Dear Students! This is a revised copy of the List of physiological normal values. The most significant data are highlighted by bold characters. If you have any comment on it, don't hesitate to contact the members of the Institute! 3 l ~33 % of body weight Total body water ~60 % of body weight on 14th of June, 2007. Peter Santha Parameter Fluid compartments, blood Plasma sodium Plasma potassium Plasma calcium Plasma magnesium Plasma chlorid Plasma bicarbonate Plasma phosphate Plasma glucose Plasma urea Plasma bilirubin Osmotic concentration of the blood plasma Osmotic pressure of the blood plasma Plasma protein concentration Plasma albumin Pl. α1 globulin Pl. α2 globulin Pl. ß globulin Pl. γ globulin Pl. fibrinogen Colloid osmotic (oncotic) pressure of the blood plasma Colloid osmotic (oncotic) pressure of the interstitium Extracellular fluid volume Interstitial fluid volume Intavasal fluid (blood plasma) volume Intracellular fluid Symbol Normálérték 143 4 2,5 1 103 24 1 4,5-5 2,5-6,3 5,0-17,0 Unit mmol/l mmol/l mmol/l mmol/l mmol/l mmol/l mmol/l mmol/l mmol/l µmol/l Transcellular fluid volume Total blood volume Rate of the blood cell production Total mass of the bone marrow Platelet count Prothrombin time Iternational Normalized Ratio, INR ~1,5 % of body weight 5,0-6,0 l 3,7x10e11 1500 150000-300000 18-20 1 Osmotic resistance of the RBCs RBC sedimantation rate White blood cell count mosmol/l 660 kPa 60-80 34-45 3.0-6.0 4,0-9,0 6,0-11,0 7,0-15,0 3 Π g/l g/l g/l g/l g/l g/l g/l 25-28 Hgmm 3-6 (M) ill. 8-10 (F) WBC 10 Hgmm 14 l 11 l ÷ mm/hour 2,0-6,0 7,0-8,0 4,8-5,2 4,3-4,7 0,1-0,2 0,44-0,46 150-160 cell/µl % of white blood cells % of white blood cells % of white blood cells % of white blood cells % of white blood cells % of white blood cells % of white blood cells µm million/µl million/µl % of RBCs ÷ g/l 135-145 g/l 6000-8000 60-80 Neutrophils, young form 0-1 Neutrophils, band 0-3 Eosinophils 1,0-5,0 Basophils 0-1 Lymphocytes 20-30 Monocytes RBC diameter RBC count (man) RBC count (woman) Reticulocyte count Hematocrit Hemoglobin (man) Hemoglobin (woman) g cell/µl 0,45-0,50 % NaCl solution Neutrophils, matured 290 cells/day Mean life span of the RBCs MCV (mean corposcular volume) MCH (mean corpuscular haemoglobin) MCHC (mean corpuscular haemoglobin conc.) Bleeding time Clotting time Relative proportion of different blood group types (Europe) O A B AB Rh positive Rh negative Respiratory functions O2 binding capacity of hemoglobin Arterial hemoglobin saturation Venous hemoglobin saturation Rate of O2 consumption (rest) Rate of CO2 production (rest) Halfsaturation (P50) O2 partial pressure 2,3-bisphosphoglycerate conc. (plasma) O2 content of arterial blood O2 content of venous blood Arteriovenous O2 AVDO2 difference CO2 content of arterial blood 120 day 94 fL(10e-15) 29 pg(10e-12 g) 0,32-0,34 g/g VVT weight min 3,0-5,0 min 5,0-8,0 42 40 10 4 85 15 1,39 97-98 74,7 % % % % % % ml O2 / g Hgb % % 250-280 ml/min 210 ml/min 26 Hgmm 2,5 mmol/l 205 ml/l 157 ml/l 56 ml/l 480 ml/l CO2 content of venous blood Arteriovenousus CO2 difference Solubility of CO2 Solubility of O2 Partial pressure of O2, arterial Partial pressure of O2, venous Partial pressure of CO2, arterial Partial pressure of CO2, venous 520 40 0,0301 0,001 ml/l mmol/l/Hgmm mmol/l/Hgmm PaO2 95-98 Hgmm PvO2 40 Hgmm PaCO2 40 Hgmm PvCO2 46 Hgmm α-value Functional Residual FRC (male/fem Capacity Lung