University of Texas at San Antonio
Office of Environmental Health, Safety and Risk Management
Chemical Safety Plan
(serves as The UTSA - Chemical Hygiene & Hazard Communication Safety Plan)
Revision 05/17/2011
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i.
Review & Signature Page
This original version of this procedure manual has been reviewed for regulatory compliance and best
management practices by the undersigned individuals and is hereby adopted for use and compliance by
all employees at all University of Texas at San Antonio owned or operated facilities.
Printed Name
Signature
Title
Date
J. Brian Moroney
Signature on file
Director, EHSRM
05/17/2011
Wendy McCoy
Signature on file
Laboratory Safety Manager
05/17/2011
This plan was reviewed/revised on 05/17/2011 and replaces the 07/01/2009 version. Changes to this
plan have been highlighted in “gray” and are summarized below:
Throughout the plan Laboratory Safety Officer has been updated to Laboratory Safety Manager. (not highlighted)
Throughout the plan spelling and grammatical corrections have been made and examples updated. (highlighted)
iiiA1: Updated response procedure.
iiiB2d: Approved eyewash statement added.
IVB5: Reference to Appendix XI and order approval added.
VA6: Clarification on glove removal and hand washing added.
VA9: Clarification on removing or securing jewelry, loose clothing and long hair.
VI:
Update of training descriptions.
VIIB2C: HF guidelines updated.
VIIC9: Update on need for secondary containment for chemical storage.
IXB4: Update on not wearing gloves outside the laboratory.
Appendix VII: Updated policy.
Appendix X:
Updated procedures.
Appendix XI:
Policy added to the plan.
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ii. Table of Contents
iii. Emergency Procedures and Contact Information.................................................... 5 I. Overview and Purpose ............................................................................................ 7 II. Scope ...................................................................................................................... 7 III. Periodic Review....................................................................................................... 7 IV. Responsibilities........................................................................................................ 7 V. General Laboratory Safety Guidelines .................................................................... 9 VI. Training Requirements .......................................................................................... 10 VII. Chemical Laboratory Safety .................................................................................. 11 VIII. Hazard Communication and the Texas Hazard Communication Act .................... 19 IX. Personal protective equipment (PPE) ................................................................... 21 X. Laboratory equipment............................................................................................ 23 XI. Chemical Waste Management .............................................................................. 26 XII. Laboratory Deactivation and Equipment Disposal................................................. 26 XIII. References ............................................................................................................ 27 XIV. Appendices............................................................................................................ 27 Appendix I: Notice to Employees ................................................................................... 29 Appendix II – Laboratory Specific Chemical Hygiene Plan ............................................ 31 Revision 05/17/2011
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Appendix III: Chemical carcinogens regulated by OSHA .............................................. 41 Appendix IV: Peroxide Forming Chemicals................................................................... 42 Appendix V: Extremely Hazardous Substance (Texas Tier II) List ............................... 44 Appendix VI: Memorandum of Understanding - DPS & THECB .................................... 65 Appendix VII: UTSA Policy on Controlled Substance Use in Research....................... 71 Appendix VIII. Drug Scheduling .................................................................................... 84 Appendix IX: Liquid Nitrogen Storage and Use............................................................. 93 Appendix X: Laboratory Clean out / Clearance Procedure ............................................ 97 Appendix XI: Hazardous Materials Requiring Institutional Approval…………………….99
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iii.
Emergency Procedures and Contact Information
Due to the multiple hazards associated with laboratories, incidents are inevitable.
Preparedness for emergencies is essential. A timely and efficient response can help minimize
or avoid injury and damage to property. For a comprehensive discussion of UTSA emergency
procedures, including internal (fire, bomb threat) and external (tornado, flooding) emergencies,
see UTSA’s Community Emergency Response Guide.
A. Chemical Spills
Response to chemical spills must be thorough and prompt to prevent further injury or
contamination.
Each laboratory should design its own response plan based on its unique hazards and the
location of the laboratory, in conjunction with the following general guidelines:
1.
Notify the people in the immediate area and, if necessary, evacuate the laboratory. The decision
to evacuate is a judgment call based on the properties and hazards of the spilled chemical. If
toxic or noxious gases or vapors result from the spill, evacuation should follow. If the vapors
have escaped the laboratory, contact Facilities Operations immediately and tell them to shut off
air handlers to prevent the spread of toxic vapors. If vapors are contained within the laboratory,
exhaust should be allowed to remove the vapors. If flammable gases or vapors result from the
spill, turn off all sources of ignition in the laboratory, if it is safe to do so. Operations can be
reached at X5277 or 458-5277.
2.
Always attend to injured people before attending to the spill. Skin areas splashed by chemicals
should be rinsed with water for at least 15 minutes in a sink, emergency shower or eyewash as
appropriate. After thorough rinsing, seek medical help. Be sure to have the identity and other
information—preferably the MSDS—about the chemical available for the medical help.
3.
Try to contain the spill to keep it from spreading. Contact EHSRM at x5250 to advise or assist in
the containment, neutralization, and cleanup of the spilled chemical. Do not attempt to clean the
spill without proper spill-control supplies or equipment.
4.
If the spill or release is likely to affect other facilities within the building or campus or emergency
medical treatment is warranted, contact the UTSA Police Department. UTSAPD can be
reached in an emergency at x4911 on a campus phone and 458-4911 on an outside phone,
such as a cell phone. For the fastest response possible, UTSAPD must be contacted.
B. Emergency equipment
Laboratory emergency equipment includes emergency showers, eyewashes and fire
extinguishers. Staff in laboratories that do not have their own emergency shower, eyewash
station, or fire extinguisher should know where the closest one is located.
1.
Showers
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An emergency shower can be used to suppress a fire or, more commonly, to decontaminate
someone who has been exposed to chemicals.
a. Remove clothing, jewelry and shoes while standing under the shower. These items trap
chemicals against the skin and will increase the damage if not removed.
b. Remain under the shower for at least 15 minutes to ensure adequate flushing of exposed
areas.
c. Seek medical attention.
d. If the shower does not have a drain, promptly clean up the water to prevent slip hazards.
e. Always keep the area under an emergency shower unobstructed.
2.
Eyewashes
a. If chemicals are splashed into your eyes, hold your top and bottom eyelids open and flush
with water continuously for at least 15 minutes. Move the eye up and down and sideways to
wash thoroughly behind the eyeball where chemicals could be trapped.
b. Seek medical attention.
c. Always flush your eyes immediately if chemicals are splashed into them. Even a delay of a
few seconds could cause permanent damage.
d. Continuous-flow eyewashes are preferred over the portable, squeeze-bottle type, whose
disadvantages include an insufficient supply of water (not 15 minutes’ worth) and easy
contamination with microorganisms. Squeeze-bottle eyewashes also require the use of
your hands to operate, preventing you from holding your eyelids open. For these reasons,
only continuous-flow eyewashes are approved for use at UTSA.
e. To ensure a clean supply of water in the eyewash, operate it weekly to flush out any
impurities.
3.
Contact Information:
Emergencies (Medical or Chemical):
Contact Police Dispatch - call 911 or x4911 from
campus phone. If using a cell phone call 458-4911.
Minor Chemical Spills / Assistance:
Contact EHSRM – call x5250 or 458-5250.
To Report Occupational Injuries:
Contact EHSRM – call x5250 or 458-5250.
Before or After Operational Hours:
Contact Police Dispatch - call 911 or x4911 from
campus phone. If using a cell phone call 458-4911
(Operation Hours = Mon – Fri: 8 AM – 5 PM)
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I.
Overview and Purpose
Research and education in science laboratories involve a variety of hazards. It is the University
of Texas at San Antonio’s (UTSA) policy to protect and promote the health and safety of
students and employees and the environment. These policies are outlined in the University’s
Handbook of Operating Procedures (HOP) www.utsa.edu/hop/chapter9/: most specifically in
HOP 9.5 - Occupational Safety and Health and HOP 9.6 - Compliance with the Texas Hazard
Communication Act. Faculty, staff and students who may be exposed to chemical hazards in
the laboratory should be informed of the nature of these hazards and how to protect
themselves and others who may also be exposed. Further information on general chemical
safety or specific items can be obtained through the Environmental Health Safety and Risk
Management (EHSRM) office. The EHSRM main office phone number is (210) 458-5250.
This Chemical Hygiene & Hazard Communication Safety Plan outlines basic good laboratory
practice and safety procedures, special procedures for this institution, and will give reference
to other sources of information to include federal and state guidelines that deal with work in
laboratories that use and store chemical agents. This plan was prepared by EHSRM personnel
after review of pertinent federal and state regulatory requirements from the Occupational
Safety and Health Administration (OSHA), the Drug Enforcement Administration (DEA), the
Texas Department of State Health Services (TDSHS), and the Texas Commission on
Environmental Quality (TCEQ).
II.
Scope
This plan applies to all UTSA operated (leased or owned) facilities and equipment (including
vehicles). It also applies to any UTSA employee, volunteer or student worker who works
directly with chemicals, or is in close proximity to anyone conducting research using chemicals
which falls under federal and state regulations or guidelines who should be familiar with all
portions pertinent to their work.
This plan discusses safe practices and procedures for research and educational laboratories. It
is not intended to be a fully comprehensive reference but rather a starting reference. There
may be chemicals, procedures and other circumstances in each laboratory that present unique
or unusual hazards not addressed here; these hazards are best addressed by the principle
investigator or supervisor of the respective laboratory with specific operating procedures
developed in consultation EHSRM if necessary. Questions can be addressed to the Laboratory
Safety Manager who also serves are the Chemical Hygiene Officer through EHSRM at 4585250.
III.
Periodic Review
This plan will reviewed at least every 3 years for needed or required updates. This plan’s
online version should be reviewed periodically for updates.
IV.
Responsibilities
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A. The Office of Environmental Health Safety and Risk Management (EHSRM) will:
1.
Have its Director serve as the Institutional / Campus Safety Officer as per HOP 9.6.
2.
Hire a qualified staff member to serve as the institution’s designated Chemical Hygiene Officer
and provide consulting services to the UTSA community for work with chemical agents. The
Laboratory Safety Manager serves as the designated Chemical Hygiene Officer.
3.
Establish the general procedures, policies and standards for the use of chemicals and hazards
they may present at UTSA in conjunction with the Laboratory Safety Committee.
4.
Develop and maintain safety plans and training programs relevant to the safe use, storage and
disposal of chemicals agents.
5.
Review applications and protocols for work with chemical agents and provide recommendations
for the safe use, storage and disposal of chemicals per established procedures. Approve the
purchase and use of hazardous chemicals and toxins that may require institutional approval.
6.
Maintain a chemical waste disposal program.
7.
Supervise decontamination and clean up activities following chemical spills.
8.
Investigate chemical spill and / or potential exposure incidents. Provide chemical monitoring to
determine potential exposure levels where appropriate.
9.
Evaluate laboratories periodically to ensure compliance with institutional, state and federal
guidelines and regulations.
B. Principal Investigators (PI), Laboratory or Technical Supervisors will:
1.
Enforce all UTSA standard operating procedures (SOP’s) and policies regarding chemicals.
2.
Develop specific safety procedures or protocols for the safe use, storage and disposal of
chemicals in their laboratory. Reference Appendix II – Laboratory Specific Chemical Hygiene
Plan
3.
Determine who within their laboratory need chemical hygiene and hazard communication
training and ensure laboratory personnel to include staff, students, volunteers and visiting
researchers have been properly trained to work safely within their laboratory or work area.
4.
Ensure that new staff attends mandatory Hazard Communication and Laboratory Safety
Training and/or Hazardous Waste Generator’s Courses as appropriate to their work and offered
by EHSRM prior to direct contact with hazardous chemicals or toxins.
5.
Advise the Office of EHSRM of any significant protocol changes and also prior to bringing new
hazardous chemical(s) onto campus. Some chemicals, biologicals and equipment require
approval prior to ordering.
See Appendix XI Hazardous Materials Requiring Institutional
Approval.
6.
Immediately report any exposures, spills, thefts or other incidents involving chemicals to
EHSRM for investigation or assistance.
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7.
Provide the Office of EHSRM with an updated and verified chemical inventory of each
laboratory or work area with chemicals at least annually.
8.
Maintain a clean and sanitary workplace.
9.
Report any plans to remodel or alter UTSA facilities (Refer to HOP 8.3 - Remodeling and/or
Alterations to University Facilities) to Facilities and EHSRM and gain permission before
proceeding.
C. Laboratory Staff or Worker will:
1.
Observe the established guidelines, departmental SOP’s and UTSA policies and procedures for
chemical safety to include accessing and reviewing MSDS’s as appropriate to determine hazard
characteristics and handling procedures.
2.
Attend all necessary or required training – refer to Section VI – Training Requirements. Only use
hazardous chemicals for which they’ve been properly trained to handle and use.
3.
Properly dispose of all laboratory wastes in accordance with laboratory standard operating
procedures and UTSA waste management policy
4.
Report all spills or incidents to their supervisor and EHSRM if necessary.
5.
Report to the PI, lab supervisor or EHSRM any unsafe practices or conditions in the laboratory.
D. The Laboratory Safety Committee will:
V.
1.
Assist in reviewing new safety issues involving laboratories at UTSA facilities and compliance
with established regulatory and institutional policy.
2.
Review facility and maintenance safety issues involving laboratories.
3.
Review continuing safety issues involving laboratories and recommend corrective action.
4.
Have as its chairperson an Assistant VP or higher level representative from the Provost’s Office,
VP for Research, or VP for Business Affairs and contain a minimum of one Assistant VP or
higher level person to represent each of these offices.
5.
Have as serving members the Director of EHSRM, the Director of Facilities Operations &
Maintenance and the Laboratory Safety Manager. Additional members / attendees may be
approved by the chairperson.
6.
Meet at least once per quarter.
General Laboratory Safety Guidelines
Everyone in the laboratory is responsible for his or her own safety and the safety of others.
Before starting any work in the laboratory, become familiar with the procedures, equipment
and chemicals that will be used and learn how to protect yourself from any associated hazards.
If you don’t understand something, ask! Each laboratory should have a chemical hygiene plan
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in place. The generic chemical hygiene plan for UTSA can be found in Appendix II. Below are
guidelines for working safely in a laboratory.
A. Guidelines
1.
Students should never work alone or unsupervised in the laboratory.
2.
If you must work alone, tell someone where you’ll be and have him or her check on you
periodically.
3.
Report dangerous activities or situations to your laboratory supervisors; if they do not respond
promptly or appropriately, contact EHSRM.
4.
Always incorporate safety into your experiments and anticipate and account for things that could
go wrong. Never compromise safety in the interest of time.
5.
Remove gloves before handling items such as the telephone, doorknobs and computer
keyboards.
6.
Always remove gloves and wash hands thoroughly before leaving the laboratory.
7.
Designate specific break areas outside the laboratory for eating and drinking. Remember,
smoking is not allowed in UTSA buildings.
8.
Store food and drinks in refrigerators designated for that use only, away from areas containing
chemical, biological or radiological hazards.
9.
Be aware of dangling jewelry, loose clothing or long hair that might get caught in equipment.
Secure or remove these items in order to work safely.
10. Do not wear shorts, sandals or open-toed shoes in the laboratory. Shoes which completely
cover the foot and shed liquids provide the most protection and should be worn in the
laboratory.
11. Always wear appropriate personal protective equipment.
12. Keep aisles and walkways clear and drawers and cabinet doors closed while you’re working.
13. Do not store hazardous chemicals on the floor in high-traffic or open areas.
14. Never pipette by mouth.
15. Do not allow minors (anyone under 18 years of age) into the laboratory without prior approval.
Additional parental consent forms may also be required.
VI.
Training Requirements
A. Hazard Communication and Laboratory Safety Training
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Hazard Communication (HazCom) training is mandated by both the federal and state
governments (Texas Health & Safety Code, Title 6, Chapter 502 – Hazard Communication
Act, section 502.009). If you will be exposed to hazardous chemicals within your work area,
you must attend the HazCom training course. Hazardous chemicals are defined as
chemicals which have a physical or health effect. An irritation is a health affect. This training
must be completed before the employee works with, or in an area containing, any hazardous
chemical.
B. Hazardous Waste Generator Training
Hazardous Waste Generator training covers chemical and biological waste disposal
procedures in accordance with federal, state and local regulations. Generators must
understand the requirements for proper bulking, packaging, labeling and disposal of
hazardous waste.
C. Laboratory / Work Area Specific Training
Each PI, Laboratory or Technical Supervisor of a laboratory or work area must provide
training in the specific standard operating procedures of that work area relative to chemical
use, storage and disposal. This training supplements the general training provided by the
EHSRM courses. This training should be documented with the subject matter covered,
date(s) of training and attendees. Refer to Appendix II – Laboratory Specific Chemical
Hygiene Plan.
VII.
Chemical Laboratory Safety
You need to be familiar with the hazardous chemical substances you are working with in the
laboratory. Being able to recognize the physical and health hazards of a chemical before you
handle it is very important. Once the potential hazards of a chemical have been determined,
you can take the appropriate steps in the handling and storage of that chemical to protect
yourself and others.
A. Classification of chemical hazards
The hazard a chemical presents depends on its physical and toxicological properties.
Chemicals are considered a physical hazard if they are flammable or reactive (i.e.,
unstable—including explosives, organic peroxides, monomers, pyrophorics, and water
reactives), or if they are combustible liquids, oxidizers or compressed gases. Chemicals that
present a physical hazard are classified according to their hazardous properties. Chemicals
that can cause reversible or irreversible damage to the human body are considered health
hazards and are classified as toxics. This classification includes systemic poisons, irritants,
carcinogens, asphyxiants, teratogens, mutagens, anesthetics and corrosives. Be aware that
many chemicals exhibit multiple hazards, in which case, the more prevalent hazard must be
considered. Contact EHSRM for help in identifying chemical hazards if you are unsure or
need further guidance on proper handling.
1.
Flammables
A flammable is any solid, liquid, vapor or gas that ignites easily and burns rapidly.
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A flammable solid is a solid, other than an explosive, that ignites readily and burns vigorously.
Examples: magnesium, sulfur, decaborane, and anhydrous sodium sulfide.
A flammable liquid is a liquid that gives off vapors readily ignitable at room temperature. The
Department of Transportation (DOT) defines it as a liquid with a flash point at or below 141°F,
and NFPA and OSHA define it as a liquid with a flash point below 100°F. (The flash point of a
liquid is the temperature at which sufficient vapors are given off by the liquid to form an ignitable
mixture with air.) Many common organic solvents have flash points well below room temperature,
including acetone, ethyl ether, hexane and benzene.
A flammable gas is a gas that at normal atmospheric pressure forms a flammable mixture with
air. Examples: hydrogen, acetylene and propane.
2.
Combustible liquids
The DOT defines a combustible liquid as a liquid with a flash point above 141°F and below
200°F. NFPA and OSHA define it as a liquid with a flash point at or above 100°F but below
200°F. These liquids, even though not classified as flammable liquids, still present a significant
fire hazard. Examples: kerosene, glacial acetic acid and phenol.
3.
Reactives
A chemical is reactive, or unstable, if it has a tendency to undergo chemical reaction either by
itself or with other materials with the release of energy. Undesirable effects such as pressure
build-up, temperature increase or the formation of noxious, toxic or corrosive byproducts may
occur because of the chemical’s reactivity to heating, shock, direct contact with other materials or
other conditions in use or in storage. Reactives can be divided into the following hazards:
a. Explosives. A material that produces a sudden, almost instantaneous release of pressure,
gas and heat when subjected to abrupt shock, pressure or high temperature. Examples:
“dry” picric acid (2, 4, 6-trinitrophenol), 2, 4, 6-trinitrotoluene (TNT) and nitroglycerine.
b. Organic peroxides. An organic compound containing the bivalent -O-O- structure. These
chemicals are very unstable and may be explosive. A common organic peroxide is benzoyl
peroxide.
c. Monomers. Under appropriate conditions, monomers undergo polymerization, in which the
monomers combine with each other to form repeating structural units, or a polymer. If not
controlled, polymerization can occur at a rate that releases large amounts of energy that
can cause fires, explosions or burst containers. Examples: formaldehyde and styrene.
d. Pyrophoric. A material that ignites spontaneously in air. Pyrophoric chemicals are also
known as air-sensitive compounds or as spontaneously combustible. Examples: the Alkali
metals (sodium, potassium), hydrides (lithium aluminum hydride) and white phosphorus.
e. Water reactive. A material that by contact with water becomes spontaneously flammable or
gives off a flammable or toxic gas. Examples: the Alkali and Alkaline Earth metals, hydrides
(sodium borohydride) and strong acids (sulfuric acid).
4.
Oxidizers
An oxidizer is a material that yields oxygen readily to cause or enhance the combustion
(oxidation) of organic matter. Materials that do not contain oxygen can also be oxidizers because
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of their ability to accept electrons. Examples: nitrates, permanganates, dichromates, peroxides,
nitric acid, perchloric acid and chlorine.
5.
Compressed gas
A compressed gas is any material which at room temperature and atmospheric pressure is a gas,
but is contained under pressure as a compressed, liquefied or dissolved gas. Compressed gases
present a physical hazard due to the storage pressure, but can also exhibit overt hazards such
as, flammability, corrosivity, or toxicity. Examples: hydrogen (compressed gas), acetylene (gas
dissolved in a solvent) and chlorine (liquefied gas).
6.
Cryogenic Materials
A cryogenic material is one which is a gas at room temperature that has been cooled to a
temperature where it condenses to a liquid. Cryogenic materials present a physical hazard due
to their extremely cold temperatures (less than -150o C). Examples: liquid nitrogen (LN2), liquid
oxygen and liquid helium.
7.
Toxics
A toxic is any chemical that, when ingested, inhaled or absorbed, or when applied to, injected
into, or developed within the body in relatively small amounts, by its chemical action may cause
damage to biological structure and/or disturbance of biological function.
