CLiNiCAL PRACTiCE Quality and Safety Unit INSIDE Code Greens REVIEW NEWSLETTER May 2004 Pg 1 Editorial 2 Letters to the Editor 2 Response Code Blue 3 Is this death preventable? 4 ALSO course 5 Approach to the shocked patient in the ED 5 How well do we huff and puff 6 Teamwork in obstetric emergencies 7 Pharmacy news 8 Code Greens What is a code green? History and process A code green is called when an immediate caesarean section is required because of impending fetal/maternal death, e.g. cord prolapse, severe persistent bradycardia. A caesarean section is a complex multi-disciplinary procedure involving obstetricians, midwives, anaesthetists, paediatricians, theatre nurses, anaesthetic nurses, as well as support services. How do you get a woman requiring immediate caesarean section, who may not even be in a birthing suite, rapidly transported to theatre and attended by all the required staff? By calling a code green, a process is initiated that allows a rapid delivery to take place. Prior to 2000, immediate caesarean sections were classified as code blue – immediate caesarean section. At that time, there were many problems with the management of these cases. Primarily, these were due to difficulties in communicating the urgency of the case to appropriate staff, including obstetricians and anaesthetists, a lack of clear understanding among staff as to the correct process to follow when a code was called, as well as the potential for confusion with the adult and paediatric code blue responses. A new code green policy was developed in May 2000. The code green name was adopted to separate it from the adult and paediatric code blue responses and also to highlight the main difference in response. Green means go! When a code green is called all the team members attend the operating theatre and the patient is transported to theatre immediately. This distinguishes it from the code blue response where the team members go to where the code blue was called. The code green response team consists of a group including obstetric, paediatric, anaesthetic, midwifery and operating theatre staff as well as other essential personnel. To minimise delays team members carry an emergency page that is set off as a group page by switchboard when they are notified of a code green. Typically a member of the obstetric or midwifery staff calls a code green. The patient is immediately transported to theatre and met in theatre by the team necessary to perform the caesarean section. In the OR, a theatre is always designated for these emergencies with the necessary equipment, drugs etc readily available to minimise delays. What is the rationale for an urgent caesarean delivery? It has been known for a long time that even with maternal death, it is still possible to deliver a neurologically intact infant if the delivery interval is short enough. Large series have demonstrated that even with intervals up to 15 minutes post maternal cardiac arrest, up to 83% of surviving infants were neurologically intact. Beyond 15 minutes, only 18% of surviving infants had no neurological sequelae. These are extreme cases but we can extrapolate to other situations where fetal well being is compromised, such as a cord prolapse or abruption. Often we can see no direct cause of fetal compromise but see severe bradycardia or other major CTG abnormality. In these situations, we hope that by expediting delivery we can improve the outcome for the baby and the mother. What are the outcomes? Code greens are becoming more frequent. Over a 7 month period to October 2003, 101 code greens were called compared to 63 for the same period in 2002. The process is working well. In the six months to December 2003, the meantime from calling a code green to patient arrival in theatre was four minutes. EDITORIAL Responding to emergencies is both a test of, and an opportunity for, improving care. Any opportunity for error, disorganisation or lack of team work is amplified in the context of the reduced time frames found in an emergency response. The RWH has been a leader in this area but as suggested above, opportunities for improvement always exist. This issue of the Clinical Practice Review Newsletter addresses the theme of responding to emergencies. There is good evidence that when a clinical situation begins to deteriorate to an emergency, a standardised, rehearsed and well understood team response improves all outcomes including survival, and reduced adverse events. Bellomo et al 1 at the Austin Hospital in Heidelberg reported last month on the results of a Rapid Response Team on a population of more than 1,000 post-surgery patients, the team found a 37 percent relative reduction in mortality and a 79 – 88% reduction in a variety of complications. In this issue of the CPR newsletter we look first at what an emergency response should be. The audit of neonatal resuscitation undertaken by Colm O’Donnell and the NICU team presented at the last Grand Round (page 6) looks at what we do, what evidence there is and addresses gaps and deficiencies in our knowledge