PCCA’s Quick Reference Base Guide
Snap the QR code to view the detailed spec sheet and comparison chart for each base!
Validation
Study
BUD
Formulations
Hypoallergenic
Transdermal Bases
Spec
Sheet
PCCA Base
Lipoderm
30-3338
First-Line Option for Most
Transdermal Needs
Anhydrous
Lipoderm
30-4283
Lipoderm
HMW ™
30-4612
PCCA Document#
98391
PCCA Document#
97857
PCCA Document#
98501
Lipoderm
ActiveMax™
30-4482
These bases are used for absorption through the skin.
Base Properties
• Increases the permeation of a variety of
actives vs traditional PLOs.
• Most studied transdermal delivery vehicle
in the industry.
Pain: 9199, 9874, 8541
Nausea: 9491, 9776
Circulatory Disorders: 8540, 9875
Veterinary: 9493, 9423, 9732
• Designed for actives that have poor stability
in the presence of water.
• Gluten-free, soy-free and egg-free, ideal
for patients with autism.
Autism: 9248, 9251, 9249
Anesthetics: 9246
• Designed for high molecular weight actives.
• Thins quickly when force is applied to it,
then returns to original viscosity.
• Does not contain lecithin, phospholipids or
eggs, appropriate choice for autistic patients.
• Designed for formulas with high salt loads.
PCCA Document#
Topical Bases
Spec
Sheet
Also available in
Lotion, Gel, Foam, Shampoo
Cream,
& Lotion
First-Line Option for Most BHRT
Needs
PCCA Document#
97711
Cosmetic HRT
30-3337
PCCA Document#
Base Properties
• Oil-free, petrolatum-free, paraben-free,
propylene glycol-free and non-comedogenic.
• A wide variety of active ingredients may be
incorporated into it.
• Thick, but rubs in very quickly, leaving a
soft, silky feel.
NataCream
™
PCCA Document#
98502
Spira-Wash™Gel
*Specialty Topical Base
30-4678
PCCA Document#
98450
Occlusaderm™
*Specialty Topical Base
30-4449
The “Patchless Patch”
PCCA Document#
98500
™
PracaSil-Plus
*Specialty Topical Base
30-4655
PCCA Document#
98436
Formula #s
BHRT: 9498, 9873
Vulvodynia: 7995, 6991
Eczema/Dermatitis/Psoriasis: 8907
Vaginal Dryness: 3474
• Paraben-free, rich in natural oils.
• Thinner consistency compared to VersaBase
Cream.
Facial Hair Reduction: 5568
BHRT: 9497
Female Sexual Dysfunction: 4932
• Composed of 100% natural ingredients of
vegetable origin.
• Non-comedogenic, hydrating, hypoallergenic,
mineral oil - and propylene glycol-free base.
• Ideal for anti-aging formulations.
Hyperpigmentation: 9600
Anti-Aging: 9601, 9599, 9597
Alpha Hydroxy Acid Cream: 9598
98503
30-4397
Neuropathy: 10014
Nausea: 10150
These bases are used for conditions on the surface of the skin with the exception of BHRT.
VersaBase Cream
30-3641
HCG: 10144
Vitamin B12: 10139, 10141
Pain: 10215, 10153, 10154
98345
PCCA Base
Formula #s
• Designed to promote a moist wound
environment ideal for the healing process while
being water washable.
• Soft opaque Polyethylene Glycol (PEG) ointment
base containing organic Meadowsweet Extract.
• Potential germicidal, anti-inflammatory and
healing properties.
• Designed to be a film former, utilizing natural
polymers and exhibiting adhesive properties.
• Once applied, Occlusaderm is impermeable
and oil-resistant.
• Ideal choice for use on all types of scar tissue,
keloids, stretch marks or any skin conditions
that would benefit from barrier protection. It
contains an Amazonian oil, Pracaxi oil, known
for its potential healing properties.
Wound Care: 10289, 10290, 10291,
10292, 10293, 10294,
10295, 10296, 10297,
10298, 10299, 10300
Acne: 10121
Rosacea: 10128
Eczema: 10132
Scars: 10232, 10233,
10234, 10235, 10236
PCCA Transdermal Bases Comparison Chart
(for Topical Bases Comparison Chart, see PCCA Document #97305)
Lipoderm®
Lipoderm® ActiveMax™
Lipoderm® HMW™
Anhydrous Lipoderm®
Pluronic Lecithin Organogel (PLO)
PCCA #
30-3338
30-4482
30-4612
30-4283
LIPS – 30-3222
Poloxamer –
30-3278 (20%) / 30-3279 (30%)
Potential Relative
Penetrating Ability
Deepest
Deepest
Deepest
Deep
Deep
The first in the highly trusted Lipoderm
line of transdermal bases. It has an
elegant lotion like feel, superior results
over PLO and a large research dossier.
