Full-Text PDF

sustainability
Article
A System-of-Systems Framework for Improved
Human, Ecologic and Economic Well-Being
Ash M. Genaidy 1, *, Ronald L. Huston 2 , Dionysios D. Dionysiou 3 and Waldemar Karwowski 4
1
2
3
4
*
Worldtek Inc., Cincinnati, OH 45249, USA
Mechanical Engineering Program, University of Cincinnati, Cincinnati, OH 45221, USA; [email protected]
Environmental Engineering & Science Program, University of Cincinnati, Cincinnati, OH 45221, USA;
[email protected]
Department of Industrial Engineering, University of Central Florida, Orlando, FL 32816-2993, USA;
[email protected]
Correspondence: [email protected]
Academic Editor: Yu-Pin Lin
Received: 12 February 2017; Accepted: 12 April 2017; Published: 15 April 2017
Abstract: “Advances in technology and management not keeping pace with the ever-increasing urban
problems” is attributed in this research to the poor understanding of person-focused governance
of societal, environmental and economic entities. The objective of this paper is to present an
adaptive institutional model of person-driven effectiveness and ineffectiveness. The model proposes
that human, ecologic and economic outcomes are heavily influenced by a complex system of
systems, spanning from individually unique “non-physical influencers” to a broader set of social and
environmental influencers that have a common impact on the larger society-environment-economy
(SEE) system. At the heart of the model is an analytic formulation that explains the phenomena
of non-physical blocker, enhancer and indifferent, which are responsible for the adaptation and
maladaptation of social agents and, accordingly, for the sustainability and unsustainability of SEE
systems. Examples are provided to illustrate the model applications: (a) the non-physical and
maladaptive syndromes as antecedents of multi-morbidity; and (b) the broadened and narrowed
minds as sources of sustainability and unsustainability at the SEE system level within the context of
emerging technologies such as engineered nanomaterials.
Keywords: sustainability; society; environment; technology
1. Introduction
In today’s world and in the foreseeable future, we will be confronted with unprecedented and
diverse global problems such as (a) increased world population; (b) rapid consumption of diminishing
natural resources; (c) increased cost of healthcare accompanied by poorer health; and (d) increasing
environmental pollution, all combined with growing urbanization in all parts of the world. Moreover,
in the absence of major changes, these problems will become more and more acute and, if not
seriously addressed, eventually they will transform into chronic events for those affected in human
populations and ecosystems. At the same time, however, the world is becoming smaller in the sense
that unprecedented advancements in communication technologies are connecting diverse parts of
the world into a kind of small village, and emerging technologies are promising to solve the global
problems. But there is a paradox, in that the profound technical advances cannot seem to be applied to
effectively reducing the world’s problems. This paradox has its roots in social, environmental, technical,
and political issues that are currently converting local entities and communities into unsustainable
systems—systems that cannot keep pace with the basic and higher needs and wants of human
populations and ecosystems.
Sustainability 2017, 9, 616; doi:10.3390/su9040616
www.mdpi.com/journal/sustainability
Sustainability 2017, 9, 616
2 of 16
Other researchers have raised similar arguments from different perspectives [1–3]. Therefore,
it has been suggested that it is time to launch a new dialogue on science and the environment with a
focused effort on simultaneously improving human, ecologic and economic well-being [1]. Our thesis
is that many of the aforementioned issues are due, in part, to our limited understanding for the
person-focused architecture (PFA) and leader-driven functioning of the institutions comprising humans,
communities, ecology, and economic and environmental entities. It is believed that, in addition to the
physical-chemical factors impacting the diverse societies, environments and economies on the planet,
intangible and intrinsic human factors play a major role in the aforementioned changes.
