Dr. John K. Walker
Assistant Professor
St. Louis University School of Medicine
Department of Pharmacology and Physiology
1402 S. Grand Blvd; Rm M366
St. Louis, MO 63104
Phone: 314-977-6427
Email: [email protected]
I.
BIOGRAPHICAL INFORMATION
Education:
1992-1999
Ph.D. in organic chemistry, Indiana University, Bloomington, IN
Dr. Paul A. Grieco, Professor of Chemistry, supervisor
Dissertation: I. Cationic [5 + 2] Cycloaddition Reactions Catalyzed by
Trimethylsilyl Trifluoromethanesulfonate in 5.0 M Lithium Perchlorate-Ethyl
Acetate. II. Efforts directed towards a Total Synthesis of (-)-Epothilone B.
1990-1992
M.S. in organic chemistry, Southern Illinois University at Edwardsville,
Edwardsville, IL
Dr. Timothy Patrick, Professor of Chemistry, supervisor
Thesis: Chiral Fluorinated Lactones
1986-1990
B.S. in chemistry, Southern Illinois University at Edwardsville, Edwardsville, IL
Research & Professional Experience:
2014-present
Assistant Professor, Department of Pharmacology & Physiology, Saint Louis
University School of Medicine, Saint Louis MO
2010-2014
Research Assistant Professor & Director of Medicinal Chemistry
Department of Nanosciences
University of Missouri-St. Louis, St. Louis, MO
2007-2010
Associate Research Fellow
Pfizer Pharmaceutical Global Research, St. Louis MO
2003-2007
Senior Principal Scientist
Pfizer Pharmaceutical Global Research, St. Louis MO
2001-2003
Senior Scientist
Pharmacia Global Research, St. Louis MO
1998-2001
Research Scientist
Monsanto, Searle Pharmaceutical Division, St. Louis MO
Honors, Awards and Fellowships:
2015
U.S. Patent 9133164, MIF inhibitors and their uses
2015
U.S. Patent 9050334, MIF inhibitors and their uses
2011
Inducted into the National Academy of Inventors
2008
U.S. Patent 7902195, Preparation of pyridine[3,4-b]pyrazinones as PDE5 inhibitors
2008
U.S. Patent 7067540, Substituted Pyridinones
2007
U.S. Patent 7057049, Process for making substituted pyrazoles
2005
U.S. patent 6979686, Preparation of heteroarylpyrazoles as p38 kinase inhibitors
1993-1994
Graduate Research Fellowship, Indiana University
1992
Graduate Research Fellowship, SIUE
1991-1992
Award for outstanding research associate, SIUE
Memberships in Professional Societies:
1998-present
Member, American Chemical Society
1998-present
Member, Division of Medicinal Chemistry
2011-present
National Academy of Inventors
II.
PUBLICATIONS AND PRESENTATIONS
II. A. Publications after arrival at SLU
1.
Curvey, Nicole S.; Marshall, Sarah E.; Walker, John K.; and Gokel, George W. Improved
Synthesis of Benzyl Hydraphile Synthetic Cation-conducting Channels. Synthesis, 2014,
46(20), 2771
2.
Flaveny, Colin A.; Griffett, Kristine; El-Gendy, Bahaa El-Dien M.; Kazantzis, Melissa;
Sengupta, Monideepa; Amelio, Antonio L.; Chaterjee, Arindam; Walker, John; Solt, Laura A.;
Kamenecka, Theodore M. Burris, Thomas P. Broad Anti-tumor Activity of a Small Molecule
that Selectively Targets the Warburg Effect and Lipogenesis. Cancer Cell, 2015, 28(1), 42
3.
Wang, Yongjun; Billon, Cyrielle; Walker, John K.; Burris, Thomas P. Therapeutic Effect of a
Synthetic RORa/g Agonist in an Animal Model of Autism. ACS Chemical Neuroscience,
2016, 7(2), 143
Manuscripts under preparation:
1.
Walker, J.K.; Haynes, K.; Chaney, J.; Abdali, N.; Zgurskaya, H.I.; Rybenkov, V.; Green, A.;
Parks, J.; Baudry, J. Novel inhibitors of the AcrA enzyme to block function of the bacterial
efflux pump AcrAB-TolC. To be submitted, 2016
II. B. Publications prior to arrival at SLU
1.