Overview
The latest in transdermal technology, this
base is focused on the delivery of large
A base that utilizes PCCA's Lipoderm
molecular weight proteins. It has a
technology in an anhydrous platform. It was
Original transdermal base used by
silicone emulsion feel and a thixotropic designed for actives that have poor stability in
The benefits of the original Lipoderm
compounders. Base will decrease in viscosity
the presence of water. It is gluten-free, soybehavior (thins quickly when force is
with an added stabilizing system to give
if it becomes cold. Lipoderm has been proven
free and egg-free; therefore, a great base for
applied to it, then returns to original
resiliency in the presence of high salt
to deliver drugs better than PLO. Lipoderm is
use in patient populations such as autism,
viscosity). Lipoderm HMW does not
loads.
superior and easier to compound with.
contain lecithin, phospholipids or eggs, where individuals tend to be sensitive to soy
and egg.
and could be an appropriate choice for
autistic patients.
pH Stability Range
3 to 9
3 to 9
4 to 6
n/a
4 to 6
Salt Resiliency
Good
Best
Low Resiliency: salt forms of drugs will
break this base.
Good
Low Resiliency: many salt forms will break
this base into two phases.
Radio-Labeled Human Insulin
Ketoprofen in Human Skin
in vitro
n/a
Studies
Numerous: 1) Promethazine;
2) Ketoprofen, 3) Tramadol in Feline
Inner Ear Skin in vitro; 4) Multi-Drug
1) Multi-Drug Study: Ketamine,
Study: Ketamine, Gabapentin, Clonidine
Gabapentin, Clonidine and Baclofen; 2)
and Baclofen in Human Skin in vitro; 5)
Lorazepam Study
Lorazepam; 6) EGCg in rats (Rutgers
study); 7) Gabapentin for Vulvodynia
(published human clinical study)
PCCA Product
Information
Document #
97480 Spec Sheet + All Validation
Studies Performed (All-in-One)
98344 Breakthrough Four-Drug
Study for Members
98345 Breakthrough Four-Drug
Study for Practitioners
97665 Promethazine Validation for
Members
97669 Promethazine Validation for
Practitioners
98301 Spec Sheet
98344 Breakthrough Four-Drug
Study for Members
98345 Breakthrough Four-Drug
Study for Practitioners
98613 Lipoderm/Lorazepam Study for
Practitioners
98614 Lipoderm/Lorazepam Study for
Members
98363 Spec Sheet for Members
98501 Spec Sheet for Practitioners
97837 Spec Sheet for Members
97857 Spec Sheet for Practitioners
n/a
FormulaPlus™
BUD Study
Formulas
9445, 9872, 9446, 9447, 9448, 9874,
9492, 9776, 9493, 9494, 9875, 9450,
9491, 9452, 9732
n/a
n/a
n/a
n/a
Rev. 08/20/13
PCCA Topical Bases Comparison Chart
(for Transdermal Bases Comparison Chart, see PCCA Document #94008)
VersaBase®
Cream
VersaBase®
Lotion
VersaBase®
Gel
VersaBase®
Foam
Cosmetic
HRT®
Vanishing
Cream
Light™
Emollient
Cream™
NataCream™
Plasticized™
Base
Aladerm™
PCCA #
30-3641
30-3653
30-3656
30-3654
30-3337
30-3295
30-3168
30-4397
30-3211
30-1142
Overview
Oil-free, petrolatumfree, paraben-free,
propylene glycol-free
and noncomedogenic.
It is an elegant yet
durable cosmetic
cream. Used in PCCA
Progesterone Study
(Document #97710)
and showed excellent
absorption. No "pilling"
occurs with this base.
Can be used anywhere
on the body. It is thick
but rubs in very
quickly, leaving a soft,
silky feel. A wide
variety of active
ingredients may be
incorporated into it.
Oil-free, petrolatumfree, paraben-free,
propylene glycol-free,
and noncomedogenic. Much
of the same versatility
as VersaBase Cream,
but with a lotion
consistency.