The research reported herein deals with the above subject, with the ultimate goal of finding
solutions to the aforementioned diverse global problems simultaneously impacting environmental,
social and economic entities. We present the phenomena of non-physical blocker (i.e., the negative
forces in a person’s inner milieu dominate the positive forces), enhancer (i.e., the positive forces
in a person’s inner milieu are ahead of the negative forces) and indifferent (i.e., both positive and
negative forces in a person’s inner milieu are in balance and hence neutralize each other) as major
influencers of the adaptability and mal-adaptability of society-environment-economy (SEE) systems at
both the individual and system levels. It is maintained in this research that sources of sustainability
and un-sustainability are largely drawn from these phenomena due to their influence on human
actions and inactions. With this in mind, we define sustainable systems as entities jointly leading to
value-added benefits with minimal or no risks to all constituents of the larger SEE system within a
defined time period.
1.1. Overview of Prior Models
This research is motivated by a multi-faceted diverse set of large-scale problems. Thus, we present
examples of prior models below. One dominant early class of economic models has been concerned
with rational behavior in economic decision-making. These models were set forth by the classic work
of Simon [4–6] over several decades in attempts to correct the notion that “an economic man” is also
a “rational” human. As the name implies, this class of models is deterministic in nature and relies
on the rational component in a person-focused architecture or “cognitive controls” as termed in the
psychological literature. We should point out that rational behavior, as will be elaborated in this
research, is the product of not only the rational component, but also other components in the system.
This issue was evaluated under the auspices of emotional controls as jointly interacting with cognitive
controls, but it was not formally documented in this class of models [6]. Furthermore, the economic
perspective should also integrate the societal and ecologic viewpoints.
A contemporary class of models characterizes human behavior in a given specific instance as
a stochastic process. Here, the analysis is formulated in terms of an iterative solution of a set of
governing equations [7–9]. This class of models assumes that people behave at a digital level, thus
simplifying the complexity of human thought and consequently ignoring the innate personality and
biases of individuals. To remedy these difficulties, researchers have developed increasingly complex
models attempting to account for the complex structure of human thought [10,11]. These advanced
models have been applied to human reaction to environmental and ecological issues [12,13].
Another class of contemporary psychological models has developed structural equations for the
mind based on mental properties without accounting for its structural entities and their collective
interactions [14]. Other psychological models have treated a group of individuals as a social network
where each social agent is treated as a node of 0 or 1 without consideration for the intrinsic entities of
the mental engine [15].
In medicine, human-mind interactions have been regarded as a given; yet, there are no models
demonstrating the structural details of non-physical entities as well as links to the intrinsic causal
factors with a call for further research into the subject [16,17]. Other attempts have been made, such
as Iyer et al. [18] who established frameworks for meditation practices in India, without discussing
entities of the mind responsible for achieving this ultimate state of peace and tranquility.
Sustainability 2017, 9, 616 3 of 16 Sustainability 2017, 9, 616
3 of 16
as Iyer et al. [18] who established frameworks for meditation practices in India, without discussing entities of the mind responsible for achieving this ultimate state of peace and tranquility. It our belief
belief that factors influencing human behavior are central to the aforementioned It isis our
that
factors
influencing
human
behavior
are central
to the aforementioned
paradox.
paradox. thesis is influencing
that these influencing must be inconsidered in order unsustainable
to transform Our thesisOur is that
these
factors mustfactors be considered
order to transform
unsustainable systems into sustainable ones. the
By influencing
examining factors
the influencing of we
human systems into sustainable
ones.
By examining
of humanfactors behavior,
can
behavior, we can address leading to by
decision‐making by institutional leaders. our address motivation
leadingmotivation to decision-making
institutional leaders.
In our model,
weIn use
a
model, we use a dynamic structure of the components forming the basis for a person’s reaction to dynamic structure of the components forming the basis for a person’s reaction to his/her environment
his/her environment and the resulting decisions. To the best of our knowledge such an attempt has and the resulting decisions. To the best of our knowledge such an attempt has not been documented in
not been documented in the published literature. the published literature.
1.2. Study Goal 1.2. Study Goal The goal goal of of our
The our research
research is
is to
to model
model aa person-focused
person‐focused system
system that
that describes
describes the
the nonphysical
nonphysical influencing
factors
for
individuals
and
their
environmental
interactions.