Patrick, T. B.; Lanahan, M.V.; Yang, C.; Walker, J.K.; Hutchinson, C.L; Neal, B.E.; New
Fluorobutenolide Templates for Synthesis, J. Org. Chem., 1994, 59, 1210
2.
Walker, J.K.; Grieco, P.A.; Intramolecular [5 + 2] Cycloadditions: Formal Total Synthesis of
(±)- Isocomene. Tetrahedron, 1997, 53, 8975
3.
Collins, J.D.; Grieco, P.A.; Walker, J.K.; Catalysis of Cationic [5+2] Cycloaddition Reactions
with Trimethylsilyl Triflate in Highly Polar Media. Tetrahedron Letters, 1997, 38, 1321
4.
Walker, J.K. I. Cationic [5 + 2] Cycloaddition Reactions Catalyzed by Trimethylsilyl
Trifluoromethanesulfonate in 5.0 M Lithium Perchlorate-Ethyl Acetate II. Efforts Directed
Towards a Total Synthesis of (-)-Epothilone B Ph.D. Dissertation Indiana University,
Bloomington IN, 1999
5.
Xing, Li; Shieh, Huey S.; Selness, Shaun R.; Devraj, Rajesh V.; Walker, John K.; Devadas,
Balekudru; Hope, Heidi R.; Compton, Robert P.; Schindler, John F.; Hirsch, Jeffrey, L.;
Benson, Alan, G.; Kurumbail, Ravi G.; Stegeman, Roderick A.; Williams, Jennifer M.;
Broadus, Richard M.; Walden, Zara; Monahan, Joseph B. Structural Bioinformatics-Based
Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804.
Biochemistry, 2009, 48, 6402
6.
Owen, Dafydd R.; Walker, John K.*; Jacobsen, E. Jon; Freskos, John N.; Hughes, Robert O.;
Brown, David L.; Bell, Andrew L.; Brown, David G.; Phillips, Christopher; Mischke, Brent
V.; Molyneaux, John M.; Fobian, Yvette M.; Heasley, Steven E.; Moon, Joseph B.; Stallings,
William C.; Rogier, D. Joseph; Fox, David N.A.; Ringer, Tracy; Rodriquez-Lens, Margarita;
Cubbage, Jerry W.; Blevis-Bal, Radhika M.; Benson, Alan, G.; Acker, Brad A.; Maddux, Todd
M.; Tollefson, Mike B.; Bond, Brian R.; MacInnes, Alan; Yu, Ying. Identification, synthesis,
and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5
inhibitors. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 4088
7.
Hughes, Robert O.; Walker, John K.; Cubbage, Jerry W.; Fobian, Yvette M.; Rogier, D.
Joseph, Heasley, Steven E.; Blevis-Bal, Radhika M.; Benson, Alan, G.; Owen, Dafydd R.;
Jacobsen, E. Jon; Freskos, John N.; Molyneaux, John M.; Brown, David l.; Stallings, William
C.; Acker, Brad A.; Maddux, Todd M.; Tollefson, Mike B.; Williams, Jennifer M.; Moon,
Joseph B.; Mischke, Brent V.; Rumsey, Jeanne M.; Zheng, Yi; MacInnes, Alan; Bond, Brian
R.; Yu, Ying. Investigation of aminopyridopyrazinones as PDE5 inhibitors: Evaluation of
modifications to the central ring system. Bioorganic & Medicinal Chemistry Letters, 2009,
19, 4092
8.
Hughes, Robert O.; Walker, John K.; Rogier, D. Joseph, Heasley, Steven E.; Blevis-Bal,
Radhika M.; Benson, Alan, G.; Jacobsen, Eric J.; Cubbage, Jerry W.; Fobian, Yvette M.;
Owen, Dafydd R.; Freskos, John N.; Molyneaux, John M.; Brown, David l.; Acker, Brad A.;
Maddux, Todd M.; Tollefson, Mike B.; Moon, Joseph B.; Mischke, Brent V.; Rumsey, Jeanne
M.; Zheng, Yi; MacInnes, Alan; Bond, Brian R.; Yu, Ying. Optimization of the
aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[(trans-4hydroxycyclohexyl)amino]-7(6-methoxypyridin-3-yl)-1-(2-propxyethyl)pyido[3,4-b]pyrazin2(1H)-one. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 5209
9.
