmental friendliness of a bio-process in most cases is not an absolute value as such, but is considered as an "added value" to a product (or process) which is at least equal or superior to conventional processes: In case 5 environmental concerns over the emission of large amounts of toxic chlorine compounds during pulp bleaching triggered the development of bleaching processes with less toxic oxidants than chlorine at the beginning of the 1990s. These environmental concerns can be considered as a prerequisite that a market for the process in case 5 has developed at all9. In case 5, the significance of these environmental benefits has, however, declined over the years: In the pulp and paper industry, the elementary chlorine free (ECF) bleaching process now seems to be preferred over totally chlorine free (TCF) bleaching processes – although the latter are technically feasible and environmentally more desirable. The company in case 5 has reacted to this development in the pulp and paper industry and now develops its bio-process for the ECF process instead of the TCF process, as it originally planned. This example shows that the resulting process is a compromise between costs, quality and environmental protection. This is also illustrated by case 3, where the engineering company explicitly stated: "You can't sell a process (or product) on its environmental friendliness alone". 9 This applies, to a certain extent, also to case 3. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 43 The relatively low importance of environmental aspects in the decisions may also be due to the fact that in case 1, 2 and 3, the ecofriendly production of the product (feed additive, antibiotic, oil) does not play a role in purchase decisions of these products. As the companies pointed out the ecofriendly production cannot be used in advertising campaigns for the product. The case may be different for paper (case 5 and 6) because eco-paper is a separate market segment. However, the bioprocesses investigated in case 5 and 6 have not yet reached the market so that this assumption cannot be tested. In the textile sector, there is also a small segment of eco-textiles. However, no information is available whether the company in case 4 explicitly serves this market segment. Although the environmental protection is not a promotion aspect for the product in case 1, the company performed a life cycle analysis (LCA) of the bio-process in order to quantitate the environmental benefits. The results of this LCA were used for company-related, not product-related public relations in order to improve the overall image of the company, especially to improve relations with neighbours who had complained about emissions from the chemical plant. Five of the six case studies performed in this study were cases in which bioprocesses were newly developed and required relatively intensive R&D efforts. However, in case 4, already existing processes with known environmental benefits were newly introduced into the company and only had to be adapted to the company's special situation. This latter case may represent a type of innovation where the greening effect of the bio-process may in general play a larger role than it did in case 4, especially as it may be suitable for companies which actively search for means to improve the ecological or economic performance of their company. In these cases, it would certainly support the broader adoption of bio-processes if the following prerequisites were fulfilled: • Implementation of an environmental management system and environamental performance indicators in the company, so that the company is informed in detail about its environmental performance and its environmental strengths and weaknesses (Thoresen 1999). • Benchmarking the environmental performance of the own company with the performance of similar companies, in order to identify one's own relative strengths and weaknesses and to define feasible targets. • Application-oriented information of benefits and costs of the bio-process, so that the company can decide whether switching to the bio-process would be beneficial and cost-efficient for the company or not. • Support in practical implementation of the new bio-process. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 5.4 44 Challenges and hindrances encountered during the innovation projects in the case studies All companies investigated experienced an individual mixture of different challenges and hindrances during their innovation project. The challenges encountered are listed in tables 5.2, 5.3 and 5.4. A summary is given in table 5.5. As can easily be seen from table 5.5, all cases investigated had some challenges and hindrances in common. These are • Technical problems in combination with lack of skills and expertise. In all the cases investigated, scientific-technical problems arose during the innovation project which were difficult to solve. These were sometimes, but not always, biotechnical problems. In all the cases investigated, the involved companies at least in part lacked the required skills and expertise to prevent these scientifictechnical problems or to solve them very quickly. In none of the cases, however, led this partial lack of expertise to a failure of the project, because all companies managed to overcome these problems and to compensate expertise deficits, mainly due to cooperations. Remarkably, in about half of the cases investigated, the companies did not have any experience with biotechnology or only had a rather limited know-how which would not have been sufficient to carry out the project. This lack of biotechnology expertise was compensated by strategic alliances and cooperations in the field of biotechnology, or by explicitly acquiring the know-how via hiring of experienced staff or "learning by doing". • Benefits difficult to assess, uncertain, long pay-off period. In all cases investigated, the companies had difficulties in assessing the comparative advantages of the biotechnological process with sufficient certainty. Therefore, there were phases in all cases in which controversial discussions were led whether to pursue the innovative project further or whether to return to established solutions. In these situations, the established solutions could always be backed with "hard facts" and extrapolations from previous experiences while for the new biotechnological process such convincing data were missing in most cases. Solutions to this controversy lay in providing these facts also for the bioprocess which required hard work of the R&D department or in using the management's hierarchical power to pursue the project further. Several factors contributed to the difficulties in assessing the comparative advantages of the bioprocess: Some of the projects were long-running, strategic projects (e. g. case 1, 2 and 5) which required foresight of future market developments and of future progress in competing technologies. For these type of developments only plausible assumptions can be made, but they cannot been predicted or foreseen with certainty – and an erroneous assessment e. g. strongly influenced the project in case 5. Another factor is a certain unfamiliarity with biotechnology: case 1 illustrates that e. g. for chemical processes sophisticated analytical tools and profound experience exist which e. g. help in assessing the Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 45 economic performance of the process and provide technical data for scale-up – comparable analytical tools for biotechnology were missing. A missing information base (lack of information for choosing the optimal enzyme for the process) was also pointed out in case 2. Moreover, in several cases, the pay-off period for the newly established process was much longer than anticipated (e. g. case 3 and 4), although the reasons for this could not be fully elucidated. In both cases, the project would have been abandoned and one would have returned to established solutions if the management had not used their hierarchical power to promote the project further. • Alterations of existing structures, equipment, facilities. An aspect which often leads to controversies in innovation projects is the alteration of existing structures, routines and facilities (Kostka and Hassan 1997). On the one hand, this has a technical and cost component: the bioprocess often requires another production plant design than the conventional process, cannot easily be integrated into existing production plants or does not fit into the existing network of processes which use side-products of other processes as substrates, and provide educts for other processes. These problems were encountered e. g in case 1, where a totally new plant for the fermentative process had to be built and where new ways for treatment and disposal of the fermentation sludge had to be developed, or in case 4, where a totally new machine was bought. Using this new equipment always requires a change in the work routines of the staff and most likely also in their qualification which can lead to controversies, as illustrated by cases 1 and 4. On the other hand, the alterations in existing structures also refer to organisational changes which, as a consequence, lead to altered allocation of resources, career opportunities and career disadvantages of staff, altered reputation of departments and