These
factors
and
interactions
influencing factors for individuals and their environmental interactions. These factors and are manifested by a person’s direction of action items. A person-focused “architecture” is defined
interactions are manifested by a person’s direction of action items. A person‐focused “architecture” as the underlying intrinsic basis for communication and interaction in urban communities and the
is defined as the underlying intrinsic basis for communication and interaction in urban communities largerthe SEElarger system.
Wesystem. explain We the phenomena
non-physical
enhancer
and indifferent
asand the
and SEE explain the ofphenomena of blocker,
non‐physical blocker, enhancer driving forces for the adaptability and non-adaptability of social agents and hence the influencers of
indifferent as the driving forces for the adaptability and non‐adaptability of social agents and hence SEE systems towards a path of sustainability or unsustainability.
the influencers of SEE systems towards a path of sustainability or unsustainability. We provide applications to illustrate the concepts from individual and SEE perspectives.
We provide applications to illustrate the concepts from individual and SEE perspectives. The The applications
show
versatility
of the
model
andits itspotential potentialimplications implicationswith with respect respect to to
applications show the the
versatility of the model and improving
human,
ecologic
and
economic
well-being.
It
should
be
noted
that
the
person-focused
improving human, ecologic and economic well‐being. It should be noted that the person‐focused architecture is is modeled modeled as as a a system
of systems
as the
architecture system of systems as the person
person is
is powered
powered by
by interactive
interactive systems
systems connecting the non-physical, physical and social states as shown in Figure 1 [19].
connecting the non‐physical, physical and social states as shown in Figure 1 [19]. Interface
Interface
Non‐Physical Health Resources
Non‐physical Domain
External to Whole Person
Factor S
Physical Domain
in Whole Person
Non‐physical Domain
in Whole Person
Entities External to Whole Person
(People, Environment, Things)
Factor N
Factor N’
Physical Health Resources
Factor K
Human Body
Factor A’
Factor M
Factor A
Social Health Resources
(b)
(a) Figure 1. Person‐focused system. (a) Interplay between non‐physical, physical and social factors; (b) Figure 1. Person-focused system. (a) Interplay between non-physical, physical and social factors;
system of systems representation. (b) system of systems representation.
Sustainability 2017, 9, 616
4 of 16
2. Person-Focused Architecture
2.1. Background
The concepts of non-physical blocker, enhancer and indifferent can be traced back through
the debate surrounding the mind-body dichotomy since the time of Descartes, due to the hidden
(invisible) and intangible nature of the mind as opposed to the visible and tangible nature of the human
body [20,21]. This debate has had great implications from a science standpoint.
The aforementioned paradox has led to the development of the biomedical model of medicine
that focuses solely on biological and bodily factors; consequently, it does not take into account the
“mind” factors [22,23]. In response, attempts have been made to account for the non-bodily factors in
the biomedical model of medicine, such as the bio-psycho-social model, which unites the biological,
psychological and social factors for treatment purposes [24]. Further attempts have considered uniting
the mind and body as integral parts of living systems [25,26].
Recently, Wade and Halligan [27] developed the biomedical model of illness in which people
have two systems, with the first describing the whole self with dysfunction, termed impairment, and
the second related to their organs with dysfunction, referred to as pathology. Although it is a good
step forward towards accounting for non-bodily factors, it does not categorize the components of the
non-physical entity. An editorial in Clinical Rehabilitation [28] echoes our appraisal, in that further
research is warranted to advance our knowledge on the role of non-bodily factors in the biomedical
model of medicine.
As already stated above and in the introduction, the structural entities of the mind have not been
modeled as part of the biomedical model of medicine, and the mind factors have been accepted into
practice as a possible explanation for the causal factors. Therefore, research is warranted to advance the
theory of, among other things, body-mind interactions with respect to human illnesses and diseases.