Selness, Shaun R.; Devraj, Rajesh V.; Monahan, Joseph B.; Boehm, Terri L.; Walker, John K.;
Devadas, Balekudru; Durley, Richard C.; Kurumbail, Ravi; Shieh, Huey; Xing, Li; Hepperle,
Michael; Jerome, Kevin D.; Benson, Alan G.; Marrufo, Laura D.; Madsen, Laura M.;
Hitchcock, Jeff; Owen, Tom J.; Christie, Lance; Promo, Michele A.; Hickory, Brian; Alvira,
Edgardo; Naing, Win. Discovery of N-Substituted Pyridinones as Potent and Selective
Inhibitors of p38 Kinase. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 5851
10.
Hughes, Robert O.; Rogier, D. Joseph; Jacobsen, E. Jon; Walker, John K.; MacInnes, Alan;
Bond, Brian R; Zhang, Lena L.; Yu, Ying Zheng, Yi; Rumsey, Jeanne M.; Walgren, Jennie L.
E.; Curtiss Sandra W.; Fobian, Yvette M.; Heasley, Steve E.; Cubbage, Jerry W.; Moon,
Joseph B.; Brown, David L.; Acker, Brad A.; Maddux, Todd M.; Tollefson, Mike B.; Mischke,
Brent V.; Owen, Dafydd R.; Freskos, John N.; Molyneaux, John M.; Benson, Alan G.; BlevisBal, Rhadika M. Design, Synthesis and Biological Evaluation of 3-[4-(2hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of PDE5. J. Med.
Chem., 2010, 53, 2656
11.
Walker, John K.*; Selness, Shaun, R.; Devraj, Rajesh; Hepperle, Michael E.; Naing, Win;
Shieh, Huey; Kurambail, Ravi; Yang, Syaulan; Flynn, Daniel L.; Benson, Alan G.; Monahan,
Joseph B. and Portanova, Joseph. Identification of SD-0006, a Potent Di-aryl Pyrazole
Inhibitor of p38 MAP Kinase, Bioorganic and Medicinal Chemistry Letters, 2010, 20, 2634
12.
Tollefson, Michael B.; Acker, Brad A.; Jacobsen, E.J.; Hughes, Robert O.; Walker, John K.;
Fox, David N. A.; Palmer, Michael J.; Freeman, Sandra K.; Yu, Ying; Bond, Brian R. 1-(2Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Bioorganic and Medicinal Chemistry Letters, 2010, 20, 3120
13.
Tollefson, Michael B.; Acker, Brad A.; Jacobsen, E.J.; Hughes, Robert O.; Walker, John K.;
Fox, David N. A.; Palmer, Michael J.; Freeman, Sandra K.; Yu, Ying; Bond, Brian R. 1-(2(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d] pyrimidines as potent phosphodiesterase 5
(PDE5) inhibitors. Bioorganic and Medicinal Chemistry Letters, 2010, 20, 3125
14.
Jerome, K.D.; Hepperle, M.E.; Walker, J. K.; Xing, L.; Devraj, R. V.; Benson, A.G.; Baldus,
J.E.; Selness, S. R. Discovery of 5-substituted-N-arylpyrdidazinones as inhibitors of p38 MAP
kinase. Bioorganic and Medicinal Chemistry Letters, 2010, 20, 3146
15.
Morris, Dale L.; O’Neil, Shawn P.; Devraj, Rajesh V.; Portanova, Joseph P.; Giles, Richard
W.; Gross, Cindy J.; Curtiss, Sandra W.; Komoscar, Wendy J.; Garner, Debra S.; Happa,
Fernando A.; Kraus, Lori J.; Nikula, Kristen J.; Monahan, Joseph B.; Selness, Shaun R.;
Galluppi, Gerald R.; Shevlin, Kimberly, M.; Kramer, Jeffrey A.; Walker, john K.; Messing,
Dean M.; Anderson, David R.; Mourey, Robert J.; Whiteley, Laurence O.; Daniels, John S.;
Yang, Jerry Z.; Rowlands, Philip C.; Alden, Carl L.; Davis II, John W.; Sagartz, John E. Acute
lymphoid and gastrointestinal toxicity induced by selective p38a map kinase and map kinaseactivated protein kinase-2 (MK2) inhibitors in the dog. Toxicologic Pathology, 2010, 38, 606
16.