Damage can be local (direct) or systemic (indirect). Local toxicity is the effect of a substance on
the body area that has been exposed to the substance. Systemic toxicity is the effect of a
substance on body tissue after absorption into the bloodstream.
Damage can also be acute (immediate) or chronic (delayed). Acute toxicity is the effect
manifested on short exposure or single contact. Chronic toxicity is the effect observed when a
toxic substance acts on the body over time. This can be due to multiple or continuous exposure.
Toxicity is affected by the following parameters: routes of entry (skin, nose, mouth, eye, lungs or
stomach), dose, exposure duration, physical condition and sensitivity of exposed individual,
synergistic effects with other chemicals, and other parameters such as age, sex and race.
Remember that all chemicals are potentially toxic—the dose makes the poison!
Toxics can be divided into the following hazards:
a. Systemic toxics. Materials which, after entering the bloodstream, adversely affect a
particular body organ or system (target organ). Systemic toxics can be classified as
1)
Hematotoxins. Chemicals that affect blood-forming tissues. Examples: cyanides and
benzene.
2)
Neurotoxins. Chemicals that affect the nervous system. Examples: carbon disulfide and
mercury.
3)
Nephrotoxins. Chemicals that damage the kidneys. Examples: chloroform and carbon
tetrachloride.
4)
Hepatotoxins. Chemicals that damage the liver. Examples: ethanol and carbon tetrachloride.
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b. Irritants. Materials that cause a reversible inflammatory effect on living tissue. Examples:
nickel, dilute solution of ammonia and acetone.
c. Carcinogens. Materials that cause cancer in humans or, because they cause cancer in
animals, are considered capable of causing cancer in humans. Examples: carbon
tetrachloride, formaldehyde, chloroform and benzene. See Appendix III for a list of
carcinogens regulated by OSHA.
d. Asphyxiants. Vapors or gases that can cause unconsciousness or death by suffocation.
Asphyxiants can be classified as simple or chemical.
1)
Simple asphyxiants. Materials that displace available oxygen in the air. Examples: nitrogen
and carbon dioxide.
2)
Chemical asphyxiants. Materials that reduce the blood’s ability to carry oxygen or interfere in
the body’s utilization of oxygen. Examples: carbon monoxide and hydrogen cyanide.
e. Anesthetics. Materials that depress the central nervous system, producing loss of sensation
or feeling. Examples: chloroform and ether.
f. Teratogens. Materials that cause physical defects in a developing embryo. Example: lead.
g. Mutagens. Materials that induce genetic mutations in DNA, usually by chronic exposure.
Examples: ethidium bromide and formaldehyde.
h. Corrosives. Materials that by direct action are damaging to body tissue or corrosive to
metal. Damage can range from minor skin irritation to actual physical disruption of body
tissue. Note that corrosives are also physical hazards. Examples: ammonia and chlorine
(gases), acids, bases, and bromine (liquids), and phenol (solids).
B. Chemical safety guidelines
Chemical hazards in the laboratory are varied and numerous. You should develop a healthy
respect for all chemicals, even those that are designated “safe” or “benign,” because
evidence may develop indicating that continued exposure may cause unexpected or
cumulative adverse effects. Never take chemical safety for granted.
Follow these general and chemical-specific guidelines for the safe handling and use of
chemicals in the laboratory.
1.
General guidelines
a. Be familiar with the chemicals you work with. Review the container labels and MSDS's for
information on the associated hazards and how to protect yourself. The more you know
about the chemicals you work with, the better you can protect yourself.
b. Always return chemicals to their proper storage location after use.
c. Perform all work with volatile and toxic chemicals in the fume hood.
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d. Do not leave chemical containers open any longer than it takes to remove what you need.
This will help minimize exposure to the chemicals and potential contamination of the
chemicals.
e. Be sure that all chemical containers are properly labeled in your laboratory. Do not use a
chemical from an unlabeled container if you are not sure of the contents.
f. Exercise great care when transporting chemicals within or between laboratories. When
transporting chemicals between floors, use the freight elevator, if one is available.
Polyethylene or rubber acid/solvent bottle carriers and utility carts for transportation provide
effective protection and containment in the event of an accident.
g. Use flammables only in an area free of ignition sources.
h. Use absorbent paper on work surfaces to help contain spills for those chemicals which are
not reactive with paper.
2.
Chemical-specific guidelines
The following chemicals deserve special attention because of their extremely hazardous
nature. These are by no means the only extremely hazardous chemicals which may be in
use on campus; therefore, it is important to review the hazards of each chemical prior to
working with it. A more thorough list of extremely hazardous chemicals can be found in
Appendix V.
a. Ethers
Ethers such as ethyl ether, isopropyl ether, p-dioxane and tetrahydrofuran deserve special
attention because of their tendency to react with oxygen from the air to form explosive
peroxides. These peroxides may detonate with extreme violence when they become
concentrated by evaporation or distillation or when they are exposed to unusual heat,
shock or friction. These are examples, not an extensive list of peroxide formers. A more
extensive list can be found in Appendix IV.
Peroxides may form in “unstablized” ethers in as little as three days. Exposure to light and
air, as in opened and partially emptied containers, accelerates the formation of peroxides
in ethers. It is important to keep ether containers tightly closed when they are not in use
and to store them in a dark place. “Stabilized” ethers, which contain peroxide inhibitors,
are available and should be used whenever possible.
The presence of peroxides can be determined with potassium iodide test strips, which turn
black in the presence of peroxides. Once the presence of peroxides is confirmed, they can
be reduced with a 30% aqueous ferrous sulfate solution (40 grams for each liter of ether).
Removal of the peroxides can be confirmed by the potassium iodide test strips. Peroxide
decontamination should only be carried out by experienced faculty.
Follow these guidelines for the proper use of peroxide-forming ethers in the laboratory:
1)
Clearly mark each container of ether with the date of receipt and the date it was first opened
to ensure disposal at the appropriate time.
2)
Unopened bottles of ether should be discarded after one year. Opened bottles of ethyl ether,
p-dioxane and tetrahydrofuran should be discarded after six months, and isopropyl ether
should be discarded after three months.
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3)
Test for peroxides frequently, especially when evaporating or distilling. Never distill ether to
dryness. Note the date and result of each test on the bottle.
4)
If crystals are observed around the cap of a container of ether, do not open it. The friction of
opening the container can be sufficient to detonate the peroxides.
5)
Since ethers have a limited shelf life, they should be bought in the smallest containers
possible (appropriate to the rate of usage in the laboratory). The cost and hazards of
disposal far outweigh any of the benefits of buying in bulk.
b. Perchloric acid
Perchloric acid can be dangerously reactive. Aqueous perchloric acid at concentrations
less than 70% at room temperatures is a strong acid. At elevated temperatures or
concentrations greater than 70% it is a strong oxidizing agent and can cause violent
explosions if misused. Anhydrous perchloric acid (greater than 85%) is unstable even at
room temperatures and ultimately decomposes spontaneously with a violent explosion.
Contact with oxidizable material can cause an immediate explosion.
Follow these guidelines for the proper use of perchloric acid in the laboratory:
1)
Perchloric acid in concentrations greater than 70% is not recommended.
2)
Any procedure involving heating of perchloric acid must be conducted in a properly
functioning perchloric acid fume hood with the sash down.
3)
Do not allow perchloric acid to come into contact with organic material or dehydrating
agents.
4)
Anhydrous perchloric acid should only be made as required and should never be stored.
Only experienced faculty should handle anhydrous perchloric acid. EHSRM should be
contacted prior to any work with anhydrous perchloric acid.
5)
Do not allow contact with metals to prevent the formation of metal perchlorates which are
very unstable and can explode.
6)
Do not allow contact with wood or paper as fires can result from such contact.
c. Hydrofluoric acid
Hydrofluoric acid (HF) is an extremely corrosive material. All forms, including vapors and
solutions, can cause severe, slow-healing burns to human tissue, including the lungs and
eyes. At concentrations greater than 50% the burning is noticeable in a matter of minutes
or less, while at concentrations below 50% the burns may not be felt until several hours
after exposure. Burns from concentrated acid involving as little as 2.5% of body surface
have resulted in death. Because it has a low boiling point and a high vapor pressure, HF
must be kept in a non-glass pressure container. HF dissolves glass; therefore, it should
never be stored in a glass container.
Follow these guidelines for the proper use of hydrofluoric acid in the laboratory:
1)
Have calcium gluconate available prior to acquiring or working with HF.
2)
Never work alone with HF.
3)
Always use HF in a properly functioning fume hood. Heating of HF, or its solutions,
requires an acid digestion fume hood.
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4)
In work involving HF, be sure to use materials that are compatible with HF. HF attacks a
variety of materials, including glass, concrete, cast iron, wood, leather and rubber. Lead,
wax, polyethylene, polypropylene and Teflon will resist its corrosive action.
5)
In HF exposures, time is crucial. Immediately wash the affected area(s) with copious
amounts of water to minimize the extent and the depth of the burn. Never let a HF burn go
untreated, as extensive damage could result. Any area that is exposed to HF must be
treated immediately with calcium gluconate or another appropriate material to stop its
reaction with human tissue. Medical attention should be sought as quickly as possible.
Ensure medical personnel are aware that HF is involved. Mistakes in treatment can occur
if a miscommunication results in treatment for a hydrochloric acid burn instead of a
hydrofluoric acid burn.
d. Mercury
Mercury and its compounds are very common in laboratories. Because of its widespread
use, mercury’s hazardous nature may be overlooked or ignored. Elemental mercury is
volatile, and its vapors are extremely toxic. Because of the vapors’ high toxicity, it is very
important to clean up mercury spills promptly and thoroughly. If this is not done, mercury
can accumulate and vaporize over time. Inorganic and organic mercury compounds are
also highly toxic.
Follow these guidelines for the proper use of mercury in the laboratory:
1)
All work with elemental mercury should be performed over trays to capture and contain any
spillage.
2)
All work involving mercury should be done in a properly functioning chemical fume hood.
3)
Clean up all mercury spills immediately. If you do not have the appropriate spill-control
equipment, do not clean the spill yourself, as you can make the situation worse by
creating small droplets that can end up in inaccessible locations such as cracks and
crevices. For assistance, contact EHSRM.
4)
Be careful not to heat any surfaces that may contain mercury residue, as increased
temperature greatly increases the vapor pressure of mercury.
5)
Red spirit thermometers are a nontoxic alternative to mercury thermometers and should be
used whenever possible.
e. Chemical carcinogens
Several common laboratory chemicals, such as benzene, chloroform and formaldehyde,
are suspected or known carcinogens. It is prudent to treat suspected carcinogens as if
they are confirmed carcinogens. These chemicals may also have other physical or health
hazards that should not be overlooked.
Follow these guidelines for the safe use of carcinogens in the laboratory:
1)
Minimize the use of carcinogens in the laboratory by using nontoxic or less toxic alternatives
whenever possible.
2)
All work with chemical carcinogens should be done in a properly functioning fume hood.
3)
All carcinogens in the laboratory should be labeled clearly and secured when not in use.
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4)
Personal protective equipment and hygiene are very important when working with chemical
carcinogens. While the fume hood should provide respiratory protection, you must also
protect your hands to avoid skin absorption. Particularly for solvents, be sure to use
protective gloves that are resistant to the chemical you are using. Wash your hands
promptly after removing gloves or when a carcinogen (or any chemical) has contacted
your skin.
C. Chemical storage
Proper chemical storage within the laboratory is an essential part of an effective laboratory
safety program. Follow these general guidelines for the safe storage of chemicals in the
laboratory:
1.
Do not indiscriminately store chemicals in alphabetical order. This can lead to incompatible
chemicals being stored next to each other. Instead, store chemicals according to their
hazards—for example, flammables, corrosives, toxics, reactives, etc. For chemicals that have
multiple hazards, segregate according to the most prominent hazard.
2.
Flammable liquids should be stored in a flammable storage cabinet. Amounts of Class IA
flammable liquids (flash point less than 73°F and boiling point less than 100°F) in the laboratory
should be kept to a minimum.
3.
Corrosives should be stored in a corrosive storage cabinet. However, acids and bases should
be stored separately to prevent their mixing and reacting violently in the event of an accident.
4.
Strong oxidizing agents should be stored away from organic materials and strong reducing
agents to prevent the risk of fire and/or violent reactions in the event of an accident.
5.
Cyanides and sulfides should be stored well away from acids to prevent the generation of the
respective toxic gases in the event of an accident.
6.
Label all new material with the date in which it was received and the date in which it was
opened. This will help prevent the accumulation of outdated chemicals and ensure that older
chemicals are used first.
7.
Promptly discard outdated chemicals or chemicals no longer needed by the laboratory. Contact
EHSRM for disposal.
8.
Do not store chemicals on the floor especially not ones in glass containers in high-traffic areas.
Large metal containers can be stored on the floor in an isolated location.
9.
All chemicals must be stored inside secondary containment, even inside flammable or corrosive
cabinets. This is a requirement of the Edwards Aquifer Authority.
10. Do not store chemicals near heat sources or in direct sunlight.
11. Label all chemical containers clearly and accurately. Remember, this is required under the
Texas Hazard Communication Act.
12. Periodically inspect storage locations for signs of corrosion or leakage and misplaced
chemicals.
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13. To avoid contact with the eyes in the event of a spill, do not store liquids above eye level.
D. Memorandum of Understanding (MOU) for controlled substances and chemical precursors
1.
To comply with a statutory requirement, a Memorandum of Understanding (MOU) between the
Texas Higher Education Coordinating Board and the Texas Department of Public Safety has
been executed. The MOU establishes the responsibilities of institutions of higher education in
implementing and maintaining a program for reporting information concerning controlled
substances, controlled substance analogs, chemical precursors and certain glassware and
chemical laboratory apparatuses used in educational or research activities.
2.
Personnel using controlled substances under the Federal Controlled Substances Act for
research, instruction and to conduct analysis are reminded that they must register annually with
the Federal Drug Enforcement Administration (DEA). Accordingly, no precursor chemical listed
may be sold or otherwise transferred to anyone who does not have the proper permit or the
specific authority to accept the controlled items. Currently, glassware and other laboratory
apparatus are not regulated by the DEA, but we must track the regulated laboratory
apparatuses consistent with MOU procedures.
3.
Precursor chemicals and listed laboratory apparatus must be properly secured within the
laboratory to prevent unauthorized persons from accessing them. Any loss must be reported to
the UTSA police department immediately. EHSRM will participate in monitoring activities
involving controlled substances. Periodic internal and external audit inspections should also be
anticipated. The precursor chemicals and listed laboratory apparatus specified in the MOU can
be found in the MOU found in Appendix VI.
4.
Controlled Substances
The official list of controlled substances can be found in Section 1308 of the most recent issue of
Title 2 Code of Federal Regulations, Part 1300 to end. EHSRM has a copy of the latest Drug
Enforcement Administration “List of Scheduling Actions and Controlled Substances.” The UTSA
Policy on Controlled Substance Use in Research can be found in Appendix VII. The policy
includes information on obtaining the proper licenses and permits and purchasing. Always check
the latest policy revision at the EHSRM website to ensure proper compliance. The schedules of
controlled substances from DEA can be found in Appendix VIII.
VIII.
Hazard Communication and the Texas Hazard Communication Act
In Texas, the Occupational Safety and Health Administration (OSHA) Hazard Communication
Standard applies to private-sector businesses only. To protect public-sector employees, the
Texas legislature passed the Texas Hazard Communication Act in 1985. The law, which was
revised in 1993, is also known as the Public Employer Community Right-to-Know Act and can
be found in the Texas Administrative Code 25 TAC § 295 or the Texas Health & Safety Code
Title 6, Chapter 502 – Hazard Communication Act. It requires public employers to provide their
employees with information on hazardous chemicals to which they may be exposed in the
workplace. Requirements under the act include compiling and maintaining workplace
chemicals lists, maintaining material safety data sheets (MSDS) and informing employees of
the hazards associated with the chemicals they use. The law is similar to OSHA’s Hazard
Communication Standard but is enforced by the Texas Department of State Health Services,
Division of Regulatory Services, Enforcement Unit.
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The Texas Hazard Communication Act applies to public schools, colleges and universities in
Texas. Chemicals in a laboratory under the direct supervision or guidance of a technically
qualified individual may be exempt if:
•
labels on incoming containers of chemicals are not removed or defaced
•
the laboratory supervisor complies with MSDS and training requirements
•
the laboratory is not used primarily to produce hazardous chemicals in bulk
for commercial purposes.
Otherwise, all requirements of the act apply. Consult with the Laboratory Safety
Manager to see if any exemptions may apply to a specific laboratory. See
Appendix I, Notice to Employees, for a brief summary of the act.
A. Requirements
1.
Container labels
Hazardous chemical containers must have a label that identifies the hazardous chemical and lists
the appropriate hazard warnings.
i. Primary or Original Containers: A label on an existing container may not be removed or
defaced unless it is illegible or inaccurate or does not conform to labeling requirements.
ii. Secondary Containers: When transfers are made from the primary chemical container
(stock bottle) to other containers, the secondary containers should be labeled with:
1. the name of the chemical (as it appears on the MSDS) and
2. the appropriate hazard warnings unless it is used immediately by the individual who
made the transfer.
2.
Material Safety Data Sheets (MSDS)
The material safety data sheets (MSDS) are an extensive compilation of chemical hazard and
safe-handling information. Each sheet provides most of the information an employee needs to
work with a chemical safely. Chemical manufacturers or distributors must develop an MSDS for
each hazardous chemical they produce or distribute and are required to provide an MSDS with
each initial shipment and with the first shipment after an MSDS is updated.
There is no required format for an MSDS, but it must include:
i. the specific chemical identity and common names of the hazardous chemical(s) involved;
ii. physical and chemical characteristics of the hazardous chemical;
iii. known acute and chronic health effects and related health information; exposure limits;
whether the chemical is considered a carcinogen by the National Toxicology Program
(NTP), the International Agency for Research on Cancer (IARC) or OSHA;
iv. precautionary measures;
v. emergency and first-aid procedures; and
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vi. the identification (including name, address and telephone number) of the organization
responsible for preparing the MSDS.
When chemicals are purchased by UTSA faculty and staff, the MSDS is usually sent to EHSRM
where a master MSDS file is maintained. If an MSDS is received with a chemical shipment,
please forward a copy to the Laboratory Safety Officer in EHSRM. Employees may request
copies by contacting the Laboratory Safety Officer; be sure to include the full chemical name as it
appears on the label and the manufacturer.
MSDS’s must be available within the workplace. Laboratories can keep paper copies of MSDS’s
for all chemicals used or can have MSDS database links on at least one computer in the
laboratory. Database links are available from EHSRM’s website http://utsa.edu/safety/. A
shortcut to the MSDS database must be maintained on the computer’s desktop.
3.
Training
All laboratory personnel who use or handle hazardous chemicals must receive training on the
hazards of those chemicals and measures they can take to protect themselves – available
courses are listed in Section VI – Training Requirements. Training must include information on
interpreting container labels and MSDS’s; the location, acute and chronic effects, and safe
handling of hazardous chemicals to which personnel may be exposed; the proper use of
protective equipment and first-aid treatment; and general safety instructions on the handling and
clean-up procedures and disposal of hazardous chemicals. Training must be provided before the
employee works with, or in a laboratory containing, any hazardous chemical. Retraining is
required when the potential for exposure to hazardous chemicals in the laboratory increases
significantly or when the principal investigator receives new and significant information concerning
the hazards of a chemical.
The principal investigator / laboratory supervisor is responsible for providing continued training as
necessary. All training must be documented, including the date, employee names and signatures,
and the subjects covered in the session. Once laboratory specific training is completed, principle
investigators must forward a copy of the training record to EHSRM.
B. Responsibilities under the Act – refer to this plan’s Section IV – Responsibilities.
IX.
Personal protective equipment (PPE)
Personal protective equipment (PPE) is a device or clothing worn to help protect you from
direct exposure to hazardous materials. Examples include safety glasses or goggles,
laboratory coats or aprons, gloves, face shields and respirators. Remember, PPE only
protects you if you use it. Consult MSDS’s or other references for information on the PPE
required for working with a particular chemical.
A. Eye and face protection
Eye protection must meet standards for impact resistance and provide splash protection.
Safety glasses with side shields usually provide adequate impact resistance with limited
splash protection and; therefore, should not be worn when working with liquid chemicals or
solutions. Chemical splash goggles (with no direct perforations around the goggles) provide
adequate impact resistance and splash protection and limited vapor protection and therefore
provide the best all-around eye protection. Vapor resistant goggles are available if needed.
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In addition to protective eyewear, face shields or freestanding shields should be used in
situations where implosion or explosion may occur. Follow these guidelines for effective eye
and face protection.
1.
Wear protective eyewear at all times in the laboratory.
2.
Wear chemical splash goggles for maximum protection, especially if you wear corrective lenses
(glasses or contacts).
B. Hand protection
Gloves protect your skin from the chemicals you work with. Not all gloves, however, are
effective in providing protection against chemicals. Disposable latex gloves protect against
water, dirt and microorganisms, but they do not protect against many solvents. There are
several varieties of gloves (i.e., butyl, Neoprene, fluorocarbon (Viton), nitrile), each of which
protect against different chemicals. There are also insulated gloves appropriate for work with
cryogenic materials or hot glassware. Follow these guidelines for effective hand protection.
1.
Wear gloves that provide the greatest protection from the chemical(s) with which you are
working. Information on chemical-resistant gloves is available from various manufacturers,
online or from EHSRM.
2.
Wash your hands promptly after removing protective gloves to avoid exposure due to
microscopic holes, tears, solvent penetration or accidental contact with the outside of the gloves
when removing them.
3.
Remove gloves when handling laboratory common items (telephones, doorknobs, etc.) to
prevent their contamination.
4.
Do not wear gloves outside the laboratory.