individuals in the company etc. In case 2, a joint venture between two companies was formed in order to realise the innovation project which – all in all – seems to have had an overall positive effect since the two parent companies have now fully merged. In case 1, the innovation project, however, meant the introduction of a new "culture" and "way of thinking" into the chemists-dominated company which gave rise to envy, scepticism and lack of trust. It took many years and the implementation of a successful process to establish biotechnology as a valuable contribution to the company's know-how and portfolio. • No need for action because compliance with environmental standards. None of the companies investigated had an immediate pressure to improve the environmental performance of its production processes. All companies could comply with current environmental standards with their established production technology. Therefore, a strong incentive from the environmental and legal point of view to start and pursue the project was missing. With the aim to promote the further use of production-integrated environmental prevention through biotechnology, this can be considered as a certain drawback. Institute for Prospective Technlogical Studies 44 Introduction of Process-integrated Biocatalysts in Companies Table 5.2: Overview of difficulties and hindering factors during the innovation projects of case 1 and case 2 Hindrance Lack of awareness PIEP not known Case 1 does not apply; PIEP not relevant at time of decision-making biotechnology unfamiliar, does not work played important role in the decision-making staff lacks qualification, time, infor- decision-makers were chemists by training and had mation prejudices towards biotechnology no need for action because compliance applies; economic and strategic, not ecological with environmental standards reasons for the decision insufficient data on environmental not relevant at time of decision-making; in later performance of company stages LCA was performed for PR reasons Perception of cost/benefit ratio as negative low innovativeness, low R&D intensity does not apply; however reluctance to take up biotechnology in chemistry-based company unfamiliar with biotechnology applies; project was the very first fermentative process in the company difficult economic situation does not apply lack of skills and expertise lack of qualified/motivated staff Institute for Prospective Technlogical Studies Case 2 does not apply; PIEP not relevant at time of decision-making does not apply does not apply; staff had monitored development closely, was eager to use it in own company applies; economic and strategic, not ecological reasons for the decision not relevant at the time of decision-making does not apply partly applies; joint venture in order to explicitly integrate bt know-how and to exploit synergies partly applies; market position was perceived as endangered, if no precautionary measures were taken; difficult to finance required R&D from product sales when antibiotic prices fell applies; biotechnology know-how was built up in- partly applies; company was one of the first players house de novo; some gaps were filled by in this emerging discipline, built up unique knowcooperations how in-house; some gaps were filled with cooperations partly applies; reluctance to take up or support does not apply biotechnology; project team itself was however very motivated Introduction of Process-integrated Biocatalysts in Companies 45 Table 5.2 continued Hindrance Case 1 alteration of existing structure, equip- applies; biotechnology meant new culture in ment, facilities chemical-based company; biotechnology was a competitor in company-internal allocation of resources; a new plant for the fermentative process had to be built; bioprocess did not fit into the "Verbund"-structure of the production site benefits difficult to assess, uncertain, applies; lack of sufficient experience and analytical long pay-off period tools to evaluate bioprocess vs. established chemical process prefer established solutions applies; indicator: chemical and fermentative plant operated for 6 years in parallel as trust in bioprocess was lacking Impaired ability to fight off adverse events and to develop viable solution scientific-technical problems scientific-technical problems arose; e. g. design of a reliable, cost-efficient process, development of treatment and disposal routes for the fermentation sludge lack of expertise to overcome technical if applicable, had no negative influence on the difficulties outcome; cooperations were sought lack of money, time, skills if applicable, had no negative influence on the outcome lack of support applies; introduction of bioprocess was a very controversial issue within the chemical company Institute for Prospective Technlogical Studies Case 2 applies; project required the formation of a joint venture; has now resulted in a merger of the parent companies applies; especially decline in product price put additional pressure and new R&D targets on the project does not apply scientific-technical problems arose; e. g. finding the right enzyme, its proper formulation, design of a reproducible, cost-efficient process if applicable, had no negative influence on the outcome; cooperations were sought if applicable, had no negative influence on the outcome does not apply 46 Introduction of Process-integrated Biocatalysts in Companies Table 5.3: Overview of difficulties and hindering factors during the innovation projects of case 3 and case 4 Hindrance Lack of awareness PIEP not known Case 3 does not apply; PIEP not relevant at time of decision-making biotechnology unfamiliar, does not work partly applies; enzymatic desizing as a standard process had already been used for years; a biochemist was hired in order to bring the biotechnology know-how into the company staff lacks qualification, time, information does not apply does not apply no need for action because compliance applies; economic and strategic, not ecological applies; economic and strategic, not ecological with environmental standards reasons for the decision reasons for the decision not relevant at the time of decision-making insufficient data on environmental per- not relevant at the time of decision-making formance of company Perception of cost/benefit ratio as negative low innovativeness, low R&D intensity does not apply does not apply; 10 % of staff engaged in applied R&D; company is said to be more innovative than competitors unfamiliar with biotechnology does not apply for engineering and enzyme partly applies; although a specialist was hired, tacit company, applies for food company knowledge had to be built up difficult economic situation does not apply fully applies; the company had to move part of the production to low-wage-country and started a retrenchment programme; sales significantly decreased lack of skills and expertise partly applies; project team was designed an a way partly applies to exploit synergies between the partners; however, one partner turned out to lack required skills lack of qualified/motivated staff does not apply does not apply alteration of existing structure, equip- only applies in parts; project partners knew each applies; a new machine was bought in connection ment, facilities other from previous projects; bioprocess required with the innovation project which bound the new plant which could be integrated into existing majority of resources and R&D budget plant design and equipment Institute for Prospective Technlogical Studies does not apply; PIEP not relevant at time of decision-making does not apply; engineering and enzyme producing company had profound experience Case 4 Introduction of Process-integrated Biocatalysts in Companies 47 Table 5.3 continued Hindrance Case 3 benefits difficult to assess, uncertain, partly applies; risks and costs could be assessed long pay-off period rather easily and were perceived to be low; however, development time turned out to be much longer than estimated prefer established solutions partly applies; as process was not cost-efficient for two years, returning to the conventional degumming process was under serious consideration in the food company Impaired ability to fight off adverse events and to develop viable solution scientific-technical problems scientific-technical problems arose, especially in finding a cost-efficient way to produce the required enzyme and to reach the pre-set cost targets for the degumming process lack of expertise to overcome technical unclear whether applicable. As the enzyme company difficulties which did not succeed in finding a cost-efficient way for producing the required enzyme did not participate in the case study the reasons for the failure could not be elucidated lack of money, time, skills if applicable, could be overcome lack of support Institute for Prospective Technlogical Studies only applies to the phase when the pilot plant did not meet the cost targets. It was a controversial issue within the food company whether more resources should be devoted to the then unsuccessful project or whether the project should be stopped at all Case 4 applies; production rates and sales estimates for the new machine turned out to be too optimistic; sales targets have not been met applies in part; staff opposed the purchase of the new machine because they feared