compliance Compliance of the respiratory system Intrapulmonal pressure Intrathoracal (Intrapleural) Pressure Maximal Expiratory Pressure Tidal Volume Expiratory Reserve Volume Residual Volume Inspiratory Reserve Volume Vital Capacity Total Lung Capacity One-second capacity (Forced Expiratory Volume - 1s) ml/l TV 2400/1700 0,2 ml l/H2Ocm 0,1 l/H2Ocm 1/-1 H2Ocm -7 H2Ocm 100 500 H2Ocm ml ERV RV 1200/800 1200/1000 ml ml IRV VC TLC 3100/1900 4800/3200 6000/4200 ml ml ml 75 % 150 5 7 ml l/min l/min FEV1/VC Anatomic Death Space Vd Alveolar ventilation Minute ventilation Frequency of respiration (rest) 14 inspiration/min Peak (Maximal) Expiratory Flow rate Fraction of O2 FO2 atmosphereic air Fraction of O2, alveolar air Partial pressure of O2, atmospheric air Partial pressure of O2, alveolar air Fraction of CO2, atmosphereic air Fraction of CO2, alveolar air Partial pressure of CO2, atmospheric air Partial pressure of CO2, alveolar air Partial pressure of H2O, alveolar air Ventilation-perfusion ratio Maximal O2 consumption Maximal CO2 production Maximal breathing capacity Kidney, urine, acidbase metabolism Glomerular filtration rate (inulin) Glomerular filtration rate (endogenous creatinin) Renal plasma flow Renal Blood Flow Range of autoregulation of RBF Fraction of filtration Kidney threshold of glucose reabsorption 7,0-10,0 l/s 19,6 % 13,7 % 149 Hgmm 104 Hgmm 0,04 % 5,6 % 0,3 Hgmm 40 Hgmm 47 Hgmm 0,9 ÷ Maximal urine osmolarity (loop of Henle, long type) Maximal urine osmolarity (loop of Henle, short type) (Osmotic) concentration of urea (loop of Henle, medullar) (Osmotic) concentration of urea (interstictium, pyramide) Daily urine production 1200 mosm/kg 600 mosm/kg 80 mosm/kg 600 mosm/kg 1,0-26,0 4000 ml/min 3200-4000 ml/min l/min 100-120 120-125 ml/min GFR (creatinin RPF RBF 90-150 660 1320 ml/min ml/min ml/min FF 90-190 0,2 Hgmm ÷ GFR (inulin) 10 mmol/l (plasma) Specific gravity of urine Osmolality of urine Daily water intake (total) Daily water intake (fluid) Daily water intake (food) Oxydative water Daily water loss Perspiratio insensibilis Perspiratio sensibilis (sweating) Stool Urine minimal daily excreted osmotic substance Free water clearance Minimal daily urine volume Daily sodium intake Daily sodium loss Plasma pH, arterial Plasma pH, venous l/day 1001-1030 70-1200 g/l mosm/kg 2100-3400 ml/day 1000-2000 ml/day 800-1000 300-400 2100-3400 ml/day ml/day ml/day 800-1000 ml/day 200 100-200 1000-2000 ml/day ml/day ml/day 650 18 - -1,5 mosm l/day 500-600 100-400 100-400 7,38-7,42 7,36-7,40 ml/day mmol/day mmol/day ÷ ÷ proton concentration at pH=7.4 (Total) Buffer Bases Base excess Standar bicarbonate Actual bicarbonate conc. Proton production, non-CO2 (volatile) acids Anion-gap Dissosiation constant, phosphate buffer Dissosiation constant, bicarbonate buffer Dissosiation constant, ammonium buffer Daily renal bicarbonate reabsorption Daily renal bicarbonate prodaction Urine pH Daily potassium intake Daily potassium loss Potassium excretion, stool Potassium excretion, urine Daily calcium loss Daily phosphate filtration Circulation, heart Cardiac output Distribution of the cardiac output Brain Heart Liver Kidney Skeletal muscle Skin BB BE 40 44-49 2,5 -2,5 23,8-24,2 nmol/l mmol/l mmol/l mmol/l 23,8-24,2 mmol/l 50-100 8,0-12.0 mmol mmol/l Pk 6,8 ÷ Pk 6,1 ÷ Pk 9,3 ÷ 4300 mmol/day 50-100 4,0-8,0 mmol/day ÷ 50-100 50-100 mmol/day mmol/day 5,0-10,0 