MATERIAL SAFETY
DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
1. PRODUCT AND COMPANY INFORMATION
CHEMICAL NAME; CLASS:
METHANOL
Packaged in Cylinders Pressurized with Nitrogen or Helium
SYNONYMS: Carbinol; Colonial Spirit; Methyl Alcohol; Methyl Hydrate; Methyl Hydroxide;
Pyroxylic Spirit; Wood Alcohol; Wood Naphtha; Wood Spirit
CHEMICAL FAMILY NAME: Aliphatic Alcohol
FORMULA: CH4O or CH3OH
Document Number: 20113
Manufacture of formaldehyde, acetic acid and
dimethyl terephthalate; used in chemicals
synthesis; solvent for nitrocellulose,
ethylcellulose, polyvinyl butyral, shellac, rosin,
manila resin, dyes; denaturant for ethanol;
dehydrator for natural gas; fuel for utility plants;
feedstock for manufacture of synthetic proteins;
source for hydrogen fuel cells; home heating oil
extender.
PRODUCT USE:
MANUFACTURED/SUPPLIED FOR:
ADDRESS:
EMERGENCY PHONE:
2700 Post Oak Drive
Houston, TX 77056-8229
CHEMTREC: 1-800-424-9300
BUSINESS PHONE:
General MSDS Information 1-713/896-2896
Fax on Demand:
1-800/231-1366
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 1 OF 10
2. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: Methanol is a flammable, colorless liquid with a slight alcoholic odor in pure form and
pungent, repulsive odor in crude form. Exposure to the vapors of Methanol may be irritating to the respiratory
tract, and eyes. Inhalation of vapors of Methanol can cause symptoms of central nervous system depression,
such as headaches, nausea, dizziness, incoordination, and confusion. Exposure to high concentrations of vapors
can also cause visual impairment and effects on other organs. Releases of Methanol present a serious fire
hazard. Vapors of Methanol are heavier than air and may spread long distances; distant ignition and flash-back
are possible. Emergency responders must wear the proper personal protective equipment (and have appropriate
fire suppression equipment) suitable for the situation to which they are responding.
SYMPTOMS OF OVER-EXPOSURE BY ROUTE OF EXPOSURE: The most significant routes of occupational overexposure are by inhalation, ingestion and eye contact. The symptoms of over-exposure to the Methanol are as
follows:
INHALATION: Inhalation of Methanol vapors can irritate the mucous membranes, the nose, throat and respiratory
tract. Symptoms may be delayed. Human systemic effects following exposure via inhalation (and ingestion) include
changes in circulation, cough, dyspnea, headache, lachrymation, nausea or vomiting, optic nerve neuropathy,
respiratory effects and visual changes or disturbances. Inhalation of the vapors of Methanol can cause symptoms of
central nervous system depression, including headache, dizziness, loss of balance and discoordination. There are
reports that inhalation of Methanol vapors can cause blindness, and may cause other health effects under
“Ingestion”. Repeated exposure via inhalation can worsen existing conditions of emphysema and bronchitis. High
concentrations of vapors, as may occur if Methanol is used or released in a poorly-ventilated area or confined space
(or during a release of large volumes of this product), can cause unconsciousness. Severe inhalation over-exposure
may be fatal.
CONTACT WITH SKIN or EYES: Contact of the vapors or liquid of Methanol is mildly irritating to the skin.
Prolonged or repeated skin contact can result in dermatitis (inflammation and redness of the skin). Vapors of
Methanol are irritating to the eyes. Liquid Methanol is a considered a moderate to severe eye irritant, which may
cause redness, pain, swelling, double or blurred vision, tearing, corneal inflammation and burns, and possible
blindness.
SKIN ABSORPTION: Methanol readily absorbs through intact skin and can produce systemic toxicity, especially
upon repeated skin exposure. Symptoms of skin absorption will be similar to those described in “Inhalation” and
“Ingestion”.