Selness, Shaun R.; Boehm, Terri L.; Walker, John K.; Devadas, Balekudru; Durley, Richard
C.; Kurumbail, Ravi; Shieh, Huey; Xing, Li; Hepperle, Michael; Rucker, Paul V.; Jerome,
Kevin D.; Benson, Alan G.; Marrufo, Laura D.; Madsen, Heather M.; Hitchcock, Jeff; Owen,
Tom J.; Christie, Lance; Promo, Michele A.; Hickory, Brian S.; Alvira, Edgardo; Naing, Win;
Blevis-Bal, Radhika; Devraj, Rajesh V.; Messing, Dean; Schindler, John F.; Hirsch, Jeffrey;
Saabye, Matthew; Bonar, Sheri; Webb, Elizabeth; Anderson, Gary; Monahan, Joseph B.
Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of
p38 kinase. Bioorganic and Medicinal Chemistry Letters, 2011, 21, 4059
17.
Selness, Shaun R.; Boehm, Terri L.; Walker, John K.; Devadas, Balekudru; Durley, Richard
C.; Kurumbail, Ravi; Shieh, Huey; Xing, Li; Hepperle, Michael; Rucker, Paul V.; Jerome,
Kevin D.; Benson, Alan G.; Marrufo, Laura D.; Madsen, Heather M.; Hitchcock, Jeff; Owen,
Tom J.; Christie, Lance; Promo, Michele A.; Hickory, Brian S.; Alvira, Edgardo; Naing, Win;
Blevis-Bal, Radhika; Devraj, Rajesh V.; Messing, Dean; Schindler, John F.; Hirsch, Jeffrey;
Saabye, Matthew; Bonar, Sheri; Webb, Elizabeth; Anderson, Gary; Monahan, Joseph B.
Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of
p38 kinase. Bioorganic and Medicinal Chemistry Letters, 2011, 21, 4059
18.
Selness, Shaun R.; Boehm, Terri L.; Walker, John K.; Devadas, Balekudru; Durley, Richard
C.; Kurumbail, Ravi; Shieh, Huey; Xing, Li; Hepperle, Michael; Rucker, Paul V.; Jerome,
Kevin D.; Benson, Alan G.; Marrufo, Laura D.; Madsen, Heather M.; Hitchcock, Jeff; Owen,
Tom J.; Christie, Lance; Promo, Michele A.; Hickory, Brian S.; Alvira, Edgardo; Naing, Win;
Blevis-Bal, Radhika; Devraj, Rajesh V.; Messing, Dean; Schindler, John F.; Hirsch, Jeffrey;
Saabye, Matthew; Bonar, Sheri; Webb, Elizabeth; Anderson, Gary; Monahan, Joseph B.
Discovery of PH-797804, a highly selective inhibitor of p38 MAP kinase. Bioorganic and
Medicinal Chemistry Letters, 2011, 21, 4066
19.
Hughes, Robert O.; Maddux, Todd M.; Rogier, D. Joseph; Lu, Sharon; Walker, John K.;
Jacobsen, E. Jon; Rumsey, Jeanne M.; Zheng, Yi; MacInnes, Alan; Bond, Brian R; Han,
Seungil. Investigation of the pyrazinones as PDE5 inhibitors: Evaluation of regioisomeric
projections into the solvent region. Bioorganic and Medicinal Chemistry Letters, 2011, 21,
6348
20.
Xing, Li; Devadas, Balekudru; Devraj, Rajesh V.; Selness, Shaun R.; Shieh, Huey; Walker,
John K.; Mao, Michael; Messing, Dean; Samas, Brian; Yang, Jerry, Z.; Anderson, Gary D.;
Webb, Elizabeth G.; Monahan, Joseph B. Discovery and Characterization of Atropisomer PH797804, a MAP p38 Kinase Inhibitor, as a Clinical Candidate. ChemMedchem, 2012, 7(2),
273
II. C. Patent Applications:
1.
Hepperle, Michael; Jerome, Kevin D.; Walker, John; Selness, Shaun; Devraj, Rajesh.