serious harm to the liquidity of the company scientific-technical problems arose; especially when experienced staff left the company became relevant when experienced staff left the company. However, remaining staff was able to solve the problems; the project could successfully be completed Lack of money was a reason for opposition of staff against the project. Opposition was in part overcome by financing staff through a special grant and by hierarchical power only applies to part of the staff who had preferred a financially less risky strategy; management always supported the project even against opposition and results that stayed behind the expectations 48 Introduction of Process-integrated Biocatalysts in Companies Table 5.4: Overview of difficulties and hindering factors during the innovation projects of case 5 and case 6 Hindrance Lack of awareness PIEP not known Case 5 does not apply; potential of the biobleaching process for PIEP was a major determinant in the decisionmaking biotechnology unfamiliar, does not work does not apply; company has profound in-house know-how in biotechnology staff lacks qualification, time, infor- does not apply mation no need for action because compliance partly applies; ecological reasons played a with environmental standards significant role in decision-making insufficient data on environmental per- not relevant at the time of decision-making formance of company Perception of cost/benefit ratio as negative low innovativeness, low R&D intensity does not apply; company itself is completely devoted to R&D unfamiliar with biotechnology does not apply; company has profound in-house know-how in biotechnology Case 6 does not apply; company was considered to be a leader in environmental protection, even received an award for its overall environmental activities partly applies; company had, however, experience with biological waste water treatment does not apply; responsible staff, although chemists by training, were very interested in biotechnology applies; however, company was considered to be a leader in environmental technologies not relevant at the time of decision-making does not apply; R&D was important within the company and was well-equipped partly applies; know-how was made available through cooperations and participation in a research network (consortium) difficult economic situation does not apply fully applies; finally led to restructuring of the company and termination of the innovation project lack of skills and expertise partly applies; missing know-how in pulp production partly applies; missing expertise was acquired was acquired via cooperations and gradually also through cooperations and participation in relevant built up in-house networks lack of qualified/motivated staff does not apply does not apply alteration of existing structure, equip- does not apply; process under development can be unclear whether relevant ment, facilities combined with all bleaching methods and pulping methods Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 49 Table 5.4 continued Hindrance Case 5 Case 6 benefits difficult to assess, uncertain, long applies; difficulties arose especially from applies because bioprocess in an infant stage has to pay-off period erroneous estimations of future development of be assessed vs. a mature established technology (competing) bleaching methods prefer established solutions does not apply partly applies; a process engineering company required for technical realisation of the project after the laboratory phase was very sceptical about the feasibility of a bio-process Impaired ability to fight off adverse events and to develop viable solution scientific-technical problems scientific-technical problems arose, especially in scientific-technical problems arose, especially in the developing a technology for the toxic by-product- pre-sterilisation of wood chips free production of the mediator, in overcoming plant capacity bottlenecks for mediator production for large-scale trials, and in the need to strategically readjust the technical and cost targets for the project due to erroneous strategic assessment of competing technologies lack of expertise to overcome technical if applicable, had no negative influence on the if applicable, had no negative influence on the difficulties outcome; cooperations were sought outcome; cooperations were sought lack of money, time, skills if applicable, had no negative influence on the was a decisive factor for discontinuing the project, as outcome the company had to be sold to other companies with different strategic foci lack of support does not apply; large market potential of the does not apply for the start of the project and the process under development justifies the devotion laboratory phase; fully applies for the technical of large sums, resources and time into the project realisation (no support from engineering company), and the time after the sale of the company Institute for Prospective Technlogical Studies 50 Introduction of Process-integrated Biocatalysts in Companies Table 5.5: Overview of difficulties and hindering factors during the innovation projects in the six case studies Hindrance Case 1 Lack of awareness • PIEP not known • biotechnology unfamiliar, does not work • staff lacks qualification, time, information • no need for action because compliance with environmental standards • insufficient data on environmental performance of company Perception of cost/benefit ratio as negative • low innovativeness, low R&D intensity • unfamiliar with biotechnology • difficult economic situation • lack of skills and expertise • lack of qualified/motivated staff • alteration of existing structure, equipment, facilities • benefits difficult to assess, uncertain, long pay-off period • prefer established solutions Impaired ability to fight off adverse events and to develop viable solution • scientific-technical problems • lack of expertise to overcome technical difficulties • lack of money, time, skills • lack of support –: +: 0: ?: PIEP: not relevant, does not apply, is no hindrance relevant, applies, is a hindrance partly relevant, partly applies, is a hindrance in certain aspects, in others not not known, information not available production integrated environmental protection Institute for Prospective Technlogical Studies Case 2 Case 3 Case 4 Case 5 Case 6 – + + + – – – – + – – – – + – – 0 – + – – – – 0 – – 0 – + – – + – + 0 + + + – 0 0 0 – + + – – – – 0 – 0 + 0 – 0 + 0 – 0 + 0 – – – 0 – – + – – 0 + 0 – ? + 0 + – – + + – – – + ? – – + 0 + –/+ + – – – + – + –/+ Introduction of Process-integrated Biocatalysts in Companies 5.5 51 Supporting factors identified in the case studies Table 5.4 does not only give an overview of the challenges and hindrances encountered during the investigated innovation processes, but also gives an indication what supporting factors and successful schemes for managing complex innovation processes are: Innovativeness A common characteristic in all case studies is that the companies are all (relatively) innovative as compared to other companies in their industrial sector. This is reflected by the fact that they all anticipate the future needs and requirements prospectively (e. g. market developments, consumer preferences, environmental regulations), that they aim at gaining (or maintaining) flexibility and at gaining a long-term economic advantage. In case 1, biotechnology, which has now advanced to a key technology in the pharmaceutical, agrobusiness and also fine chemicals sector of the company, was for the first time introduced into the chemical-based company and also enabled the company to enter a new market (feed additives). In case 2, synergies between the antibiotics section of company 1 and the biotechnology section of company 2 were exploited in a joint-venture, and these synergies now form core competencies of the recently merged parent companies. In case 3, the innovation project meant a logical follow-up activity of previous projects which made use of unique know-how within the engineering company and also opened new market opportunities for this company. In case 4, the explicit aim was to broaden the product range of the company and to gain more flexibility in response to quickly changing customers' needs. In case 5, the innovation project made use of the unique know-how of the company and is intended to open an extraordinary large market for the company. In case 6, the innovation project was a logical follow-up activity of previous projects in the field of biotechnology and environmentally friendly technologies in the pulp and paper industry. Therefore, all innovation projects investigated follow the pattern of a company strategy which sees the biotechnology project with an environmental benefit as a means to widen the competencies of the company strategically as a response to the anticipated future requirements. Assessment of the benefit/cost ratio Table 5.4 also shows that in all cases investigated the assessment of the cost/benefit ratio of the project is not clearly in favour of the innovation project – in every company there are serious hindrances or costs which could have prevented other companies from pursuing such a project. The success factor may be, however, that in cases of uncertainty and risk, the companies investigated tend to decide in favour of the innovative project instead of