An example is in order, here, to explain the implications of not considering the mind as an
integral part of living systems from sustainability perspective. Consider two identical twins who
have developed type II diabetes at about the same time, living in the same household and treated
by the same physicians (i.e., primary care physician and/or specialists). With all these similarities,
however, one of the twins is affected with an additional number of acute complications compared to
the other. A question may then arise as to why the cost of care of one sibling is double relative to the
other (assuming everything is the same). The obvious answer is the non-bodily factors that greatly
influence lifestyle factors—and hence the body—in feed-forward and feedback fashion as depicted in
Figure 1a. In this diagram, social entities are added in order to provide the minimum structure for
person-focused functioning in a larger system and generalize the views of mind-body entities at an
SEE level. All in all, if these factors are not accounted for, the US healthcare system will remain on a
path toward unsustainability [29,30].
To address these issues, we built the PFA architecture based upon research in the scientific,
philosophical, and even spiritual literature. Specifically, the components of the PFA and their
interrelationships were initially inspired by accounts in ancient writings (including those in the
Bible and the Koran) together with the smart logic of common sense, civil discourse, and conventional
wisdom. From this broad background, the PFA was built upon the acquired knowledge and experience
of the authors in engineering, human factors, and environmental sciences, including earlier writings of
the authors [31,32].
2.2. Model Description
The person-focused architecture (PFA) of an individual is discussed with reference to a
“community” consisting of people and other living beings (e.g., animals and birds in an ecosystem) and
non-living entities (e.g., buildings), some of which are visible and obvious to an individual and others
which may be less obvious and intangible but still have significant influence on the person (e.g., the
health of an individual is influenced by the health of those with whom he/she interacts). An analogy
Sustainability 2017, 9, 616
5 of 16
may be gravity: it can’t be seen but it can be measured, hence, one can determine its influence on
physical items. Other less obvious examples may be unknown and undetectable pollutants, high
frequency vibrations, and background noise.
The PFA Model maintains that a person consists of two layers: physical or outer (i.e., visible
or human body, physical environment, etc.), and nonphysical or inner (i.e., “hidden” such as
developmental, cellular, chromosomal, etc.). We know much about the physical human body
via scientific discoveries because it is obviously tangible. On the other hand, we have a limited
understanding of the complex interactions of the many nonphysical influencers, some of which are less
tangible (e.g., how does childhood stress result in permanent chromosomal telomere changes which
then influence a person’s health for their entire life?).
The internal complex system of systems (SOS) is a collection of collaborative systems bonded
together under defined rules and regulations with the goal of exhibiting the complex properties of
living systems [33–35]. In this context, each individual has a component structure of “1” or “0” decision
nodes that lead to action/inaction, which in turn exerts its resultant influence on the overall SOS.
An imbalance in these influencers can push one toward poorer or better human outcomes. For purposes
of this discussion, this internal SOS is described in general terms in order to then describe the structure
and function use and relate it in the next section to examples on human and ecological health.
The inner layer of PFA consists of three components, (a) factor “A”; (b) factor “N”; and (c) factor
“K” (Figure 1b) and makes up the non-physical resources for the person. These three components are
influenced by two external invisible inputs, factor “S” and factor “M”, with unipolar forces (i.e., one
force is only negative “S”, and the other is purely positive “M”). The net output of the interactions of
these factors is what we believe drives individual actions/inactions resulting in net human outcomes
(e.g., overall health status both physical and mental). A brief definition is given below for each
component followed by a discussion of their roles and their relationships in the person-focused
architecture:
(a)
(b)
(c)
(d)
Factor A is a rational component that is powered by the voice of reason and logic. It is
modeled as a bipolar force (i.e., cognitive force), assuming that the power of logic and reason
is modeled as a positive phenomenon and the power of illogic and unreason is regarded as a
negative phenomenon.
Factor N is the source of energy for the person, but with limited logic and reason capabilities (i.e.,
impulsive energy). This source of energy can be positive (i.e., enhancing the person’s capability)
or negative (i.e., diminishing the person’s capability).
Factors A and N are in constant interaction with the resultant value providing an input to factor K.