C. Body protection
The most common form of body protection in the laboratory is the laboratory coat. Laboratory
coats protect your skin and clothes in the event of a spill or a splash. Chemical-resistant
aprons provide extra frontal protection when there is a greater potential for spills or splashes,
as when you are transferring chemicals from one container to another. Follow these
guidelines for effective body protection.
1.
Protective clothing should be easily removable and free from rips or tears.
2.
Wear your laboratory coat or apron only in the laboratory to prevent the potential spread of
contamination.
3.
Always wash laboratory clothes separately from personal laundry.
4.
The following are not to be worn in laboratories: high-heeled or open-toed shoes, sandals or
woven shoes, shorts or miniskirts, or excessive jewelry.
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D. Respiratory protection
Respiratory protection in the laboratory is normally provided by engineering controls such as
the ventilation system and chemical fume hood(s). When a higher level of respiratory
protection is required, a half- or full-face respirator can be used. Contact EHSRM for
assistance in selecting the correct respirator and cartridges. Medical assessment, fit testing
and training on proper use and storage are necessary prior to using a respirator. Follow these
guidelines for effective respiratory protection:
X.
1.
To note chemical odors, use a wafting motion of the hand to dilute the fumes before they reach
your nose. Never inhale chemical fumes directly.
2.
Do not use a respirator unless you have been trained to do so and have undergone a medical
evaluation as well as had the respirator fit-tested.
3.
If you are wearing a respirator, be sure the appropriate cartridges are used.
4.
Properly store a respirator to prevent continued contamination and exhaustion of the cartridges.
Laboratory equipment
A general understanding of laboratory equipment and how it works is essential to work safely
in the laboratory.
A. Chemical fume hood
The laboratory chemical fume hood is a ventilated enclosure designed to capture, contain
and exhaust fumes, gases, vapors, mists and particulate matter generated within the hood
interior. The fume hood is one of the most common and important safety devices in a
laboratory, so it is important to ensure that fume hoods are achieving maximum containment
to provide maximum protection. Several factors decrease fume hood containment: excessive
storage of equipment and chemicals inside the hood; high traffic, fans, air-conditioning vents
and doors to hallways being propped open; blockage of baffle slots (exhaust openings in the
back of the hood); and a high sash position (open hood face). These factors result in the
generation of turbulence inside the hood, cross-drafts that disrupt hood air-flow patterns and
decreased face velocity. The optimum flow rate on a fume hood is 100 feet per minute plus
or minus 20 percent.
Follow these guidelines for proper hood use:
1.
If large equipment must be used or stored inside the fume hood, place the equipment on blocks
at least two inches off the work surface so the baffle slots are not blocked. This allows air to flow
beneath the equipment.
2.
Do not use the fume hood interior for a chemical storage cabinet. However, if some chemical
storage inside the hood is necessary, place the containers on shelving against the side walls
(not the back wall) of the hood so the baffle slots are minimally blocked.
3.
Do not keep loose paper, towels or Kim wipes inside the hood. These materials can get caught
in the exhaust fan and result in fume hood downtime.
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4.
Equipment and other materials should be kept at least six inches behind the sash (hood
opening) during experiments. This will reduce the exposure of personnel to chemical fumes that
may escape into the laboratory due to small cross-drafts.
5.
When the hood is not in use, keep the sash all the way down. When the hood is in use, keep
the sash as low as possible to protect yourself against explosions or chemical splashes.
6.
The fume hood is not a substitute for personal protective equipment. Wear your safety goggles,
gloves and laboratory coat while working in a fume hood.
7.
Ensure the exhaust fan is on and operating before you use a fume hood.
8.
Newer models of fume hoods have audible alarms that go off when the face velocity in the hood
falls below a certain level. Discontinue all work if the alarm sounds and ensure that the problem
has been corrected before you continue.
9.
Examinations and maintenance of all laboratory fume hoods are performed by Facilities
personnel. Ensure that the system is tested at least annually and that a visual inspection sticker
is placed on the system.
10. Place a visual indicator that shows air movement at the face of the hood. A strip of tissue paper
works well. If the indicator is being pulled into the fume hood, the hood is functioning. If the
indicator is hanging straight down stationary, the hood is not functioning. If the indicator is
blowing out into the laboratory, the hood is not functioning and any contaminants in the hood
are flowing into the laboratory. If the hood is not functioning, contact Facilities Work Control
immediately to have the hood repaired.
B. Perchloric acid hood
Perchloric acid is a highly reactive, dangerous chemical. Its use inside a fume hood results in
the deposition of perchloric acid precipitates that are potentially explosive. All work involving
perchloric acid must be performed in an appropriate perchloric acid fume hood equipped with
a wash-down system in the duct work to avoid precipitate buildup. Since perchloric acid
reacts violently with other chemicals—such as organic materials or dehydrating agent—the
perchloric acid hood must be washed down after each use and dedicated only to work
involving perchloric acid. These hoods should be marked “perchloric acid hood.” Contact
EHSRM for the location of the perchloric acid fume hoods on campus.
C. Radioisotope fume hood
A radioisotope hood is designed to minimize the risk of exposure by making it easier to
maintain the hood in an uncontaminated condition. This hood is constructed of stainless steel
and sealed to eliminate hard-to-clean areas that would allow the accumulation of radioactive
materials. In situations where relatively high levels of radioactive materials are used or where
the levels of radioactive fumes generated are substantial, a two stage, in-line high-efficiency
particulate air (HEPA) filter may be necessary. Hoods for radioisotope use should be marked
with the radioactive material symbol and “radioisotope hood.”
D. Compressed Gas Cylinders
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Compressed gas cylinders can present a dual hazard in the laboratory because the contents
are under pressure and may contain hazardous materials, such as flammables, corrosives or
toxics.
Follow these guidelines for proper use of compressed gas cylinders:
1.
Compressed gas cylinders, empty or full, must be chained in place or otherwise secured at all
times.
2.
Cylinder caps must be in place except when the cylinder is in use.
3.
Do not transport gas cylinders without the cylinder cap in place and an appropriate dolly with a
securing strap.
4.
Cylinder and delivery valves should be closed when not in use (especially true for toxic,
flammable or corrosive gases).
5.
Highly toxic, corrosive, and reactive gases present greater degrees of hazard. Work with these
gases might require special containment, PPE, ventilation, piping systems, or alarm systems.
Prior to ordering or working with these types of gases contact EHSRM for a risk assessment
and determination of requirements.
6.
Liquid nitrogen or any other liquefied gas can present additional hazards for handling and
storage. Details on proper handling and storage can be found in Appendix IX.
E. Centrifuges
Improper centrifuge use can result in the generation and release of hazardous aerosols.
Centrifuges present a contamination problem when tubes break and the contents are
released.
Follow these guidelines for proper centrifuge use:
1.
Make sure the lid is on and secured before operating the centrifuge and remains secured until
the centrifuge has come to a complete stop.
2.
Always balance the load in the centrifuge. If you are not filling the entire centrifuge rack, position
the tubes opposite one another. If you have an odd number of samples, use an empty tube with
enough water to equal the weight.
3.
If vibration occurs, stop the centrifuge and check the load balances. Never operate an
unbalanced centrifuge; this could result in breaking the centrifuge tube(s) and generating
hazardous aerosols. Also, unbalanced rotors have the potential to become projectiles.
4.
Keep the rotors and buckets clean, and promptly clean breakages or spills.
5.
Ensure that the proper rotor is used for the centrifuge or the conditions of centrifugation.
F. Refrigerators
Follow these guidelines for proper laboratory refrigerator use:
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1.
Flammable liquids must be stored in flammable or explosion-proof refrigerators.
2.
Refrigerators must be labeled prominently to indicate whether they are suitable for storage of
flammable liquids.
3.
Never place food or beverages in a refrigerator where chemicals are stored.
4.
Refrigerators containing chemicals must be labeled “No Food or Drink.”
G. Glassware
Follow these guidelines for proper laboratory glassware use:
XI.
1.
Inspect all glassware before use. Discard broken, cracked or chipped glassware.
2.
Fire-polish all cut-glass tubing and rods before use.
3.
When inserting glass tubes or rods into stoppers, be sure the diameter of the tube is compatible
with the diameter of the stopper; lubricate the glass with water or glycerol; wear heavy gloves
and insert the glass tube carefully with a twisting motion.
4.
Dispose of broken glassware in an appropriate “broken glass” container, not the ordinary trash.
Chemical Waste Management
Chemical and toxic waste generated at UTSA is managed in accordance with the HOP 9.25 Hazardous Waste Management Program. This program is managed by EHSRM personnel in
the Environmental Protection & Construction Safety Division. Individual lab chemical waste
pick-ups may be arranged by completing an online request form available on the EHSRM
website. For more information on chemical waste disposal, refer to Part B - Chemical Waste
Management Safety Plan, which may be accessed on the EHSRM website at
http://utsa.edu/safety/.
XII.
Laboratory Deactivation and Equipment Disposal
A. Equipment Disposal Procedure: See Appendix X for details.
Equipment to be disposed of should be wiped down with an appropriate disinfectant solution
such as a bleach solution or an ethanol solution for biological contamination or residue and
the appropriate solvent followed by a detergent solution to remove any chemical
contamination or residue.
Once the equipment has been cleaned, EHSRM should be contacted to check the equipment
and place proper signage on it stating that it has been reviewed and is ready to be removed.
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Laboratory personnel should then contact the Surplus Department to have the equipment
removed from the laboratory.
B. Laboratory Deactivation Procedure: See Appendix X for details.
EHSRM should be contacted before a laboratory deactivation begins.
Pertinent personnel from EHSRM will come by the laboratory to review what items need to be
dealt with. For instance, the Laboratory Safety Manager or designee will review what areas
and equipment need to be cleaned due to possible biological or chemical contamination.
The Radiation Safety Officer will review for possible radiological contamination and determine
what measures must be taken to deal with it.
Chemical and biological wastes will also be reviewed by the appropriate personnel. Once
areas and equipment have been properly cleaned using a disinfectant or appropriate solvent,
EHSRM personnel will need to review to determine if all cleaning has been done properly.
Any equipment will be labeled as ready to move, repair, or to be disposed of. The area or
laboratory itself will be labeled as appropriately decontaminated and ready for Housekeeping
staff to do routine cleaning to prepare for its future occupants.
XIII.
References
A. Chapter 502 of the Health and Safety Code. Texas Hazard Communication Act, Revised
1993. Texas Department of State Health Services, Division of Regulatory Services,
Enforcement Unit.
B. Handbook of Laboratory Safety. Chemical Rubber Company, Third Edition, 1990.
C. Working Safely with Chemicals in the Laboratory. Genium Publishing, Second Edition, 1994.
D. Hazardous Chemicals in the Laboratory: A Guide for their Safe Use and Disposal. The
University of Texas Southwestern Medical Center at Dallas, Office of Environmental Health
and Safety, 1994.
E. Laboratory Safety Manual. The University of Texas at Austin, Office of Environmental Health
and Safety, Hazardous Materials Division, 1995.
XIV. Appendices
Appendix I
- Notice to Employees
Appendix II - Laboratory Specific Chemical Hygiene Plan
Appendix III - Chemical Carcinogens Regulated by OSHA
Appendix IV - Peroxide Forming Chemicals
Appendix V - Extremely Hazardous Substances (Texas Tier II List)
Appendix VI - Memorandum of Understanding
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Appendix VII - Controlled Substance Policy
Appendix VIII- DEA Schedules of Controlled Substances
Appendix IX - Liquid Nitrogen Storage and Use
Appendix X - Laboratory and Equipment Clearance Procedures
Appendix XI - Hazardous Materials Requiring Institutional Approval
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Appendix I: Notice to Employees
On the following page is the Notice to Employees from the Texas Department of State Health
Services. A version in Spanish is available from TDSHS online or from EHSRM.
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NOTICE TO EMPLOYEES
MATERIAL SAFETY DATA SHEETS
The Texas Hazard Communication Act (revised 1993), codified as Chapter 502 of the Texas Health
and Safety Code, requires public employers to provide employees with specific information on the
hazards of chemicals to which employees may be exposed in the workplace. As required by law, your
employer must provide you with certain information and training. A brief summary of the law follows.
HAZARDOUS CHEMICALS
Hazardous chemicals are any products or
materials that present any physical or health
hazards when used, unless they are exempted
under the law.
Some examples of more
commonly used hazardous chemicals are fuels,
cleaning products, solvents, many types of oils,
compressed gases, many types of paints,
pesticides, herbicides, refrigerants, laboratory
chemicals, cement, welding rods, etc.
WORKPLACE CHEMICAL LIST
Employers must develop a list of hazardous
chemicals used or stored in the workplace in
excess of 55 gallons or 500 pounds. This list
shall be updated by the employer as necessary,
but at least annually, and be made readily
available
for
employees
and
their
representatives on request.
EMPLOYEE EDUCATION PROGRAM
MATERIAL SAFETY DATA SHEETS
Employees who may be exposed to hazardous
chemicals shall be informed of the exposure by
the employer and shall have ready access to the
most current material safety data sheets
(MSDS’s), which detail physical and health
hazards and other pertinent information on those
chemicals.
LABELS
Employees shall not be required to work with
hazardous chemicals from unlabeled containers,
except portable containers for immediate use,
the contents of which are known to the user.
EMPLOYEE RIGHTS
Employees have rights to:
C
access copies of MSDS’s
C
information on their chemical exposures
C
receive training on chemical hazards
C
receive appropriate protective equipment
C
file complaints, assist inspectors, or testify
against their employer
Employers shall provide training to newly
assigned employees before the employees work
in a work area containing a hazardous chemical.
Employees may not be discharged or
Covered employees shall receive training from
discriminated against in any manner for the
the employer on the hazards of the chemicals
exercise of any rights provided by this Act. A
and on measures they can take to protect
waiver of employee rights is void; an employer’s
themselves from those hazards. This training
request for such a waiver is a violation of the Act.
shall be repeated as needed, but at least
Employees may file complaints with the Texas
whenever new hazards are introduced into the
Department
of State Health Services at the toll
workplace or new information is received on the
free
number
provided
below.
chemicals which are already present.
EMPLOYERS MAY BE SUBJECT TO ADMINISTRATIVE PENALTIES AND CIVIL OR CRIMINAL
FINES RANGING FROM $50 TO $100,000 FOR EACH VIOLATION OF THIS ACT
Further information may be obtained from:
Texas Department of State Health Services
DivisionforRegulatoryServices
Enforcement Unit
1100 West 49th Street
Austin, Texas 78756
Revision 05/17/2011
(512) 834-6665
Fax (512) 834-6605
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Appendix II – Laboratory Specific Chemical Hygiene Plan
CHEMICAL HYGIENE PLAN FOR
____________________________________
A. Purpose of the Chemical Hygiene Plan
This Chemical Hygiene Plan is intended to summarize policies, protocols, and
procedures regarding the use of chemicals in (building/room #) ______________ at
the University of Texas at San Antonio. All personnel involved in laboratory
research efforts should be familiar with this document and the protocols which
pertain to their work. Every employee is responsible to ensure these procedures
are followed. This written program is available in ________________________
office.
B. General Principles
1.
Minimize exposures
Precautions for handling all laboratory chemicals should be adopted. The Permissible
Exposure Limits of the Occupational Safety and Health Administration (OSHA) and
the Threshold Limit Values of the American Conference of Governmental Industrial
Hygienists should not be exceeded.
2.
Do not underestimate the risk
Even for substances with no known significant hazard, exposure should be
minimized. Unless otherwise known, assume any mixture will be more toxic than its
most toxic component and all substances of unknown toxicity are hazardous.
3.
Control Exposure
If possible, substitute less toxic materials. Secondly, prevent chemical vapors and
mists escaping into the laboratory atmosphere by the use of fume hoods and other
ventilation devices. Where other controls do not adequately control the hazard, wear
appropriate personal protective equipment to prevent exposures, e.g. gloves, eye
protection, laboratory coats, or respirators. Never eat in the laboratory, store food
in refrigerators designated for chemical or biological storage, or place
chemicals in a container where they might be ingested.
C. Procedures
1.
Hazard Evaluation and Planning
a. Plan Ahead
Identify the potential hazards. Consider all weak links and things that could go
wrong. Try to prevent their failure or occurrence. If the hazard still exists, build
in safe guards and backups. Define small spills that are capable of being
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cleaned by area personnel – typically less than 1 liter in volume. Also define
large spills (typically > 1 liter in volume) which require UTSA’s Environmental
Health Safety and Risk Management (EHSRM) office to take action or
possibly contact additional resources for assistance. EHSRM can deal with
spills too large for area personnel, but too small to require SAFD assistance.
These spill amounts should be determined and communicated to the
Laboratory Safety Officer. Spill kits, including absorbent material and
personal protective equipment must be on site. Personnel should be trained
and drill on how to respond to possible events.
b. Spill Response
1. Assist any injured personnel. For eye or skin contact immediately
remove any contaminated clothing and flush with water for 15
minutes. Seek medical attention.
2. Promptly contain chemical spills and alert people in all parts of the
facility including isolated areas or restricted areas.
3. Small spills of < __________: Clean up small spills using appropriate
protective apparel and equipment. Remember to dispose of
contaminated articles as hazardous waste. Contact EHSRM
personnel at 458-5250 if you need assistance.
4. For large spills > __________: Clear the area and call the UTSA
Police dispatcher at x4911 or 458-4911. The dispatcher will contact
Environmental Health Safety and Risk Management at 458-5250 or
can reach EHSRM personnel in off hours. Move to a safe location
and wait for the responders to arrive at the scene – they will need
your important information.
2.
Prohibitions
a. Eating, Smoking, etc.: Do not smell or taste chemicals. Eating, drinking,
smoking, gum chewing or application of cosmetics is prohibited in areas where
laboratory chemicals are present. Wash hands before conducting these
activities. Do not store or handle/consume food or beverages in laboratory
areas, refrigerators, glassware or utensils which are also used for laboratory
operations.
b. Horseplay: Avoid practical jokes or other behavior which might confuse, startle,
or distract another worker.
c. Mouth suction: Do not use mouth suction for pipetting or starting a siphon.
d. Working alone: If the procedures being conducted are hazardous do not work
alone in the laboratory.
3.
Equipment and glassware
Handle and store laboratory glassware with care to avoid damage; do not use
damaged glassware. Use extra care with Dewar flasks and other evacuated glass
apparatus. Shield or wrap them to contain chemicals and fragments should implosion
occur. Use equipment only for its designed purpose.
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4.
Emergency Eyewash and showers
Safety showers and eye washes must be within 10 seconds walking distance and
less than 100 feet from where they may be needed. They must be well identified,
remain on without the use of the operator’s hands, and be capable of running
continuously for 15 minutes. Showers should be tested at least quarterly by Facilities
Maintenance personnel and eyewash stations inspected weekly by designated
laboratory users, but preferably all equipment monthly by Facilities Maintenance.
Documentation should be annotated on the inspection form next to the system.
D. Personal Protective Equipment
Each laboratory should include protective apparel compatible with the required
degree of protection for substances being handled. This can be determined from
information on the MSDS or with assistance from Environmental Health Safety
and Risk Management.
1.
Eye Protection
ANSI approved eye wear must be worn anytime there is the possibility for an injury to
the eye. This might be a splash, mist, explosive, ultraviolet radiation or particulate
hazard to the eye. Protective eye wear is required in laboratories, chemical storage
rooms and designated contaminated areas where work with chemicals is being
performed by any of the laboratory personnel. Appropriate protection should be made
available to visitors who enter the laboratory.
2.
Gloves
Gloves should be worn whenever protection is needed against chemical or physical
agents. They should be worn to handle corrosive materials, to prevent accidental
exposure to toxic chemicals or with very hot or cold materials. Numerous materials
are available including rubber, neoprene, butyl rubber, vinyl or leather. The
appropriate glove can be determined by consulting MSDS’S, the material
compatibility lists available from glove manufacturers, or contacting EHSRM. Inspect
the gloves before each use. Wash reusable ones before removal and replace them
frequently to avoid contaminating yourself and other objects such as door handles.
Chemicals Used
Gloves Required
______________
______________
______________
______________
______________
______________
3.
Foot Wear
Shoes must be worn at all times in buildings where chemicals are used or stored.
Perforated shoes, sandals, or cloth shoes should not be worn in laboratories where
chemicals are used. Only leather shoes are appropriate in that instance. Shoes
which completely enclose the foot are the best. Open-toed shoes are never
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appropriate in a laboratory. Steel-toed shoes should be worn when heavy objects
are being handled.
4.
Clothing
Where the potential for chemical contamination exists, personal clothing that will be
worn home should be covered by protective apparel. Examples include laboratory
coats, aprons, shoe covers, and sleeve covers. Remove permeable protective
clothing, such as laboratory coats, immediately on significant contamination. Dirty
laboratory coats should not be worn outside of the work area or offices, clean
corridors, rest rooms, lunchrooms, libraries, or conference rooms. Re-useable cloth
lab coats should not be taken home for washing – use an appropriate commercial
service or purchase disposable lab coats.
5.
Respirators
Respirators to protect employees shall be provided and used in areas when air
contaminant concentrations are not sufficiently reduced by engineering controls. In
accordance with the Occupational Safety and Health Administration (OSHA)
standard, the UTSA respirator program requires Standard Operating Procedures for
respirator use, training, medical evaluation, and fit-testing anytime respirators are to
be used. Departments are required to provide respiratory protection equipment when
determined to be necessary and enroll affected employees in the UTSA Occupational
Health Program. Approval for respirator type, medical evaluations and fit testing
should be arranged with the EHSRM Occupational Safety Coordinator (458-5304).
6.
Hearing Protection
Ear protection should be worn when working around dangerous noise levels. As a
rule of thumb, background noise levels are dangerous when conversation requires
raised voices at 3 feet. The following areas require ear protection: (list any in the work
area) ________________________.