Substituted pyridazinones as inhibitors of p38 kinase. PCT Int. Appl. WO2003059891 A1
2.
Devadas, Balekudru; Walker, John; Selness, Shaun R.; Boehm, Terri L.; Durley, Richard C.;
Devraj, Rajesh; Hickory, Brian S.; Rucker, paul V.; Jerome, Kevin D.; Madsen, Heather M.;
Alvira, Edgardo; Promo, Michele A.; Blevis-Bal, Radhika M.; Marrufo, Laura D.; Hitchcock,
Jeff; Owen, Thomas; Naing, Win; Xing, Li; Shieh, Huey S.; sambandam, Aruna; Lui Shuang;
Scott, Ian L.; McGee, Kevin F. Preparation of substituted pyridinones as modulators of p38
MAP kinase. PCT Int. Appl. WO03068230 A1
3.
Allen, Kimberly C.; Anderson, Dennis K.; Baldus, John E.; Boehlow, Todd; Clark, Jerry D.;
Dukesherer, Daniel R.; Edney, Albert D.; Fevig, Tom; Kundra, Sastry; Lawson, Jon P.; Lau,
Patrick P.; McDermott, Lisa L.; Mao, Michael K.; Moe, Jodi L.; Mudipalli, Partha; Naing,
Win; Selness, Shaun R.; Seymour, Christine B.; Schilke, Tobin C.; Wiswanath, Shekhar;
Walker, John K.; Yalamanchili, Gopichand. Preparation of substituted pyrazoles, tautomers
and salts thereof for pharmaceutical uses. U.S. Pat. Appl. US 20030225108
4.
Benson, Alan G.; Fraher, Thomas Phillip; Hepperle, Michael E.; Jerome, Kevin D.; Naing,
Win; Selness, Shaun Raj; Walker, John K. Preparation of pyrazoles as p38a kinase, TNF
and/or cyclooxygenase inhibitors. PCT Int. Appl. WO2003104223 A1
5.
Devraj, Rajesh; Hepperle, Michael; Jerome, Kevin; Selness, Shaun; Walker, John Keith.
Preparation of substituted pyridizinones as inhibitors of p38. PCT Int. Appl. WO2005007632
A1
6.
Hepperle, Michael; Jerome, Kevin; Walker, John; Selness, Shaun; Devraj, Rajesh. Preparation
of substituted pyridizinones as inhibitors of p38. U.S. Pat. Appl. US2005018557
7.
Chekal, Brian P.; Dukesherer, Daniel R.; Mao, Michael K.; Naing, Win; Selness, Shaun R.;
Walker, John K.; Wettach, Richard H.; Yalamanchili, Gopichand. Process for preparation of
substituted pyrazoles. PCT Int. Appl. WO2005061485 A1
8.
Acker, Brad Alan; Hughes, Robert Owen; Jacobsen, Eric John; Lu, Hwang-Fun; Rogers,
Thomas Edward; Tollefson, Michael Brent; Walker, John Keith. Preparation of novel 5,7diaminopyrazolo[4,3-d]pyrimidines as PDE5 inhibitors for treating hypertension. PCT Int.
Appl. WO2006046135 A2
9.
Bell, Andrew Simon; Benson, Alan George; Brown, David Graham; Brown, David Louis,
Fobian, Yvette Marlene; Freskos, John Nicholas; Heasley, Steven Edward; Hughes, Robert
Owen; Jacobsen, Eric Jon; Mischke, Brent Virgil; Molyneaux, John Major; Owen, Dafydd
Rhys; Palmer, Michael John; Phillips, Christopher; Rogier Jr., Donald Joseph; Walker, John
Keith. Preparation of pyrido[2,3b]pyrazinones as PDE-5 inhibitors for treating cGMPmediated conditions. PCT Int. Appl. WO2006126081
10.
Benson, Alan George; Bell, Andrew Simon; Brown, David Graham; Brown, David Louis,
Fobian, Yvette Marlene; Freskos, John Nicholas; Heasley, Steven Edward; Hughes, Robert
Owen; Jacobsen, Eric Jon; Mischke, Brent Virgil; Molyneaux, John Major; Owen, Dafydd
Rhys; Palmer, Michael John; Phillips, Christopher; Rogier Jr., Donald Joseph; Walker, John
Keith. Preparation of pyrido[3,4-b]pyrazinones as PDE-5 inhibitors for treating cGMPmediated conditions. PCT Int. Appl. WO2006126082
11.
