Issue 1 - 2016 NEWSLETTER Sperm Sorters at the Nucleus Phase one of Fast Genetics’ new technology introduction is well underway. Since July 21, 2015, Fast Genetics has invested heavily in human resources and technical training to accommodate the introduction of sperm sorters. On January 8, 2016, Fast Genetics installed its first sperm sorter in Northern Saskatchewan, in order to best service its farms. The sorting process is highly accurate and well proven. The combination of Fast Genetics’ investment in scientific personnel as well as the installation of its new technology will permit the successful implementation of sex sorted sperm at the nucleus level. All Fast Genetics customers will benefit from the introduction of sperm sorters at the nucleus level. Specifically, sex sorted sperm and low dose semen technology at the nucleus level will allow Fast Genetics to skew gender ratio, accelerating genetic progress in all product lines. Introducing sex sorted sperm throughout Fast Genetics’ multiplication is phase two of the new technology introduction plan. The implementation at the multiplication level will allow for an increase in product supply. In phase three, Fast Genetics plans to implement sex sorted sperm at the commercial level. The introduction at the commercial level will allow customers to skew gender ratio based on many economic and management factors including slaughter plant partnerships. In summary, our new technology implementation is well underway and will soon be utilized by our nucleus farms. Fast Genetics is spending considerable time developing low sperm dose protocols and proprietary catheters as well as many other initiatives that will improve the overall Fast Genetics program. Stay tuned for the first gender-skewed litters born in Saskatchewan and more innovations! Fast enetics INSIDE THIS ISSUE Sperm Sorters at the Nucleus PG. 1 Acquisition of Genomics Laboratory PG. 2 & 3 Doubling Down on FIRE Feeders PG. 4 Frekings Named MN Pork 2016 Family of the Year PG. 4 Personnel Profile: Dr. Daniela Grossi PG. 4 Acquisition of Genomics Laboratory Recently, Fast Genetics’ parent company, Sexing Technologies, acquired genomics laboratory Genetic Visions from Accelerated Genetics. Genetic Visions was founded in 1988 and is headquartered in Middleton, Wisconsin. Genetic Visions is a genotyping service provider. Sexing Technologies’ ownership of Genetic Visions will allow Fast Genetics to significantly increase genomic testing. The benefits of dramatically increasing genomic testing and evaluations, via Genetic Visions, are enormous for Fast Genetics and its customers. Before explaining the benefits of genotyping, let’s take a trip down memory lane to high school biology (see Figure 1). Figure 1 In most cells there is a nucleus, containing genetic information or the complete blueprint of the body. The nucleus houses chromosomes (structures of DNA). DNA is a double-helix (like a twisted ladder) comprised of nucleic acid pairings. The four nucleic acids, present on DNA, are cytosine, guanine, adenine, and thymine. Cytosine pairs with guanine and adenine pairs with thymine (forming the rungs of the ladder). Genes are certain sections of DNA that act as instructions to produce proteins with specific biological functions. Within the same species, the sequencing of nucleic acids is mostly the same. However, when these sequences differ they are called Single Nucleotide Polymorphisms (SNPs) (see Figure 2). SNPs can be responsible for differences in an animal’s observable characteristics (e.g. feed conversion). Using Figure 2 as an example, the SNP in Animal 1 may represent the norm for feed conversion, whereas the SNP in Animal 2 may be associated with excellent feed conversion. Now that we have refreshed our memory, let’s turn to why SNP information (gathered by genotyping) is so important and valuable. PAGE 32 The genotyping process begins with a sample of blood, tissue, semen, or any biological material containing cells being sent to Genetic Visions. Once the sample is received, DNA is extracted from cell nucleuses and genotyped. The process of genotyping identifies the SNPs. This information is then transferred to Fast Genetics where it is analyzed by geneticists. Fast Genetics evaluates tens of thousands of SNPs per animal using proprietary genomic evaluations. The two main purposes for genomic analysis include the use of genomic EBVs for genomic selection and the detection of abnormalities. The use of Genomic EBVs enables accurate selection of young animals by using SNP information to make accurate estimates of how progeny will develop. This is done even before animals have matured or have their own litters. The prediction of genomic EBVs requires a large reference population in order to link hundreds-of-thousands of SNPs with performance characteristics. The best estimate of a breeding value is obtained by using a combination of SNP genotyping to predict an animal’s worth along with its own actual records (phenotype). Although rare, routinely testing SNPs for associations with abnormalities enables Fast Genetics’ geneticists to take the best course of action against such abnormalities. Figure 2 Practically, both the creation of genomic EBVs for genomic evaluations and the tracking of abnormalities translate into significantly faster and more accurate rates of genetic gain, creating better products for Fast Genetics customers. The acquisition of Genetic Visions will allow Fast Genetics to dramatically increase its genomic testing and evaluations, a significant advantage as described by Shannon Meyers, Fast Genetics’ Chief Operating Officer. “The use of genomic EBVs is a well proven method to accelerate genetic progress. Having our own genotyping lab within our internal group of companies gives us one more tool to be at the forefront of this technology and will make us industry leaders in this field.” Fast Genetics is excited about Sexing Technologies’ acquisition of Genetic Visions, as it brings tremendous value to all Fast Genetics customers! PAGE 3 4 Doubling Down on FIRE Feeders Fast Genetics’ significant Feed Intake Recording Equipment (FIRE) feeder infrastructure expansion is complete. FIRE feeders automate the measurement of individual feed intake. The “doubling down” on proven technology such as FIRE feeders will allow for faster genetic progress on feed conversion and growth rate. Fast Genetics’ large investment in FIRE feeders was FAST, as it was planned and implemented after the July, 2015 acquisition. Fast Genetics already had a significant FIRE feeder program in both its maternal and terminal genetic nucleus systems, but doubling down on FIRE feeder numbers allows for full finishing intake measurement which further improves progress. The current and planned implementation of technologies such as additional FIRE feeders is exciting as it will translate into benefits for all Fast Genetics customers. Frekings Named MN Pork 2016 Family of the Year The Frekings, owners of New Fashion Pork and long-time Fast Genetics customer, were named the 2016 Family of the Year by the Minnesota Pork Board. The Frekings and New Fashion Pork, a leading pork producer in Minnesota, Indiana, Illinois, South Dakota, and Wyoming, were recognized not only for their success story, but also for their commitment to the communities they serve. To read the Minnesota Pork Board’s full article on the Freking family, visit http://goo.gl/VO4H5y. On behalf of everyone at Fast Genetics, congratulations to the Frekings and New Fashion Pork on this award and recognition! Personnel Profile: Dr. Daniela Grossi Dr. Daniela Grossi was recently hired as Fast Genetics’ Molecular Geneticist. Dr. Grossi obtained her D.V.M. and Ph.D. from Brazil. She was formerly a Post-Doctoral Researcher at the University of Guelph and Statistical Geneticist with a genomics laboratory. Her inclusion to the team couldn’t come at a better time, as Fast Genetics’ parent company Sexing Technologies recently acquired Genetic Visions. With a genomics laboratory owned by its internal group of companies, Fast Genetics will significantly increase genomic testing. Dr. Grossi’s role will involve on all research and development programs but will focus on molecular genetics and genomic EBVs. Stay tuned for the Fast Genetics next Personnel Profile. #2-2175 Airport Drive, Saskatoon, SK S7L 7E1 (306) 667-1420 www.fastgenetics.com Fast enetics
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