23andMe Research:
By the People, For the People
Carrie Northover, PhD
Manager, Research Partnerships
Health Datapalooza 2016
What is 23andMe?
•
Direct to consumer genetic testing company
•
Customers receive raw genotype data and 60+ reports
•
1.2M+ genotyped customers
Copyright © 2016 23andMe, Inc. All rights reserved.
2
Our Mission:
To help people access,
understand and benefit from
the human genome
Copyright © 2016 23andMe, Inc. All rights reserved.
Access: First and only DTC service with
reports that meet FDA standards
35+
Carrier Status*
3
Ancestry
5+
Wellnes
s
19+
Traits
*Our tests can be used to determine carrier status in adults from saliva collected using an FDA-cleared collection device (Oragene DX model
OGD.500.001), but cannot determine if you have two copies of the genetic variant. Each test is most relevant for people of certain ethnicities. The
tests are not intended to diagnose a disease, or tell you anything about your risk for developing a disease in the future. On their own, carrier status
tests are not intended to tell you anything about the health of your fetus, or your newborn child’s risk of developing a particular disease later in life.
Copyright © 2016 23andMe, Inc. All rights reserved.
4
Understand: User Comprehension
•
•
600+ people in 5 cities across the United States
Demographically diverse: age, race/ethnicity, education level
>90%
comprehension
Copyright © 2016 23andMe, Inc. All rights reserved.
5
Our Mission:
To help people access,
understand and benefit from
the human genome
Copyright © 2016 23andMe, Inc. All rights reserved.
Benefit: Personalized Medicine and
More Efficient Drug Development
•
•
Use genetics to personalize treatment
Understand risk to maximize prevention
•
Help industry develop better drugs and diagnostics
using genomic data from everyday people
• Nine out of ten drugs deemed successful in
animal tests fail in human clinical trials
• Drugs with human genetic support are 1.5-2x times
more likely to succeed
Copyright © 2016 23andMe, Inc. All rights reserved.
7
23andMe Research
Opt-in
Participation is easy
IRB approved protocol
Geography
not a barrier
Aggregated and
anonymized
Everyone in multiple
studies
Copyright © 2016 23andMe, Inc. All rights reserved.
8
Engaged Consumers Enable a
New Model for
TotalResearch
of Pink
(1,306 total)
80%
75%
consent
≥ survey
Genotype data
345M+
questions
answered
Phenotype data
Longitudinal data
Biobanked samples
Ability to re-contact
Copyright © 2016 23andMe, Inc. All rights reserved.
maximize
discoveries
through
collaborations
Copyright © 2016 23andMe, Inc. All rights reserved.
Apple ResearchKit Module
Supports existing and new 23andMe
customers
Allows researchers to obtain permission
to access customer data
Two partner apps:
•
Stanford MyHeartCounts
•
Mt. Sinai Asthma Health
Copyright © 2016 23andMe, Inc. All rights reserved.
11
Academic Collaborations
•
30+ ongoing free collaborations
Copyright © 2016 23andMe, Inc. All rights reserved.
12
Academic Collaborations
•PRNP variants previously thought pathogenic are at least
30X more common than expected
•Some benign, others incomplete penetrance → Changed
prognoses, therapeutic clues
Copyright © 2016 23andMe, Inc. All rights reserved.
13
Industry Partnerships
Research Platform (existing participants)
Surveys
Clinical Trial
Recruitment
Copyright © 2016 23andMe, Inc. All rights reserved.
14
Industry Partnerships
Disease Initiatives (new participants)
Copyright © 2016 23andMe, Inc. All rights reserved.
15
Richard Scheller, PhD
CSO and Head of Therapeutics
Former Genentech EVP of research and early development
Lasker Award winner
Member, American Academy of Arts & Sciences Member
Member, National Academy of Sciences
“
I have dedicated my life to research aimed at fulfilling
unmet needs for very sick people….I am excited
about the potential for what may be possible through
23andMe’s database. It is unlike any other.
Copyright © 2016 23andMe, Inc. All rights reserved.
”
By the people, for the people
Participants
database
reports
and
papers
23andMe
Research
23andMe
Therapeutics
therapies
biotech/
pharma
Copyright © 2016 23andMe, Inc. All rights reserved.
17
Copyright © 2016 23andMe, Inc. All rights reserved.