preferring established solutions. This behaviour Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 52 is supported by the fact that they do not view the project simply as a means to reduce costs or increase productivity, but take a wider perspective of the benefits (see above). Open-minded staff may also be regarded as a supporting factor. Moreover, the companies investigated are also characterised by their systematic and iterative assessment of the benefits versus the costs, and their ability to adjust the project according to the results of this repeated assessment. Skills and expertise Skills, expertise and previous experience with biotechnology certainly is helpful. The case studies show, however, that this is not a strict prerequisite for starting the project and for its successful completion. What seems to be more important is a general "innovativeness", an open-mindedness of the management staff towards new ideas and new technologies, and also the ability to recognise and compensate any lack of skills and expertise. This compensation is realised in the form of participation in appropriate networks, of cooperations and strategic alliances, and the timely acquisition of qualified staff, know-how and expertise. In case 1, cooperations were built throughout the world to contribute to the vitamin project; in case 2, a joint-venture was formed and cooperations mainly with university institutes were sought. In case 3, the project team was designed in a way that each partner contributed complementary know-how and skills and the "cultural fit" had been tested in previous projects. In case 4, an enzyme expert was hired (what is rather unusual for a SME in the textile sector) and, as such a specialist was not easily financed by the company, a special grant which covered part of the personnel costs, was acquired. In case 5, in order to compensate for certain in-house deficits in pulping technology the company employed consultants, engaged in cooperations and actively built up a network of possible customers which are interested to implement the process under development. In case 6, the company took actively part in an international research consortium which provided important information and also made a benchmarking of the own research progress with internationally leading groups possible. Moreover, the company intensively cooperated with a university institute specialised in this field. Therefore, the active engagement in a network of appropriate partners seems to be a success factor common to all companies investigated. Scientific-technical know-how is certainly a key requirement for successful projects, but not sufficient – additional skills are required. The successful companies investigated had all implemented a stringent project management which included an iterative critical assessment of the work progress, which made money, time, and skills available if milestones were met (and denied these resources if milestones were not met), but which also included constant support and a reliable commitment of the management for the project. The importance of support by the top management for the success of environmental improvement acitivities has also been pointed out by Thoresen (1999). This support and commitment also helped to Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 53 overcome difficult phases in the projects. This aspect, however, implies that the company also must have the ability to fight off adverse events, such as unanticipated market changes (e. g. case 2: falling product prices which set new cost targets for the new process, case 5: trend towards cheaper competing technologies which again set new cost targets for the new process), technical problems (e. g. problems with achieving cost targets (case 3), reproducibility of the process (case 1), waste disposal (case 1), unanticipated presence of toxic sideproducts (case 5)), internal controversies about the continuation of the project (case 1, 3, 4, 6) or a difficult financial situation of the company (case 4 and 6). Cases 4 and 6 are also examples for the importance of the ability to "survive" difficult phases in the innovation project: both companies had impaired abilities to fight off adverse effects due to their financial situation; and their innovation projects did not meet all pre-set targets or were terminated at all. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies Institute for Prospective Technlogical Studies 54 Introduction of Process-integrated Biocatalysts in Companies 6. 55 Summary In this study, six case studies were performed in companies which had implemented biotechnical processes for production-integrated environmental protection (PIEP). To investigate successful cases and to identify success factors is a more recent analytical approach complementary to the still predominating studies on hindering factors. In the success approach, it is analysed empirically to which extent favourable conditions (absence of hindrances) explain the successful implementation, and which factors have led to overcoming hindrances which are also present in successful cases (Ostertag et al. 1998, Conrad 1996). The six cases covered the industrial sectors chemical industry, textile industry, food industry and pulp and paper industry, and comprised large multinational companies as well as SMEs. Moreover, the companies investigated were enzyme users only, enzyme producers only, and also enzyme users and producers. With respect to the geographical location of the companies, a bias towards Germany has to be noted (4 of 6 cases investigated). Due to the lack of coverage of southern European countries in this study, the findings and derived recommendations will hold true for North to Central European countries. Whether they also apply to southern European countries which were not included in this study cannot be answered on the basis of this project. All innovation projects aimed at replacing a conventional process or conventional process steps by biotechnical ones which had a substantial greening effect. With respect to the "ambitiousness", the innovation projects covered a broad spectrum, from complex projects lasting a decade or more from the first idea until its market introduction, to the adaptation of already established processes to the special situation of the company. 6.1 Requirements, prerequisites From the analysis of the six case studies and information from the literature it can be concluded that the following requirements must be fulfilled for the introduction of biotechnical processes for production-integrated environmental protection into companies (Hüsing et al. 1998): • Awareness. Decisions about the start of PIEP innovation projects are usually made by high-level management staff. This staff must be aware of the possibilities of production-integrated environmental protection, and must be informed that biotechnology may be a technical option within the concept of production-integrated environmental protection. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 56 • Perception of benefit/cost ratio as positive. An innovation project will most likely only be started and continued if the expected or realised benefits outweigh the costs. Costs do not only mean direct costs for equipment or R&D expenditures, but also indirect costs such as transaction costs (e. g. for cooperations, for learning and acquisition of know-how, organisational change in the company induced by the innovation project etc.). • Skills, expertise. The successful introduction of biotechnical productionintegrated environmental protection requires know-how in different fields: Expertise in environmental management of the company, expertise in biotechnology, expertise in the relevant production process, and expertise in the relevant markets, customer needs and preferences, product characteristics etc. Moreover, the ability to manage complex innovation processes is also required if the project is a complex and ambitious one. • Ability to fight off adverse events. The progress and success of an innovation project is inevitably threatened by adverse events, such as scientific-technical problems, difficulties in project management, lacking resources for the innovation project, lack of support for the innovation project, critical economic situation of the company, altered market situation etc. Therefore, the ability to prevent, manage and "survive" such difficult phases is of importance for the successful completion of an innovation project. • Competitive solution which meets targets. Finally, the company must be able to generate a viable, competitive solution which is satisfactory with respect to costs, quality and environmental protection. 6.2 Hindering and supporting factors In the following paragraphs, hindering and supporting factors will be summarised, as they can be derived from the case studies and the literature. As biotechnical solutions for production-integrated environmental protection are not yet widely distributed (OECD 1998), there must be several hindrances which hamper the implementation of these innovative technologies. First of all, it must be noted that this is also a characteristic of production-integrated environmental protection as a whole, not only for the biotechnical options within this concept, because approximately 80 % of environmental expenditures are still invested in additional, end-of-pipe environmental technologies. