Aneuploidy PGS Report
Tel: 310-497-1335
Fax: 818-936-0511
www.PacGenomics.com
Patient:
DOB:
Specimen:
Abc, Def
11/11/1911
Blastomere (Day 4)
Physician:
Facility:
Address:
Test
performed:
Aneuploidy PGS for 24 chromosomes.
Test date:
07/08/2013
Phone:
Fax:
Biopsied and Cell loaded by: ML
Sample
tube #
1-AD
2-AD
PacGenomics ID
080713-01-D4
080713-02-D4
Analyzed by: ML
CMA results
47, XX, +18
46, XX,
Dr. Smart Smart
Perfect Fertility Center
11111 Wherever Blvd, Suite 11111
Los Angeles, CA 11111
111-111-11111
111-111-11111
Interpretation
Notes
Aneuploidy: trisomy 18
Euploidy
CMA charts
1-AD
080713-01-D4
47, XX, +18
2-AD
080713-02-D4
46, XX,
(Westlake Village office)
PacGenomics
2625 Townsgate Rd, suite 330
Westlake Village, CA 91361
(Thousand Oaks laboratory)
Village Medical Center, suite 203
166 N. Moorpark Road
Thousand Oaks, CA 91360
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Aneuploidy PGS Report
Tel: 310-497-1335
Fax: 818-936-0511
www.PacGenomics.com
Comments and Interpretation
Aneuploidy
Aneuploidy refers to cells with a chromosome number that is not a multiple of the haploid number, i.e., any variation in
chromosome number that involves individual chromosomes rather than entire sets of chromosomes.
Euploidy
Euploidy refers to cells with an exact multiple of the haploid number. For example, a normal diploid human somatic cell
has 46 chromosomes, which is a multiple of the haploid number, 23. A polyploid human somatic cell with abnormal, but
integral, multiples of this full set (e.g. 69 chromosomes) would also be considered as euploid.
Limitations
Chromosomal Microarray is a collection of hundreds of thousands of DNA spots representing specific genomic sites on a
pre-processed glass slide. Preimplantation Genetic Screening (PGS) with Chromosomal Microarray Analysis (CMA) is
to analyze these hundreds of thousands of DNA spots to screen for aneuploidy. The analysis of multiple genomic data
helps enhance the accuracy of PGS.
However, due to a wide variety of factors, including the mosaicism in the early developing embryo, PGS with CMA does
not always identify an aneuploid embryo.
Also, due to the limitation of this technology, PGS with CMA does not detect polyploidy, balanced translocation and
inversion.
The clinical significance of PGS with CMA in detecting chromosomal abnormalities in human embryos has not been
formally validated in double-blind clinical trials. This test does not always detect chromosomal abnormalities of tested
embryos due to potential limitations of the technology. This analysis is not considered as a routine medical care. This test
does not replace amniocentesis or chorionic villus sampling (CVS), which is the gold-standard method of prenatal
diagnosis.
Confirmed by _
_____________
_
Man Li, PhD, HCLD, CLS (MB)
(Westlake Village office)
PacGenomics
2625 Townsgate Rd, suite 330
Westlake Village, CA 91361
(Thousand Oaks laboratory)
Village Medical Center, suite 203
166 N. Moorpark Road
Thousand Oaks, CA 91360
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