base of neonatal resuscitation. Sheila Bryan writes on the response in the emergency dept to a shocked patient (page 5). Ruth Bergman, Andrew Beuttner and others report on how we respond; the Code Blue and Code Green experience at the RWH, (pages 1 & 3) the latter being a unique home grown response with impressive benefits for patient outcomes. Glenys Jansen reports on the ALSO course she attended, a multi-disciplinary education program responding to obstetric emergencies (page 5). It is clear that teamwork is the glue that sticks the differing disciplines together when responding to an emergency (page 7). Mary Draper looks at improvements and outcome that could be achieved by a medical emergency team on (page 5). Finally on (page 3) Sharyn Donovan summarises the CPGs and our policies on reponses to emergencies Not-so-trivial fact for the day: If you go to Advanced Google and type in the phrase – obstetrics emergency, limited to .au, it finds 8,230 hits. Number one hit? RWH emergency dept. Well done guys! Leslie Reti Editor [email protected] Reference 1. Bellomo R. et al Prospective controlled trial of effect of medical emergency team on postoperative morbidity and mortality rates. Crit Care Med. 2004 Apr; 32(4):916-21. 23% of patients took more than five minutes to arrive in theatre but only three patients took more than ten minutes to arrive. During a similar time period in 2002 the mean time to patient arrival in theatre was 5 minutes. 27% of patients took more than five minutes and five patients took more than ten minutes. These results compare well with other centres. Tuffnell et al 1 reported a large series from a district general hospital in the UK performing a similar number of deliveries to RWH. 69% of patients in the series from 1997 onwards arrived in theatre within a target time of ten minutes. These figures suggest that the process of code greens is working. They do not tell us if they are resulting in better outcomes. The increase in the code green rate implies that the incidence of fetal distress is increasing. This may not be the case and indicates that the diagnosis of fetal distress is imprecise. The rationale for performing a code green is to improve fetal and maternal safety. In the vast majority of instances, however, the code is called for a fetal indication. It may be that the code green process increases the risk for women undergoing the caesarean section. In 2002/3 the general anaesthetic rate for elective caesarean sections at RWH was 6%. For code green caesareans the general anaesthetic rate was 54%. We know that general anaesthetics for caesarean sections are a hazardous procedure but the urgency of a code green means that a general anaesthetic will be required far more often. We need to ensure that the code green process continues to work well, is refined where necessary and that fetal and maternal outcomes are monitored to guarantee that the goal of improved fetal and maternal safety is realised. Dr Andrew Buettner Deputy Director Anaesthesia RWH Reference 1.Tuffnell DJ, Wilkinson K, Beresford N. Interval between decision and delivery by caesarean section – are current standards achievable? Observational case series. [see comment]. Bmj. 2001; 322:1330-3. LETTERS TO THE EDITOR Dear Les, It is a minor point, but just for the record, I wanted to correct a statement in the most recent (April 2004) Clinical Practice Review Newsletter. On the second page, Tony Smith’s Grand Round on 25 March 2004 was described as the second Grand Round for 2004. In fact, it was the third. The first was on Thursday 29 January 2004 on ‘Obesity and Pregnancy Complications’ – Data from the Danish Birth Cohort" given by Ellen Nohr. The second was given on Thursday 26 February 2004 by Babill Stray-Pedersen on ‘Reproductive Health of Immigrant Women’. Cheers, Shaun Reply: Absolutely right, as usual – ed. Dear Editors, Well done on producing a newsletter that is interesting, refreshing and widely read, but please take care with your headings. Last month’s edition had a heading ‘… hots up’. I almost wrote back then to complain that hot is a noun and heat is the verb but thought I’d let such an indiscretion pass! This month though another suspect heading ‘Does Albumin Kill?’ The SAFE study was, as Ruth Bergman correctly states, set out to compare mortality and morbidity for intensive care patients receiving either albumin or saline. To suggest the study cleared Albumin from ‘killing’ is a tabloid approach not befitting a ‘quality’ newsletter. I look forward to a quality improvement in next month’s headlines. Cheers, Geoff Steele Reply: Actually, ‘hot’ is an adjective, certainly not a verb, we agree. It is only a noun in the plural as in ‘has the hots for!’ With regard to our tabloid tendencies, the original title of the presentation by Simon Finfer, was ‘Does Albumin Kill? Results of a Randomised Control Trial of 7,000 Patients.’ Now there’s a sentence that’s too long for a newsletter! The shorter version does grab the attention – ed. Respond Code Blue A code blue is called in the event of an unexpected medical emergency. This includes a respiratory arrest, cardiac arrest, epileptic seizure or another condition where it is deemed that urgent medical attention is required. (RWH Policy and Procedure manual 9W-04-2-124). An audit of Code Blue responses conducted for quality assurance purposes has shown 2 arrests have occurred in the past 12 months and in 2003 there were a total of 31 ‘Respond Code Blue’ and of these, 18 were faints. Consequently, at the RWH, when a code is called it is less likely that the patient has had a cardiac arrest, but rather medical staff are required urgently. It is less likely that a Code Blue is called for a ward and more likely that it is called for outpatient and visitor areas. A variety of settings over the past 12 months have included Frances Perry House, ground floor admissions, the RWH Emergency Department car park, Physiotherapy, Health Information Services, Grattan Street Café, Outpatient clinics and Women’s Social Support Services. The various locations have highlighted the issue of easy access for the resuscitation trolley and numbers in attendance. Policies, Procedures and Guidelines Policies and Procedures Clinical Practice Guidelines Located in RWH Policy and Procedure Manual on the Intranet. Located on the RWH CPG website on both the Intranet and Internet. • Guidelines for Management of Intrapartum Fetal Distress 9W-04-2-117 • Code Green – Immediate Caesarean Section 9W-02-2-001 • Fetal Distress requiring Caesarean Section 9W-02-2-035 • Resuscitation: Neonatal Cardiopulmonary – Delivery Suite 9W-04-2-020 • Resuscitation: Neonatal – Cardiopulmonary, Intensive and Special Care Nurseries, Postnatal Ward and Community Setting 9W-04-2-028 • Respond Code Blue 9W-04-2-124 • • • • • Cardiopulmonary Resuscitation (adult) Ectopic Pregnancy Pre Eclampsia: Management Shoulder Dystocia Primary Post Partum Haemorrhage: Management – this guideline includes links to other CPGs; - Advanced management of PPH - Anaesthetic management of PPH. Websites Department of Reproductive Health and Research – World Health Organisation http://www.who.int/reproductive-health/impac/Clinical_Principles/ Emergencies_C15_C16.html Managing complications in pregnancy & childbirth – A guide for midwives and doctors CREST Clinical Resource Efficiency Support Team – Northern Ireland Management of Pre Eclampsia and Eclampsia http://www.crestni.org.uk/publications/severe_eclampsia.pdf In addition, it is important to tell switchboard the floor and exact location, for example ‘Level 1 Special Clinics’, so the code blue response group (anaesthetic registrar and consultant, obstetric resident and registrar, perioperative nurse, after hours co-ordinator and porter) know exactly where to go. ‘Cervical cancer not yet beaten – and at what cost?’ Clinical symposium on cervical cancer Women’s health practitioners, trainees and non-medical staff are invited to the The Royal Women’s Hospital on Ruth Bergman, Sharyn Donovan, Kate McLean and Andrew Buettner Saturday July 17th 2004 8.30am – 5.00pm Teamwork at its best! The Royal Women’s Hospital Sailing Team, Glenys second from the left. See (page 5) for the full story. Contact Renae Paul (03) 9344 2439 or [email protected] Is this death preventable? It became apparent, when clinicians looked more closely at patients who died of a cardiac arrest in hospital, that signs of clinical instability had been apparent from one to six hours beforehand. During that time, there were nurses and medical officers who were concerned about the patient, but the chain of communication went up the traditional clinical hierarchy. There were often significant delays because of other commitments, for example, a registrar completing an outpatient clinic. There were then further delays when a registrar needed to call a more senior clinician or other specialist via their registrar. These delays were multiplied throughout this complex communication hierarchy. By this time, the patient had often gone on to a full cardiac arrest. Then a Code Blue would be called. The survival rate for patients who have an in hospital cardiac arrest is poor (about 60%). A view emerged that a number of these deaths were preventable. Two Victorian hospitals, the ARMC and Dandenong hospital, received funding from DHS to audit their current practice and trial the concept of the medical emergency team (MET). The MET was an innovation introduced at the Liverpool hospital in Sydney. The typical team comprises a medical registrar, an intensive care registrar, and a senior intensive care nurse and is equipped with resuscitation drugs, fluids, and equipment. Any member of the hospital staff can activate the MET. The criteria for calling the MET were available on a small card similar to the one for codes and well publicised in wards. The two Victorian projects were very successful. The incidence of in-house cardiac arrests was reduced by 65% in the ARMC project and by 50% in the Dandenong project . At both hospitals, unexpected cardiac arrest deaths were reduced by about half. In