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 6.2.1 57 Awareness – Hindrances It has to be noted that the concept of production-integrated environmental protection is not yet widely known. Environmental protection is still often linked to add-on, end-of-pipe technologies. This is especially true for environmental biotechnology – very often, only end-of-pipe processes such as biological waste water treatment, biological exhaust gases clean-up or bioremediation of contaminated sites are summarised under this term while the potential of biotechnology for prevention of environmental pollution is only rarely recognised. From this, it can be concluded that companies in the chemical, textile, food and pulp and paper sector which could in principle make use of (biotechnical) PIEP do not do so because their high-level staff simply is not aware of this option. Moreover, biotechnology is often perceived as an "immature technology which does not work". This may partly be due to the fact that PIEP and biotechnology were not part of their vocational training. Moreover, in their demanding every-day work they often lack the time to inform themselves about these options. This is also due to the fact that practically oriented, concise information especially compiled for and targeted at this target group can only rarely be found10. Moreover, structural factors such as the prevalence of small and medium-sized companies, a low research intensity, a difficult economic situation and a conservative-traditional attitude (as outlined in chapter 4) are further hindrances to a proactive, innovation-oriented information management within the companies. Another reason for a certain lack of awareness is that many companies can comply with the present environmental standards – not least because they have invested substantial sums into end-of-pipe environmental technologies during the last years. Therefore, an immediate need for action to improve the environmental performance of the company is often lacking. Nevertheless, there may be "weak spots" in the company where improvement would be advisable both from an ecological and economic point of view. However, this requires sufficiently detailed data on the environmental performance of the company (environmental performance indicators), and also the possibility to benchmark the performance of one's own company against the company's environmental policy and against the performance of similar companies. These data, however, are often lacking which is mainly due to the fact that environmental management systems, such as the ISO 14000 series or others, have 10 Good examples are the "Biotechnology means Business" and BIO-WISE initiatives of the British Department of Trade and Industry. They comprise a package of measures (e. g. written material, road shows, helpline) designed to improve UK competitiveness by raising the awareness of the commercial potential of biotechnology for UK user industries and stimulating its take up by them (http://www.dti.gov.uk/biowise/). Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 58 not yet been implemented. Especially the chemical industry and the automobile industry have been most active in developing and implementing such systems, while other industrial sectors, such as the food industry, are still lagging behind (Boudouropoulos and Arvanitoyannis 1999). Moreover, the international scientific community has not yet agreed upon a general set of essential environmental end effects that may be used to define the priorities for environmental improvement action on the local, regional or global scale. Furthermore, the proposal for a new, international standard for environmental performance evaluation (ISO TC 207/SC) does not express any clear directions in this respect (Thoresen 1999). 6.2.2 Awareness – supporting factors A common characteristic of the companies in the six case studies investigated was that a key element of their corporate strategy is innovativeness. This means that the companies have implemented mechanisms which enable them to prospectively anticipate future trends, needs and requirements in different fields, such as markets, technologies, environmental regulations, consumer preferences etc. As a result of this anticipation, they widen their competencies strategically in order to gain flexibility in response to changes in "the outside world" and to aim at long-term economic advantages. Companies which are at the forefront of environmental innovations deny that "they act 'green' out of environmental conviction". Their overall strategy is being innovative, and this strategy also extends to the environmental sector (Dresel 1997). "Greening" in terms of compliance with environmental standards and cost reduction is not seen as a target as such, but as an integral part of a more comprehensive strategy. That general aims of the company strategy can be achieved by environmental innovations is illustrated by the list of improvements companies have achieved which had implemented environmental management systems (Boudouropoulos and Arvanitoyannis 1999): • Environmental liability (ensure that environmental issues are considered strategically, rather than as a one-off special exercise), • Reduced operating costs (through prevention and waste reduction), • Management of change in supply (checking if certain supplies will be available in the near term and in the long term), • Increased productivity, • Improved financial performance, • Maintenance of consistent compliance with legislative and regulatory requirements, • Declining paperwork, Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 59 • Waste reduction, • Improved community and customer relations (public image), • Employee motivation ("feel-good factor", and increased motivation suggesting improvements and cost savings), • Improved environmental performance, • Potential impact on world trade (need for uniform standards, WTO). Such an innovation-oriented company strategy is closely linked to open-minded staff – also a common characteristic of the successful companies investigated in the six case studies. This open-mindedness enabled the top management to decide in favour of the biotechnical PIEP project despite the fact that they were often unfamiliar with biotechnology by training. They managed to compensate this unfamiliarity, e. g. by actively building relevant information channels, employing consultants, building cooperations etc. 6.2.3 Assessing the benefit/cost ratio – Hindrances An assessment of the benefit/cost ratio of a certain innovation project will take place before the start of the project when it must be decided whether to engage in the project at all. Moreover, it is an integral part of project management that this assessment should regularly be repeated at certain milestones. Even if the top management staff is aware of biotechnical PIEP options, they often prefer established solutions because they assess the benefit/cost ratio as negative before the start of the project. Moreover, during the project, they often tend to give up the project at an early stage in favour of established options if difficulties arise. This behaviour can often be found in companies or industrial sectors with a low innovativeness in general, with a low R&D intensity, and with a prevailing conservative-traditional attitude. Especially the food-, textiles- and pulp and paper industry have these characteristics (chapter 4). Moreover, the economic situation of the company may be difficult: declining market shares, sales, turnover and profit margins make it difficult to devote substantial resources to innovation projects of often uncertain outcome, especially if economic benefits from the innovation can only be expected in time scales which are larger than the planning horizon of the company. For the application of biotechnical processes in production integrated environmental protection, extensive expertise in biotechnology and enzyme technology is required as well as in production integrated environmental protection, in market structures, market requirements and customers' needs. This comprehensive know-how is most Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 60 likely present in the chemical industry, but is the exception in companies or research institutes of the other industrial branches investigated. As biotechnology is very research intensive it is difficult for the food-, pulp and paper- and textile industry with low research intensities to build up own biotechnical expertise. Moreover, small and medium-sized companies prevail, and in these types of enterprises environmental management is often in an infant stage so that production integrated processes in general are difficult to implement (Boudouropoulos and Arvanitoyannis 1999). The above mentioned problems sum up for the implementation of biotechnical processes in production integrated environmental protection. Although this knowhow can in principle be made available via cooperations and participation in appropriate networks, it increases the costs of the innovation. Small and mediumsized companies, a low research intensity, a difficult economic situation and a conservative-traditional attitude are structural and economic hindrances. Production-integrated environmental protection innovations often require