Brown, David Louis; Owen, Dafydd Rhys; Phillips, Christopher; Palmer, Michael John; Bell,
Andrew Simon; Freskos, John Nicholas; Fobian, Yvette Marlene; Walker, John Keith;
Hughes, Robert O.; Jacobsen, Eric Jon; Tollefson, Michael Brent; Brown, David Graham;
Mischke, Brent Virgil; Molyneaux, John Major. Preparation of pyridopyrazinones derivatives
as PDE-5 inhibitors. PCT Int. Appl. WO2007020521 A1
12.
Michelson, John Warren; Bhattacharya, Samit Kumar; Brown, Matthew Frank; Dorff, Peter
Hans; LaGreca, Susan Deborah; Maquire, Robert John; Cornicelli, Joseph Anthony; Brown,
David Louis; Jennings, Rex; Walker, John Keith; Huff, Rita Marie. Preparation of oxadiazole
cyclobutyl carboxylic acid derivatives as S1P receptor modulators for treating
hyperproliferative and autoimmune disorders. PCT Int. Appl. WO2009060278 A1
13.
Gaweco, Anderson; Walker, John; Monahan, Joseph, B.; Cubbage, Jerry W.; Carroll, Jeffrey.
Preparation of MIF inhibitors for treatment of disease. PCT Int. Appl. WO2012142498 A2
14.
Gaweco, Anderson; Tilley, Jefferson W.; Walker, John; Palmer, Samantha; Blinn, James.
Preparation of quinoline compounds as ROR (retinoid-related orphan receptor) modulators and
their uses, PCT Int. Appl. WO2013159095
15.
Gaweco, Anderson; Tilley, Jefferson W.; Walker, John; Palmer, Samantha; Blinn, James.
ROR Modulators and their uses, PCT Int. Appl. WO2013166013
16.
Gaweco, Anderson; Tilley, Jefferson W.; Walker, John; Palmer, Samantha; Blinn, James.
ROR Modulators and their uses, PCT Int. Appl. WO2013166015
II. D. Invited Conference Presentations:
1. American Chemical Society National Meeting “Discovery of a potent and selective S1P1
receptor agonist for the treatment of rheumatoid arthritis”, San Francisco CA, 2010
II. E. Invited Research Seminars.
1.
Montana State University, Dept. of Chemistry & Biochemistry, Bozeman MT, 2008
2.
University of Missouri-St. Louis, Dept. of Chemistry and Biochemistry, St. Louis, MO, 2011
3.
Southern Illinois University at Edwardsville, School of Pharmacy, Edwardsville, IL, 2012
4.
Washington University School of Medicine, Dept. of Biochemistry & Molecular Biophysics,
St. Louis, MO, 2012
5.
University of Missouri-Kansas City School of Medicine, Dept. of Biological Sciences, Kansas
City, MO, 2013
6.
Oak Ridge National Laboratory, Dept. of Molecular Biophysics, Oak Ridge, TN, 2014
7.
Saint Louis University, Dept. of Chemistry, St. Louis, MO, 2014
II. F. Abstracts and Presentations
1.
Walker, John K.; Jacobsen, E. J.; Hughes, Robert O.; Fobian, Yvette M.; Brown, David L.;
Heasley, Steven E.; Owen, Dafydd; Freskos, John; Mischke, Brent V.; Molyneaux, John;
Tollefson, Michael B.; Blevis-Bal, Radhika; Brown, David G.; Moon, Joseph B.; Phillips,
Christopher; Rogier, Joseph D.; Maddux, Todd; Benson, Alan; Optimization of the
Pyridopyrazinone Scaffold as Novel Inhibitors of PDE5. Philadelphia ACS Meeting; August
17-21, 2008
2.
Heasley, Steven E.; Jacobsen, E.J.; Walker, John K.; Hughes, Robert O.; Freskos, John;
Brown, David L.; Fobian, Yvette M.; Owen, Dafydd; Mischke, Brent V.; Tollefson, Michael
B.; Molyneaux, John; Blevis-Bal, Radhika; Maddux, Todd; Brown, David G.; Moon, Joseph
B.; Phillips, Christopher; Rogier, Joseph D.; Benson, Alan; Synthesis and optimization of
pyridopyrazinones as PDE5 inhibitors. Philadelphia ACS Meeting; August 17-21, 2008
3.