simple terms, the ARMC project saved 80 lives in four months and was associated with a 26% reduction in overall hospital mortality. Not only did these projects save lives, an unexpected side effect was a significant boost to morale, especially for nurses and junior medical staff. Following a Coroner’s report into a child’s death, the RCH introduced a paediatric MET. There is now an Australian wide trial where hospitals have been randomised to trial the MET concept further – just to make sure it really works. Like the RWH Code Green, the MET is a simple organisational innovation. These MET projects contested some taken-for granted aspects of hospital life – preventable deaths and hierarchical communication and referral. What does this mean for RWH? We are not confronted with the same risks of cardiac arrests, but we do have a number of patients where there is a story that sounds a bit like this, where a patient deteriorates, say from post partum haemorrhage, and it seems as if the hospital responds all too slowly and suddenly there is an emergency. Does the RWH need a Rapid Response Team and what would it look like? What do you think? Emergency response training website The SIMULATION CENTRE supports education and research activities using realistic, ‘hands-on’ simulation. The facility has been designed in such a way as to maximise the benefit from the experience of a high-fidelity simulation session, in that it replicates the full complexity of a wide variety of clinical areas – including Operating Theatre, Intensive Care Unit, Emergency Department Bay, Delivery suite, and general ward areas. Criteria for calling the medical emergency team - Airway - Respiratory distress - Threatened airway - Breathing - Respiratory rate > 30/min - Respiratory rate < 6/min - SaO2 < 90% on oxygen - Difficulty speaking - Circulation - Blood pressure < 90 mm Hg despite treatment - Pulse rate > 130/min - Neurology - Any unexplained decrease in consciousness - Agitation or delirium - Repeated or prolonged seizures - Other - Concern about patient - Uncontrolled pain - Failure to respond to treatment - Unable to obtain prompt assistance Dandenong Hospital Mary Draper Turn to www.southernhealth.org.au/simcentre to see what’s on offer. All CRM programs involve joint medical and nursing staff training. That now familiar link between the medical team and the air craft crew was employed to enhance teamwork amongst anaesthetists. On this website you may learn of specific courses for anaesthetists, emergency department staff and rural general practitioners and nurses. Susan Braybrook Whoops correction for last month’s website address www.nice.org.uk ALSO (Advanced Life Support in Obstetrics) course The ALSO course is an internationally recognised and accredited educational program designed to assist health professionals in developing and maintaining the knowledge and practical skills needed to manage the emergencies that may arise in maternity care. The philosophy that underpins ALSO is that women and their families will benefit from the standardised, and multi-disciplinary approach to maternity care that the ALSO provider course engenders. Several staff members at the RWH are accredited trainers and many staff have attended the course. It is usually over subscribed. Some of the emergencies included in the course are: • Shoulder dystocia • Postpartum haemorrhage • Forceps and vacuum extraction • Intrapartum fetal monitoring • Medical complications of pregnancy and many more. Before the course, participants receive a manual with pre-reading material. The course involves both theory and practical sessions on obstetric emergencies. At the completion of the course participants complete a theory and practical exam. The highlights of the course are the clearer understanding of the theory behind obstetric emergency management and having the opportunity to practice, using mannequins, in a small group setting. The only negative aspect of the course is that the manual is based on an American course that is yet to be updated to an Australian program. As a midwife working in birth suites, the family birth centre and antenatal clinics, the course was a very worthwhile. The use of mnemonics such as: DR C BRAVADO which stands for: Determine Risk Contractions Baseline Rate Variability Accelerations Decelerations Overall Assessment provide logical and clear steps in dealing with obstetric emergencies. I would recommend it to other midwives and doctors working in obstetrics. The cost of the course is approximately $800 and all the facilitators volunteer their time to run the program. In 2004 the ALSO program will continue to be offered across Australia and New Zealand. The next program in Melbourne is July 31 – Aug 1. Further enquiries can be sent to [email protected] or Helen Balwin PO Box 4684 Alice Springs NT 0871 Glenys Jansen Approach to the shocked patient in the Emergency Department Shock is not a common presentation to the RWH emergency department. However it is one of the commonest emergencies that we treat. Assessment