Factor K is the recipient and integrator of information from the internal milieu via factors A and
N as well as factors S and M (see below). Structurally, it combines attributes of factors A and N
for post-processing purposes. In addition, Factor K has extra sensory capabilities connecting it
with the external environment for receipt of information input via two mechanisms: (1) directly
via the channels of communication of the body (e.g., visual, auditory); and (2) indirectly by other
means unknown to us. Information from the external environment is passed via factor K without
any further processing to factor A for storage in its internal memory. This information is also
temporarily stored in the memory of factor K for later usage in a decision making process in
a given situation. Collectively, factor K renders the final decision on the basis of information
from the internal and external milieus for action item orders to the outer layer. After it is made,
information on the final decision is passed to factor A where it is stored in the long-term memory,
residing as part of its cumulative experience amassed over the course of diverse situations and
scenarios. (A note of clarification is warranted on the unknown route of information input
to factor K. This mechanism can be activated for example in extreme circumstances such as
emergency situations or near death experiences).
Sustainability 2017, 9, 616
(e)
(f)
6 of 16
Factor M is a positive phenomenon and provides consultative reason and logic to factor A via
a one-to-one relationship. This unipolar positive phenomenon also has direct input to factor K,
particularly at times when the internal milieu is in a great state of turbulence.
Factor S is a negative complex phenomenon and interacts with factors N, A and K via a
one-to-many relationship. Its goal is to augment the power of unreason and to diminish the
power of reason via continuous monitoring of the inner layer in the PFA.
The state of factor N (i.e., output) can be described in terms of two-dimensional variables, that
is, level of activation and energy type. Factor N may reside in one of four general sources of energy:
(1) high-positive; (2) low-positive; (3) high-negative; and (4) low-negative. A person may reside
anywhere in the spectrum of those four general states, with his/her position determined by the relative
balance of the influencing factors (Figure 2a). An example of a high-positive energy source is hope
(or optimism). This state is a major source of personal energy. Alternatively, despair (or pessimism) is
a low state of negative energy source that is the opposite of hope and acts as a barrier for constructive
human actions, often by leading to inaction. The low-positive energy source, such as peace and
tranquility, leads to steady human actions in the most efficient and effective ways. Contrary to that,
a high-energy negative source, such as anger and distress, results in a suboptimal source of energy,
though it may be an essential component for survivability.
The state of factor A can also be described in terms of two parameters: (a) thinking mode—positive
and negative; and (b) force magnitude—low and high (Figure 2b). Both parameters are influenced by
stored personal experiences, interaction with factor N, and inputs from factors S and M. At birth, the
default value for factor A is positioned in the positive domain. As people get older, they navigate across
the full spectrum of positive and negative thinking with the resultant at any given time depending on
the aforementioned influencers. Of particular interest here is the interaction between factors A and N.
When factor A is in a state of positive thinking and factor N is in a state of positive energy, the
role of factor N can be regarded as an amplifier for the positive thinking mode of factor A. In this
instance, the power of positive irrationality has a major impact on human actions allowing a person to
behave in an exhilarated style. We maintain, here, that rational productive behavior is the product
of the positive thinking mode of factor A and the positive rational mode of factor N. For example,
consider a salesperson with great enthusiasm and belief in his/her product and with a high energy
level. This is likely to lead to high sales. Alternatively, when factor N behaves as a negative energy
source, it can act as a de-amplifier to factor A and steer it toward a state of negative thinking, if it can
exceed the level of positive thinking for factor A. As expected, this will lead to irrational unproductive
human behavior. If the above salesperson has doubts about the value or quality of his/her product
and is tired with low energy level, sales are likely to be low.
When operating in a negative thinking mode, factor A is more likely than not synchronized with
the negative domain of factor N. Under these circumstances, the negative thinking process is operating
in a destructive (i.e., negative) mode from a base of negative experiences. In a “low” negative thinking
mode, the person acts in a suboptimal fashion, but yet is still functional. “High” negative thinking
makes the person move toward the path of negative irrational behavior that is detrimental to the
community. An example is a disgruntled employee.
To enhance the negative phenomenon in the internal milieu of a person, factor S provides ideas
and support on a constant basis to factor N in order to influence factor A towards the mode of negative
thinking. Because of its destructive nature, factor S is capable of creating a barrage of negative concepts
over time in the internal milieu. That is, it can be modeled as a train of negative impulses during
the course of time, with each impulse being short lived and different from others in the train. Factor
N, on the other hand, may persist with one negative thought and promotes it on a continuous basis;
therefore, it can be modeled as a finite step function simulating the “all” or “nothing” approach in a
given situation.