Hope, Heidi R.; Schindler, John F.; Jungbluth, Gail L.; Devraj, Rajesh, Selness, Shaun R.;
Burnette, Barry L.; Guzova, Julie A.; Hirsch, Jeff L.; Saabye, Matthew J.; Compton, Robert P.;
Zhang, Jian; Keith, Robert H.; Anderson, Gary D.; Stillwell, Loreen I.; Mbalaviele, Gabriel;
Webb, Elizabeth D.; Li, Xiong; Bonar, Shari; Sommer, Cynthia D.; Blom; Jason D.; Meyer,
Debra M.; Walker, John K.; Anti-inflammatory Properties of a Novel N-phenyl Pyridinone
Inhibitor of p38 MAP Kinase: Preclinical to Clinical Transition; EULAR 2009; Copenhagen,
Denmark; June 10-13, 2008
4.
Nagiec, Marek, Funckes-Shippy, Chris; Hiebsch, Ron; Radi, Zaher, Wendling, Jay; Walker,
John K.; Gierse, Jim; Huff, Rita; Targeting S1P signaling for inflammation. FASEB Summer
Research Conference; Carefree, Arizona; June 28-July 3, 2009.
III.
RESEARCH SUPPORT
Current Support:
1.
NIH R21AI113552-01
Convertase Inhibitors”
7/01/2014-6/30/2016
B. Geisbrecht, P.I.
“Chemoinformatic Discovery of Alternative pathway C3 Pro-
J. Walker, Co-P.I. (subcontract from B. Geisbrecht. Direct costs to J. Walker $50,000)
2.
NIH 2R01AI052293-11A1 “ Transport across two membranes by AcrAB-TolC”
7/01/2014-6/30/2019
H. Zgurskaya, P.I.
J. Walker, Co-P.I. (subcontract from H. Zgurskaya. Direct costs to J. Walker $276,239)
3.
NIH 7R01MH093429-03 “REV-ERB ligands for the treatment of anxiety disorders”
08/21/2014-7/31/2017
T. Burris, P.I.
J. Walker, Co-P.I.
4.
NIH R01MH092769 “Development of RORalpha and RORgamma for treatment of Behavioral
Disorders, Grant Award $3,044,874
02/16/2016-01/31/2021
J. Walker & T. Burris, P.I.’s
Pending Support:
1.
NIH R01 “ERRgamma Agonists for the Treatment of Muscular Dystrophy”
J. Walker & T. Burris, P.I,’s
Past Grant Support:
1.
University of Missouri Interdisciplinary Intercampus Research Program
“Collaborative, Design, and Evaluation of Anti-Infective Drugs”
6/01/2013-5/31/2014
P.I. H. Miziorko
J. Walker, Co-I
IV.
MEMBERS OF THE RESEARCH GROUP
Postdoctoral Fellow
Aug. 2014-present
Dr. Arindam Chatterjee
July 2015-present
Dr. Keith Haynes
May 2016-present
Dr. Carissa Hampton
Undergraduate Students
June 2015-present
Ms. Carly Robinson
V.
TEACHING EXPERIENCE
Course Lectures:
1.
PPY511, Advanced Topics in Pharmacological and Physiological Science I, 4 lecture hours on
drug design and medicinal chemistry. Write exam questions and grade. (fall 2014)
2.
PPY511, Introduction to Pharmacology (Revised PPY511/513), 2015-present, course director,
4 lecture hours on drug design and development, coordinate schedule and exams.
3.
PPY513, Systems Physiology and Pharmacology II, 2 lecture hours on Treatment of infection,
write exam questions and grade. (Spring 2016)
VI.
PROFESSIONAL SERVICE
Saint Louis University
2015
Reviewed grant proposals for Presidents Research Fund
Department of Pharmacology and Physiology, Saint Louis University School of Medicine
2014-present:
Member of the Departments Seminar Committee
2014-present:
Member of committee evaluating offering online courses for department
Spring 2015:
Member of committee to redesign graduate courses 511/513