an alteration of existing structures, routines and facilities (Kostka and Hassan 1997, Thoresen 1999). On the one hand, this has a technical and cost component: the bioprocess often requires another production plant design than the conventional process, cannot easily be integrated into existing production plants or does not fit into the existing network of processes which use side-products of other processes as substrates, and provide educts for other processes. On the other hand, the alterations of existing structures also refer to organisational changes which, as a consequence, lead to altered work routines, altered allocation of resources, career opportunities and career disadvantages of staff, altered reputation of departments and individuals in the company etc. These aspects often lead to controversies in innovation projects (Kostka and Hassan 1997), make the company-internal decision-making a very complex process which requires a thorough planning and management and support by top management (Thoresen 1999). While the cost side of an innovation project can often be assessed with a certain confidence, it seems to be much more difficult to assess the benefits of the project, especially if the company feels unfamiliar with the required technologies and skills. While uncertainty is inevitable in long and complex innovations which require a larger amount of R&D, the situation could be better for established biotechnical PIEP processes which "only" have to be implemented in the company and adapted to its special situation. However, companies stress that practical support, appropriate tools and easy-to-use instruments are missing which allow the company a reliable assessment whether the biotechnical process will be useful and costefficient for them (Hüsing et al. 1998). These tools are, however, often available for competing, established technologies which are then preferred over biotechnical ones (Kostka und Hassan 1997). Although life cycle methods might in principle be Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 61 helpful in this respect, they are only in infrequent use in industry, are often perceived as too complicated by companies so that not "full LCAs" but simplified or modified versions are applied, and substantial difficulties are encountered in gathering valid data (Verschoor and Reijnders 1999). 6.2.4 Assessing the benefit/cost ratio – Supporting factors As was outlined in chapter 5.4 and table 5.4, the above-mentioned hindrances also apply to successful companies to a certain extent. However, their overall assessment of the benefit/cost ratio of the innovation project is positive. This is primarily due to the fact that the companies view the innovation project in a wider strategic context and do not only focus on cost reduction and pollution prevention targets. As they take a wider scope of relevant benefits into account the weighing of pros and cons often comes to a different result than in companies with a narrower focus. Taking a broader perspective of benefits into consideration also enables the successful companies to support the project further even if difficult phases are encountered from time to time. It must, however, be mentioned that PIEP innovations are initially often rather costly and have relatively long pay-off times. This is often due to the fact that alterations in structures, facilities and routines are required. Therefore, companies with a larger flexibility in their allocation of resources are certainly more likely to carry out such an innovation. A key characteristic of successful companies also seems to be that they try to reduce the inevitable uncertainties and risks associated with the innovation by certain measures. Among them are a stringent project management which requires a systematic critical reassessment of achievements, costs and benefits at certain milestones. Depending on the result of this assessment, money, time and skills are made available if the milestones are met. If required, the project is readjusted in order to reach its targets. This also includes that unsuccessful projects which cannot reach their targets are stopped and are not pursued any further. Another decisive factor of successful companies is that they critically assess which skills and expertise are required for the project, which part of the know-how is available or can be generated in-house, and which know-how has to be acquired. For the acquisition of know-how, the appropriate options are chosen; e. g. participation in appropriate networks, different forms of cooperation, and also different forms of acquisition of qualified staff. Choosing from these different options enables the company to compensate for know-how deficits which may be present. These supporting factors also strengthen the company's ability to fight off adverse events and to develop a viable solution. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies Institute for Prospective Technlogical Studies 62 63 Introduction of Process-integrated Biocatalysts in Companies 7. Conclusions for policy purposes In general, supporting schemes for the broader use of biotechnology in productionintegrated environmental protection (PIEP) can be part of biotechnology programmes, of environmental programmes or of general innovation/industrial innovativeness programmes (see figure 7.1). The programme chosen will determine the focus of the supporting scheme for the broader use of biotechnology in PIEP: in a biotechnology programme, the focus will be on biotechnology with the aim of PIEP; in environmental programmes, the most important aim will be PIEP, e. g. by means of biotechnology; and in general innovation programmes the main focus will be improvement of industrial innovativeness by means of advanced technology (biotechnology) and PIEP. It is recommended that any supporting scheme for the broader use of biotechnology in PIEP – independent of its "location" in a certain programme – should comprise elements of all three areas (biotechnology, PIEP, innovativeness) in order to avoid that e. g. on the one hand biotechnology is funded "for the sake of biotechnology", or that, on the other hand, biotechnology is unduly put at a disadvantage. Figure 7.1: Supporting schemes for the broader use of biotechnology in production-integrated environmental protection (PIEP) are located at the interface of biotechnology programmes, of environmental programmes and of general industrial innovativeness programmes Biotechnology Environment Industrial innovativeness Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 64 Conclusions for policy purposes, derived from the analysis of hindering and supporting factors for the introduction of biotechnical PIEP into companies, can be grouped into four areas. These areas are • Enlarging the knowledge base and technology development, • Raising awareness and motivation of high-level staff, • Improving qualification and motivation of scientific-technical staff, • Increasing the transparency of the benefit/cost ratio, reduction of transaction costs. There is certainly need to further enlarge the scientific-technical knowledge base for biotechnical production-integrated environmental protection, and to publicly support appropriate R&D projects and R&D programmes. Although it is beyond the scope of this report to provide a detailed description of the research needs several recommendations for the design of possible R&D programmes can be given: • Since the comprehensive expertise required for the development and implementation of biotechnical preventive techniques as a rule does not exist in single companies or research institutions, supporting measures should strengthen existing alliances of different experts, complement gaps in expertise by adding new partners to the project consortium or should initiate such consortia for the first time. • Due to the difficult economic situation especially of the textile and food industry it is often difficult for the companies to allocate considerable own resources for research projects. This should be taken into account when the conditions for the financing modes of the support programme are defined. In addition, companies wish a less bureaucratic, simple application procedure for publicly funded projects in which the decision whether a proposal will be funded is made in a short time. • As will be pointed out in more detail below, there is a need for developing or providing practically oriented aids and instruments for assessment (e. g. life cycle analysis) for biotechnical preventive techniques, and test them for their usefulness in companies. They should be complemented by measures which improve the internal environmental management in the companies. Such modules could be integral parts of funded projects or separate projects. Moreover, in order to enhance the intended demonstration purpose of the research projects they should be flanked by measures which increase the publicity and reduce existing prejudices against biotechnical procedures (e. g. courses, brochures, practical demonstrations, model companies). A significant hindrance to the full exploitation of the potential of biotechnology for production-integrated environmental protection is a lack of awareness in the companies. In order to improve this situation, measures are required which are Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 