E. Engineering Controls (Check box if present in the work area)
Where a hazard can not be eliminated completely, mechanical means of
controlling the hazard are the safest. They attempt to control the hazard typically
at the source. Some common examples are:
1.
Negative Air Flow: All work areas that use hazardous chemicals are to have
single pass room exhaust (not re-circulated to other areas) that is at a negative
pressure differential to the air in the adjoining room or corridor. In other words air
movement should flow into the work area from the outside corridor or adjoining
room and be exhausted out of the room by mechanical means. If you believe your
work area to be out of air balance, contact EHSRM to verify that airflows are
appropriate for your work area.
2.
Chemical Fume Hoods: Chemical fume hoods are built in cabinet enclosures
typically with a pull down glass sash that are connected to an external building
exhaust fan. These units are maintained and tested by Facilities Operations &
Maintenance personnel and should be tagged with a sticker indicating the last date
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of testing and the negative air flow rate that should typically be between 80 – 120
lfpm. Contact Work Control for assistance.
3.
Fume extraction devices & snorkels: Some laboratories are equipped with these
bench top devices that can be put directly at or near the fume source and draw
heavier than air fumes down and away or lighter than air fumes up and away from
the worker’s breathing zone. They are typically connected to the building exhaust
and should be verified for negative air flow with an indicating device such as a
tissue paper before use. If you suspect poor negative airflow, contact Work Control
and EHSRM for assistance.
4.
Biosafety Cabinets: Biological safety cabinets are typically designed to provide
both worker and product protection from infectious organisms. They are equipped
with high efficiency particulate air (HEPA) filters and may or may not exhaust air out
of the laboratory. Therefore they may or may not be acceptable for use of volatile
solvents. Prior to work with hazardous materials, these units must be tested and
certified annually to ANSI/NSF-49 standards by licensed workers under contract
with EHSRM. Units should be tagged with a sticker indicating status – contact
EHSRM for assistance. Class and Type of BSC’s specific to your work area:
5.
Class (I, II): ____; Type (A1, A2, B1, B2): ____; Manuf.: ___________; Serial#:
________
Class (I, II): ____; Type (A1, A2, B1, B2): ____; Manuf.: ___________; Serial#:
________
Class (I, II): ____; Type (A1, A2, B1, B2): ____; Manuf.: ___________; Serial#:
________
Bench Top Negative Airflow, filtered cabinet enclosures:
A number of
manufacturers produce units in this category for specialized use such as rodent
anesthetization with isofluorane. They are typically built out of an acrylic enclosure
and contain a carbon impregnated filter that must be periodically changed. Specific
operating and maintenance procedures per manufacturer instructions must be
developed and adhered to for safe and proper operation of these units.
Manufacturer: ____________; Model #: ____________
F. Chemical Use Procedures
1.
Procurement
Before a substance is received, information on proper handling, storage, and
disposal should be known by those who will be using, storing, or transporting the
substance. Preferably, all substances should be received through Central Receiving.
All material safety data sheets (MSDS) must be maintained in the immediate area as
hard copies or online through a database or accessed through the EHSRM office for
chemicals being used. A chemical inventory must also be maintained by the
laboratory ordering and storing or using the chemicals. This will assist with the
requirements mentioned and comply with federal and state regulations.
2.
Labels
a. Laboratory entryways must have labels with an indication of the potential
hazards and emergency telephone numbers of laboratory workers or
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supervisors. These will normally be posted by EHSRM personnel and updated
at the periodic lab evaluation.
b. No container should be accepted without an adequate identifying label. Do not
remove or deface labels. Identity labels must show contents of the containers
(including waste receptacles) and associated hazards.
c. Location signs should mark sites of safety showers, eyewash stations, exits,
and other safety and first aid equipment and should not be obstructed.
d. It is not permissible to place chemicals in a food container.
3.
Material Safety Data Sheets (MSDS)
a. MSDS’s for all hazardous chemicals to which employees or students may be
exposed shall be accessible either in hard copy or via an online database. The
chemical user should review the MSDS for each chemical prior to the use of
that chemical. The MSDS’s are available for reference or to copy at EHSRM.
b. If MSDS’s are not available or new chemicals in use do not have an MSDS,
immediately contact EHSRM. MSDS’s are available through the chemical
manufacturer or EHSRM. Chemicals should not be used until the MSDS’s are
accessible.
c. The laboratory supervisor will review incoming MSDS’s for new and significant
health/safety information. Contact EHSRM for assistance as needed and see
that any new information is passed on to the affected employees.
d. Additional toxicological information and procedural assistance is available
through EHSRM.
4.
Storage and Distribution
a. Stockrooms
Substances should be segregated in a well identified area with local exhaust
ventilation providing at least six air changes per hour. Stored chemicals should
be examined periodically (at least annually) for replacement, deterioration, and
container integrity. Stockrooms/storerooms should be open during normal
working hours and be controlled by one person. They should not be used as
preparation or repackaging areas.
b. Laboratory Storage
Amounts permitted should be as small as practical. Explosion proof storage
cabinets should be used. Storage on bench tops and in hoods is inadvisable.
Exposure to heat or direct sunlight should be avoided. Periodic inventories
should be conducted, with unneeded items being properly disposed of or
returned to the storeroom/stockroom.
c. Distribution
When chemicals are hand carried, containers should be packed in a secondary
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container or bucket. Use freight elevators to transport the chemicals to different
floors.
5.
Compressed gas cylinders
Compressed gas cylinders are to be securely fastened during transit, storage, while
in use and when designated as empty. Stationary cylinders should be chained at 2/3
their height, or placed in stable racks, with valve caps attached. Use a wheel cart to
transport large cylinders. Valves should be closed on empty cylinders and marked as
empty. The regulator should be removed and the valve cap replaced.
6.
Environmental Monitoring
Regular instrumental monitoring of airborne concentrations is not usually justified or
practical in laboratories but may be appropriate when testing ventilation devices or
when a carcinogenic or highly toxic substance is stored or used regularly. Contact
EHSRM for chemical monitoring assistance.
7.
Waste Disposal
a. Waste containers must be labeled “Hazardous Waste” and lids must be
attached and secured except when adding waste.
b. Follow disposal instructions as described in the University Part B - Chemical
Waste Management Safety Plan. Do not dispose of any chemicals down the
sewer system, by allowing it to evaporate, or by placing it in the garbage
without confirming proper interpretation of the plan with EHSRM.
c. Prior to permanently leaving the laboratory, responsible parties must properly
dispose of, return to storage or sign over to the next person all chemicals prior
to their departure. Refer to UTSA’s Policy on Laboratory Deactivation.
G. Inspections and Investigations
Formal housekeeping and chemical hygiene compliance should be conducted at
least quarterly by the laboratory supervisor. Laboratory evaluations will be
conducted periodically, but at least once per year by EHSRM’s Laboratory Safety
Division. Whenever an incident occurs in the laboratory, an internal incident
investigation will be carried out. An Incident Report must be filed with EHSRM.
The information will be used to prevent similar situations from occurring in the
future.
H. Worker’s Compensation Insurance (WCI) Policy
1.
For any work-related exposure reported to a supervisor or in which a supervisor has
knowledge, an incident report should be completed and submitted to the EHSRM
Occupational Health and WCI Coordinator (x5304 or x5250). Report Forms are
available on the EHSRM website at http://utsa.edu/safety/. An employer should
keep record of the employee’s medical surveillance to ensure WCI coverage should
the exposure result in an injury or disease.
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Editor note: An exposure does not meet the definition of an injury. UT System
therefore cannot, under the TWCC Act, cover expenses incurred from an exposure
unless the exposure results in an actual injury. UTSA however, has established
funding to cover needle sticks and similar exposures. Contact the Occupational
Health & WCI Coordinator at x5304 or x5250.
2.
Medical surveillance under the direction of a licensed physician must be paid at no
cost to the employee for work related injuries if:
a. The employee exhibits signs or symptoms associated with exposure to a
hazardous chemical used in the laboratory.
b. A spill, leak or explosion occurs resulting in the likelihood of a hazardous
exposure.
c. Any employee is exposed routinely above the action level, or in the absence of
an action level, above the permissible exposure limit for which there are
exposure monitoring or medical surveillance requirements.
d. If the employee is a student, they can be seen by the UTSA Student Health
Services. If further examination by a physician is required, the student will be
referred. The first report of injury form will still be required by EHSRM as well
as follow-up documentation.
3.
I.
The laboratory supervisor or his/her representative should provide the physician
with the identity of the chemicals, description of exposure conditions and symptoms,
if any. The physician’s opinion must be written and include any need for follow-up,
results, any increased risk and a statement that the employee has been notified of
the previous items.
Worker’s Compensation Insurance (WCI) and Reporting Injuries or Illness on
the Job
1.
An employee of UTSA who suffers an accidental injury or occupational disease that
arises out of and in the course and scope of employment should notify his or her
supervisor to complete a first report of injury or illness form http://utsa.edu/safety/
within 24 hours. If an employee’s injury is found to be compensable under the WCI
Program, the employee is entitled to healthcare reasonably required by the nature
of the compensable injury.
2.
Injuries or chemical exposures that result in the hospitalization of 5 or more
employees or the death of any one employee are to be reported to both the UTSA
Police and Office of EHSRM immediately. EHSRM and Police personnel will ensure
proper authorities are notified.
3.
Responsibilities to the injured employee include:
a. Notify the injured employee that his or her injury may be covered under
worker’s compensation insurance.
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b. Arrange for appropriate treatment in an emergency situation (keep in mind that
an injured employee has a right to select his or her own healthcare provider).
J. Training
1.
Environmental Health Safety and Risk Management offers a laboratory safety class
several times a semester to assist in complying with the Public Employers Worker
Right-to-Know Act. This course is also available online. Laboratories must adhere
to requirements listed in the UTSA Chemical Hygiene & Hazard Communication
Safety Plan. All of the elements specified below must be provided to the
employees in this work area.
a. An overview of the requirements contained in the UTSA Chemical Hygiene &
Hazard Communication Safety Plan, its location and availability.
b. Hazardous chemicals present in their work place operations.
c. Physical and health hazards of the hazardous chemicals in their work area to
include the Occupational Safety and Health Administration (OSHA) permissible
exposure limits and the American Conference of Governmental Industrial
Hygienists (ACGER) Threshold Limit Values (TLV).
d. Methods and observation techniques used to determine the presence or
release of hazardous chemicals in their work area.
e. How to lessen or prevent exposure using personal protective equipment.
f. Steps the University/EHSRM has taken to lessen or prevent exposure to these
hazardous chemicals.
g. Symptoms associated with exposure to chemicals found in the area.
h. Emergency procedures to follow if they are exposed to hazardous chemicals.
i. How to read labels and review a MSDS to obtain appropriate hazard
information.
j. Location of MSDS file and hazardous chemical list for their work area.
2.
UTSA’s Office of Business Continuity and Emergency Management (BCEM) has
developed a Comprehensive Emergency Management Plan to assist all
departments in case of an emergency. Various other resources are offered on
campus. Training is periodically offered through EHSRM or BCEM. DVD’s / Video
tapes are also available on loan for safety, health and radiation training subjects.
K. Records
1.
Accident records should be written and retained according to the UTSA record
retention schedule by department supervisors. A copy should be sent to EHSRM.
2.
Inventory and usage records for high-risk substances should be kept.
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3.
Medical reports (correspondence and physician’s employee health evaluations) are
retained by EHSRM. All documentation on employees is maintained by Human
Resources on an indefinite basis.
4.
Training records should be maintained for at least three years. These records
should include the contents of the training, date, presenter, and name of attendees.
L. Contacts
1.
Fire/Ambulance/Police: 911 or x4911 (campus phone) / 458-4911 (off campus
phone)
2.
University Police: x4242 (non-emergency)
3.
Office of Business Continuity and Emergency Management:
4.
Student Health Services:
5.
Office of Environment Health Safety and Risk Management (EHSRM): x5250
6.
EHSRM - Occupational Health & Workers’ Compensation Insurance: x5250 or
x5304
7.
EHSRM - Chemical Hygiene Officer/Laboratory Safety Manager/Radiation Safety
Officer: x6101
8.
EHSRM - Environmental Protection & Construction Safety Manager/Waste
Disposal:
x5808
x6756
x4142
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Appendix III: Chemical carcinogens regulated by OSHA
2-Acetylaminofluorene
4-Dimethylaminoazobenzene
Acrylonitrile
Ethyleneimine
4-Aminodiphenyl
Ethylene oxide
Arsenic, inorganic
Formaldehyde
Asbestos
Methyl chloromethyl ether
Benzene
Methylene chloride
Benzidine
Methylenedianiline
1,3-Butadiene
a-Naphthylamine
bis-Chloromethyl ether
b-Naphthylamine
Cadmium
4-Nitrobiphenyl
Coke oven emissions
N-Nitrosodimethylamine
1,2-Dibromo-3-chloropropane
b-Propiolactone
3,3’-Dichlorobenzidine (and its salts)
Vinyl chloride
This list of carcinogens is only one of many available lists of confirmed and
suspected human carcinogens. Contact EHSRM to see any of the lists of
carcinogens published by the following agencies and organizations:
American Conference of Governmental Industrial Hygienists (ACGIH)
International Agency for Research on Cancer (IARC)
National Institutes of Occupational Safety and Health (NIOSH)
National Toxicology Program (NTP)
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Appendix IV: Peroxide Forming Chemicals
Materials that are susceptible to peroxide formation (i.e., auto-oxidation) are ones
that typically react with air, moisture or impurities and produce a change in their
chemical composition in normal storage. The peroxides that form are less volatile
than the solvent itself and thus tend to concentrate. This is particularly dangerous if
peroxides are present during a distillation, where the applied heat to the
concentrated solution may trigger a violent explosion. Equally dangerous is to allow
a container of this material to evaporate to dryness, leaving the crystals of peroxide
at the bottom of the container.
Chemicals that are sensitive to peroxide formation can be broken into
three categories (Jackson, J. Chem. Ed., 1970) as shown in the
following table.
A. Peroxide hazard after prolonged storage. Form potentially explosive peroxides
without
concentrating.
All have been responsible for fatalities.
Test for peroxide formation or discard after 3 months.
isopropyl ether
divinyl acetylene
potassium metal
potassium amide
sodium amide
vinylidene chloride
B. Chemicals which become a peroxide hazard if concentrated, such as through
distillation or evaporation. Test for peroxide formation or discard after 1
year.
dioxane
diethyl ether
tetrahydrofuran
acetal
cumene
cyclohexane
cyclopentene
diacetylene
dicyclopentadiene
ethylene glycol dimethyl ether
furan
methyl acetylene
methyl cyclopentane
methyl-isobutyl ketone
tetrahydronaphthalene
vinyl ethers
C. Chemicals which are a hazard due to peroxide initiation of polymerization.
The peroxide forming potential increases for liquids of this group.
peroxide formation or discard after 1 year.
butadiene
pyridine
chlorobutadiene
chlorotrifluoroethylene
acrylonitrile
styrene
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Test for
vinyl
tetrafluoroethylene
vinyl acetate
vinyl acetylene
vinyl chloride
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Appendix V: Extremely Hazardous Substance (Texas Tier II) List
EXTREMELY HAZARDOUS SUBSTANCES (EHS) AND THEIR THRESHOLD PLANNING
QUANTITIES (TPQ) LIST
All RQ (Reportable Quantities) and TPQ quantities are in pounds.
Facilities that file the Texas Tier Two Report with the Texas Department of State
Health Services, Tier Two Registration Section are also required to submit
photocopies of this Report to the local fire department having jurisdiction over the
reporting facility and to the Local Emergency Planning Committee (LEPC) for the
county or area in which the reporting facility is located.
Although a filing fee is not required with these submissions, please consider
providing a donation to your LEPC along with the photocopy of your report. Contact
the Tier Two Registration Section at 1-800-452-2791 for a free copy of the LEPC
Brochure, which contains information on the services provided by LEPC's and
suggestions on how you can help support these volunteer organizations.
