Advanced solutions for peripheral nerve surgery.
For the protection of compressed, scarred or
partially injured nerves.
Integra’s Ultra Pure Collagen™ technology.
Biocompatible and completely resorbable.
Minimizes potential for neuroma formation.
NeuraGen
nerve guide
For the repair of completely severed nerves.
NeuraGen nerve guide
For the REPAIR of completely severed nerves.
NeuraGen Nerve Guide
An efficient alternative to nerve graft or direct suture:
• The level of functional recovery achieved
with the NeuraGen Nerve Guide is
equivalent to direct suture repair (animal
trials) and is stable over long time periods
(3 to 4 years).2
• In animal trials, there were no episodes of
compression neuropathy reported with other
more rigid or non biodegradable materials.5
• Isolates and provides an environment for the
extension of axons and growth of Schwann
cells that are the elements responsible for
functional recovery following nerve injury.2,3,7
• Absorption process is complete and
operates via normal metabolic pathways. In
these studies, there was no reported scar
tissue or inflammatory response to this
material.3,4 The results of the animal study
demonstrated that the complete resorption
of the collagen nerve guide minimized the
possibility of nerve entrapment and thereby
degradation of the repair.
• Provides a protective environment for axonal regrowth across the nerve gap2,7
• Minimal potential for scar formation, encapsulation and nerve entrapment
• Semi-permeable, Type I collagen tube for peripheral nerve repair2,7
• Open collagen structure facilitates suture placement
For the PROTECTION of compressed, scarred or partially injured nerves.
NeuraWrap Nerve Protector
• Designed to provide an interface
between the nerve and the
surrounding tissue.
• Remains in place during the
active phase of tissue healing
and is completely resorbed after
tissue response has resolved.
• Porous outer layer comprises a
tubular matrix that mechanically
resists compression from
surrounding tissue and excludes
scar tissue ingrowth.
• Semi-permeable inner membrane
allows passage of small molecules
(i.e. water, ions, metabolites,
nutrients), but prevents the
escape of endogenous growth
factors (i.e. Nerve Growth Factor).1
For intact nerves that are compressed, scarred or partially injured:
• Protects the neural environment
• Isolates nerve tissue during the healing process1
• Collagen structure retains suture1
• Recovers and maintains closure once placed around the nerve
Integra
Regenerative Product
Innovation Timeline
1970–1980’s
1994
1996
2001
2002
2004
Collagen Matrix
Development
ORTHOPEDIC SURGERY
BURN SURGERY
NeuraGen™
Nerve Guide
PLASTIC and
RECONSTRUCTIVE
NeuraWrap™
Absorbable Collagen
Sponge with Bone
Growth Factor
PLASTIC and
RECONSTRUCTIVE
NeuraGen
nerve guide
NeuraGen
NeuraGen Ordering Information
nerve guide
NeuraWrap Ordering Information
DIAMETER (mm)*
CATALOG NUMBER
SIZE
PNG130
1.5mm (ID) x 3cm (length)
PNG220
2mm (ID) x 2cm (length)
PNG230
2mm (ID) x 3cm (length)
PNG320
3mm (ID) x 2cm (length)
NW320
3mm (ID) x 2cm (length)
PNG330
3mm (ID) x 3cm (length)
NW340
3mm (ID) x 4cm (length)
PNG420
4mm (ID) x 2cm (length)
PNG430
4mm (ID) x 3cm (length)
PNG520
5mm (ID) x 2cm (length)
NW520
5mm (ID) x 2cm (length)
PNG530
5mm (ID) x 3cm (length)
NW540
5mm (ID) x 4cm (length)
PNG620
6mm (ID) x 2cm (length)
PNG630
6mm (ID) x 3cm (length)
PNG720
7mm (ID) x 2cm (length)
NW720
7mm (ID) x 2cm (length)
PNG730
7mm (ID) x 3cm (length)
NW740
7mm (ID) x 4cm (length)
NW1020
10mm (ID) x 2cm (length)
NW1040
10mm (ID) x 4cm (length)
2cm
SIZE
NeuraWrap not available in 1.5mm diameter
NeuraWrap not available in 2mm diameter
NeuraWrap not available in 4mm diameter
NeuraWrap not available in 6mm diameter
NeuraGen not available in 10mm diameter
Products available in the following lengths:
*Lengths not available in all diameters.
CATALOG NUMBER
3cm
4cm
ADVERSE EVENTS
Possible complications can occur with any peripheral nerve surgical procedure including pain, infection, decreased or increased nerve sensitivity, and complication associated with the use of anesthesia.
Advanced solutions for peripheral nerve surgery.
Integra LifeSciences Corporation
311 Enterprise Drive
Plainsboro, NJ 08536
www.Integra-LS.com
609-275-0500 (outside USA)
609-275-5363 (fax)
Customer Service
800-997-4868 (USA and Canada)
800-654-2873 (USA and Canada)
REFERENCES
1 Data on file, Integra LifeSciences
2 Archibald, S.J., Shefner, J., Krarup, C., and Madison, R.D. Monkey median nerve repaired by nerve graft or collagen
nerve guide tube. J. Neurosci. 1995; 15(5):4109-4123.
3 Archibald, S.J., Krarup, C., Shefner, J., Li, S.T. and Madison, R.D. Collagen-based nerve guide conduit for peripheral
nerve repair: and electrophysiological study of nerve regeneration in rodents and non-human primates. J. Comp.
Neurol.1991;306(4):685-696.
4 Li, S.T., Archibald, S.J., Krarup, C., and Madison, R. Peripheral Nerve repair with collagen conduits. Clinical Materials.
1992;9:195-200.
5 Mackinnon, S.E., Dellon, A.L., Hudson, A.R. and Hunter, D.A. A primate model for chronic nerve compression.
J.Reconstr.Microsurg. 1985;1:185-194.
6 Lundborg, G. Nerve Injury and Repair. 1988. New York: Churchill Livingstone.
7 Archibald, S.J., Krarup, C., and Madison, R.D. Factors that influence peripheral nerve regeneration:
eletrophysiological study of the monkey median nerve. Annals of Neurology. 2002;51(1):69-81.
NeuraGen Nerve Guide, NeuraWrap Nerve Protector, Ultra Pure Collagen and the Integra wave logo are trademarks of Integra LifeSciences Corporation.
©2005 Integra LifeSciences Corporation. All rights reserved.
Printed in U.S.A. NS926-08/05