and treatment of the shocked patient occurs simultaneously. Specific treatment is guided by the diagnosis and a rapid assessment must be made to generate a working diagnosis. Common gynaecological diagnoses include “cervical shock” which results in bradycardia and hypotension secondary to dilation of the cervix by products of conception (POC) in the cervix. Shock can also be caused by hypovolaemia due to occult blood loss secondary to a ruptured ectopic pregnancy or a bleeding corpus luteal cyst. Vaginal bleeding from ante-partum haemorrhage, miscarriage, or genital tract trauma may also present as shock secondary to hypovolaemia. Other pregnancy related causes of shock such as pulmonary embolism or amniotic fluid embolism also need to be considered during the initial assessment. Sepsis can present as shock especially in the elderly or in oncology patients post chemotherapy. An uncommon form of sepsis is toxic shock syndrome which is caused by Staph Aureus sepsis. The source of which may be a retained tampon. Non gynaecological causes of shock include anaphylaxis, myocardial conditions (infarction or myocarditis) and drug overdose. The basic principles of management are a coordinated team approach in which medical and nursing staff provide oxygen, intravenous fluids, initiate monitoring and institute a number of investigations. ECG’s, ultrasound and biochemical analysis are often performed. Specific therapy is guided by the diagnosis and may be as simple as removing POC from the cervix in the case of cervical shock or giving adrenaline for anaphylaxis. However referral to an inpatient unit is often required for definitive management such as laparoscopy or urgent delivery. Sheila Bryan APRIL GRAND ROUND How well do we huff and puff ? studies of neonatal resuscitation On the 22nd of April the staff of The Royal Women’s Hospital were treated to the fourth grand round, and the first paediatric Grand Round for the year. Introduced by Dr Neil Roy, the presentation was led by Dr Colm O’Donnell, neonatology research fellow, and delved into the topic of neonatal resuscitation and research in this field. This is an international body of neonatologists which convenes every five years to recommend evidence-guided practice, but even still, this may fall short of the ideal, as Colm went on to illustrate. The current principles of neonatal resuscitation as we know it are: thermoregulation; observation and evaluation; positive pressure ventilation The impetus for such a discussion arose (either via mask or endotracheal from the fact that whilst neonatal tube); and to a lesser extent resuscitation is one of the external cardiac massage commonest practices in Current resuscitation and pharmacotherapy. neonatology, it is the least Colm then proceeded to studied area in this field, based on adults is discuss the ILCOR recomand our practices are poorly evaluated in mendations regarding these poorly evidence-based. the neonate key steps and compared Colm quoted 3% to 5% of them to the evidence available. babies delivered worldwide Whilst ILCOR suggests rapid will require some form of drying of the newborn and wrapping resuscitation at delivery, making it the infant with pre-warmed wraps under a common and important intervention. a radiant heater, it did not discuss Although we always aim to provide the polyethylene wrapping, for which there is best care, the problem is that current evidence from randomised trials available. resuscitation principles are based on adult Whilst ILCOR advises evaluating the resuscitation, and this approach is poorly newborn’s heart rate with a stethoscope evaluated in the neonate. Even with these or feeling for cord pulsations, there is techniques borrowed from adult medicine, evidence that accuracy is poor when it those used in neonatology are still primitive comes to assessing heart rate by both compared to those currently being auscultation and palpation. ILCOR also employed in intensive care situations. advises the determination of cyanosis by Also, our approach to resuscitation of the examining central structures and mucous newborn is based on Dawes’ model of membranes, but it is well recognised that single aspyhxial insult, which does not take this is a generally poor gauge of oxyinto account the pathophysiology of acute genation. In terms of positive pressure versus chronic in-utero and intra-partum ventilation, ILCOR states that ‘most newly hypoxic insults. Despite all of this, there has born infants can be adequately ventilated been an attempt at providing guidelines with a bag and mask’. Studies have, and consistency in our practice via the however, shown that adequate tidal volume neonatology subcommittee of ILCOR is rarely produced via the bag and mask (International Liaison Committee on in term infants, and there is a paucity of Resuscitation). information regarding positive pressure ventilation via the bag and mask in preterm infants. ILCOR also recommends the use of 100% oxygen in the management of central cyanosis, however, there are randomised trials which