65 especially targeted at relevant decision-makers in companies, such as CEOs, the executive board or high-level management staff and which meet their ways of assimilating information and their information needs. Relevant information must be concise, easy to understand and to remember, objective and from reliable sources. It must be easily applicable to one's own company or process, and must give concrete figures which economic and ecological benefits can be expected. Moreover, widening the focus of possible benefits beyond simple economic and ecological advantages can be helpful in order to gain support in the company. In addition, information from peers is most often perceived as especially helpful, motivating and reliable by high-level staff. It often provides the possibility to compare the own company with similar companies, and to obtain first-hand information on practical experience with the implementation in other companies. Appropriate measures for this kind of information, qualification and motivation of high-level staff are • Lectures at conferences, seminars, meetings of industrial associations, • Half-day seminars and workshops, • Attractive social evening events with a keynote lecture on this topic, with the opportunity for networking, • Information brochures especially tailored for the needs of the target group, • Excursions to model companies, video films about positive examples. All measures should emphasise the feasibility, efficiency and profitability of the innovation, should give supportive information for the decision-making process, and peers should provide practical experience with the implementation. Once the innovation project is to be planned in detail and to be implemented, it is necessary to improve the qualification and motivation of the scientific-technical staff who will be directly concerned with the development and implementation of the new process. Appropriate measures are • Conferences, workshops, courses and seminars, • Networks, such as e. g. COST actions, • Tools for a better assessment of the technical performance of biotechnical processes (in comparison to conventional processes), • Tools for the further integration of environmental aspects into R&D management. In contrast to the measures for high-level management staff, these measures targeted at scientists, engineers and technicians must focus on technical information and practical skills. An important aspect is to include cross-discipline skills, e. g. biotechnology for textile engineers, or textile processing for natural scientists. Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 66 In addition to the above mentioned measures to raise awareness and motivation and to improve qualification, measures are required which support companies in recognising the full benefits of the new process and at the same time in reducing their transaction costs. Appropriate measures are • Supporting the introduction of environmental management systems (e. g. such as certification according to the ISO 13000 series) into companies, especially in the food and textile sector, • Giving companies the opportunity to benchmark their own economic and environmental performance with that of similar companies, • Giving companies the opportunity to learn from positive examples (e. g. by workshops, seminars, networks, excursions, lectures from colleagues), • Develop and provide practically oriented tools for a quick and simple assessment whether a given biotechnical PIEP process will be beneficial for a company, • Develop and provide model calculations or calculation software for pay-off periods which take into account several variables, • Develop and provide tools for a better integration of environmental aspects into R&D management. While the above mentioned policy measures apply to the field of biotechnology for PIEP as a whole, individual measures seem to be of different importance depending on the overall aim of support schemes and the target group of the policy measure. Two trajectories can be followed in pursuing the overall aim of a broader use of biotechnology for PIEP: (1) the development of new biotechnological processes for PIEP, (2) the implementation and broad diffusion of already existing biotechnological processes for PIEP. The relevant players are different in these two trajectories: in trajectory (1), the main players will be companies and research institutions which can act as "providers of biotechnology PIEP solutions". They are most likely enzyme companies, biotechnology companies, companies from the equipment sector, academia and research institutes, and R&D consortia with an appropriate knowhow. In trajectory (2), the main players are companies which are "(potential) users of biotechnology PIEP solutions". They can most likely be found among SMEs and in the food and beverages industry, the textile industry and pulp and paper industry, but are not restricted to these groups and sectors. Another type of players are "intermediate companies" which can be both providers and users of biotechnology PIEP solutions, and which therefore fall into both categories mentioned above. The relevance of the above mentioned policy measures is different for the two trajectories and the involved players, respectively (table 7.1). For trajectory (1) with Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 67 the aim to develop and implement new biotechnological processes for PIEP, measures are most important which serve the following purposes: • Raising awareness of the top management in provider and intermediate companies as well as research institutes that developing and providing biotechnology PIEP solutions for user companies may offer interesting market opportunities for the providers, • Developing and providing tools how the PIEP idea can be more efficiently, consistently and routinely be implemented into the R&D management of the providers, • Improving the knowledge base through joint R&D projects and through support of appropriate networks, • Supporting the qualification of scientific-technical staff. For trajectory (2) with the aim to implement already existing biotechnological processes for PIEP and to achieve a broader diffusion in user companies, measures are most important which serve the following purposes: • Raising awareness of the top management in user and intermediate companies that PIEP solutions in general may offer interesting economic as well as ecological opportunities for them, • Raising awareness of the top management in user and intermediate companies that biotechnology can be a feasible solution within the PIEP concept, • Supporting awareness of PIEP by the broader implementation of environmental management systems in user companies, by the development and implementation of environmental performance indicators and by benchmarking the economic and ecological performance of a given company with comparable companies, • Providing targeted information and appropriate, easy-to-use analytical tools for the assessment whether a given biotechnology PIEP solution may be beneficial for a company, • Supporting the qualification of scientific-technical staff. These measures can partially be provided by "provider companies" or "intermediate companies" with a commercial interest in a certain process, but can partially also be integral parts of publicly funded supporting schemes. Table 7.1 summarizes the most appropriate policy measures for the two trajectories. Institute for Prospective Technlogical Studies 69 Introduction of Process-integrated Biocatalysts in Companies Table 7.1: Policy measures for a) development of new biotechnology processes for PIEP and b) further diffusion of existing biotechnology processes for PIEP Awareness and motivation of high-level staff Research and technology development Policy measures R&D programmes, R&D projects with appropriate application procedures and funding modes Formation and support of alliances and networks Demonstration projects Increase publicity through courses, brochures, practical demonstrations, model companies Development of practically oriented tools and instruments for assessment of bioprocesses Development and implementation of environmental performance indicators Interdisciplinary lectures at conferences, seminars, meetings Half-day seminars and workshops Attractive social evening events (keynote lecture, networking, positive examples) Especially tailored information brochures, excursions to model companies Further integration of environmental aspects into R&D management Environmental management, environmental performance indicators, benchmarking Institute for Prospective Technlogical Studies Aim of policy measure Diffusion of Development of existing new processes processes xx x xx x x x x xx xx xx xx xx x x xx xx xx xx xx xx xx xx x xx 70 Introduction of Process-integrated Biocatalysts in Companies Table 7.1 continued increase transparency of benefits, reduce transaction costs Qualification of scientifictechn. staff Policy measures Conferences, workshops, courses and seminars Networks (e. g. COST actions) Tools for assessment of technical performance of bioprocess in comparison to conventional process Tools for further integration of environmental aspects into R&D management Support of implementation of environmental management systems Development and implementation of environmental performance indicators, benchmarking Learn from positive examples Development and providing of practically oriented model calculations for pay-off periods depending on several variables Practically oriented tools for quick and simple assessment of benefits of a given bioprocess for a certain company Support of interdisciplinary information and knowledge transfer, formation of appropriate networks Tools for better integration of environmental aspects into R&D management Institute for Prospective Technlogical Studies Aim of policy measure Development of Diffusion of new processes existing processes xx xx xx x xx xx xx x x xx x xx x xx x xx x xx xx xx xx x Introduction of Process-integrated Biocatalysts in Companies Institute for Prospective Technlogical Studies 71 Introduction of Process-integrated Biocatalysts in Companies 8. 