INGESTION: Ingestion is not anticipated to be a significant route of industrial over-exposure for Methanol. Ingestion
of Methanol can cause very serious health effects. Symptoms of ingestion exposure can include, nausea,
headache, abdominal pain, vomiting, convulsions, circulatory collapse, respiratory failure, visual disturbances,
blindness and death. Blindness is usually permanent. Death has been reported after ingestion of less than 30 mL of
Methanol. The lethal dose by ingestion is estimated to be 1-8 ounces (100-250 mL). The main toxic effect of
Methanol upon ingestion exposure are effects on the central nervous system, particularly the optic nerves and
possibly the retina, leading to blindness. Methanol is very slowly eliminated from the body and should be regarded
as a cumulative toxin. Coma resulting from massive exposures can last as long 2-4 days. Once in the system,
Methanol oxidizes to form formaldehyde and formic acid, both of which are also toxic. The oxidization of Methanol
can lead to metabolic acidosis with adverse effects on the heart, liver and kidneys.
INJECTION: Injection is not anticipated to be a significant route of over-exposure for Methanol. If Methanol is
“injected” (as may occur through punctures by contaminated, sharp objects), local swelling and irritation can occur.
Symptoms similar to those seen for “Inhalation” or “Ingestion” may occur.
OTHER HEALTH EFFECTS: Based on animal evidence, Methanol exposure may present a possible reproductive
hazard by causing harm to the fetus. See Section 11 (Toxicological Information) for further information.
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 2 OF 10
2. HAZARD IDENTIFICATION (Continued)
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Over-exposure to Methanol
may cause the following health effects:
ACUTE: Inhalation of low concentrations of vapors of Methanol will cause irritation to the upper respiratory tract.
Inhalation of high concentrations of Methanol vapors can cause systemic effects including central nervous system
depression, visual disturbances, changes in circulation, cough, dyspnea, headache, lachrymation, nausea or
vomiting. Symptoms may be delayed. Severe inhalation over-exposure may be fatal. Brief contamination of skin
may be irritating. Contact of the vapors of Methanol can be irritating. Direct contact of the liquid with the eyes may
cause severe eye irritation, burns or even blindness. Ingestion of even small quantities of Methanol can cause
permanent blindness or can be fatal. Massive over-dose by ingestion may cause heart, lever kidney or central
nervous system effects, severe gastrointestinal distress and acidosis of the organs, leading to damage.
CHRONIC: Prolonged or repeated skin over-exposure may cause irritation and dermatitis. Chronic over-exposure
via inhalation may lead to symptoms of central nervous system depression, and can worsen pre-existing conditions
of asthma, emphysema and bronchitis. Repeated exposure by inhalation or skin absorption may cause systemic
poisoning, brain disorders, impaired vision and blindness. See Section 16, Toxicological Information, for further
information.
TARGET ORGANS: Skin, eyes, respiratory and central nervous system, heart, liver, kidneys.
3. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME
CAS #
% mole
EXPOSURE LIMITS IN AIR
ACGIH
TLV
STEL
ppm
ppm
Methanol
67-56-1
100%
200,
Skin
250
PEL
ppm
200
Skin (Vacated
1989 PEL)
OSHA
STEL
ppm
250
(Vacated
1989 PEL)
IDLH
ppm
OTHER
ppm
6000
NIOSH: 200 TWA; 250
STEL, Skin
This material is classified as hazardous under OSHA regulations in the United States and the WHMIS in
Canada.
NE = Not Established
C = Ceiling Limit
See Section 16 for Definitions of Terms Used.
NOTE: all WHMIS required information is included. It is located in appropriate sections based on the ANSI Z400.1-2004 format.
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO THIS PRODUCT
WITHOUT ADEQUATE PERSONAL PROTECTIVE EQUIPMENT, OR BY THEMSELVES. If necessary,
Self-Contained Breathing Apparatus and fire retardant clothing should be worn.
INHALATION: If vapors, mists, or sprays of Methanol are inhaled, remove victim to fresh air. If necessary, use
artificial respiration to support vital functions. Only trained personnel should administer supplemental oxygen and/or
cardio-pulmonary resuscitation. Remove or cover gross contamination to avoid exposure to rescuers.
SKIN EXPOSURE: If Methanol contaminates the skin, immediately begin decontamination with running water.
Minimum flushing is for 15 minutes. Remove exposed or contaminated clothing, taking care not to contaminate
eyes. Victim must seek medical attention if any adverse reaction occurs.
EYE EXPOSURE: If the liquid or vapors of Methanol enter the eyes, open victim's eyes while under gently running
water. Use sufficient force to open eyelids. Have victim "roll" eyes. Minimum flushing is for 15 minutes. Victim must
seek immediate medical attention.