demonstrate that air is as effective as oxygen and a meta-analysis that shows the use of air decreasing perinatal mortality. To complicate matters, there is the inconsistency of our use of 100% dry oxygen at the delivery (either in the delivery suite or in theatre) but then the use of warmed, humidified gases once the baby is transferred to NICU. Superimposed on this is the concern of hyperoxia and the potential for oxidative injury in premature infants. The situation is made even more difficult when the issue of resuscitation of preterm infants is thrown into the picture. These infants are more prone to cold stress and evaporative loss, and have a more variable respiratory drive. They also have more delicate lungs and are more likely to suffer from cerebral haemorrhages than term infants. Superimposed on these difficulties is the even greater dearth of evidence about resuscitation in premature infants. In an effort to address the obvious deficiencies in our knowledge base of neonatal resuscitation, Colm and his team developed a research plan to describe our practice at the Royal Women’s Hospital. Specifically, he was hoping to investigate the efficacy of positive pressure ventilation, the utility of pulse oximetry and the performance of staff at resuscitation procedures. This was done via a variety of techniques, including video camera recordings of the resuscitation itself, with pulse oximetry and physiological data (primarily a flow sensor and pressure line that measures tidal volumes and airway pressures). He then confirmed how clearly the video recordings were able to demonstrate the process of resuscitation by playing a taped example. The pilot results of the study included 54 taped resuscitations, with no objections from staff members and agreement from 52 sets of parents to allow the video tape for use for audit and educational purposes (only 1 set of parents refused permission on grounds unrelated to the study). Colm also managed to address the ethical issues in research such as this, when parents often find themselves in a stressful and emotive period in their lives. Prior to commencement, the Human Research and Ethics Committee endorsed the study. However, permission was of course sought from the parents prior to using the video recordings for research purposes (hopefully at a time when they are more removed from the acute anxiety of delivery). He outlined the sensitive and confidential manner in which the tapes were handled, where no staff member or patient could be identified, and that they were securely stored and viewed in private, and then erased after their analysis. Colm then finished his highly enjoyable and informative presentation by concluding that the study was acceptable to both staff and family members, and that it allowed us to accurately study our resuscitation techniques at The Royal Women’s Hospital. This has vast potential value in assessing performance and education, as well as defining the use of oximetry and positive pressure ventilation in the resuscitation of newborns. Ultimately, this can only serve to improve our practice. Weiqing Huang TEAMWORK IN OBSTETRIC EMERGENCIES 0“It’s not what you know, rather who you know” Our disciplinary backgrounds differ hence our professional cultural emphasis in turn may also vary. As obstetricians, anaesthetists and midwives, we aim to arrive at the same conclusions regarding our patients. In emergency situations, however, our differences are exposed and the potential for medical error is magnified. In the United States, medical error is the eighth most common cause of death. Research in safety critical industries tells us that to overcome this problem we must better understand the system used to deliver care 1. The system, however, is often reliant on a group of people who are working in a highpressure environment and are often coping with stress and fatigue. As we well know, this combination of factors may have a detrimental impact on our teamwork. These factors have a prevailing impact on our labour ward environment. Unlike the operating theatre where surgeons, anaesthetists, nurses and technicians work together on a daily basis 2, the ‘Labour Ward Emergency Team’ only comes together in an urgent situation. Medical training emphasises technical skills in managing crises. Making the correct diagnosis, prescribing medication and dissecting the appropriate tissue are paramount above communicating in a courteous yet effective manner with all our colleagues. Our performance as healthcare professionals is undermined in emergency situations when our colleagues choose to bark orders instead of communicating and in some extreme cases, even hurl instruments. This type of behaviour has been the standard for too long in medicine. We need to look for proactive ways to improve our working environment as well as encourage team work. I believe teams function better if they have met before hand. Whilst this is often difficult in large hospitals, it is not impossible. Attending each other’s staff meetings, introductions in the labour ward and theatre or ‘coffee’ are informal ways that we can encourage team interaction. Communication is made easier when the barrier of hierarchy is removed. The aviation industry has used methods such as simulated emergencies specifically challenging team performance in an emergency situation. Although not verified, the aviation ‘Crew Resource Management’ approach has more than likely contributed to the dramatic increase in aviation safety 3. As we face more deliveries and complex obstetric cases each year, we should add non-technical skills to our training focus in the labour ward. Because, there is no ‘I’ in team! Barbara Chia Fellow in Anaesthesia RWH References 1. Leape LL, Error in Medicine. JAMA. 1994; 272:1851-7. 