MHTP Infectious and Inflammatory Diseases
Theme Special Seminar
Centre for Inflammatory Diseases
School of Clinical Sciences at Monash Health, Monash University
and
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research
CD1-Reactive T cells Mediate Human Response to
Tuberculosis Infection
Prof D. Branch Moody MD
Professor of Medicine
Brigham and Women’s Hospital
Harvard Medical School
Harvard Club of Australia Fellow
After more than two decades of focus on T cell recognition
of MHC-peptide, immunologists were surprised to learn
Tuesday 9 August
that T cell receptors recognize lipid antigens bound to CD1
proteins. Emphasizing recently published and unpublished
TIME:
12.00 – 1.00 pm
data, the talk explains that many lipids are displayed by
VENUE:
Seminar Room 1
Level 2
Translation Research Facility
cellular CD1 proteins and describes ex vivo T cell
responses detected by CD1 tetramers in tuberculosis
patients. These studies provide several further surprises
and a broader view of T cell function that includes
response to cellular lipids.
Originally from Irving, Texas, Dr. Moody is a graduate of
the Johns Hopkins University School of Medicine and
serves as physician and immunologist at Harvard Medical
School. His laboratory focuses on basic and applied
research on how human T cells and macrophages respond
to infection in human tuberculosis disease. This work is
supported by the NIH Tuberculosis Research Unit
Network, the Pew Foundation, the Burroughs Welcome
Foundation and the Bill and Melinda Gates Foundation.
Lunch will be served at 11.45am in the
Seminar Room Foyer, level 2
TRF Building
(no food and drink in the seminar room)