INGESTION EXPOSURE: If Methanol is swallowed, CALL PHYSICIAN OR POISON CONTROL CENTER FOR
MOST CURRENT INFORMATION. If professional advice is not available, do not induce vomiting. Victim should
drink milk, egg whites, or large quantities of water. If vomiting occurs naturally, have victim lean forward to reduce
risk of aspiration. Never induce vomiting or give diluents (milk or water) to someone who is unconscious, having
convulsions, or unable to swallow.
Victims of chemical exposure must be taken for medical attention. Rescuers should be taken for medical attention if
necessary. Take a copy of label and MSDS to health professional with victim. Physicians should refer to Section 11
(Toxicology Information) for additional guidance.
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 3 OF 10
5. FIRE-FIGHTING MEASURES
FLASH POINT (Tag Closed Cup): 11°C (52°F)
AUTOIGNITION TEMPERATURE: 385-470°C (725-878°F)
FLAMMABLE LIMITS (in air by volume, %):
Lower (LEL):
6.0%
Upper (UEL): 36.0%
FIRE EXTINGUISHING MATERIALS:
Water Spray: YES (for cooling only)
Carbon Dioxide: YES
Foam: YES
Dry Chemical: YES
Halon: YES
Other: Any "B" Class.
UNUSUAL FIRE AND EXPLOSION HAZARDS: Methanol is a Class IB flammable liquid. When involved in a fire,
Methanol may decompose and produce toxic gases (including carbon monoxide and carbon dioxide). Methanol
burns with a non-luminous, bluish flame that may be difficult to see during daylight. Vapors of Methanol can form
explosive mixtures with air at room temperature. The vapors of Methanol are heavier than air and may spread long
distances; distant ignition and flash-back are possible. Vapors can accumulated in confined spaces, creating a
toxicity and flammability hazard. Mixtures of 20% Methanol and water can ignite. Methanol can float on water;
therefore, water contaminated with this product can spread the flammable liquid and can spread fire.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: Static discharge may cause mixtures of Methanol vapors and air to ignite.
SPECIAL FIRE-FIGHTING PROCEDURES: In the event of fire, cool containers of this product with water to prevent
failure. Use a water spray or fog to reduce or direct vapors; water will not be effective to extinguish the fire as it will
not cool Methanol below its flash point. Move containers from fire area if it can be done without risk to personnel.
Stop leaks or discharges if possible. For small releases, if it is not possible to stop the leak and it does not endanger
personnel, let the fire burn itself out. Incipient fire responders should wear eye protection. Structural fire fighters
must wear Self-Contained Breathing Apparatus and full protective equipment. If this product is involved in a fire, fire
run-off water should be contained to prevent possible environmental damage.
6. ACCIDENTAL RELEASE MEASURES
LEAK RESPONSE: Uncontrolled releases should be responded to by trained personnel using pre-planned
procedures. Proper protective equipment should be used. In case of a large spill, clear the affected area, protect
people, and respond with trained personnel.
In the event of a non-incidental release, minimum Personal Protective Equipment should be Level B: triple-gloves
(rubber gloves and nitrile gloves over latex gloves), chemical resistant suit and boots, hard-hat, and SelfContained Breathing Apparatus. Monitor the surrounding area for combustible vapor levels. The level of
combustible vapors must be below 10% of the LEL (LEL = 6.0%) before personnel are allowed into the spill area.
The atmosphere must have levels of Methanol lower than those listed in Section 2 (Composition and Information
on Ingredients) and at least 19.5 percent oxygen before personnel can be allowed in the area without SelfContained Breathing Apparatus. Colorimetric tubes are available for detection of Methanol.
Eliminate all sources of ignition before cleanup operations begin. Use non-sparking tools. Prevent material from
entering sewer or confined spaces. Absorb spilled liquid with activated carbon, polypads, or other suitable absorbent
materials. Decontaminate the area thoroughly. Place all spill residue in an appropriate container and seal. Dispose
of in accordance with Federal, State, and local hazardous waste disposal regulations (see Section 13, Disposal
Considerations).
THIS IS AN EXTREMELY FLAMMABLE LIQUID: Protection of all personnel and the area must be maintained.
All responders must be adequately protected from exposure.