CAS #
NAME
TPQ Pounds
RQ Pounds
75-86-5
Acetone cyanohydrin
1,000
10
1752-30-3
Acetone thiosemicarbazide
1,000/10,000
1,000
107-02-8
Acrolein
500
1
79-06-1
Acrylamide
1,000/10,000
5,000
107-13-1
Acrylonitrile
10,000
100
814-68-6
Acrylyl chloride
100
100
111-69-3
Adiponitrile
1,000
1,000
116-06-3
Aldicarb
100/10,000
1
309-00-2
Aldrin
500/10,000
1
107-18-6
Allyl alcohol
1,000
100
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CAS #
NAME
TPQ Pounds
RQ Pounds
107-11-9
Allylamine
500
500
20859-73-8
Aluminum phosphide
500
100
54-62-6
Aminopterin
500/10,000
500
78-53-5
Amiton
500
500
3734-97-2
Amiton oxalate
100/10,000
100
7664-41-7
Ammonia (Anhydrous)
500
100
300-62-9
Amphetamine
1,000
1,000
62-53-3
Aniline
1,000
5,000
88-05-1
Aniline, 2,4,6-trimethyl-
500
500
7783-70-2
Antimony pentafluoride
500
500
1397-94-0
Antimycin A
1,000/10,000
1,000
86-88-4
ANTU
500/10,000
100
1303-28-2
Arsenic pentoxide
100/10,000
1
1327-53-3
Arsenous oxide
100/10,000
1
7784-34-1
Arsenous trichloride
500
1
7784-42-1
Arsine
100
100
2642-71-9
Azinphos-ethyl
100/10,000
100
86-50-0
Azinphos-methyl
10/10,000
1
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CAS #
NAME
TPQ Pounds
RQ Pounds
98-87-3
Benzal chloride
500
5,000
98-16-8
Benzenamine, 3-(trifluoromethyl)-
500
500
100-14-1
Benzene, 1-(chloromethyl)-4-nitro-
500/10,000
500
98-05-5
Benzenearsonic acid
10/10,000
10
3615-21-2
Benzimidazole, 4,5-dichloro-2-(trifluoromethyl)-
500/10,000
500
98-07-7
Benzotrichloride
100
10
100-44-7
Benzyl chloride
500
100
140-29-4
Benzyl cyanide
500
500
15271-41-7
Bicyclo[2.2.1]heptane-2-
500/10,000
500
carbonitrile, 5-chloro-6-((((methylamino)carbonyl)oxy)imino)-,(1-alpha,2-beta,4-alpha,5-alpha,6E))-
534-07-6
Bis(chloromethyl) ketone
10/10,000
10
4044-65-9
Bitoscanate
500/10,000
500
10294-34-5
Boron trichloride
500
500
7637-07-2
Boron trifluoride
500
500
353-42-4
Boron trifluoride compound with methyl ether (1:1)
1,000
1,000
28772-56-7
Bromadiolone
100/10,000
100
7726-95-6
Bromine
500
500
1306-19-0
Cadmium oxide
100/10,000
100
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
2223-93-0
Cadmium stearate
1,000/10,000
1,000
7778-44-1
Calcium arsenate
500/10,000
1
8001-35-2
Camphechlor
500/10,000
1
56-25-7
Cantharidin
100/10,000
100
51-83-2
Carbachol chloride
500/10,000
500
26419-73-8
Carbamic acid, methyl-, O-
100/10,000
1
(((2,4-dimethyl-1,3-dithiolan-2-yl)methylene)amino)-
1563-66-2
Carbofuran
10/10,000
10
75-15-0
Carbon disulfide
10,000
100
786-19-6
Carbophenothion
500
500
57-74-9
Chlordane
1,000
1
470-90-6
Chlorfenvinfos
500
500
7782-50-5
Chlorine (Gas)
100
10
24934-91-6
Chlormephos
500
500
999-81-5
Chlormequat chloride
100/10,000
100
79-11-8
Chloroacetic acid
100/10,000
100
107-07-3
Chloroethanol
500
500
627-11-2
Chloroethyl chloroformate
1,000
1,000
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
67-66-3
Chloroform
10,000
10
542-88-1
Chloromethyl ether
100
10
107-30-2
Chloromethyl methyl ether
100
10
3691-35-8
Chlorophacinone
100/10,000
100
1982-47-4
Chloroxuron
500/10,000
500
21923-23-9
Chlorthiophos
500
500
10025-73-7
Chromic chloride
1/10,000
1
10210-68-1
Cobalt carbonyl
10/10,000
10
62207-76-5
Cobalt, ((2,2’-(1,2-
100/10,000
100
ethanediylbis(nitrilomethylidyne))bis(6-fluorophenylato))(2-)-N,N’,O,O’)-
64-86-8
Colchicine
10/10,000
10
56-72-4
Coumaphos
100/10,000
10
5836-29-3
Coumatetralyl
500/10,000
500
95-48-7
Cresol (o-) (Cresylic Acid)
1,000/10,000
100
535-89-7
Crimidine
100/10,000
100
4170-30-3
Crotonaldehyde
1,000
100
123-73-9
Crotonaldehyde, (E)-
1,000
100
506-68-3
Cyanogen bromide
500/10,000
1,000
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
506-78-5
Cyanogen iodide
1,000/10,000
1,000
2636-26-2
Cyanophos
1,000
1,000
675-14-9
Cyanuric fluoride
100
100
66-81-9
Cycloheximide
100/10,000
100
108-91-8
Cyclohexylamine
10,000
10,000
17702-41-9
Decaborane(14)
500/10,000
500
8065-48-3
Demeton
500
500
919-86-8
Demeton-S-methyl
500
500
10311-84-9
Dialifor
100/10,000
100
19287-45-7
Diborane
100
100
111-44-4
Dichloroethyl ether
10,000
10
149-74-6
Dichloromethylphenylsilane
1,000
1,000
62-73-7
Dichlorvos
1,000
10
141-66-2
Dicrotophos
100
100
1464-53-5
Diepoxybutane
500
10
814-49-3
Diethyl chlorophosphate
500
500
71-63-6
Digitoxin
100/10,000
100
2238075
Diglycidyl ether
1,000
1,000
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
20830-75-5
Digoxin
10/10,000
10
115-26-4
Dimefox
500
500
60-51-5
Dimethoate
500/10,000
10
2524-03-0
Dimethyl phosphorochloridothioate
500
500
77-78-1
Dimethyl sulfate
500
100
75-78-5
Dimethyldichlorosilane
500
500
57-14-7
Dimethylhydrazine
1,000
10
99-98-9
Dimethyl-p-phenylenediamine
10/10,000
10
644-64-4
Dimetilan
500/10,000
1
534-52-1
Dinitrocresol
10/10,000
10
88-85-7
Dinoseb
100/10,000
1,000
1420-07-1
Dinoterb
500/10,000
500
78-34-2
Dioxathion
500
500
82-66-6
Diphacinone
10/10,000
10
152-16-9
Diphosphoramide, octamethyl-
100
100
298-04-4
Disulfoton
500
1
514-73-8
Dithiazanine iodide
500/10,000
500
541-53-7
Dithiobiuret
100/10,000
100
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
316-42-7
Emetine, dihydrochloride
1/10,000
1
115-29-7
Endosulfan
10/10,000
1
2778-04-3
Endothion
500/10,000
500
72-20-8
Endrin
500/10,000
1
106-89-8
Epichlorohydrin
1,000
100
2104-64-5
EPN
100/10,000
100
50-14-6
Ergocalciferol
1,000/10,000
1,000
379-79-3
Ergotamine tartrate
500/10,000
500
1622-32-8
Ethanesulfonyl chloride,2-chloro-
500
500
10140-87-1
Ethanol, 1,2-dichloro-, acetate
1,000
1,000
563-12-2
Ethion
1,000
10
13194-48-4
Ethoprophos
1,000
1,000
538-07-8
Ethylbis(2-chloroethyl)amine
500
500
371-62-0
Ethylene fluorohydrin
10
10
75-21-8
Ethylene oxide
1,000
10
107-15-3
Ethylenediamine
10,000
5,000
151-56-4
Ethyleneimine
500
1
542-90-5
Ethylthiocyanate
10,000
10,000
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
22224-92-6
Fenamiphos
10/10,000
10
115-90-2
Fensulfothion
500
500
4301-50-2
Fluenetil
100/10,000
100
7782-41-4
Fluorine
500
10
640-19-7
Fluoroacetamide
100/10,000
100
144-49-0
Fluoroacetic acid
10/10,000
10
359-06-8
Fluoroacetyl chloride
10
10
51-21-8
Fluorouracil
500/10,000
500
944-22-9
Fonofos
500
500
50-00-0
Formaldehyde
500
100
107-16-4
Formaldehyde cyanohydrin
1,000
1,000
23422-53-9
Formetanate hydrochloride
500/10,000
1
2540-82-1
Formothion
100
100
17702-57-7
Formparanate
100/10,000
1
21548-32-3
Fosthietan
500
500
3878-19-1
Fuberidazole
100/10,000
100
110-00-9
Furan
500
100
13450-90-3
Gallium trichloride
500/10,000
500
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
77-47-4
Hexachlorocyclopentadiene
100
10
4835-11-4
Hexamethylenediamine, N,N’-dibutyl-
500
500
302-01-2
Hydrazine
1,000
1
74-90-8
Hydrocyanic acid
100
10
7647-01-0
Hydrogen chloride (gas only)
500
5,000
7664-39-3
Hydrogen fluoride
100
100
7722-84-1
Hydrogen peroxide (Conc.>52%)
1,000
1,000
7783-07-5
Hydrogen selenide
10
10
7783-06-4
Hydrogen sulfide
500
100
123-31-9
Hydroquinone
500/10,000
100
13463-40-6
Iron, pentacarbonyl-
100
100
297-78-9
Isobenzan
100/10,000
100
78-82-0
Isobutyronitrile
1,000
1,000
102-36-3
Isocyanic acid, 3,4-dichlorophenyl ester
500/10,000
500
465-73-6
Isodrin
100/10,000
1
55-91-4
Isofluorphate
100
100
4098-71-9
Isophorone diisocyanate
100
100
108-23-6
Isopropyl chloroformate
1,000
1,000
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
119-38-0
Isopropylmethylpyrazolyl dimethylcarbamate
500
1
78-97-7
Lactonitrile
1,000
1,000
21609-90-5
Leptophos
500/10,000
500
541-25-3
Lewisite
10
10
58-89-9
Lindane
1,000/10,000
1
7580-67-8
Lithium hydride
100
100
109-77-3
Malononitrile
500/10,000
1,000
12108-13-3
Manganese, tricarbonyl methylcyclopentadienyl
100
100
51-75-2
Mechlorethamine
10
10
950-10-7
Mephosfolan
500
500
1600-27-7
Mercuric acetate
500/10,000
500
7487-94-7
Mercuric chloride
500/10,000
500
21908-53-2
Mercuric oxide
500/10,000
500
10476-95-6
Methacrolein diacetate
1,000
1,000
760-93-0
Methacrylic anhydride
500
500
126-98-7
Methacrylonitrile
500
1,000
920-46-7
Methacryloyl chloride
100
100
30674-80-7
Methacryloyloxyethyl isocyanate
100
100
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
10265-92-6
Methamidophos
100/10,000
100
558-25-8
Methanesulfonyl fluoride
1,000
1,000
950-37-8
Methidathion
500/10,000
500
2032-65-7
Methiocarb
500/10,000
10
16752-77-5
Methomyl
500/10,000
100
151-38-2
Methoxyethylmercuric acetate
500/10,000
500
80-63-7
Methyl 2-chloroacrylate
500
500
74-83-9
Methyl bromide
1,000
1,000
79-22-1
Methyl chloroformate
500
1,000
60-34-4
Methyl hydrazine
500
10
624-83-9
Methyl isocyanate
500
10
556-61-6
Methyl isothiocyanate
500
500
74-93-1
Methyl mercaptan
500
100
3735-23-7
Methyl phenkapton
500
500
676-97-1
Methyl phosphonic dichloride
100
100
556-64-9
Methyl thiocyanate
10,000
10,000
78-94-4
Methyl vinyl ketone
10
10
502-39-6
Methylmercuric dicyanamide
500/10,000
500
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
75-79-6
Methyltrichlorosilane
500
500
1129-41-5
Metolcarb
100/10,000
1
7786-34-7
Mevinphos
500
10
315-18-4
Mexacarbate
500/10,000
1,000
50-07-7
Mitomycin C
500/10,000
10
6923-22-4
Monocrotophos
10/10,000
10
2763-96-4
Muscimol
500/10,000
1,000
505-60-2
Mustard gas
500
500
13463-39-3
Nickel carbonyl
1
10
54-11-5
Nicotine
100
100
65-30-5
Nicotine sulfate
100/10,000
100
7697-37-2
Nitric acid
1,000
1,000
10102-43-9
Nitric Oxide
10
100
98-95-3
Nitrobenzene
10,000
1,000
1122-60-7
Nitrocyclohexane
500
500
10102-44-0
Nitrogen dioxide
100
10
62-75-9
Nitrosodimethylamine
1,000
10
991-42-4
Norbormide
100/10,000
100
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
NONE
Organorhodium Complex (PMN-82-147)
10/10,000
10
630-60-4
Ouabain
100/10,000
100
23135-22-0
Oxamyl
100/10,000
1
78-71-7
Oxetane, 3,3-bis(chloromethyl)-
500
500
2497-07-6
Oxydisulfoton
500
500
10028-15-6
Ozone
100
100
1910-42-5
Paraquat dichloride
10/10,000
10
2074-50-2
Paraquat methosulfate
10/10,000
10
56-38-2
Parathion
100
10
298-00-0
Parathion-methyl
100/10,000
100
12002-03-8
Paris green
500/10,000
1
19624-22-7
Pentaborane
500
500
2570-26-5
Pentadecylamine
100/10,000
100
79-21-0
Peracetic acid
500
500
594-42-3
Perchloromethyl mercaptan
500
100
108-95-2
Phenol
500/10,000
1,000
4418-66-0
Phenol, 2,2’-thiobis[4-chloro-6-methyl-]
100/10,000
100
64-00-6
Phenol, 3-(1-methylethyl)-, methylcarbamate
500/10,000
1
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
58-36-6
Phenoxarsine, 10,10’-oxydi-
500/10,000
500
696-28-6
Phenyl dichloroarsine
500
1
59-88-1
Phenylhydrazine hydrochloride
1,000/10,000
1,000
62-38-4
Phenylmercury acetate
500/10,000
100
2097-19-0
Phenylsilatrane
100/10,000
100
103-85-5
Phenylthiourea
100/10,000
100
298-02-2
Phorate
10
10
4104-14-7
Phosacetim
100/10,000
100
947-02-4
Phosfolan
100/10,000
100
75-44-5
Phosgene
10
10
732-11-6
Phosmet
10/10,000
10
13171-21-6
Phosphamidon
100
100
7803-51-2
Phosphine
500
100
2665-30-7
Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester
500
500
2703-13-1
Phosphonothioic acid, methyl-,
500
500
100
100
O-ethyl O-(4-(methylthio)phenyl) ester
50782-69-9
Phosphonothioic acid, methyl-,
S-(2-(bis(1-methylethyl)Amino)ethyl) O-ethyl ester
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
3254-63-5
Phosphoric acid, dimethyl 4-(methylthio) phenyl ester
500
500
2587-90-8
Phosphorothioic acid, O,O-
500
500
dimethyl-s-(2-(methylthio)ethyl)ester
7723-14-0
Phosphorus
100
1
10025-87-3
Phosphorus oxychloride
500
1,000
10026-13-8
Phosphorus pentachloride
500
500
7719-12-2
Phosphorus trichloride
1,000
1,000
57-47-6
Physostigmine
100/10,000
1
57-64-7
Physostigmine, salicylate (1:1)
100/10,000
1
124-87-8
Picrotoxin
500/10,000
500
110-89-4
Piperidine
1,000
1,000
23505-41-1
Pirimifos-ethyl
1,000
1,000
10124-50-2
Potassium arsenite
500/10,000
1
151-50-8
Potassium cyanide
100
10
506-61-6
Potassium silver cyanide
500
1
2631-37-0
Promecarb
500/10,000
1
106-96-7
Propargyl bromide
10
10
57-57-8
Propiolactone (beta-)
500
10
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
107-12-0
Propionitrile
500
10
542-76-7
Propionitrile, 3-chloro-
1,000
1,000
70-69-9
Propiophenone, 4’-amino
100/10,000
100
109-61-5
Propyl chloroformate
500
500
75-56-9
Propylene oxide
10,000
100
75-55-8
Propyleneimine
10,000
1
2275-18-5
Prothoate
100/10,000
100
129-00-0
Pyrene
1,000/10,000
5,000
140-76-1
Pyridine, 2-methyl-5-vinyl-
500
500
504-24-5
Pyridine, 4-amino-
500/10,000
1,000
1124-33-0
Pyridine, 4-nitro-, 1-oxide
500/10,000
500
53558-25-1
Pyriminil
100/10,000
100
14167-18-1
Salcomine
500/10,000
500
107-44-8
Sarin
10
10
7783-00-8
Selenious acid
1,000/10,000
10
7791-23-3
Selenium oxychloride
500
500
563-41-7
Semicarbazide hydrochloride
1,000/10,000
1,000
3037-72-7
Silane, (4-aminobutyl)diethoxymethyl-
1,000
1,000
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
7631-89-2
Sodium arsenate
1,000/10,000
1
7784-46-5
Sodium arsenite
500/10,000
1
26628-22-8
Sodium azide (Na(N3))
500
1,000
124-65-2
Sodium cacodylate
100/10,000
100
143-33-9
Sodium cyanide (Na(CN))
100
10
62-74-8
Sodium fluoroacetate
10/10,000
10
13410-01-0
Sodium selenate
100/10,000
100
10102-18-8
Sodium selenite
100/10,000
100
10102-20-2
Sodium tellurite
500/10,000
500
900-95-8
Stannane, acetoxytriphenyl-
500/10,000
500
57-24-9
Strychnine
100/10,000
10
60-41-3
Strychnine, sulfate
100/10,000
10
3689-24-5
Sulfotep
500
100
3569-57-1
Sulfoxide, 3-chloropropyl octyl
500
500
7446-09-5
Sulfur dioxide
500
500
7783-60-0
Sulfur tetrafluoride
100
100
7446-11-9
Sulfur trioxide
100
100
7664-93-9
Sulfuric acid
1,000
1,000
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
77-81-6
Tabun
10
10
7783-80-4
Tellurium hexafluoride
100
100
107-49-3
TEPP
100
10
13071-79-9
Terbufos
100
100
78-00-2
Tetraethyl lead
100
10
597-64-8
Tetraethyl tin
100
100
75-74-1
Tetramethyl lead
100
100
509-14-8
Tetranitromethane
500
10
10031-59-1
Thallium sulfate
100/10,000
100
6533-73-9
Thallous carbonate
100/10,000
100
7791-12-0
Thallous chloride
100/10,000
100
2757-18-8
Thallous malonate
100/10,000
100
7446-18-6
Thallous sulfate
100/10,000
100
2231-57-4
Thiocarbazide
1,000/10,000
1,000
39196-18-4
Thiofanox
100/10,000
100
297-97-2
Thionazin
500
100
108-98-5
Thiophenol
500
100
79-19-6
Thiosemicarbazide
100/10,000
100
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
5344-82-1
Thiourea, (2-chlorophenyl)-
100/10,000
100
614-78-8
Thiourea, (2-methylphenyl)-
500/10,000
500
7550-45-0
Titanium tetrachloride
100
1,000
584-84-9
Toluene-2,4-diisocyanate
500
100
91-08-7
Toluene-2,6-diisocyanate
100
100
110-57-6
trans-1,4-Dichlorobutene
500
500
1031-47-6
Triamiphos
500/10,000
500
24017-47-8
Triazofos
500
500
1558-25-4
Trichloro(chloromethyl)silane
100
100
27137-85-5
Trichloro(dichlorophenyl)silane
500
500
76-02-8
Trichloroacetyl chloride
500
500
115-21-9
Trichloroethylsilane
500
500
327-98-0
Trichloronate
500
500
98-13-5
Trichlorophenylsilane
500
500
998-30-1
Triethoxysilane
500
500
75-77-4
Trimethylchlorosilane
1,000
1,000
824-11-3
Trimethylolpropane phosphite
100/10,000
100
1066-45-1
Trimethyltin chloride
500/10,000
500
Revision 05/23/2011
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CAS #
NAME
TPQ Pounds
RQ Pounds
639-58-7
Triphenyltin chloride
500/10,000
500
555-77-1
Tris(2-chloroethyl)amine
100
100
2001-95-8
Valinomycin
1,000/10,000
1,000
1314-62-1
Vanadium pentoxide
100/10,000
1,000
108-05-4
Vinyl acetate monomer
1,000
5,000
81-81-2
Warfarin
500/10,000
100
129-06-6
Warfarin sodium
100/10,000
100
28347-13-9
Xylylene dichloride
100/10,000
100
1314-84-7
Zinc phosphide
500
100
58270-08-9
Zinc,
dichloro(4,4-dimethyl- 100/10,000
5((((methylamino)carbonyl)oxy)imino)pentanenitrile)-, (T-4)-
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100
Appendix VI: Memorandum of Understanding - DPS & THECB
Memorandum of Understanding between the Texas Department of Public safety and
the Texas Higher Education Coordinating Board
Pursuant to Texas Health and Safety Code, Section 481.0621 (b), the Texas Department
of Public Safety (DPS) and the Texas Higher Education Coordinating Board (THECB)
enter into this memorandum of understanding in order to establish the responsibilities of
the DPS, the THECB, and the public or private institutions of higher education for
implementing and maintaining a program for reporting information concerning controlled
substances, controlled substance analogues, chemical precursors, and chemical
laboratory apparatus used in education or research activities of institutions of higher
education.
A. Definitions
1) Agent – any peace officer or other person who is authorized by law to enforce
or administer state or federal drug laws.
2) Central Location – location within an institution of higher education where
records are maintained.
3) 21 CFR, Part 1301 – 21 Code of Federal Regulations, Part 1301 to End,
providing for the Registration of Manufacturers, Distributors, and Dispensers of
Controlled Substances and any amendments to these regulations hereafter
adopted.
4) Client – any person or entity to which DPS has issued a permit authorizing the
purchase, sale, transfer or furnishing of a controlled item.
5) Controlled Glassware – condensers; distilling apparatus; vacuum dryers; single,
two-and three-necked flasks; distilling flasks; Florence flasks; filter funnels;
Buchner funnels; separatory funnels; Erlenmeyer flasks; round-bottom flasks;
thermometer flasks; filtering flasks; Soxhlet extractors; and adapter tubes made of
glass.
6) Controlled Item – precursor chemicals and laboratory apparatus listed in Texas
Health and Safety Code Section 481.002 (51) and 481.002 (53) and as named by
rule by the Director of the Department of Public Safety pursuant to the Texas
Health and Safety Code Section 481.077(b) and 481.080(c).
The table below lists the controlled items as of September 1, 2005.
Precursor Chemicals
Laboratory Apparatus
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1. Methylamine
A. Condensers
2. Ethylamine
B. Distilling apparatus
3. D-lysergic acid
C. Vacuum dryers
4. Ergotamine tartrate
D. Three-necked flasks
5. Diethyl malonate
E. Distilling flasks
6. Malonic acid
F. Tableting machines
7. Ethyl malonate
G. Encapsulating machines
8. Barbituric acid
H. Filter funnels, Buchner funnels,
and separatory funnels.
9. Piperidine
10. N-acetylanthranilic acid
I. Erlenmeyer flasks, two-necked
flasks, single neck flasks,
roundbottom flasks, Florence
flasks,
thermometer flasks,
and filtering
flasks
J. Soxhlet extractors
11. Pyrrolidine
K. Transformers
12. Phenylacetic acid
L. Flask heaters
13. Anthranilic acid
M. Heating mantles
14. Hypophosphorus acid
N. Adapter tubes
15. Ephedrine
16. Pseudoephedrine
17. Norpseudoephedrine
18. Phenylpropanolamine
19. Red phosphorus
7) (g) Controlled Substance – a substance, including a drug, an adulterant and a
dilutant as defined by the Health and Safety Code, Chapter 481, the Texas
Controlled Substances Act.
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8) (h) Controlled Substance Analogue – (1) a substance with a chemical structure
substantially similar to the chemical structure of a controlled substance in
Schedule I or II or Penalty Group 1, 1-A, or 2 of the Texas Health and Safety
Code, Chapter 481, Texas Controlled Substances Act; and (2) a substance
specifically designed to produce an effect substantially similar to, or greater than,
the effect of a controlled substance in Schedule I or II or Penalty Group 1, 1-A, or
2 of the Texas Health and Safety Code, Chapter 481, Texas Controlled
Substances Act.
9) DPS – Department of Public Safety Narcotics Service Regulatory Program that
is charged with the regulation of controlled substances and items listed in this
MOU.
10) Institution of Higher Education or Institution – this term includes an institution
of higher education, as defined in Texas Education Code, Section 61.003(8), a
private or independent institution of higher education, as defined in Texas
Education Code, Section 61.003(15), and a private postsecondary educational
institution, as defined in Texas Education Code, Section 61.302(2).
11) MOU – memorandum of understanding as required by the Texas Health and
Safety Code, Section 481.0621(b).
12) Nar-22 – form prepared and issued by DPS Narcotics Service to clients to
report sale, transfer, or furnishing of a controlled substance or item.
13) Site – a specific location at an institution where controlled items are utilized
and/or stored.
14) THECB – Texas Higher Education Coordinating Board.
15) Unacceptable Discrepancy – any difference in the amount on hand and the
amount documented that cannot reasonably be explained by accidental or normal
loss.
B.
C.
PROCEDURES
Institutions of higher education in Texas shall adopt procedures in compliance
with this MOU. When requested, the DPS shall provide technical advice to the
institution or site, and educational materials or presentations if funds and
personnel are available.
RECORDS AND REPORTS
1.
The site shall maintain all purchase order records, in accordance with the minimum
retention requirements established by the Texas State Library and Archives
Commission, of the incoming controlled substances, controlled substance
analogues, precursor chemicals and laboratory apparatus (including controlled
glassware) covered in this MOU that have been purchased or received by the site
or central location.
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2.
An institution or site that discovers a readily unacceptable discrepancy, loss,
pilferage or theft of a controlled substance, controlled substance analogue,
precursor chemical or laboratory apparatus (including controlled glassware) shall
submit a written report of the incident to the appropriate law enforcement agency no
later than 5 business days after the date of discovery of the discrepancy, loss,
pilferage or theft. The institution shall forward the report to DPS within 5 additional
business days after the report is submitted to the appropriate law enforcement
agency.
3.
Upon request, the DPS shall assist the law enforcement agency conducting an
investigation regarding the pilferage or theft of the controlled substance, precursor
chemical, or laboratory apparatus named in this MOU.
4.
The DPS may request that an institution or site provide a duplicate of any record(s)
covered by this MOU and the institution or site shall provide such record(s) within
10 business days of the request. The record(s) may be provided in electronic or
hard copy form.
D. SALE, TRANSFER OR FURNISHING OF CONTROLLED ITEMS
1.
The institution or site shall prohibit the sale, furnishings, or transfer of controlled
items, including glassware, covered by this MOU to any person or entity not holding
a DPS permit, unless the recipient is specifically exempted by law or rule.
2.
The institution shall report to the DPS on a Nar-22 form or any form mutually agreed
upon by all parties, every sale, furnishing or transfer of a controlled item leaving the
institution. The site shall submit these reports to the DPS within 30 days of the
furnishing or transfer of the controlled items. This report shall include the name,
address, telephone number, permit number (if applicable), driver license number,
and date of birth of the client receiving the controlled items.