2. Sexton JB, Thomas EJ, Helmreich RL, Error, stress and teamwork in medicine and aviation: cross sectional surveys. BMJ 2000; 320:745-749. 3. Pizzi L, Goldfarb NL, Nash DB. Chapter 44. Crew Resource Management and its Applications in Medicine. Making Health Care Safer. A Critical Analysis of patient safety practices. University of California at San Francisco 2/09/03. Pharmacy news Metronidazole Dosing Oral or IV? 12 hourly or 8 hourly? There is a wide variation in dosing practice at the RWH. Metronidazole (Flagyl®, Metrogyl®, Metronide®) has a serum peak 1-2hrs after an oral dose and a half life of 6-14hrs. The minimum inhibitory concentration (MIC) of metronidazole required to inhibit 90% or more of most Gram-negative and Grampositive anaerobes ranges from 0.25 to 4 mg/L (Freeman et al, 1997). Items discontinued by manufacturer Vitamin B Group and ascorbic acid injection Morphine-aspirin tablets Conjugated oestrogens injection Cefotetan injections Intravite® Morphalgin® Premarin IV ® Apatef® Stock items currently unavailable Oxycodone 30mg suppositories (expected late April 2004) (consider oral oxycodone tablets or morphine injections) Metaraminol 10mg injection (expected late April 2004) (consider phenylephrine injections – see dosage chart – avail in operating theatres) Recent Australian Adverse Drug Reaction Bulletins ‘For the treatment of mixed aerobic and anaerobic infection in these guidelines, metronidazole is recommended in a dose of 400 mg orally and 500 mg IV, with a 12-hourly dosing schedule. This is based on pharmacokinetic data and minimum inhibitory concentrations of the pathogens involved, rather than formal clinical studies.’(Antibiotic Guidelines 2003). So, the dosage recommended is: 400 mg orally every 12hours or 500 mg IV every 12hours or 500mg rectally every 12 hours. As excellent absorption means that tablets and suppositories achieve optimal blood levels, always consider, is IV use necessary? Swee Wong There have been several recent reports in the Australian Adverse Drug Reaction (ADR) Bulletins that are relevant to the Royal Women’s Hospital these are worth a browse. Details can be found on www.tga.health.gov.au/adr Australian ADR Bulletin Edition Report June 2003 Pregnancy despite medroxyprogesterone Implanon and vaginal bleeding Hyponatraemia with SSRIs August 2003 Maternal SSRI use and neonatal effects October 2003 Anti-epileptic drugs, pregnancy and foetal malformations Hormone replacement therapy December 2003 Meningococcal C vaccine: early experience Post-partum NSAIDs may cause hypertension February 2004 Serotonin syndrome Victorian Travelling Fellowship Program The Victorian Travelling Fellowship Program is for health professionals, clinicians and managers presently working within the Victorian Public Health System and aims to increase innovation and improve patient care by encouraging international learning and information sharing. The Program gives Fellows a chance to conduct short professional investigations that will be of value professionally and personally. The program offers short fellowships of up to 12 weeks to study a host country’s health system and to exchange interventions, methodologies and experiences with overseas colleagues. Fellows will receive funding up to a maximum of A$12,000. See http://www.health.vic.gov.au/travelfellowships/ for details. Applications close 18th July 2004. Mary Draper, telephone: (03) 9344 2722 or email: [email protected] Please let the associate editors have your views on the contents of this newsletter, or any other matters involving clinical practice which may be of interest to our readers. Susan Braybrook, telephone: (03) 9344 2606 or email: [email protected] The Quality and Safety Unit homepage www.rwh.org.au/quality_rwh Weiqing Huang, email: [email protected] Jean Wong, telephone: (03) 9344 2752 041341 Designed by the Educational Resource Centre, Women’s & Children’s Health. May 2004 Surgical patients given either METRONIDAZOLE 400 mg orally every 12 hours or METRONIDAZOLE 500 mg intravenous (IV) every 12 hours achieved and maintained serum concentrations in excess of the MICs for most obligate anaerobes. Trough serum concentrations averaged 5.5 mg/L and 6.7 mg/L with the oral and IV routes, respectively (Earl et al, 1989).
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