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 4 OF 10
7. HANDLING AND STORAGE
WORK PRACTICES AND HYGIENE PRACTICES: Avoid all contact with this material. All employees who handle
this material should be trained to handle it safely. Avoid breathing the vapors, sprays, or mists generated by this
material. Wash thoroughly after handling this material. Do not eat or drink while handling this material. All work
practices should minimize the release of this material. Eyewash stations and safety showers should be in areas of
use of this material.
STORAGE AND HANDLING PRACTICES: Cylinders should be stored upright and be firmly secured to prevent
falling or being knocked over. Cylinders can be stored in the open but, in such cases, should be protected from
extremes of weather and from the dampness of the ground to prevent rusting. Cylinders of this product must be
properly labeled. Cylinders should be stored in dry, well-ventilated areas away from sources of heat, ignition, and
direct sunlight. Keep storage area clear of materials that can burn. Do not allow area where cylinders are stored to
exceed 52°C (125°F). Store containers away from heavily trafficked areas and emergency exits. Store away from
process and production areas, elevators, building and room exits, and main aisles leading to exits. Protect cylinders
against physical damage. Consideration should be taken to install leak detection and alarm equipment for storage
areas.
Cylinders should be separated from oxygen cylinders or other oxidizers by a minimum distance of 20 ft. or by a
barrier of non-combustible material at least 5 ft. high, having a fire resistance rating of at least 0.5 hours. Isolate from
other incompatible chemicals, such as strong oxidizers, metals, and metal oxides (refer to Section 10, Stability and
Reactivity for more information).
Storage areas must meet national electrical codes for Class 1 Hazardous Areas. Post “No Smoking or Open
Flames” signs in storage or use areas. Consider installation of leak detection and alarm for storage and use areas.
Have appropriate extinguishing equipment in the storage area (i.e., sprinkler system, portable fire extinguishers).
Use only compatible materials for cylinders, process lines, and other Methanol handling equipment. Lines should be
purged with dry nitrogen both before and after maintenance activity. Use a check valve or other protective device in
the discharge line to prevent hazardous backflow. Never tamper with pressure relief valves and cylinders.
Use non-sparking ventilation systems, approved explosion proof equipment, and appropriate electrical systems.
Electrical equipment used in gas-handling operations or located in storage areas should be non-sparking or
explosion proof. Use a check valve in the discharge line to prevent hazardous backflow. Never tamper with
pressure relief devices in valves and cylinders.
Periodic inspections of process equipment by knowledgeable persons should be made to ensure that the equipment
is used appropriately and that the system is kept in suitable operating condition.
Keep the smallest amount necessary on site at any one time. Full and empty cylinders should be segregated. Use a
first-in, first-out inventory system to prevent full containers from being stored for long periods of time.
SPECIAL PRECAUTIONS FOR HANDLING CYLINDERS: Cylinders of Methanol can present significant safety
hazards. The rules on the following page are applicable to work situations in which cylinders are being used.
Before Use: Move cylinders with a suitable hand truck. Do not drag, slide, or roll cylinders. Do not drop cylinders
or permit them to strike each other. Secure cylinders firmly. Leave the valve protection cap (where provided) in
place until cylinder is ready for use.
During Use: Use designated CGA fittings and other support equipment. Do not use adapters. Do not heat cylinder
by any means to increase the discharge rate of the product from the cylinder. Do not use oils or grease on cylinder
handling fittings or equipment. Immediately contact the supplier if there are any difficulties associated with operating
cylinder valve. Never insert an object (e.g., wrench, screwdriver, pry bar, etc.) into valve cap openings. Doing so
may damage valve, causing a leak to occur. Use an adjustable strap wrench to remove overly tight or rusted caps.
Never strike an arc on a compressed gas cylinder or make a cylinder part of and electric circuit.
After Use: Close main cylinder valve. Valves should be closed tightly. Replace valve protection cap. Mark empty
cylinders “EMPTY”.
NOTE: Use only DOT or ASME code containers designed for corrosive storage. Close valve after each use and
when empty.
STANDARD VALVE CONNECTIONS FOR U.S. AND CANADA: Use the proper CGA connections, DO NOT
USE ADAPTERS:
THREADED: CGA-510
PIN-INDEXED YOKE: Not applicable.
ULTRA HIGH INTEGRITY: Not applicable.