72 Literature Bajpai, P.; Bajpai, P. 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(1994): Biopulping: An overview of developments in an environmentally safe paper-making technology. FEMS Microbiology Reviews 13, 351-364 OECD (1996): STAN and ANBERD Database. Paris: Organisation for Economic Co-Operation and Development OECD (1998): Biotechnology for clean industrial products and processes. Towards industrial sustainability. Paris: Organisation for Economic Co-Operation and Development Ostertag, K.; Böde, U.; Gruber, E.; Radgen, P. (1998): Erfolgreiche Beispiele für die Überwindung von Hemmnissen der rationellen Energieanwendung in Industrie und Kleinverbrauch. Karlsruhe: Fraunhofer Institute for Systems and Innovation Research (ISI), 1998 Pantaleone, D. (1999): Biotransformations: "green" processes for the synthesis of chiral fine chemicals. In: Ager, D. (ed): Handbook of Chiral Chemicals. New York: Marcel Dekker Inc.; 245-286 Schulze, B; Wubbolts, M. G. (1999): Biocatalysis for industrial production of fine chemicals. 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Paper for the OECD workshop: Biotechnology for Clean Industrial Products and Processes. Sept. 11-12, 1997, Potsdam Traill, B.; Grunert, G.: Product and Process Innovation in the Food Industry. London: Chapman & Hall 1997 Verschoor, A. H.; Reijnders, L. (1999): The use of life cycle methods by seven major companies. Journal of Cleaner Production 7, 375-382 von Schriltz, D. N. (1998): From the petrochemical industry to bioprocesses. Technol. Chim. 18, 151-155 Walker, V.; Griffin, M.; Spiccio, M.; Trout, J.; Marchant, R.: Biotechnology Application in the European Food & Drink Sector. Biotechnology in Europe: Manpower, Education and Training. Clifton 1998a Walker, V.; Griffin, M.; Spiccio, M.; Trout, J.; Marchant, R.: Biotechnology Application in the European Textile Sector. Biotechnology in Europe: Manpower, Education and Training. Clifton 1998b Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 76 Annex Guidance for performing case studies interviews 1. Information about the interviewee(s) • Name • Position/function in the company • Role/function in the case investigated 2. Information about the company • Age • Size (e. g. number of employees, turnover, sales) • Business units, products • Market position • Importance of R&D for the company • Importance of environmental protection for the company • Importance of biotechnology for the company • In which respect is the company typical/representative/not typical for its economic sector? Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 3. The innovation process ("case") 3.1 Situation of the company before/at the beginning of the innovation process • 77 Description of the situation of the company out of which the innovation grew (e. g): − When? − Who suggested the idea? − Based on which information/knowledge? What was known at that time, what was uncertain/unknown? − − − − − − − − 3.2 How important was the innovation process considered? Why? Were there explicit supporters and opponents of the innovations process? How did the innovation project fit into the company strategy? How was the company’s expertise assessed? Where did you perceive deficits? How was the feasibility, the required competences and resources, the potentials and difficulties of the idea assessed in more detail at the beginning of the innovation process? with which results? Did you use special analytical instruments? Which ones? Was this usual for your company? How novel/ambitious was the innovation a) for your company, b) for your industrial sector? Which reasons/expectations were the deciding factors for initiating the project? What was the role of environmental protection, of biotechnology in this decision? Which resources (personnel, budget, competences) were allocated to the project? In comparison to other projects/to the actually required resources: was this sufficient? Were milestones and go/no-go criteria defined? Which ones? How were they controlled? How did the innovation project proceed after its successful start? • When was the innovation process carried out? • Who was involved in the innovation process? • What are the technical features of the innovative process/product? Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 78 • What is the environmental benefit of the innovative process? • Which knowledge, skills, know-how (scientific, engineering, marketing, environment, innovation management) were required to carry out the innovation process? Differentiate with respect to certain phases of the innovation process! How was this expertise made available? Did you have to (partially) acquire this expertise externally? What were your experiences relative to your expectations? • What were extraordinary challenges? How did you cope with them? • Were the initial assessments with respect to competences, scientific-technical challenges, the required resources, the expectations of the company, the market situation and the competitors, the relevant frame conditions correct? Which assessments had to be corrected over time, and why? • Which role did external research institutions/cooperation partners play in the different phases of R&D and market introduction? • How did you find appropriate cooperation partners? How did you gain access to the relevant networks? • Which forms of cooperation were chosen? Why? What were your experiences? • How do you assess the cooperation? In which respect did your company benefit/not benefit from this cooperation? What could have been improved? • Have there been critical stages for the project? How were they overcome? 3.3 Outcome of the innovation process for the company • What was the outcome of the innovation process for your company, relative to initial expectations? • In which way do you use the new process/product at present? Do you plan any changes? If yes, which ones? • What does the new process/product mean for your company with respect to sales, market and competetive position, compliance with regulatory requirements, fulfilling of customers‘ needs, your technological competences, environmental protection, production costs, qualification and motivation of employees, participation of your company in relevant networks, your company’s image, others? • Did you achieve your initial goals? Which were achieved, which were not achieved, which goals were abandoned or considered less important, which new goals emerged or were rated higher in the course of the innovation process? Why? • What have you/has your company learnt from this innovation process? What are the consequences for future actions with respect to future innovations, Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 79 innovations in biotechnology, innovations in process-integrated environmental protection? 4. Relevant frame conditions, supporting and hindering factors • What were important supporting factors which definitely promoted the innovation process? Which of them were located in your company, which were external factors? • Which of these supporting factors do you consider essential/indispensable? • Which factors hindered the innovation process? Which of them were company internal, which were external factors? • How can these hindrances be avoided/reduced? 5. What is specific, what can be generalised? • Which of the supporting and hindering factors are specific − for your company? − for your industrial sector? − for your type of company? − for this case? − for innovations in biotechnology in general? − for innovations in production-integrated environmental protection? • Which factors can be generalised for − other companies in your industrial sector, − other industrial sectors, − other types of companies, − innovations in general? 6. • Recommendations Should the introduction of process-integrated biocatalysts into companies be supported? Why (not)? Institute for Prospective Technlogical Studies Introduction of Process-integrated Biocatalysts in Companies 80 • What are appropriate instruments to support the introduction of processintegrated biocatalysts into companies? • How could such a support programme look like from which your company/companies from your industrial sector could benefit? • What should be the role of the EU, what the role of national agencies? 7. Important aspects, not yet discussed? • Which aspects do you feel important which have not yet been discussed? • Which aspects would you like to emphasise again? Institute for Prospective Technlogical Studies
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