Excellent spreadability.
Leaves a silky-smooth
feel after application.
Great for people who
like a thinner
consistency in their
creams.
Alcohol-free aqueous
gel.
The gelling agent is
fairly concentrated in
VersaBase Gel, so it
has a slightly sticky feel
in its pure form. When
diluted down, it is much
more cosmetically
elegant and provides a
silky feel. Dilute with
water or alchol or use
as is. Great stability at
low pH. It can handle a
high concentration of
alcohol and DMSO,
and still maintain
viscosity. Withstands
high shear. May be
used to
thicken/stabilize
emulsions. May be
used on mucous
membranes.
Description
Smooth with "dry"
touch, thick cream
Smooth, soft touch,
lotion-like
Good For Sensitive
Skin?
ƇƇƇƇ
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ƇƇƇ
ƇƇ
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Moisturizing
Capability
ƇƇƇƇ
ƇƇƇ
Ƈ
Ƈ
ƇƇƇ
Vaginal Use
Yes
Yes
Yes
No
pH
Approx. 6
5 to 6
4.5 to 5
Preservative
Methylchloroisothiazolinone /
Methylisothiazolinone
Methylchloroisothiazolinone /
Methylisothiazolinone
PCCA Product
Information
Document #
97074
FormulaPlus™
BUD Study
Formulas
9812, 9675, 9674,
9677, 9676, 9873,
9496, 9498
Clear solution of
amino-acid based
surfactants.This
surfactant solution
requires the use of a
foam dispenser
(PCCA #35-3533) to
Paraben-free, rich in
form the foam.
Versatile and
Leave-on foams or natural oils. Designed
Petrolatum-free,
resilient. Contains
foam cleansers (wash
for topical HRT
paraben-free and
petrolatum and
off) may be prepared
therapy.
non-comedogenic.
mineral oil.
with this base. LeaveIt has a thinner
A lighter cream base Thick cream base used
on foams have a
consistency
than emollient cream.
for its emollient
lower percentage of
compared to
properties.
the foam base.
VersaBase Cream.
Actives such as
corticosteroids may
be used.
Cosmeceutical foams
such as DMAE may
be used to formulate
facial cleansers.
Lighter than emollient
Cleanser - smooth
Slight oily feel. Thin
Heavy oily feel. Takes
Slightly sticky but silkyafter wash. Leave on cream. Slight oily feel,
to medium cream
longer to rub in, very
smooth upon drying,
slightly tacky, but
medium to thick
(lotion consistency).
thick cream.
thick gel
smooth after drying.
cream.
Non-comedogenic,
hydrating,
hypoallergenic,
mineral oil- and
A polyethylene and
propylene glycol-free
mineral oil gel base
base.
commonly used for
Composed of 100%
topical and oral
natural ingredients of
preparations. Often
vegetable origin. The
seen in dental
high performance
preparations as well as
emulsion system
topical anesthetics
makes it ideal for anti- before laser treatments.
aging formulations as
well as
pharmaceutical-type
treatments.
Water-in-oil emulsion
base containing
petrolatum and urea
20%. Hydrating base
that softens dry skin.
Excellent for callused
areas.
Leaves the skin soft,
but not oily or shiny,
with a matte finish
effect.
Soft elegant feel and is
completely anhydrous.
Thick cream
ƇƇ
ƇƇƇƇ
Ƈ
Ƈ
ƇƇ
ƇƇƇ
ƇƇƇƇ
ƇƇƇ
ƇƇƇ
Yes
Yes
Yes
Yes
n/a
n/a
Approx. 6
6 to 7
6 to 7
6 to 7
5.5-7
n/a
5-6.8
Methylchloroisothiazolinone /
Methylisothiazolinone
Methylchloroisothiazolinone /
Methylisothiazolinone
K Sorbate /
Phenoxyethanol
K Sorbate
Methylchloroisothiazolinone /
Methylisothiazolinone
Naturally preserved
with NataPres™
n/a
K Sorbate
97267
97144
97257
97325
n/a
n/a
98176
n/a
n/a
n/a
9451, 9930
n/a
9891, 9892, 9497,
9495
n/a
n/a
n/a
n/a
n/a
.H\Ƈ 3RRUƇƇ *RRGƇƇƇ *UHDWƇƇƇƇ ([FHOOHQW
Rev. 08/20/13