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 5 OF 10
7. HANDLING AND STORAGE (Continued)
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices
indicated in Section 6 (Accidental Release Measures). Make certain that application equipment is locked and
tagged-out safely. Purge gas handling equipment with inert gas (i.e., nitrogen) before attempting repairs. Always
use product in areas where adequate ventilation is provided.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation. Use a mechanical fan or vent
area to outside. Where appropriate, use a non-sparking, grounded ventilation system separate from other exhaust
ventilation systems. Ensure eyewash/safety shower stations are available near areas where this product is used.
RESPIRATORY PROTECTION: Maintain exposure levels of Methanol below the levels listed in Section 2
(Composition and Information on Ingredients) and oxygen levels above 19.5% in the workplace. Use supplied air
respiratory protection if Methanol levels exceed exposure limits and if oxygen level is below 19.5% or during
emergency response to a release of this product. If respiratory protection is required, follow the requirements of the
Federal OSHA Respiratory Protection Standard (29 CFR 1910.134) or equivalent State standards.
RESPIRATORY PROTECTION (continued): The following NIOSH respiratory protection recommendations are for
Methanol (as Methyl Alcohol).
CONCENTRATION
RESPIRATORY EQUIPMENT
Up to 2000 ppm:
Supplied Air Respirator (SAR).
Up to 5000 ppm:
Supplied Air Respirator (SAR) operated in a continuous-flow mode.
Up to 6000 ppm:
Supplied Air Respirator (SAR) with a tight-fitting facepiece, operated in a continuousflow mode, full facepiece Self Container Breathing Apparatus (SCBA), or full facepiece
Supplied Air Respirator (SAR).
Emergency or Planned Entry into Unknown Concentration or IDLH Conditions: Positive-pressure, full facepiece
SCBA or positive pressure, full facepiece SAR with an auxiliary positive pressure SCBA.
Escape
Gas mask with organic vapor canister or escape-type SCBA.
The IDLH concentration for Methanol is 6000 ppm.
EYE PROTECTION: Splash goggles or safety glasses and face shield.
HAND PROTECTION: Wear leather gloves when handling cylinders of this product. During use of Methanol,
chemical impervious gloves should be used. Use triple gloves for spill response (see Section 6, Accidental Release
Measures).
BODY PROTECTION: Safety shoes are recommended when handling cylinders. Use body protection appropriate
for task. Fire retardant clothing should be worn for emergency response operations as well as SCBA. Eyewash
and safety showers must be located in areas of Methanol use.
9. PHYSICAL and CHEMICAL PROPERTIES
VAPOR DENSITY (air = 1) @ 15°C (59°F): 1.105
BOILING POINT: 64.5°C (148°F)
FREEZING/MELTING POINT: -97.8°C (-144°F)
SPECIFIC GRAVITY (water = 1): 0.79
pH: Not applicable.
SOLUBILITY IN WATER (by volume): Soluble.
MOLECULAR WEIGHT: 32.05
EVAPORATION RATE (nBuAc = 1): 2.1
EXPANSION RATIO Not applicable.
VAPOR PRESSURE 20°C (68°F): 96.0 mm Hg
SPECIFIC VOLUME: Not applicable.
ODOR THRESHOLD: 2000 ppm; 1000 ppm (irritation)
LOG COEFFICIENT WATER/OIL DISTRIBUTION: Log P (oct) = -0.77
APPEARANCE AND COLOR: Clear, colorless liquid. In pure form, Methanol has a slight odor of alcohol. The
crude form of Methanol may have a pungent, repulsive odor.
HOW TO DETECT THIS SUBSTANCE (warning properties): The odor is not a good warning property for
Methanol as the odor threshold is several times higher than the TLV.
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 6 OF 10
10. STABILITY and REACTIVITY
STABILITY: Normally stable.
DECOMPOSITION PRODUCTS: When exposed temperatures above 49°C (120°F), this product will ignite and
yield carbon monoxide and carbon dioxide.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Methanol is explosive in the form of vapor when
exposed to heat or flame. Methanol is incompatible with strong oxidizing agents (i.e. barium perchlorate, bromine,
sodium hypochlorite, chlorine, hydrogen peroxide) which will increase the risk of fire and explosion. Methanol is
incompatible with beryllium dihydride, metals such as potassium and magnesium, potassium tert-butoxide, mixtures
of carbon tetrachloride and metals such as aluminum, magnesium, zinc; dichloromethane. Methanol may react
violently or vigorously with alkyl aluminum salts, acetyl bromide, mixtures of chloroform and sodium hydroxide,
cyanuric chloride and nitric acid. Contact with diethyl zinc, mixtures of chloroform, and sodium methoxide with
Methanol will lead to an explosive reaction.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Contact with incompatible materials and exposure to heat, sparks, and other sources of
ignition.