E. CONTROLLED
ANALOGUES
SUBSTANCES
AND
CONTROLLED
SUBSTANCE
1.
The institution or site is responsible for complying with the established procedures
as required in 21 CFR, Part 1301 to End and as required by any amendments to 21
CFR Part 1301.
2.
Upon request, the DPS shall provide technical advice to the institution or site
regarding the inventories required in 21 CFR, Part 1301 to End.
3.
Upon request, the DPS shall assist the law enforcement agency conducting any
investigation regarding any significant loss, pilferage or theft of the controlled
substances or controlled items contained in this MOU.
F. AUDITS AND INSPECTIONS
The institution or site shall permit any DPS agent to conduct audits and
inspections of all records made in accordance with the MOU at any reasonable
time and shall not interfere with the discharge of the agent’s duties.
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G. SECURITY AND STORAGE
The institution or site shall ensure the security of the controlled items by costeffective means that afford a reasonable sense of safety and accountability, such
as electronic records keeping and physical security. In addition, the institution or
site shall require that the controlled substances and precursor chemicals are
stored in accordance with recommendations of the manufacturer, the Texas
Commission on Environmental Quality and the Federal Environmental Protection
Agency.
H. CONTACT PERSON(S)
Each institution or site shall appoint one or more individuals, as needed, to be
responsible for implementing the security measures established by the institution
or site. The institution shall annually provide a list of these individuals to the DPS
and shall ensure that these individuals serve as the contact between the institution
and the DPS. The initial list of contact persons shall be provided within ninety (90)
days after the effective date of this Memorandum of Understanding.
The general provisions of this Memorandum of Understanding shall be effective
on the date of signature by representatives of both parties. This agreement, upon
review of both parties, may be amended by written agreement whenever such
action is necessary.
I.
Suggestions for Implementing MOU Procedures
1.
Notify all personnel involved with environmental and safety issues about the MOU.
2.
Notify all science and health laboratory personnel about the MOU.
3.
Provide information to appropriate personnel regarding the potential problem of
diversion of laboratory chemicals and apparatus to illegal drug operations.
4.
Notify the Department of Public Safety (DPS) of the person designated to act as the
liaison between the institution and the DPS.
5.
Notify all personnel involved in the sale or transfer of surplus equipment that none
of the precursor chemicals or laboratory apparatus, including glassware, listed as
controlled items in the MOU should be sold or otherwise transferred to anyone who
does not have the proper permit or the specific authority to purchase or accept the
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controlled items. Personnel involved in the transfer or sale of these items should be
provided with copies of the Nar-22 form, which should be used to report the sale,
transfer, or furnishing of the listed precursor chemicals or laboratory apparatus. Any
party involved in an auction of surplus equipment should be informed of the MOU.
6.
Establish procedures to assure an appropriate level of security for controlled items
in educational and research laboratories and storerooms. Designate an individual
to be responsible for establishing security measures.
7.
Encourage all personnel to be alert and attentive to the disappearance of any of the
controlled items and to report losses to the institution’s contact person for controlled
substances.
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Appendix VII: UTSA Policy on Controlled Substance Use in Research
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Review and Signature Page
This policy has been reviewed for regulatory compliance and best management
practices by the undersigned individuals and is hereby adopted for use and compliance
by all employees at the University of Texas at San Antonio.
Printed Name
James Weaver
Signature
Signature on file
J. Brian Moroney
Signature on file
Wendy McCoy
Signature on file
Title
Director, Institutional
Compliance and Risk
Director, EHSRM
Date
1/30/09
1/30/09
Review Date
May 20, 2011
Laboratory Safety
Manger
1/30/09
Signature of Director of EHSRM
Signature on file
This plan was reviewed/revised on 5/20/2011 and replaces the 5/28/2008 version.
Changes to this plan have been highlighted in “gray” and are summarized below:
Throughout: Laboratory Safety Officer (LSO) has been updated to Laboratory Safety
Manager (LSM). (not highlighted)
VIII:
Intra-facility Tranfers has been revised.
IX:
More information on the Form 41 has been provided.
XI:
The website has been updated.
Appendix B: The inventory form has been updated.
Appendix C: A new question has been added to the checklist.
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Table of Contents
I.
Purpose and Scope
4
II.
Application and Licensing
4
III.
Committee Approval
5
IV.
Ordering Controlled Substances
5
V.
Delivery and Receiving
6
VI.
Storage and Security
6
VII.
Appointing a Designee
7
VIII. Intra-facility Transfers
7
IX.
Disposal
8
X.
Abandoned Controlled Substances
8
XI.
Schedules of Controlled Substances
8
Appendix A Designee Letter
9
Appendix B Inventory Form
11
Appendix C Inspection Checklist
13
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I. Purpose and Scope
Through a Memorandum of Understanding (MOU) between the Texas Higher Education
Coordinating Board and the Texas Department of Public Safety (TDPS), UTSA
researchers are allowed to use controlled substances in their research on campus
under the conditions listed in this policy. A controlled substance is defined in 21 U.S.C.
802, section 102 as, “a drug or other substance, or immediate precursor, included in
Schedules I, II, III, IV, or V of part B of this subchapter. The term does not include
distilled spirits, wine, malt beverages, or tobacco, as those terms are defined or used
in subtitle E of the Internal Revenue Code of 1986.” The regulations for controlled
substances may be found in Title 21 of the Code of Federal Regulations – Food and
Drug Administration, Chapter 2 – Drug Enforcement Administration (DEA),
Department of Justice, Parts 1300-1316 (21 CFR §1300-1316).
No Principle Investigator (PI or Licensee) may use controlled substances on campus
for research purposes until they have obtained licenses from the DEA and TDPS and
these licenses have been registered with the UTSA Office of Environmental Health,
Safety and Risk Management (EHSRM) and the Laboratory Safety Manger (LSM).
II. Application and Licensing
The PI must first obtain federal licensure from the DEA. The application can be
obtained from the DEA website. Prior to applying, certain documentation is needed for
an interview with DEA. This documentation may need to be submitted to the local
DEA office and should be on hand prior to an interview. Information packets on this
documentation and the application process are available in EHSRM from the LSM. First
time applications and reapplication after a period of non-licensure will most likely
require a phone interview by the local DEA office and possibly an inspection.
Licenses must be renewed on a yearly basis.
DEA will send out renewal
documentation/notices a few months prior to the expiration of the license. If no
changes are necessary, including controlled substance listings, then the renewal can
be done online. A copy of the completed online renewal form should be printed out
and kept with the PI’s controlled substance records. A copy of this renewal form must
be sent to EHSRM immediately.
Initial and paper renewal applications for the DEA license must be routed through the
office of the Vice President for Business Affairs (VPBA) via the Senior Administrative
Assistant. The application will be sent to the UTSA Police Department (UTSA-PD) and
to EHSRM for their approval. After approval and signature by the VPBA or AVPBA as
the certifying official, the application is returned to the PI to be forwarded to DEA.
Once the DEA license is obtained, the PI must apply to the Texas Department of Public
Safety (TDPS) for state licensure. This application will then be routed for processing
and approval in the same manner as the DEA application. TDPS sends out renewal
forms a few months prior to the renewal deadline. As with the DEA license, the TDPS
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license must be renewed on a yearly basis. Once the application is approved by the
TDPS and both licenses are in place in the laboratory and a readable copy of each has
been provided to EHSRM, the PI may order controlled substances as allowed by the
licenses. Licenses are issued for specific schedules of controlled substances and only
the specified items on the specific schedules may be ordered. If an item not specified
on the license is needed, the PI must contact the local DEA office to add this item to
the license and get approval before an order can be placed.
Compliance with all federal regulations is solely the responsibility of the licensee.
Failure to comply can result fines of up to $10,000 per item. Failure to comply can
also result in loss of license or imprisonment.
III. Committee Approval
All research involving controlled substances must be approved by the appropriate
committee prior to the start of any project.
The PI must obtain appropriate
committee approval prior to the start of any project.
•
The Institutional Animal Use and Care Committee (IACUC) must approve
research projects involving animals and controlled substances.
•
The Institutional Review Board (IRB) must approve research projects involving
humans and controlled substances.
According to the scope of these projects, approval of the Institutional Biosafety
Committee (IBC) and/or the Chemical Safety Committee (CSC) may be required as
well. The institutional Laboratory Safety Committee (LSC) has oversight for
compliance with federal, state, local and UTSA regulations and policies pertaining to
laboratories including work with controlled substances.
IV. Ordering Controlled Substances
Prior to placing a first order for controlled substances, the licensee should contact
EHSRM to set up an appointment with the LSM to review UTSA procedures and some
of the federal regulations pertinent to inventory and storage. The LSM strives to stay
updated on pertinent federal regulations, but in no way should be the only source of
information utilized by a licensee.
The licensee has the sole responsibility for
compliance with federal regulations and is subject to penalties and fines if not in
compliance.
All purchase orders (PBOs, PB4s) for controlled substances must utilize the
commodity code 190-36. Use of this commodity code will route the order to EHSRM
for approval. Failure to use this code may result in disciplinary action. The individual
placing the order will require the vendor to label the package directly to the PI and to
ensure the packing slip is secured to the outside of the package. A Form 222 must be
sent to the vendor when placing orders for Schedule I or II controlled substances. Form
222 must be obtained from DEA in advance.
EHSRM will verify that the PI has a current license, and provide to the PI and any other
appropriate University offices any additional direction regarding the order that may be
required. The requestor must be the person who holds the licenses for use of controlled
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substances. A designee is not allowed to place controlled substance orders for approval.
Proper labeling on the box will indicate that only the addressee (licensed PI) should open
the box.
No purchases of controlled substances may be made using a Procard or
personal credit card. Such use can result in revocation of Procard privileges or
other actions.
V. Delivery and Receiving
All controlled substance orders will be delivered to Central Receiving Warehouse
(CRW). EHSRM will inform CRW personnel when the order is placed as well as
anticipated delivery date and any information necessary to identify the package,
including PO number, PI, and vendor. Proper labeling on the box will indicate that
only the addressee should open the box. CRW personnel will lock the package in a
secure location and contact the PI. The PI or approved designee must go to CRW in
person to pick up the package and be prepared to present a valid UTSA ID or Texas
driver’s license picture identification card. A designee as described in section VII may
pick up the package if proper documentation has been provided to CRW and EHSRM in
advance of ordering. A designee must be approved in advance by EHSRM.
Upon receipt of the package the addressee must provide the necessary receipt
documentation to the CRW personnel including a signature. The PI or designee will
open the package and confirm the amount received in the presence of CRW personnel.
CRW personnel will serve as a witness and will document and verify shipment content
by providing a signature on the packing slip. The PI or designee must also sign the
packing slip. Any discrepancy must be annotated on the packing slip.
VI. Storage and Security
Once the controlled substance is released to the PI or designee, it must be taken
directly to the laboratory and secured in accordance with DEA regulations. Exact
inventories with annotations of amounts received and amounts used along with the
dates used must be kept in the laboratory. Biennial Inventories must be done at least
every two years. It is strongly recommended that these “biennial” inventories be
done more frequently such as quarterly. Audits of the inventories will be conducted
periodically by the university Compliance Office, IACUC, and/or EHSRM. The use of
the UTSA Controlled Substance Inventory form is mandatory (Appendix B).
The controlled substance must be secured at all times when not in use in the
laboratory. The University Compliance Office, IACUC and/or EHSRM personnel will
review the storage location and security precautions during their periodic audits – any
suspected security issues noted will be reported to UTSA-PD for advice and
consultation with the license holder as well as the Laboratory Safety Committee. The
laboratory itself must be secured at all times when unoccupied. Only the licensed PI,
or designee as appointed in section VII, should have access to the storage area.
No extra keys or lock combinations can be given out other than to the designee. Any
known or suspected theft should be reported immediately to the UTSA-PD. The LSM
should also be contacted immediately. At no time should students be given
unsupervised access to controlled substances.
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VII. Appointing a Designee
At their discretion, the licensee can designate one other person to have access to the
storage area and carry out other functions except ordering of controlled substances.
This person must be a staff member. To designate this individual, the licensee must
fill out a “Power of Attorney” letter. An example letter is given in Appendix A of this
document. This letter must be stored with the controlled substances and provided to
DEA at their request. Copies must be provided to the LSM, Central Receiving
Warehouse (CRW), and UTSA-PD. If a person is being removed as a designee, for
whatever reason, the LSM, CRW, and UTSA-PD must be notified immediately (within
24 hours) by email or phone.
VIII. Intra-facility Transfers
The DEA has recommended against intra-facility transfers. The Laboratory
Safety Manager (LSM) can provide alternatives according to the situation.
Prior to undertaking any transfer, please contact the LSM.
IX. Disposal
UTSA has been granted permission by DEA to dispose of controlled substances
through a registered chemical waste stream. The approved procedure involves the PI,
the local DEA office, UTSA-PD and EHSRM. Appropriate notice must be given to the
LSM whenever disposal using this procedure is needed. The LSM will coordinate the
arrangements for disposal and acquire the necessary DEA documentation. EHSRM will
submit a form 41 request for disposal to the DEA on behalf of the PI. In order to
submit this form, EHSRM will need the name of the drug, number of containers,
concentration and amount of each drug requested for disposal. Upon pick up for
disposal, the PI will sign the form 41. After disposal has occurred, the person carrying
out the disposal and the witnessing police officer will sign the form 41. Copies of the
signed form will be provided to DEA, the PI, UTSA-PD and to EHSRM. A copy of each
form 41 shall be added to a PI’s controlled substance inventory logbook as proof of
such disposal.
The other approved option for disposal is utilizing a reverse distributor. In no case
may controlled substances be disposed of by any other methods.
X. Abandoned Controlled Substances
A PI cannot abandon a controlled substance. Such abandonment is subject to DEA
fines and penalties.
Any controlled substances found abandoned in research
laboratories will be turned over to UTSA-PD for storage. The licensed PI will be
contacted to arrange proper disposal. If UTSA is unable to contact the PI or if the PI
does not arrange for proper disposal within seven (7) days of being contacted by
UTSA, UTSA will contact the DEA. The DEA may take criminal and other action
against the licensee.
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XI. Schedules of Controlled Substances
Schedules I-V for controlled substances (The term “listed chemical” means any list I
chemical or any list II chemical) may be obtained at the following link:
http://www.deadiversion.usdoj.gov/schedules/#list
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Appendix A
Designee Letter
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Controlled Substance Designee Letter As a controlled substance licensee, I designate _______________________________ to carry out all needed actions in regard to the use of controlled substances in my laboratory with the exception of ordering. This person is allowed to have access to the storage location, provide dilutions to other lab personnel for immediate use in their work, properly administer the substances to animals, update inventory records, pick-­‐up orders of controlled substances from Central Receiving Warehouse and any other actions as needed except as noted above. DEA License #_______________________ TDPS License#___________________________ Licensee’s Name (Print) __________________________________________ Licensee’s Signature _____________________________________________ Date_______________________________ As a designee, I understand the federal, state, local and UTSA regulations, policies, and procedures in regards to the use of controlled substances in research on campus. I am aware that failure to comply with these regulations, policies, and procedures could result in disciplinary actions up to and including termination, fines, criminal penalties and other actions. I understand that I cannot order controlled substances. Designee’s Job Title _________________________________ Designee’s Name (Print) _______________________________ Designee’s Signature _________________________________ Date _____________________________________ This designation of authority ends with separation of the designee from UTSA or upon leaving employment with the licensee. Original must be stored with controlled substance inventory. Copies must be provided to LSM, Designee, UTSA Police Department, and Warehouse Manager. Revision 05/23/2011
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Appendix B
Inventory Form
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Appendix C: Inspection Checklist Items Security
& Access
1.
2.
3.
License & 4.
Inventory 5.
6.
7.
8.
9.
10.
11.
12.
13.
Theft
& 14.
Disposal
15.
16.
Transfer
17.
18.
Other
19.
Is access to Lab area secured?
Are the controlled substance(s) properly
secured?
Is access to controlled substance(s) limited to
the licensee and designee (if applicable)?
Are DEA and TDPS licenses current?
Is storage limited to the controlled substance(s),
their records, and inventories?
Is documentation of orders available, including
Form 222 if pertinent?
Is an initial inventory available?
Is a biennial inventory available?
When was the biennial inventory conducted?
Is the biennial inventory properly annotated?
Is the inventory updated on a daily basis or as
the controlled substance is used?
Does the physical inventory match the written
inventory?
Is a designee letter available?
Has there been a loss or theft of a controlled
substance on site?
If a theft or loss has occurred is the appropriate
documentation available?
Is a Form 41 available for disposal of controlled
substances?
Have any intra-facility transfers occurred?
Is the appropriate documentation available for
any transfers?
Any additional concerns or observations?
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Appendix VIII. Drug Scheduling
This document is a general reference and not a comprehensive list. This list describes the basic or
parent chemical and does not describe the salts, isomers and salts of isomers, esters, ethers and
derivatives which may also be controlled substances.
Schedule I
Substance
1-(1-Phenylcyclohexyl)pyrrolidine
1-(2-Phenylethyl)-4-phenyl4acetoxypiperidine
1-[1-(2-Thienyl)cyclohexyl]piperidine
1-[1-(2-Thienyl)cyclohexyl]pyrrolidine
1-Methyl-4-phenyl-4propionoxypiperidine
2,5-Dimethoxy-4-ethylamphetamine
2,5-Dimethoxyamphetamine
3,4,5-Trimethoxyamphetamine
3,4-Methylenedioxyamphetamine
3,4-Methylenedioxymethamphetamine
3,4-Methylenedioxy-Nethylamphetamine
3-Methylfentanyl
3-Methylthiofentanyl
4-Bromo-2,5-dimethoxyamphetamine
4-Bromo-2,5dimethoxyphenethylamine
4-Methoxyamphetamine
4-Methyl-2,5-dimethoxyamphetamine
4-Methylaminorex (cis isomer)
5-Methoxy3,4methylenedioxyamphetamine
Acetorphine
Acetyl-alpha-methylfentanyl
Acetyldihydrocodeine
Acetylmethadol
Allylprodine
Alphacetylmethadol
except
levoalphacetylmethadol
Alpha-Ethyltryptamine
Alphameprodine
Alphamethadol
Alpha-Methylfentanyl
Alpha-Methylthiofentanyl
Aminorex
Benzethidine
DEA
Number
7458
9663
Non
Narcotic
N
7470
7473
9661
N
N
TCP, tenocyclidine
TCPy
MPPP, synthetic heroin
7399
7396
7390
7400
7405
7404
N
N
N
N
N
N
DOET
DMA, 2,5-DMA
TMA
MDA, Love Drug
MDMA, Ecstasy, XTC
N-ethyl MDA, MDE, MDEA
9813
9833
7391
7392
N
N
China White, fentanyl
Chine White, fentanyl
DOB, 4-bromo-DMA
Nexus, 2-CB, has been sold as Ecstasy, i.e. MDMA
7411
7395
1590
7401
N
N
N
N
PMA
DOM, STP
U4Euh, McN-422
MMDA
9319
9815
9051
9601
9602
9603
7249
9604
9605
9814
9832
1585
9606
Other Names
PCPy, PHP, rolicyclidine
PEPAP, synthetic heroin
Acetylcodone
Methadyl acetate
N
ET, Trip
N
China White, fentanyl
China White, fentanyl
has been sold as methamphetamine
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Benzylmorphine
Betacetylmethadol
Beta-Hydroxy-3-methylfentanyl
Beta-Hydroxyfentanyl
Betameprodine
Betamethadol
Betaprodine
Bufotenine
Cathinone
Clonitazene
Codeine methylbromide
Codeine-N-oxide
Cyprenorphine
Desomorphine
Dextromoramide
Diampromide
Diethylthiambutene
Diethyltryptamine
Difenoxin
Dihydromorphine
Dimenoxadol
Dimepheptanol
Dimethylthiambutene
Dimethyltryptamine
Dioxaphetyl butyrate
Dipipanone
9052
9607
9831
9830
9608
9609
9611
7433
1235
9612
9070
9053
9054
9055
9613
9615
9616
7434
9168
9145
9617
9618
9619
7435
9621
9622
Drotebanol
Ethylmethylthiambutene
Etonitazene
Etorphine (except HCl)
Etoxeridine
Fenethylline
9335
9623
9624
9056
9625
1503
N
Captagon,amfetyline,ethyltheophylline amphetamine
Furethidine
Gama Hydroxybutyric Acid (GHB)
9626
2010
N
GHB, gama hydroxybutyrate, sodium oxybate
Heroin
Hydromorphinol
Hydroxypethidine
Ibogaine
Ketobemidone
Levomoramide
Levophenacylmorphan
Lysergic acid diethylamide
Marijuana
9200
9301
9627
7260
9628
9629
9631
7315
7360
China White, fentanyl
China White, fentanyl
N
N
Mappine, N,N-dimethylserotonin
Constituent of “Khat” plant
Palfium, Jetrium, Narcolo
N
DET
Lyspafen
N
DMT
Dipipan, phenylpiperone HCl, Diconal, Wellconal
Metebanyl, oxymethebanol
Diacetylmorphine, diamorphine
N
Constituent of “Tabernanthe iboga” plant
Cliradon
N
N
LSD, lysergide
Cannabis, marijuana
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Mecloqualone
Mescaline
Methaqualone
2572
7381
2565
N
N
N
Nubarene
Constituent of “Peyote” cacti
Quaalude, Parest, Somnafac, Opitimil, Mandrax
Methcathinone
Methyldesorphine
Methyldihydromorphine
Morpheridine
Morphine methylbromide
Morphine methylsulfonate
Morphine-N-oxide
Myrophine
N,N-Dimethylamphetamine
N-Ethyl-1-phenylcyclohexylamine
N-Ethyl-3-piperidyl benzilate
N-Ethylamphetamine
N-Hydroxy3,4methylenedioxyamphetamine
Nicocodeine
Nicomorphine
N-Methyl-3-piperidyl benzilate
Noracymethadol
Norlevorphanol
Normethadone
Normorphine
Norpipanone
Para-Fluorofentanyl
Parahexyl
Peyote
Phenadoxone
Phenampromide
1237
9302
9304
9632
9305
9306
9307
9308
1480
7455
7482
1475
7402
N
N-Methylcathinone, “cat”
N
N
N
N
N
PCE
JB 323
NEA
N-hydroxy MDA
N
Vilan
JB 336
Phenomorphan
Phenoperidine
Pholcodine
9647
9641
9314
Piritramide
Proheptazine
Properidine
Propiram
Psilocybin
Psilocyn
Racemoramide
Tetrahydrocannabinols
9642
9643
9644
9649
7437
7438
9645
7370
Thebacon
Thiofentanyl
9315
9835
9309
9312
7484
9633
9634
9635
9313
9636
9812
7374
7415
9637
9638
Phenyldimazone
N
N
China White, fentanyl
Synhexyl,
Cactus which contains mescaline
Operidine, Lealgin
Copholco, Adaphol, Codisol, Lantuss, Pholcolin
Piridolan
N
N
Algeril
Constituent of “Magic mushrooms”
Psilocin, constituent of “Magic mushrooms”
N
THC, Delta-8 THC, Delta-9 THC and others
Acetylhydrocodone, Acedicon, Thebacetyl
Chine white, fentanyl
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Tilidine
Trimeperidine
9750
9646
Tilidate, Valoron, Kitadol, Lak, Tilsa
Promedolum
Schedule II
1-Phenylcyclohexylamine
1-Piperidinocyclohexanecarbonitrile
Alfentanil
Alphaprodine
Amobarbital
Amphetamine
Anileridine
Benzoylecgonine
Bezitramide
Carfentanil
Coca Leaves
Cocaine
Codeine
7460
8603
9737
9010
2125
1100
9020
9180
9800
9743
9040
9041
9050
Dextropropoxyphene,
dosage forms)
Dihydrocodeine
Diphenoxylate
Diprenorphine
Ecgonine
Ethylmorphine
Etorphine HCl
Fentanyl
9273
Propoxyphene
9120
9170
9058
9180
9190
9059
9801
Didrate, Parzone
bulk
(non-
N
N
N
N
Precusor of PCP
PCC, precusor of PCP
Alfenta
Nisentil
Amytal, Tuinal
Dexedrine, Biphetamine
Leritine
Cocaine metabolite
Burgodin
Wildnil
Methyl benzoylecgonine, Crack
Morphine methyl ester, methyl morphine
M50-50
Cocaine precursor, in Coca leaves
Dionin
M 99
Innovar, Sublimaze, Duragesic
Glutethimide
Hydrocodone
2550
9193
N
Doriden, Dorimide
dihydrocodeinone
Hydromorphone
Isomethadone
Levo-alphacetylmethadol
9150
9226
9648
Dilaudid, dihydromorphinone
Isoamidone
LAAM, long acting methadone, levomethadyl acetate
Levomethorphan
Levorphanol
Meperidine
Meperidine intermediate-A
9210
9220
9230
9232
Levo-Dromoran
Demerol, Mepergan, pethidine
Meperidine precursor
Meperidine intermediate-B
Meperidine intermediate-C
Metazocine
Methadone
Methadone intermediate
Methamphetamine
9233
9234
9240
9250
9254
1105
Methylphenidate
Metopon
Moramide-intermediate
1724
9260
9802
Meperidine precursor
Meperidine precursor
N
Dolophine, Methadose, Amidone
Methadone precursor
Desoxyn, D-desoxyephedrine, ICE, Crank, Speed
N
Ritalin
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Morphine
9300
MS Contin, Roxanol, Duramorph, RMS, MSIR
Nabilone
Opium extracts
7379
9610
Opium fluid extract
Opium poppy
Opium tincture
Opium, granulated
Opium, powdered
Opium, raw
Oxycodone
9620
9650
9630
9640
9639
9600
9143
Papaver somniferum
Laudanum
Granulated opium
Powdered Opium
Raw opium, gum opium
OxyContin, Percocet, Tylox, Roxicodone, Roxicet,
Oxymorphone
Pentobarbital
Phenazocine
Phencyclidine
Phenmetrazine
Phenylacetone
9652
2270
9715
7471
1631
8501
Numorphan
Nembutal
Narphen, Prinadol
PCP, Sernylan
Preludin
P2P, phenyl-2-propanone, benzyl methyl ketone
Piminodine
9730
Poppy Straw
9650
Opium poppy capsules, poppy heads
Poppy Straw Concentrate
Racemethorphan
Racemorphan
Remifentanil
Secobarbital
Sufentanil
Thebaine
9670
9732
9733
9739
2315
9740
9333
Concentrate of Poppy Straw, CPS
N
N
N
N
N
N
Cesamet
Dromoran
Ultiva
Seconal, Tuinal
Sufenta
Precursor of many narcotics
Schedule III
Amobarbital & noncontrolled active
ingred.