mmol/day 45-90 2,5-7,5 mmol/day mmol/day 235 mmol/day 5500 ml/min 750 250 300 1200 1000 200 ml/min ml/min ml/min ml/min ml/min ml/min Distribution of the O2 consumption Brain Heart Liver Kidney Skeletal muscle Skin Total Peripheral Resistance Mean Arterial Blood Pressure (aorta) Viscosity of water 18 10 30 6 20 2 TPR MABP 16,5 Hgmm/l 0,03-0,04 Hgmm poise (dinxsxcm2) poise (dinxsxcm2) poise (dinxsxcm2) 2,5 1,0-2,0 0,1-1 20-200 5,0-7,0 20-500 0,15-1,5 1,5-3 cm cm cm µm µm µm cm cm 93 0,01 Viscosity of blood plasma Viscosity of blood % % % % % % 0,015 Diameter of the individual blood vessels Aorta Elastic arteries Muscular arteries Arterioles Capillares Venules Medium sized veins Large veins Linear blood flowvelocity (aorta Linear blood flow velocity (capillaries) Transit time (capillary) Linear blood flow velocity (cc. cavae) Cross sectional diameter of aorta Total cross sectional diameter, capillares Cross sectional diameter of vv. Cavae Systolic blood pressure (aorta) Diastolic blood pressure (aorta) 22,5 cm/s 0,1 0,8-1 cm/s s 15 cm/s 4 cm2 2500-3000 cm2 6,0-8,0 cm2 120 Hgmm 80 Hgmm Pulse pressure (pulse amplitude) Blood pressure drop in the arterioles Capillary hydrostatic pressure (mean) Hydrostatic pressure in the interstitium Colloid osmotic pressure of the plasma Colloid osmotic pressure of the interstitium Reflection coefficient of the endothelium σ (average) Lymph recirculation in the vv. Cavae Central venous CVP pressure Hydrostatic pressure in the postcapillary venules Mean systemic filling SFP pressure Volume (blood) shift during orthostasis Hydrostatic pressure in the leg veins during orthostasis critical closing pressure Proportion of the blood volume in the systemic circulation Diastolic blood pressure, right ventricle (aorta) Systolic blood pressure, right ventricle Diastolic pressure, arteria pulmonalis 40 Hgmm 50-60 Hgmm 25 Hgmm -1 Hgmm 25 Hgmm 0,2-10 Hgmm 0,95 3,0-4,0 ÷ l/day 0-2 Hgmm 10,0-20,0 Hgmm 7 Hgmm 500 ml 100 Hgmm 6-40 Hgmm 73 % 1,0-2,0 Hgmm 24 Hgmm 9 Hgmm Pulse pressure (pulse amplitude), a. pulmonalis Mean arterial Blood Pressure (a. pulmonalis) Blood pressure, left atrium Perfusion pressure (pulmonary circulation) Total pulmonary circulatory resistance Proportion of the blood volume in the pulmonary circulation Hydrostatic pressure in the lung capillaries Intrinsic pacemaker frequency of the sinoatrial node Intrinsic pacemaker frequency of the atrioventricular node Intrinsic pacemaker frequency of the Purkinje fibres Conduction velocity in the sinoatrial node Conduction velocity in the atrial myocardium Conduction velocity in the atrioventricular node Conduction velocity in the bundle of His Conduction velocity in the bundles of Tawara Conduction velocity in the Purkinje system Conduction velocity in the ventricular myocardium Length of different phases of cardiac cycle Ventricular systole 15 Hgmm 14 Hgmm 8 Hgmm 6 Hgmm 1,5 Hgmm/l 27 % of total blood volume 10,5 Hgmm 100 1/s 40-55,0 1/s 25-40 1/s <0,01 m/s 1,0-1,2 m/s 0,02-0,05 m/s 1,2-2,0 m/s 2.0-4,0 m/s 2,0-4,0 m/s 0,3-1,0 m/s 270 ms Isovolumetric contraction Rapid ejection Decreased ejection Ventricular diastole Protodiastole Isovolumetric relaxation 50 90 130 530 40 ms ms ms ms ms 80 110 ms ms SV 190 110 420 70-80 ms ms ms ml LVESV 40-80 ml LVEDV 110-160 ml 0,5-0,7 5,5 3,2 ÷ l/min l/min/m2 Rapid ventricular filling Decreased filling (diastasis) Atrial systole Stroke