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The following toxicology data are for Methanol.
Skin-Rabbit, adult 20 mg/24 hours
Moderate irritation effects
Eye effects-Rabbit, adult 100 mg/24
hours Moderate irritation effects
DNA Inhibition-Human: lymphocyte 300
mmol/L
Microsomal Mutageniticity AssayMouse: lymphocyte 7900 mg/L
Oral-Rat TDLo: 7500 mg/kg (17-19 days
preg): Reproductive effects
Inhalation-Rat TCLo: 10,000 ppm/7
hours (7-15 days preg):Teratogenic
effects
Oral-Man LDLo :6422 mg/kg: Central
nervous system effects, Pulmonary
system effects, Gastrointestinal tract
effects
Oral-Man TDLo: 3429 mg/kg: Eye
effects
Oral-Human LDLo: 428 mg/kg: Central
nervous system effects, Pulmonary
system effects
Oral-Human LDLo: 143 mg/kg: Eye
effects, Pulmonary system effects,
Gastrointestinal tract effects
Oral-Woman TDLo: 4 g/kg
Oral-Woman TDLo: 4 g/kg: Eye effects,
Pulmonary system effects,
Gastrointestinal tract effects
Inhalation-Rat LC50: 64,000 ppm/4 hours
Inhalation-Human TCLo: 86,000 mg/m3:
Eye effects, Pulmonary system
effects
Inhalation-Human TCLo: 300 ppm: Eye
effects, Central nervous system
effects, Pulmonary system effects
Oral-Rat LD50: 5628 mg/kg
Intraperitoneal-Rat LD50: 7529 mg/kg
Intravenous-Rat LD50: 2131 mg/kg
Oral-Mouse LD50: 7300 mg/kg
Subcutaneous-Mouse LD50: 9800 mg/kg
Intravenous-Mouse LD50: 4710 mg/kg
Oral-Monkey LDLo: 7000 mg/kg
Inhalation-Monkey LCLo: 1000 ppm
Skin-Monkey LDLo: 393 mg/kg
SUSPECTED CANCER AGENT: Methanol is not found on the following lists: FEDERAL OSHA Z LIST, NTP, IARC,
CAL/OSHA; therefore, it is not considered to be, nor suspected to be a cancer-causing agent by these agencies.
IRRITANCY OF PRODUCT: Methanol can be severely irritating to contaminated eyes; it is mildly irritating to
contaminated skin.
SENSITIZATION TO THE PRODUCT: Methanol is not known to be a sensitizer with prolonged or repeated use.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of Methanol on the
human reproductive system.
Mutagenicity: Human mutation data are available for Methanol; these data were obtained during clinical studies
involving specific human tissues exposed to this compound.
Embryotoxcity: Embryotoxicity data are not currently available for Methanol
Teratogenicity: Teratogenicity data are available for Methanol; these data were obtained during clinical studies on
test animals exposed to relatively high doses of Methanol. Slight behavioral effects were seen in the offspring of
female rats ingesting methanol during pregnancy.
Reproductive Toxicity: Reproductive toxicity data are available for Methanol; these data were obtained during
clinical studies on test animals exposed to relatively high doses of Methanol.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate
through generation lines. An embryotoxin is a chemical which causes damage to a developing embryo (i.e. within the first
eight weeks of pregnancy in humans), but the damage does not propagate across generational lines. A teratogen is a
chemical which causes damage to a developing fetus, but the damage does not propagate across generational lines. A
reproductive toxin is any substance which interferes in any way with the reproductive process.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Pre-existing dermatitis, other skin conditions,
respiratory conditions such as asthma, or emphysema, and central nervous system conditions and conditions of the
liver and kidneys may be aggravated by over-exposure to Methanol. Eye disorders may also be aggravated after
over-exposure to Methanol.