Amobarbital suppository dosage form
Anabolic steroids
Aprobarbital
Barbituric acid derivative
Benzphetamine
Boldenone
2126
N
Amobarbital/ephedrine capsules
2126
4000
2100
2100
1228
4000
N
N
N
N
N
N
“Body Building” drugs
Alurate
Barbiturates not specifically listed
Didrex, Inapetyl
Equipoise, Parenabol, Vebonol, dehydrotestosterone
Buprenorphine
9064
Butabarbital
Butalbital
Chlorhexadol
2100
2100
2510
N
N
N
Butisol, Butibel
Fiorinal, Butalbital with aspirin
Mechloral, Mecoral, Medodorm, Chloralodol
Chlorotestosterone (same as clostebol)
Chlorphentermine
Clortermine
4000
1645
1647
N
N
N
if 4-chlorotestosterone then clostebol
Pre-Sate, Lucofen, Apsedon, Desopimon
Voranil
Buprenex, Temgesic
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Clostebol
4000
N
Codeine & isoquinoline alkaloid 90
mg/du
Codeine combination product 90 mg/du
9803
Codeine with papaverine or noscapine
9804
Empirin, Fiorinal, Tylenol, ASA or APAP w/codeine
Dehydrochlormethyltestosterone
Dihydrocodeine combination product
90 mg/du
Dihydrotestosterone
(same
as
stanolone)
Dronabinol in sesame oil in soft gelatin
capsule
Drostanolone
Ethylestrenol
4000
9807
N
Oral-Turinabol
Synalgos-DC, Compal
4000
N
see stanolone
7369
N
Marinol, synthetic THC in sesame oil/soft gelatin
4000
4000
N
N
Drolban, Masterid, Permastril
Maxibolin, Orabolin, Durabolin-O, Duraboral
Ethylmorphine combination product 15
mg/du
Fluoxymesterone
9808
4000
N
Anadroid-F, Halotestin, Ora-Testryl
Formebolone (incorrect spelling in law)
Hydrocodone & isoquinoline alkaloid
15 mg/du
Hydrocodone combination product 15
mg/du
Ketamine
Lysergic acid
Lysergic acid amide
Mesterolone
Methandienone
(see
Methandrostenolone)
Methandranone
Methandriol
Methandrostenolone
Methenolone
4000
9805
N
Esiclene, Hubernol
Dihydrocodeinone+papaverine or noscapine
9806
Alfa-Trofodermin, Clostene, 4chlorotestosterone
Tussionex, Tussend, Lortab, Vicodin, Hycodan, Anexsia
++
Ketaset, Ketalar, Special K, K
LSD precursor
LSD precursor
Proviron
7285
7300
7310
4000
4000
N
N
N
N
N
4000
4000
4000
4000
N
N
N
N
?incorrect spelling of methandienone?
Sinesex, Stenediol, Troformone
Dianabol, Metabolina, Nerobol, Perbolin
Primobolan, Primobolan Depot, Primobolan S
Methyltestosterone
Methyprylon
Mibolerone
Morphine
combination
product/50
mg/100 ml or gm
Nalorphine
Nandrolone
Norethandrolone
Opium combination product 25 mg/du
Oxandrolone
Oxymesterone
4000
2575
4000
9810
N
N
N
Android, Oreton, Testred, Virilon
Noludar
Cheque
Oxymetholone
4000
9400
4000
4000
9809
4000
4000
N
N
Nalline
Deca-Durabolin, Durabolin, Durabolin-50
Nilevar, Solevar
Paregoric, other combination products
Anavar, Lonavar, Provitar, Vasorome
Anamidol, Balnimax, Oranabol, Oranabol 10
N
Anadrol-50, Adroyd, Anapolon, Anasteron, Pardroyd
N
N
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Pentobarbital & noncontrolled active
ingred.
Pentobarbital suppository dosage form
Phendimetrazine
Secobarbital & noncontrolled active
ingred
Secobarbital suppository dosage form
Stanolone
2271
N
FP-3
2271
1615
2316
N
N
N
WANS
Plegine, Prelu-2, Bontril, Melfiat, Statobex
various
2316
4000
N
N
various
Anabolex, Andractim, Pesomax, dihydrotestosterone
Stanozolol
Stimulant
compounds
excepted
Sulfondiethylmethane
4000
1405
N
N
Winstrol, Winstrol-V
Mediatric
2600
N
2605
2610
2100
4000
4000
2100
2100
7295
N
N
N
N
N
N
N
N
Lotusate
Teslac
Android-T, Androlan, Depotest, Delatestryl
Surital
Pentothal
Telazol
4000
2100
N
N
Finaplix-S, Finajet, Parabolan
Delvinal, vinbarbitone
previously
Sulfonethylmethane
Sulfonmethane
Talbutal
Testolactone
Testosterone
Thiamylal
Thiopental
Tiletamine & Zolazepam Combination
Product
Trenbolone
Vinbarbital
Schedule IV
Alprazolam
Barbital
Bromazepam
Butorphanol
Camazepam
Cathine
Chloral betaine
Chloral hydrate
Chlordiazepoxide
Clobazam
Clonazepam
Clorazepate
Clotiazepam
Cloxazolam
Delorazepam
Dexfenfluramine
Dextropropoxyphene dosage forms
2882
2145
2748
9720
2749
1230
2460
2465
2744
2751
2737
2768
2752
2753
2754
1670
9278
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Xanax
Veronal, Plexonal, barbitone
Lexotan, Lexatin, Lexotanil
Stadol, Stadol NS, Torbugesic, Torbutrol
Albego, Limpidon, Paxor
Constituent of “Khat” plant
Beta Chlor
Noctec
Librium, Libritabs, Limbitrol, SK-Lygen
Urbadan, Urbanyl
Klonopin, Clonopin
Tranxene
Trecalmo, Rize
Enadel, Sepazon, Tolestan
Diazepam
Dichloralphenazone
Diethylpropion
Difenoxin 1 mg/25 ug AtSO4/du
Estazolam
2765
2467
1610
9167
2756
N
N
N
Valium, Valrelease
Midrin, dichloralantipyrine
Tenuate, Tepanil
Motofen
ProSom, Domnamid, Eurodin, Nuctalon
N
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Redux
Darvon, propoxyphene, Darvocet, Dolene, Propacet
Ethchlorvynol
Ethinamate
Ethyl loflazepate
Fencamfamin
Fenfluramine
2540
2545
2758
1760
1670
N
N
N
N
N
Placidyl
Valmid, Valamin
Fenproporex
Fludiazepam
Flunitrazepam
Flurazepam
Halazepam
Haloxazolam
Ketazolam
Loprazolam
Lorazepam
Lormetazepam
Mazindol
Mebutamate
Medazepam
Mefenorex
Meprobamate
1575
2759
2763
2767
2762
2771
2772
2773
2885
2774
1605
2800
2836
1580
2820
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Gacilin, Solvolip
Methohexital
Methylphenobarbital (mephobarbital)
Midazolam
Modafinil
Nimetazepam
Nitrazepam
Nordiazepam
Oxazepam
Oxazolam
Paraldehyde
Pemoline
Pentazocine
2264
2250
2884
1680
2837
2834
2838
2835
2839
2585
1530
9709
N
N
N
N
N
N
N
N
N
N
N
N
Brevital
Mebaral, mephobarbital
Versed
Provigil
Erimin
Mogadon
Nordazepam, Demadar, Madar
Serax, Serenid-D
Serenal, Convertal
Paral
Cylert
Talwin, Talwin NX, Talacen, Talwin Compound
Petrichloral
Phenobarbital
Phentermine
2591
2285
1640
N
N
N
Pentaerythritol chloral, Periclor
Luminal, Donnatal, Bellergal-S
Ionamin, Fastin, Adipex-P, Obe-Nix, Zantryl
Pinazepam
Pipradrol
Prazepam
Quazepam
Sibutramine
SPA
2883
1750
2764
2881
1675
1635
N
N
N
N
N
N
Domar
Detaril, Stimolag Fortis
Centrax
Doral, Dormalin
Meridia
1-dimethylamino-1,2-diphenylethane, Lefetamine
Temazepam
2925
N
Restoril
Tetrazepam
2886
N
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Reactivan
Pondimin, Ponderal
Rohypnol, Narcozep, Darkene, Roipnol
Dalmane
Paxipam
Anxon, Loftran, Solatran, Contamex
Ativan
Noctamid
Sanorex, Mazanor
Capla
Nobrium
Anorexic, Amexate, Doracil, Pondinil
Miltown, Equanil, Deprol, Equagesic, Meprospan
Triazolam
Zaleplon
Zolpidem
2887
2781
2783
N
N
N
Halcion
Sonata
Ambien, Stilnoct,Ivadal
Schedule V
Codeine preparations - 200 mg/100 ml
or 100 gm
Difenoxin preparations - 0.5 mg/25 ug
AtSO4/du
Dihydrocodeine
preparations
10
mg/100 ml or 100 gm
Diphenoxylate preparations 2.5 mg/25
ug AtSO4
Ethylmorphine
preparations
100
mg/100 ml or 100 gm
Opium preparations - 100 mg/100 ml or
gm
Pyrovalerone
Cosanyl,Robitussin AC,Cheracol,Cerose,Pediacof
Motofen
Cophene-S, various others
Lomotil, Logen
Parepectolin, Kapectolin PG, Kaolin Pectin P.G.
1485
N
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Centroton, Thymergix
Appendix IX: Liquid Nitrogen Storage and Use
I.
Liquid Nitrogen (LN2)
A. Description
Liquid nitrogen, often abbreviated as LN2, is an inert, odorless, stable cryogenic
chemical. Nitrogen makes up almost 80% of the atmosphere however, it is not life
supporting
B. Physical Properties
1.
Molecular weight: 28.01
2.
Boiling pint @ 1 amt.: -320.5ºF, -195.8ºC, 77K
3.
Expansion ratio: 1 to 696.5
4.
Liquid Density: 50.7 lb/ft³
5.
Specific Gravity: 0.967
6.
Color: None
C. Uses
Liquid nitrogen is mainly used to cryogenically store laboratory materials, including
but not limited to cell, substrates and biological agents.
II.
Handling and Storage
A.
PPE required
2.
3.
Full face shield and goggles
Thermal insulated or leather gloves that should be loose fitting so they are able to
removed quickly if necessary.
4.
Long sleeved clothing and pants
5.
Closed-toe shoes
B.
Standard Operating Procedure for Removing Items form Liquid Nitrogen
2.
Always wear appropriate PPE when using liquid nitrogen or cryogenic containers.
3.
Work in an open, well-ventilated location and NEVER directly over an open vat of
liquid nitrogen
4.
Boiling and splashing can occur when inserting objects into cryogenic liquids
such as nitrogen. Perform these tasks slowly to minimize splashing.
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.
5.
Use tongs to withdraw objects immersed in liquid nitrogen.
6.
Do not touch anything that has been immersed in liquid nitrogen until it has reached
room temperature.
C. Standard Operating Procedure for transferring Liquid Nitrogen
1.
Use a special separator or special filling funnel to prevent splashing and spilling
when transferring liquid nitrogen into or from a dewar. The top of the funnel should
be partly covered to reduce splashing
2.
Use only small, easily handled dewars for pouring liquid.
3.
Use only fitted transfer tubes designed for use with dewar containers. Cracked or
damaged insulation on transfer tubes should be replaced.
4.
Do not pour liquid while holding secondary container. The container should be on a
stable stand or hung so that the transfer tube rests securely on the neck of the
secondary container.
D. Storage
1.
Do not store in a confined space.
2.
Never allow any unprotected part of the body to come into contact with uninsulated
pipes or equipment that contains liquid nitrogen.
3.
Do not drop, tip or roll containers on their sides.
4.
Do not remove or interchange connections.
5.
Do not use adapters.
E. Containers
Liquid nitrogen containers are insulated, vacuum-jacketed pressure vessels. They
are equipped with relief valves and rupture discs to protect against pressure build
up. NEVER CLOSE RELIEF VALVES. The containers operate at pressures up
to 250 psig. They can hold from 80 to 450 liters of liquid. Cryogenic containers
and dewars should not be filled to more than 80% of capacity.
III.
Standard Operating Procedure for Ventilation, Transport, &
Disposal
A. Ventilation/Engineering Controls
1.
Local exhaust should be used to prevent oxygen deficiency.
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2.
Mechanical or general exhaust ventilation may be used if it can maintain an
adequate supply of air.
B. Transportation
1.
Cryogenic containers should be transported in a secure position.
2.
Shipment of cryogenic containers that have been filled without the owner’s consent
is a violation of federal law [49 CFR 173.301(b)].
C. Waste/Disposal
IV.
1.
Do not attempt to dispose of residual or unused quantities.
2.
Return containers to supplier
Health Effects of Liquid Nitrogen
A. Possible risks
1.
Simple asphyxiant – displaces the level of oxygen in the air required to support life
2.
Inhalation in excessive amounts can cause dizziness, nausea, vomiting, loss of
consciousness and death
3.
Neither liquid nitrogen nor liquid air should be used to cool a flammable mixture in
the presence of air which can lead to an explosion hazard when oxygen condenses
from the air.
4.
Direct contact with cold gas or liquid can cause severe frostbite.
B. Symptoms of exposure
1.
Dizziness
2.
Nausea
3.
Vomiting
4.
Frostbite
5.
Loss of consciousness; possible death
C. Spill/Contamination
1.
Evacuate all personnel from spill/contaminated area.
2.
Shut off flow if you can do so without risk.
3.
Avoid contact with spilled liquid and allow to evaporate
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4.
V.
CONTACT EHSRM IMMEDIATELY!
Regulatory Information & Emergency Contact
A. Agencies
1.
EPA
a. CERCLA (40 CFR Parts 117 and 302)
b. SARA Sections 302/304 (40 CFR Part 55), Sections 311-312, Section 313 (40
CFR Part 372), 40 CFR 68, TSCA
2.
OSHA 29 CFR 1910.119
B. Responsible Parties
1.
Principle Investigator
2.
Supplier
3.
The University of Texas at San Antonio
C. Emergency Contact
1.
EHSRM – (210) 458-5250
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Appendix X: Laboratory and Equipment Clearance Procedures
LABORATORY CLEAN OUT / CLEARANCE PROCEDURE
When laboratories have been vacated, the previous occupants need to ensure they have cleaned their
areas of all hazardous biological, chemical (including controlled substances) and radioactive materials
in preparation for renovation or reoccupation. Environmental Health Safety and Risk Management
(EHSRM) must certify a laboratory to be cleared of hazards prior to Facilities Services personnel
entering for final housekeeping clean out and potential renovation work.
 When leaving a laboratory, the occupants must clean out any remaining hazardous materials.
Cabinets, countertops, and all equipment, including chemical fume hoods, must be cleaned /
decontaminated to remove any hazardous materials or residue including chemicals and potentially
infectious biological agents (ABSL/BSL-2 or above).
o For biological agents: An appropriate tuberculocidal grade disinfectant such as 1-10% dilution of
household bleach (5.25-6% sodium hypochlorite solution) applied for a contact time of 10-20 minutes
should be used. Alternately, a commercially available detergent-disinfectant solution such as
Dispatch®, Clorox Clean-up®, Lysol IC®, etc. may be used following manufacturer’s instructions.
Caution – most disinfectants are also corrosive – proper PPE should be worn (gloves & faceshield or
goggles) and metal surfaces especially should be rinsed with water and wiped down after application.
o For chemicals: An appropriate solvent for the chemical residues which may be present should be
used, followed by a detergent cleaning.
o For radioactive material areas: Wipe tests shall be completed prior to an appropriate detergent
solution wipe down. If wipe tests confirm areas of contamination, then all decontamination materials
must be kept for radioactive waste disposal. If applicable, final wipe tests shall be conducted to verify
proper decontamination. All wipe tests and survey locations must be documented.
 EHSRM must be contacted to remove any remaining waste biological agents or hazardous chemicals
for disposal. Environmental Safety Division is the contact for this service.
 If radioactive materials were used in the laboratory then Radiation Safety Personnel (RSP)must be
contacted to clear the area. Once complete, RSP will complete and sign the radiation portion of the
laboratory clearance form or equipment tag for items remaining and / or going to surplus.
 For biological or chemical clearance of lab surfaces or equipment, either the Environmental or
Laboratory Safety Division can be contacted to do the final walkthrough of the area and fill out the
clearance form or equipment tag.
 Once the clearance form or equipment tag has been signed and posted by pertinent EHSRM
personnel, Facilities Services is cleared to enter the area and remove surplus equipment or any
household type trash, and begin any general cleaning or necessary renovations.
CONTACTS:
Environmental Safety Division X6698, X5808
Laboratory Safety Division X6697, X5807, X6101
Radiation Safety Personnel X6697, X6101
See http://utsa.edu/safety/ for more contact information.
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EQUIPMENT CLEAN OUT / CLEARANCE PROCEDURE
When equipment that is used with hazardous materials, requires repair or disposal laboratory personnel
need to ensure the equipment is cleaned of all hazardous biological, chemical and radioactive
materials. Environmental Health Safety and Risk Management (EHSRM) must certify equipment to be
cleared of hazards prior to repair, shipping for repair, sending to surplus or disposing of equipment.