volume Left-ventricular endsystolic volume Left-ventricular enddiastolic volume Left ventricular ejection fraction Cardiac output Heart index Cardiac output at maximal exercise Heart rate (rest) Heart rate at maximal exercise Left ventricular stroke volume at maximal exercise Length of different phases of ECG PQ-interval QT-interval QRS-duration P-wave RR-interval Classification of the axis of ECG (QRS vector) in the frontal plane horizontal normal (indifferent) vertical (steep) rightward deviation leftward deviation LVEF CO HR SV Gastrointestinal functions Daily intake of carbohydrates Recommended dietary allowance of protein 24 70 l/min 1/min 187 1/min Daily intake of fats (triglycerids) Daily intake of fluid and fibres Total secretory product of GIT glands Water reabsorption in the small intestine Water reabsorption in the large intestine Saliva production Daily gastric juice production Daily fluid secretion small intestine Daily bile secretion Daily pancreatic juice secretion Daily amount of stool Proton concentration in the gastric juice ml Basal Acidic Output Maximal acidic Output 127 < 0,2 0,32-0,39 <0,1 <0,1 0,86 0-30 30-60 60-90 90-120 0--30 s s s s s degree degree degree degree degree Peak Acidic Output Daily calcium intake Net calcium absorption Daily iron loss Recommended dietary allowance of iron Recommended dietary allowance of iodide Recommended dietary allowance of vitamin B12 Recommended dietary allowance of folate 300 g/day 60-80 g/day 50-100 g/day 1500-2000 ml/day 6000-8000 ml/day 5000-6000 ml/day 1500-2000 500 ml/day ml/day 1200 ml/day 8000 600 ml/day ml/day 200-700 75-150 ml/day g/day 70-80 5 mmol/l mmol/h 15-20 50 1000 mmol/h mmol/h mg/day 200 1 (M), 2-3 (F) mg/day mg/day 10,0-20,0 mg/day 500 µg/day 1,0-2,0 µg/day 200 µg/day Recommended dietary allowance of vitamin C 60-100 Energy metabolism Efficiency of the skeletal muscle Fuel value (heat of combustion) of carbohydrates Fuel value (heat of combustion) of fats Fuel value (heat of combustion) of proteins Energy equivalent of carbohydrates Energy equivalent of fats Energy equivalent of proteins respiratory coefficient of carbohydrates respiratory coefficient of fats respiratory coefficient of proteins Mean respiratory coefficient Mean energy equivalent Basal metabolic rate Metabolic rate, light physical exercise Metabolic rate, sever physical exercise Tehrmoregulation core temperature neutral thermal environment Maximal tolerable body temperature Heat production of the body (rest) BMR mg/day <25 % 17,2 kJ/kg 39 kJ/kg 17,2 kJ/kg 21,2 kJ/l O2 19,7 kJ/l O2 19,2 kJ/l O2 1 ÷ 0,7 ÷ 0,8 ÷ 0,82 ÷ 20,2 7100 kJ/l O2 kJ/day 21 kJ/min 100 kJ/min 37,5 °C 21-23 °C 42-43 °C 4-40 kJ/h Proportion of the cutaneous heat loss Proportion of the pulmonary heat loss Total cuteanous blood perfusion (rest) Total cuteanous blood perfusion (heat load) Body surface area Nervous system Cerebrospinal fluid volume Production of CSF Hydrostatic pressure of CSF Classification of the EEG waves Delta wave Theta wave Alpha wave Beta wave Gamma wave Vision Refractive index of the air Refractive index of the cornea Refractive index of the aqeous humor Refractive index of the lens Refractive index of the vitreous humor Total refractive (focal) power of the eye Refractive (focal) power of the cornea Radius of the cornea Physiological astigmatism Refractive (focal) power of the lens Near point distance Intraocular