11. TOXICOLOGICAL INFORMATION (Continued)
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 7 OF 10
RECOMMENDATIONS TO PHYSICIANS: The following information is from the “Toxicology of Commercial
Chemical Products” (5th Edition, 1984): Ethyl alcohol, when consumed at the same time as methyl alcohol, prolongs
the latent period before toxic symptoms appear. It has also been observed that some of the severe symptoms of
methanol poisoning are alleviated by the ingestion of ethanol, and for this reason the recommended treatment
includes the administration of ethanol by mouth, by stomach tube, and/or by intravenous infusion. A blood ethyl
alcohol level of 0.1% is regarded as optimal. In extreme cases, ethanol may be given intravenously as a dilute
solution in bicarbonate or saline. Other treatments include gastric lavage, administration of sodium bicarbonate (4 g
every 15 minutes) for the treatment of acidosis, administration of oxygen, and hemodialysis. Due to Methanol’s
impact on the eyes, protect the patient’s eyes.
BIOLOGICAL EXPOSURE
associated with Methanol.
INDICES (BEIs):
Currently, the following Biological Exposure Indices (BEIs) are
CHEMICAL DETERMINANT
METHANOL
• Methanol in urine
SAMPLING TIME
• End of shift
BEI
• 15 mg/L
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: Methanol will be degraded over time into other organic compounds. Additional
environmental data are available as follows:
METHANOL: The 5-day Biological Oxygen Demand (BOD) values reported for Methanol are 0.6 to 1.12 lb/lb. The Log Kow of Methanol is -0.77.
The bio-concentration factor BCF for Methanol is estimated at 0.2 from a recommended regression-derived equation.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Methanol may be harmful or fatal to contaminated plant and
animal-life (especially if large quantities of this product are released). Refer to section 11 (Toxicological Information)
for additional information regarding the effects of Methanol on test animals.
EFFECT OF CHEMICAL ON AQUATIC LIFE: Methanol can be harmful or fatal to contaminated aquatic plant and
animal life. Additional aquatic toxicity data are available as follows:
LC50 Pimephales promelas (fathead minnow) 29.4 g/L/96 hours, (28-29 days old), confidence limit = 28.5-30.4; with water temperature of 25°C,
dissolved oxygen - 7.3 mg/L, water hardness 43.5 mg/L calcium carbonate, alkalinity 46.6 calcium carbonate, tank volume 6.31, additions 5.71 V/D,
pH 7.66 (0.03), conditions of bioassay not specified.
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate Federal, State,
and local regulations. Return cylinders with any residual product to Air Liquide. Do not dispose of locally.
14. TRANSPORTATION INFORMATION
THIS MATERIAL IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION.
PROPER SHIPPING NAME:
Methanol or Methyl Alcohol
HAZARD CLASS NUMBER and DESCRIPTION: 3 (Flammable Liquid)
UN IDENTIFICATION NUMBER:
UN 1230
PACKING GROUP:
PG II
DOT LABEL(S) REQUIRED:
Flammable Liquid
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (1996): 131
MARINE POLLUTANT: Methanol is not classified by the DOT as a Marine Pollutant (as defined by 49 CFR
172.101, Appendix B).
SPECIAL SHIPPING INFORMATION: Cylinders should be transported in a secure position in a well-ventilated
vehicle. The transportation of compressed gas cylinders in automobiles or in closed body vehicles presents serious
safety hazards and should be discouraged.
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 8 OF 10
14. TRANSPORTATION INFORMATION (Continued)
NOTE: Shipment of compressed gas cylinders which have not been filled with the owner’s consent is a violation of
Federal law (49 CFR, Part 173.301 (b).
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: THIS MATERIAL IS
CONSIDERED AS DANGEROUS GOODS. Refer to the above information for Canadian Shipments.
LABEL(S) REQUIRED:
Flammable Liquid; Poison
15. REGULATORY INFORMATION
SARA REPORTING REQUIREMENTS: Methanol is subject to the reporting requirements of Sections 302, 304, and
313 of Title III of the Superfund Amendments and Reauthorization Act, as follows:
COMPONENT
Methanol
SARA 302
NO
SARA 304
YES
SARA 313
YES
This product is subject to the reporting requirements of Sections 311 and 312 of Title III of the Superfund
Amendments and Reauthorization Act (40 CFR 370.21).
SARA THRESHOLD PLANNING QUANTITY: Not applicable.
TSCA INVENTORY STATUS: Methanol is listed on the TSCA Inventory.
CERCLA REPORTABLE QUANTITY (RQ): 5000 lbs.
