CHAPTER II.5.11 Cochlear Prostheses PROBLEMS Problem 1 Sound at the level of the tympanic membrane demonstrates a pressure peak at a frequency of 2.5 kHz in the human. Consider the boundary conditions of the ear canal and explain why that resonance occurs. Problem 2 Considering the areas of the stapes and the tympanic membrane, as well as the properties of the ossicular chain, compute the approximate ratio of pressures that is found when the tympanic membrane is driven at low frequency. Note that this is an approximate calculation that does not consider the dynamics of the system. Problem 3 Focusing stimuli has been proposed by several people (Suesserman and Spelman, 1993; Jolly et al., 1996) as a solution to the problem of field interference between monopole sources. Consider using dipole and quadrupole sources. Assume that the sources are 50 μm hemispheres located on the surface of an insulating boundary. Let the hemispheres be separated by 200 μm in both cases. Plot the potential fields along two lines: one that is 100 μm above and parallel to the sources, the other that is 200 μm above and parallel to the sources. Describe the properties of the fields that are produced. Look particularly at the peak potentials and the halfamplitude widths of the fields. Hints: A dipole consists of two sources, one carrying current I and the other carrying current −I. A quadrupole is a special case of a tripole. Three sources are used. The central source carries current I, while the two flanking sources carry current −I/2. For ease of calculation, place one of the sources at the origin, and let the other sources lie on, e.g., the x-axis. Problem 4 Two electrode array designs are considered. One uses a silicone substrate, and the other a liquid crystal polymer substrate. If a circular cross-section is used, with an outside diameter of 200 μm, find the force that would be exerted on a free end whose length is 1 mm and whose deflection is 20 μm. The modulus of elasticity of silicone is 2.76 Mpa, and that of liquid crystal polymer is 158 MPa. The polar moment of inertia is: 4 Ip = πd 32 . Problem 5 Izzo and Richter address the intensity of optical stimuli to excite the inner ear in terms of the energy density required to stimulate neurons. They state that the energy density well above threshold is 3 mJ/cm2 at a pulse width of 5 μsec. Assume that the optical source is a Vertical Cavity Surface Emitting Laser (VCSEL) whose emitter has a 20 μm diameter. Assume further that pulses repeat every 100 μsec (Izzo et al., 2008). How much DC power is required per channel if the VCSEL is 15% efficient? ANSWERS Problem 1 The ear canal is bounded at one end by the tympanic membrane (a closed end), at the other by the opening in the pinna (an open end). The canal can be approximated by a cylinder about 1 cm in diameter with a length of about 2–3.5 cm. The first resonance will occur at a frequency whose wavelength is 8–14 cm (a quarter-wave resonance, since the proximal end is closed and the distal end of the canal is opened). The velocity of sound in air is 331.6 m/sec. The resonant frequency is: f= c λ Hz If λ, the wavelength, is 1.33 cm, then f = 2.5 kHz. Problem 2 The area of the tympanic membrane is 20 times that of the footplate of the stapes. The pressure at the footplate of the stapes will be 20 times that applied to the tympanic membrane. However, the motion of the footplate of the stapes is about 75% of that of the tympanic membrane. There is an additional mechanical advantage of 4/3 for force. Hence, the pressure at the footplate of the stapes will be about 27 times that applied to the tympanic membrane. e1 Problem 3 field. Note also that the quadrupole field decreases more rapidly with distance than does the dipole field. The fields can be computed by summing the potentials produced by the sources. The potential produced by a spherical source is identical to that produced by a point source and is: Problem 4 V(r) = Iρ 4π volts The maximum deflection of a cantilever beam occurs at its loaded end and is: ymax = where I is the applied current in Amperes, assumed to be 10 μA in this case; ρ is the resistivity in ohm-cm, here, let the resistivity be 53 ohm-cm (the resistivity of perilymph); r is the radial distance from the source. For a source on an insulator, the potential field is twice that produced by the same source in a conductive medium. Since the medium is linear, it is possible to superpose the sources that produce the dipole and quadrupole fields. Using Mathcad® 2000 (MathSoft, Cambridge, MA) to compute the fields, it is possible to get the following results. Figure II.5.11.3 shows that the peak potential of the dipole source is greater than that of the quadrupole (about twice as much), and that the half amplitude width is greater as well. The quadrupole produces a more focused Pl3 3EI solving for P, the force necessary to deflect the beam: P= 3EIymax l3 For this beam, d = 200 μm and I = 1.57 × 10−16 m4. Thus: P = 9.425 × 10 –12 E N E for silicone is 2.76 Mpa, and 158 MPa for silicone and liquid crystal polymer, respectively. The force required to deflect the silicone is 2.6 × 10−5 N, or about 2.6 mg. The liquid crystal polymer requires a force of 1.5 × 10−3 N or 150 mg to deflect. This is the program Question3, that determines the potential fields 100 and 200 microns above a dipole and quadrupole source. The sources are separated by 200 microns. In the case of the dipole, the sources are at x= -100 and x= +100 microns. In the case of the quadrupole, the sources are at x= -200, x= 0 and x= +200 microns. Current is 10 A. Compute the potential fields: rh := 53 −5 I := 10 ohmcm x1 := −0.01 cm i := 0 .. 800 x2 := 0.01 k := rh⋅ I 2⋅π x3 := −0.02 cm cm i − 1 400 xi := 0.04 ⋅ A cm j := 1 .. 2 Vcm x4 := 0.02 cm y j := 0.01 ⋅ j 1 1 − 0.5 0.5 2 2 2 2 (xi − x1) + (y j) (xi − x2) + (y j) Vdi , j := ( k) ⋅ cm volts 1 −0.5 0.5 + − 0.5 0.5 0.5 2 2 2 2 2 2 (xi − x1) + (y j) (xi) + (y j) (xi − x2) + (y j) Vqi , j := ( k) ⋅ e2 volts Potential vs Distance for Dipole and Quadrupole Sources 0.00 0.00 0.00 0.00 0 FIGURE II.5.11.3 Potential pro- 0.00 0.00 0.00 0.00 0.04 0.0 0.0 0.0 0 0.0 Problem 5 The energy density of the optical pulse is given as 3 mJ/cm2. The width of the pulse applied to the cochlea is 5 μsec. Assume that the applied energy doesn’t vary during its application. In that case, the power density is given by: papp = wapp tpulse And papp = Or, 0.003 5 · 10 − 6 W / cm2 papp = 600 W / cm2 The light source is a VCSEL with a small area of emission, Svcsel = π(10 −3 2 2 ) cm Svcsel = 3.14159 × 10 − 6 cm2 0 .0 0 .0 0 .04 duced by the dipole and quadrupole sources of problem 3. The dipole field is shown in orange for a distance of 100 microns and in blue for 200 microns. The quadrupole field is shown in green for a distance of 100 microns and in cyan for 200 microns. This shows that while the quadrupole source produces a more focused potential field, the field is dramatically smaller than that produced by dipole. The applied power is the product of the power density and the area of emission: Papp = papp (Svcsel )W Papp = 1.884 × 10 − 3 W Now the VCSEL is 15% efficient, and the applied power per pulse is the optical power divided by the efficiency of the VCSEL. However, the pulsatile power is applied for only 5% of the repetition rate, so that the total required DC power will be 5% of the power required per pulse. Thus, PDC = Papp / 0.03 W PDC = 1.884 × 10 − 3 / 0.03 W PDC = 0.628 mW The power per stimulus channel is quite reasonable, indeed, ten channels could be driven simultaneously with less than ten milliwatts of power. e3
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