pressure 85 % 15 % 0,3 l/min 8,1 1,7-1,8 l/min m2 140 500 ml ml/day 5 Hgmm 1,0-3,0 4,0-7,0 8,0-13,0 14,0-30,0 30-50 Hz Hz Hz Hz Hz 1 ÷ 1,376 ÷ 1,336 ÷ 1,416 ÷ 1,336 ÷ 60 D 40-43 7,8 0,5 17-20 10 16 D mm D D cm Hgmm Average number of rods Average number of cones Transmembrane potential of the photoreceptors - dark Transmembrane potential of the photoreceptors illumination Wavelength range of the visible light Physiological light intensity range Absorption maxima of different photopigments blue pigment green pigment red pigment Maximum of the wavelength - sensitivity function: photopic vision 120 million 6 million -40 mV -70 mV 400-700 nm 10e-6 - 10e7 cd/m2 nm nm nm 555 nm 500 nm Maximal activity of the warm-sensitive afferents 90 Hz 22-25 Hz Neutral temperature range (local temperature of the skin) Critical fusion frequency - photopic vision Critical fusion frequency - scotopic vision 16,7 0,8-1,5 Auditory functions Frequency range of the hearing Intensity range of the hearing Endolymph-hair cell potential 420 538 558 Maximum of the wavelength - sensitivity function: scotopic vision nodal point - retina distance (reduced eye modell) Two point discrimination threshold of the vision Frequency range of the hearing - speach Intensity range of the hearing - speach Reference sound pressure level width of the lamina basilaris Number of the outer hair cells Number of the inner hair cells Number of the afferent fibres supplying the cochlea Endocochlear potential mm arc minute 20-20000 Hz 0-120 dB Somatosensory system Two point discrimination threshold in the skin Maximal activity of the cold-sensitive afferents Threshold of the noxious heat sensation Threshold of the noxious cold sensation Local densitiy of the cold points in the skin Local densitiy of the warm points in the skin Local densitiy of the tactile (mechanoceptive) points in the skin 1000-4000 Hz 40-70 dB 2x10e-5 Pa (N/m2) 100-500 µm 20000 cells 3500 cells 60-70000 fibres 60-80 mV 150 mV 0,01-7 cm 23-28 °C 38-43 °C 31-36 °C 43-45 °C 17 °C 0,1-0,5 point/cm2 0,4 point/cm2 20 point/cm2 Local densitiy of the pain (nociceptive) points in the skin Cellular neurophysiology Classification of the nerve fibres in a mixed peripheral nerve according Erlanger & Gasser Aα Aβ Aγ Aδ B C Classification of the sensory fibres in the peripheral nerve according to Hunt & Lloyd I II III IV Proteinate anion 200 point/cm2 25-30 mmol/l day 10,0-12,0 date of the LH surge 100 50 20 15 7 1 m/s m/s m/s m/s m/s m/s 75 55 11 1 m/s m/s m/s m/s 1 ms Myocardial cell 10 200-300 ms ms Synaptic delay 1-1,5 ms Duration of the action Potentials Neural action potential Skelet muscle fibre a.p. Ionic composition of the cytoplasm - mammalian muscle fibre Sodium Potassium Calcium Cloride Bicarbonate Endocrinology, reproductive functions length of the menstrual cycle duration of the LH surge 155 12 155 10e-8-10e-7 4 8 mmol/l mmol/l mmol/l mmol/l mmol/l date of the luteolysis Duration of the menstruation Volume of the menstrual bleeding Number of spermiums in the sperm duration of the viability of the spermia Total volume of sperm Duration of the migration of the oocyte Implantation of the blastocyst Length of the pregnancy hour day of the 14 menstrual cycle days after 9,0-14,0 ovulation 4,0-6,0 day 30-50 ml 250 million 48 3,0-4,0 hour ml 1,0-2,0 7 day days after ovulation 40 week
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