 All equipment, including chemical fume hoods, must be cleaned / decontaminated to remove any
hazardous materials or residue including chemicals, potentially infectious biological agents, and
radioactive materials.
o For biological agents: An appropriate tuberculocidal grade disinfectant such as 1-10% dilution of
household bleach (5.25-6% sodium hypochlorite solution) applied for a contact time of 10-20 minutes
should be used. Alternately, a commercially available detergent-disinfectant solution such as
Dispatch®, Clorox Clean-up®, Lysol IC®, etc. may be used following manufacturer’s instructions.
Caution – most disinfectants are also corrosive – proper PPE should be worn (gloves & faceshield or
goggles) and metal surfaces especially should be rinsed with water and wiped down after application.
o For chemicals: An appropriate solvent for the chemical residues which may be present should be
used, followed by a detergent cleaning.
o For radioactive material areas: Wipe tests shall be completed prior to an appropriate detergent
solution wipe down. If wipe tests confirm areas of contamination, then all decontamination materials
must be kept for radioactive waste disposal. If applicable, final wipe tests shall be conducted to verify
proper decontamination. All wipe tests and survey locations must be documented..
 Some equipment will need specialized cleaning/decontamination. For example, biological safety
cabinets will need to be decontaminated with formaldehyde, vaporized hydrogen peroxide or other
materials. Currently this type of decontamination is not done in-house. Contact the Laboratory Safety
Division for more information.
 EHSRM must be contacted to remove any remaining waste biological agents or hazardous chemicals
for disposal. Environmental Safety Division is the contact for this service.
 If radioactive materials were used in the equipment then Radiation Safety Personnel (RSP) must be
contacted to clear the area. Once complete, RSP will complete and sign the radiation portion of the
equipment clearance tag.
 For biological or chemical clearance of equipment, either the Environmental or Laboratory Safety
Division can be contacted to do the review and fill out the equipment clearance tag.
 Once the equipment clearance tag has been signed and posted by pertinent EHSRM personnel, the
equipment can be repaired or removed from the lab for service, surplus or disposal.
CONTACTS:
Environmental Safety Division X6698, X5808
Laboratory Safety Division X6697, X5807, X6101
Radiation Safety Personnel X6697, X6101
See http://utsa.edu/safety/ for more contact information.
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Appendix XI: Hazardous Materials Requiring Institutional Approval
Hazardous Materials Requiring Institutional Approval
Office of Environmental Health, Safety & Risk Management
INSTRUCTION: Based on the health effects, regulatory status, or potential
handling requirements, several classes of hazardous materials or devices
require specific institutional approval prior to purchase. If a substance or
device is listed below or specifically in the attached appendices contact the
institutional contact prior to placing an order for the hazardous material.
List of Hazardous Materials
Biological “Select Agent or Toxin”
Radioactive Materials:
Radiation Producing Machine
Military/ Other Chemical Agents of Concern
Toxic/Extremely Hazardous Chemicals
Controlled Substances
Laser (class 3b or 4)
Chemicals/Items prohibited by Fire code
P-Listed Wastes
Institutional Contact: Laboratory Safety Division
Contact Phone: 210-458-6697/5807
Definitions
HHS Select Agent or Toxin: A biological agent (bacterium, virus, fungus, etc.), or its toxin,
conforming to the most current list published in 42 CFR § 73.3 or an overlap select agent or toxin
as listed in 42 CFR § 73.4. See Appendix A.
USDA Select Agents or Toxins: A biological agent (bacterium, virus, fungus, etc.), or its toxin,
conforming to the most current list published in 9 CFR § 121.3 or an overlap select agent or toxin
as listed in 9 CFR § 121.4. See Appendix A.
USDA Plant Protection and Quarantine (PPQ) Select Agent or Toxin: A biological agent or its toxin
determined to pose a severe threat to plant health or plant products and as listed in 7 CFR § 331.3
(a). See Appendix A.
Radioactive Materials: Any material (solid, liquid, or gas) that spontaneously emits radiation as
defined in 25 TAC § 289.201(b)(80).
Radiation Producing Machine Any device capable of producing ionizing radiation and not an
exempt machine (contact Laboratory Safety Division to confirm exempt status) as defined in 25
TAC § 289.201(b)(78).
Military / Other Chemical Agents of Concern: Any chemical agent that has been
developed or may potentially be used as a weapon of mass casualty / destruction,
explosive, or is otherwise of concern. See Appendix B.
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Toxic/Extremely Hazardous Chemicals: Any substance with a threshold planning quantity (TPQ) of
10 pounds or less, as listed in the Extremely Hazardous Substance list as defined in 49 CFR §
302-304, 311, or 312 and cross-listed in the Texas Community Right-to-Know Act Chapter 505-507
of the Texas Health & Safety Code. See Appendix C.
Controlled Substances: Any substance regulated or specifically listed in 21 CFR Part 1300-1399.
The Drug Enforcement Agency’s Diversion Control Program regulates these substances. See
Appendix D.
Class 3b or 4 laser: Any laser that permits human access during operation to levels of visible laser
radiation in excess of limits listed in 25 TAC §289.301(d)(9) for Class 3a lasers, or access to
levels of invisible laser radiation in excess of limits in 25 TAC §289.301(d)(7) for Class 1 lasers
but less than limits contained in §289.301(d)(11) for Class 4 lasers is considered Class 3b.
Any laser that permits human access during operation to levels of laser radiation in excess of limits
contained in §289.301(d)(10) is considered Class 4 Commercially manufactured lasers are
required by law to be sold with a laser class designation. Any modified or “home-built” laser must
have its laser class determined by the UTSA Radiation Safety Officer before being put into use.
See Appendix E.
Chemicals/Items prohibited by Fire code: The NFPA Fire Code prohibits certain materials from
being used or stored in buildings categorized as business occupancies. All buildings housing
laboratories at UTSA are categorized as business occupancies. See Appendix F
P-Listed Wastes: These chemicals are listed by EPA for purposes of waste disposal and are
classified acute hazardous waste. See Appendix G
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Appendix A
List of HHS/USDA Select Agents and Toxins under 42 CFR 73; 9 CFR 121; & 7 CFR
331
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HHS Select Agents and Toxins
Abrin
Botulinum neurotoxins
Botulinum neurotoxin producing species of
Clostridum
Cercopithecine herpesvirus 1 (Herpes B virus)
Clostridium perfringens episilon toxin
Coccidioides posadasii/Coccidioides immitis
Conotoxins
Coxiella burnetii
Crimean-Congo heamorrhagic fever virus
Diacetoxyscirpenol
Eastern Equine Encephalitis virus
Ebola virus
Francisella tularensis
Lassa fever virus
Marburg virus
Monkeypox virus
Reconstructed replication competent forms of
the 1918
pandemic influenza virus containing any
portion of
the coding regions of all eight gene
segments
(Reconstructed 1918 Influenza virus)
Ricin
Rickettsia prowazekii
Rickettsia rickettsii
Saxitoxin
Shiga-like ribosome inactivating proteins
Shigatoxin
South American Haemorrhagic Fever viruses
Flexal
Guanarito
Junin
Machupo
Sabia
Staphylococcal enterotoxins
T-2 toxin
Tetrodotoxin
Tick-borne encephalitis complex (flavi) viruses
Central European Tick-borne encephalitis
Far Eastern Tick-borne encephalitis
Kyasanur Forest disease
Omsk Hemorrhagic Fever
Russian Spring and Summer encephalitis
Variola major virus (Smallpox virus)
Variola minor virus (Alastrim)
Yersinia pestis
Overlap Select Agents and Toxins
Bacillus anthracis
Brucella abortus
Brucella melitensis
Brucella suis
Burkholderia mallei (formerly Pseudomonas
mallei)
Burkholderia
pseudomallei
(formerly
Pseudomonas
Pseudomallei)
Hendra virus
Nipah virus
Rift Valley fever virus
Venezuelan Equine Encephalitis virus
USDA Select Agents and Toxins
African horse sickness virus
African swine fever virus
Akabane virus
Avian influenza virus (highly pathogenic)
Bluetongue virus (exotic)
Bovine spongiform encephalopathy agent
Camel pox virus
Classical swine fever virus
Ehrlichia ruminantium (Heartwater)
Foot-and-mouth disease virus
Goat pox virus
Japanese encephalitis virus
Lumpy skin disease virus
Malignant catarrhal fever virus
(Alcelphine herpesvirus type 1)
Menangle virus
Mycoplasma
capricolum
subspecies
capripneumoniae
(contagious caprine pleuropneumonia)
Mycoplasma mycoides subspecies mycoides
small
colony (MmmSC) (contagious bovine
pleuropneumonia)
Peste des petits ruminants virus
Rinderpest virus
Sheep pox virus
Swine vesicular disease virus
Vesicular stomatitis virus (exotic): Indiana
subtypes
VSV-IN2, VSV-IN3
Virulent Newcastle disease virus
USDA Plant Protection and Quarantine (PPQ)
Select Agents and Toxins
Peronosclerospora
philippinensis
(Peronosclerospora
sacchari)
Phoma glycinicola (formerly Pyrenochaeta
glycines)
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Ralsonia solanacearum race 3, biovar 2
Rathayibacter toxicus
Sclerophthora rayssiae var zeae
Synchytrium endobioticum
Xanthanomonas oryzae
Xylella fastidiosa (citrus variegated chlorosis
strain
The above list was current as of the date of this document listed at the bottom of the
page.
The latest listing of select agents and toxins, restrictions, definitions and exemptions is
available online at:
http://www.selectagents.gov/Select%20Agents%20and%20Toxins%20List.html.
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Appendix B
List of Military / Other Chemical Agents of Concern
Military / Other chemical agents of concern (excluding biological select agents) that can
be used as a potential weapon of mass casualty / destruction or is potentially explosive
or is toxic or highly flammable:
Type Common Name
Technical Name
Formula
CAS Number
Bis (2-chlorethyl) sulfide
Bis (2-chlorethyl) sulfide
Dichloroformoxime
Dichloro-(2-chlorovinyl)arsine
(CLCH2CH2)2S
C4H8Cl2S
CHCl2NO
ClCHCHAsCL2
505602
Hydrogen Cyanide
Chlorocyan
HCN
CNCl
74-90-8
506-77-4
COCl2
Cl2
NH3
754445
7782505
7664417
Blister Agents
Mustard Gas (H)
Mustard Gas (HO)
Phosgene Oxime (CX)
Lewisite (L)
1794-86-1
541253
Asphyxiants
Hydrogen Cyanide (AC)
Cyanogen Chloride (CK)
Choking Agents
Phosgene Gas (CG)
Chlorine Gas (Cl2)
Anhydrous Ammonia
Carbonyl Chloride
Chlorine
Anhydrous Ammonia
Nerve Agents
Sarin (GB)
Soman (GD)
Tabun (GA)
VX
Isopropyl Methyphosphono- C4H10FO2P
fluoridate
Pinacolyl Methylphosphono- (CH3)(C6H13)POF
fluoridate
O-ethyl N-dimethylphosphor- C5H11N2O2P
amidocyanidate
O-ethyl S-(2-diisopropylamino)
69-9
107448
96-64-0
77816
C11H26NO2PS 50782-
Ethyl methylphosphonothiolate
Explosives/Reactives
Picric Acid
Perchloric Acid
TNT
2,4,6-trinitrophenol
hydronium perchlorate
Trinitrotoluene
(NO2)3C6H2OH
88-89-1
HClO4
7601-90-3
C6H2(NO2)3CH3
118-96-7
Explosives or explosive percursors not otherwise listed
Other Chemicals of Concern
Fluorine
Hydrofluoric Acid
Silane
Fluorine
Hydrogen fluoride
Silane
F
HF
SiH4
7782-41-4
7664-39-3
7803-62-5
Any pyrophoric chemical not otherwise listed
Any hazardous gases with a 3 or 4 in one of the hazard categories not otherwise listed (including
mixtures)
Examples include: hydrogen sulfide and hydrogen.
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This list was developed using Bevelacqua and Stilp’s Terrorism Handbook for Responders (2002).
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Appendix C
List of Toxic/Extremely Hazardous Chemicals
The following list was developed using the Extremely Hazardous Substance list (Texas
DSHS) Tier II Chemical Reporting Program with any chemical agent having a Threshold
Planning Quantity of 10 lbs or less:
Common Name
Threshold Planning Quantity
(lbs)
Azinphos-methyl
10/10,000
Benzenearsonic acid
10/10,000
Bis(chloromethyl) ketone
10/10,000
Carbofuran
10/10,000
Chromic chloride
1/10,000
Cobalt carbonyl
10/10,000
Colchicine
10/10,000
Digoxin
10/10,000
Dimethyl-p-phenylenediamine
10/10,000
Dinitrocresol
10/10,000
Diphacinone
10/10,000
Emetine, dihydrochloride
1/10,000
Endosulfan
10/10,000
Ethylene fluorohydrin
10
Fenamiphos
10/10,000
Fluoroacetic acid
10/10,000
Fluroacetyl chloride
10
Hydrogen selenide
10
Lewisite
10
Mechlorethamine
10
Methyl vinyl ketone
10
Monocrotophos
10/10,000
Nickel carbonyl
1
Nitric Oxide
10
Organorhodium Complex (PMN2147)10/10,000
Paraquat dichloride
10/10,000
Paraquat methosulfate
10/10,000
Phorate
10
Phosgene
10
Phosmet
10/10,000
Propargyl bromide
10
Sarin
10
Sodium fluoroacetate
10/10,000
Tabun
10
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Reportable Quantity
(lbs)
1
10
10
10
1
10
10
10
10
10
10
1
1
10
10
10
10
10
10
10
10
10
10
100
10
10
10
10
10
10
10
10
10
10
CAS Number
86500
98055
534076
1563662
10025737
10310681
64868
20830755
99989
534521
82666
316427
115297
371620
22224926
144490
359068
7783075
541253
51752
78944
6923224
13463393
10102439
None
1910425
2074502
298022
75445
732116
106967
107448
62748
77816
Appendix D
List of Controlled Substances
Schedule I – See 21 CFR Section 1308.11
Schedule II – See 21 CFR Section 1308.12
Schedule III – See 21 CFR Section 1308.13
Schedule IV – See 21 CFR Section 1308.14
Schedule V – See 21 CFR Section 1308.15
Title 21 of the Congressional Federal Register (CFR) may be accessed on-line at the
following URL: http://www.gpoaccess.gov/cfr/index.html
Listings of Schedule I-V Controlled Substances can also viewed at the Drug
Enforcement Administration (DEA) website at the following URL:
http://www.deadiversion.usdoj.gov/schedules/index.html
Refer to the UTSA policy on Controlled Substances for information on obtaining
licenses from the Texas Department of Public Safety and the DEA prior to ordering
Controlled Substances.
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Appendix E
Specifications for Class 3b and Class 4 lasers
AMERICAN NATIONAL STANDARD Z136.1 - 2000
The following laser definitions are excerpted with
permission from the ANSI Z136.1 – 2000 American
National Standard for Safe Use of Lasers.
and repetitive-pulse lasers and laser systems which can
emit accessible radiant energy exceeding the appropriate
Class 1 AEL for the maximum duration inherent in the
design or intended use of the laser or laser system, but
not exceeding the Class 1 AEL for any applicable pulse
(emission) duration < 0.25 s and not exceeding an
average radiant power of 1 mW.
3.3.3 Class 3 Lasers and Laser systems.
3.3.3.1 Class 3a lasers and laser systems include lasers
and laser systems which have an accessible output
between 1 and 5 times the Class 1 AEL for wavelengths
shorter than 0.4 µm or longer than 0.7 µm, or less than 5
times the Class 2 AEL for wavelengths between 0.4 and
0.7 µm.
3.3.3.2 Class 3b lasers and laser systems include:
3.3.1 Class 1 Lasers and Laser Systems
3.3.1.1 Any laser, or laser system containing a laser, that
cannot emit accessible laser radiation levels in excess of the
applicable Class 1 AEL for any emission duration within
the maximum duration inherent in the design or intended
use of the laser or laser system is a Class 1 laser or laser
system during operation and is exempt from all control
measures or other forms of surveillance with the exception
of applicable requirements for embedded lasers (see
Section 4.3.1.1). The maximum exposure duration is
assumed to be no more than 30,000 s, except for infrared
systems not intended to be viewed (> 0.7 µm), 100 s
shall be used. The exemption strictly applies to emitted
laser radiation hazards and not to other potential hazards
(see Section 7, Non-Beam Hazards).
3.3.1.2 Lasers or laser systems intended for a specific use
may be designated Class 1 by the LSO on the basis of that
use for a limiting exposure duration of Tmax less than 100
s, provided that the accessible laser radiation does not
exceed the corresponding Class 1 AEL for any emission
duration within the maximum duration inherent in that
specific use.
(1) Ultraviolet (0.18 to 0.4 µm) and infrared (1.4 µm
to 1 mm) lasers and laser systems which can emit
accessible radiant power in excess of the Class 3a AEL
during any emission duration within the maximum
duration inherent in the design of the laser or laser
system, but which (a) cannot emit an average radiant
power in excess of 0.5 W for 0.25 s or (b) cannot
produce a radiant energy greater than 0.125 J within an
exposure time < 0.25 s.
(2) Visible (0.4 to 0.7 µm) or near-infrared (0.7 to 1.4
µm) lasers or laser systems which emit in excess of the
AEL of Class 3a but which (a) cannot emit an average
radiant power in excess of 0.5 W for 0.25 s and (b)
cannot produce a radiant energy greater than 0.03 J per
pulse.
3.3.4 Class 4 Lasers and Laser, Systems. Class 4 lasers
and laser systems are those that emit radiation that
exceed the Class 3b AEL.
From ANSI Z136.1 (2000) American National Standard for
Safe Use of Lasers. Copyright 2000, Laser Institute of
America. All rights reserved.
3.3.2 Class 2 Visible Lasers and Laser Systems. Class
2 lasers and laser systems are visible (0.4 to 0.7 µm) CW
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Appendix F
Chemicals/Items Prohibited by Fire Code
(Contact EHSRM prior to ordering or bringing on campus any chemicals/items listed below to
discuss options for use and storage if these chemicals or items are necessary for research.)
•
•
•
•
Consumer fireworks (1.4G)
Class 4 oxidizers (examples)
o
Ammonium perchlorate (particle size > 15 microns)
o
Ammonium permanganate
o
Guanidine nitrate
o
Hydrogen peroxide solutions >91%
o
Tetranitromethane
Unclassifiable/detonable organic peroxides
Class I and II organic peroxides
Class I and II organic peroxides definitions and typical formulations:
“Class I" describes those formulations which are capable of deflagration, but not detonation. Fire
hazard characteristics: Class I formulations present a deflagration hazard through easily initiated,
rapid explosive decomposition. Class I includes some formulations that are relatively safe only under
closely controlled temperatures. Either excessively high or low temperatures may increase the
potential for severe explosive decomposition.
“Class II" describes those formulations that burn very rapidly and that present a severe reactivity
hazard. Fire hazard characteristics: Class II formulations present an NFPA fire hazard similar to Class
I flammable liquids such as acetone or toluene. The decomposition is not as rapid, violent, or
complete as that produced by Class I formulations. As with Class I formulations, this class includes
some formulations that are relatively safe when used under controlled temperatures or when diluted.
Typical Class I Formulations
Organic Peroxide
t-Butyl hydroperoxide
t-Butyl monoperoxymaleate
t-Butyl peroxyacetate
t-Butyl peroxyacetate
t-Butyl isopropyl carbonate
Dibenzoyl peroxide
2,2-Di(t-butylperoxy) butane
Diisopropyl peroxydicarbonate
Di-n-propyl peroxydicarbonate
Di-n-propyl peroxydicarbonate
Concentration
90
98
75
60
92
98
50
99
98
85
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Diluent
Water and t-BuOH
----Odorless mineral spirits
Odorless mineral spirits
Odorless mineral spirits
----Toluene
--------Odorless mineral spirits
Typical Class II Formulations
Organic Peroxide
Concentration
t-Amyl peroxybenzoate
96
n-Butyl-4,4-di(t-butylperoxy)
98
valerate
t-Butyl hydroperoxide
70
t-Butyl peroxybenzoate
98
t-Butyl peroxy-2-ethyl hexanoate
97
t-Butyl peroxyisobutyrate
75
t-Butylperoxy isopropyl carbonate
75
t-Butyl peroxypivalate
75
Diacetyl peroxide
25
Dibenzoyl peroxide
78
1,1-Di(t-butylperoxy) cyclohexane
80
Di-sec-butyl peroxydicarbonate
98
Di-sec-butyl peroxydicarbonate
75
1,1-Di(t-butylperoxy)-3,3,5-trimethyl
75-95
cylcohexane
Di(2-ethylhexyl) peroxydicarbonate
97
2,5-Dimethyl-2,5-di(benzoylperoxy)
95
hexane
2,5-Dimethyl-2,5-dihydroperoxy hexane 70
Peroxyacetic acid, Type E, stabilized
43
Abbreviations used above:
DTBP—Di-tertiary-butyl peroxide
DMP---Dimethyl phthalate
BBP---Butyl benzyl phthalate
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Diluent
--------DTBP and t-BuOH
--------Odorless mineral spirits
Odorless mineral spirits
Odorless mineral spirits
DMP
Water
Odorless mineral spirits or BBP
----Odorless mineral spirits
------------Water
Water, Acetic acid, and H2O2
Appendix G
P-Listed Wastes
P-listed Wastes are of concern for ordering purposes due to the potential for changing UTSA’s waste
generator status once the chemicals need to be disposed of as waste. The list of these chemicals
can be found at the EPA’s website at the following link:
http://www.epa.gov/osw/hazard/wastetypes/listed.htm.
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