OTHER U.S. FEDERAL REGULATIONS:
• Methanol is subject to the reporting requirements of CFR 29 1910.1000. Methanol is listed on Table Z.1.
•
Methanol is not subject to the reporting requirements of Section 112(r) of the Clean Air Act.
•
Depending on specific operations involving the use of Methanol, the regulations of the Process Safety
Management of Highly Hazardous Chemicals may be applicable (29 CFR 1910.119). Under this regulation,
Methanol is not listed in Appendix A; however, any process that involves a flammable liquid on site in one location
in quantities of 10,000 lbs (4,553 kg) or greater is covered under this regulation unless it is used as a fuel.
•
Methanol does not contain any Class I or Class II ozone depleting chemicals (40 CFR part 82).
•
Methanol is not listed as a Regulated Substance per 40 CFR, Part 68 of the Risk Management for Chemical
Release Prevention.
OTHER CANADIAN REGULATIONS: Methanol is categorized as a Controlled Product, Hazard Classes B2, D1A,
D2A and D2B, as per the Controlled Product Regulations.
STATE REGULATORY INFORMATION: Methanol is covered under specific State regulations, as denoted below:
Alaska - Designated Toxic and Hazardous
Substances: Methanol.
California - Permissible Exposure Limits
for Chemical Contaminants: Methanol.
Florida - Substance List: Methanol.
Illinois - Toxic Substance List: Methanol.
Kansas - Section 302/313 List: Methanol.
Massachusetts
Substance
List:
Methanol.
Michigan - Critical Materials List: No.
Minnesota
List
of
Hazardous
Substances: Methanol.
Missouri - Employer Information/Toxic
Substance List: Methanol.
New Jersey - Right to Know Hazardous
Substance List: Methanol.
North Dakota - List of Hazardous
Chemicals,
Reportable
Quantities:
Methanol.
Pennsylvania - Hazardous Substance
List: Methanol.
Rhode Island - Hazardous Substance
List: Methanol.
Texas - Hazardous Substance List:
Methanol.
West Virginia - Hazardous Substance
List: Methanol.
Wisconsin - Toxic and Hazardous
Substances: Methanol.
CALIFORNIA PROPOSITION 65: Methanol is not on the California Proposition 65 lists.
METHANOL - CH4O or CH3OH - MSDS
EFFECTIVE DATE: AUGUST 31, 2005
PAGE 9 OF 10
16. OTHER INFORMATION
HAZARDOUS MATERIAL INFORMATION
SYSTEM
NFPA RATING
FLAMMABILITY
HEALTH
3
HEALTH
0
1
1
(BLUE)
REACTIVITY
FLAMMABILITY
(RED)
3
(YELLOW)
0
OTHER
REACTIVITY
PROTECTIVE EQUIPMENT C
EYES
RESPIRATORY
HANDS
BODY
See Section 8
For routine industrial applications
MIXTURES: When two or more gases or liquefied gases are
mixed, their hazardous properties may combine to create additional, unexpected hazards. Obtain and evaluate
the safety information for each component before you produce the mixture. Consult an Industrial Hygienist or
other trained person when you make your safety evaluation of the end product. Remember, gases and liquids
have properties that can cause serious injury or death.
Further information can be found in the following pamphlets published by Compressed Gas Association Inc.
(CGA), 4221 Walney Road 5th floor, Chantilly, VA 20151-2923. Telephone: (703) 788-2700.
P-1
AV-1
PREPARED BY:
“Safe Handling of Compressed Gases in Containers”
“Safe Handling and Storage of Compressed Gases”
CHEMICAL SAFETY ASSOCIATES, Inc.
9163 Chesapeake Drive, San Diego, CA 92123-1002
619/565-0302
Fax on Demand:
1-800/231-1366
This Material Safety Data Sheet is offered pursuant to OSHA’s Hazard Communication Standard, 29 CFR, 1910.1200. Other government
regulations must be reviewed for applicability to this product. To the best of Air Liquide’s knowledge, the information contained herein is
reliable and accurate as of this date; however, accuracy, suitability or completeness are not guaranteed and no warranties of any type, either
express or implied, are provided. The information contained herein relates only to this specific product. If this product is combined with other
materials, all component properties must be considered. Data may be changed from time to time. Be sure to consult the latest edition.
METHANOL - CH4O or CH3OH - MSDS
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PAGE 10 OF 10