Sustainability
2017, 9, 616
Sustainability 2017, 9, 616 7 of 16
7 of 16 Level of Activation
High Positive
High Negative
e.g., Distress
High
e.g., Hope
Low Negative
e.g., Despair
Low Positive
Low
e.g., Tranquility
Negative
Positive
Type of Energy
(a)
Force Magnitude
High Negative
Low Negative
High
Low
High Positive
Low Positive
Negative
Positive
Thinking mode
(b)
Figure 2. States of factors A and N. (a) States of factor N; (b) states of factor A. Figure 2. States of factors A and N. (a) States of factor N; (b) states of factor A.
The role of factor S in influencing factor A is focused on limiting its functional capabilities via two routes: (1) distracting and confusing thinking capabilities; and (2) enhancing the via
The role of factor
S in influencing
factor the A ispositive focused
on limiting
its functional
capabilities
negative thinking model. Inhibiting the
the positive
positive thinking
thinking capabilities;
capabilities of factor A may be the
two routes:
(1) distracting
and confusing
and
(2) enhancing
negativeaccomplished in several ways. The first way is via a “false” positive signal that attempts to portray thinking model. Inhibiting the positive thinking capabilities of factor A may be accomplished
the negative phenomena in life as a pseudo‐positive experience to factor A to promote the in several
ways. The first way is via a “false” positive signal that attempts to portray the negative
performance of such actions. Another way is via a “false” negative signal. An example might be to phenomena in life as a pseudo-positive experience to factor A to promote the performance of such
paint a picture of a person who contributes to charity as becoming poor if he/she continues to do actions.good deeds to others or perform actions that may benefit nature at large. A third way is to block the Another way is via a “false” negative signal. An example might be to paint a picture of a
person memory channels for the positive thinking mode; consequently, factor A cannot carry out its own who contributes to charity as becoming poor if he/she continues to do good deeds to others
or perform
actions that may benefit nature at large. A third way is to block the memory channels for
function. To enhance the negative thinking capability for factor A, factor S works on replacing the the positive
thinking mode; consequently, factor A cannot carry out its own function. To enhance the
stored experience for making good decisions with false information leading to bad decisions. It can negativeadditionally act to disturb the existing stored experiences. thinking capability for factor A, factor S works on replacing
the stored experience for making
In view of the above, a person must be able to distinguish between the “true” and “false” signals good decisions
with false information leading to bad decisions. It can additionally act to disturb the
existingobtained by the internal milieu to make rational and positive decisions. The false signal is indeed stored experiences.
In inputted as discussed from factor S and the “true” signal is obtained from factor M as well as the view of the above, a person must be able to distinguish between the “true” and “false” signals
indirect mechanism unknown to us. In this regard one may, for example, be able to distinguish it as obtained by the internal milieu to make rational and positive decisions. The false signal is indeed
inputted as discussed from factor S and the “true” signal is obtained from factor M as well as the
indirect mechanism unknown to us. In this regard one may, for example, be able to distinguish it as
Sustainability 2017, 9, 616
8 of 16
follows: if it is too good to be true or it is too depressing, then the signal stems from factor S, otherwise
it emanates from factor M or the indirect mechanism unknown to us.
Finally, the components of the internal milieu inside the person may be influenced by feedback
from other persons in a community (e.g., factors A’ and N’ in Figure 1b). The roles of A’ and N’
exemplified in other people who come in contact with the person can have a major impact on the
decision-making capability of the person. That is, there are two types of feedback signals that are
channeled to factors A and N of a person. The positive ideas are enhanced via the rational component
of factor A and the irrational positive mode of factor N. On the other hand, the negative ideas are fed
to the negative thinking mode of factor A and the irrational negative mode of factor N. This may be
best exemplified by the classic example of the advice of good parents to their kids to avoid hanging
around “bad kids” and to stick to “good” ones. Therefore, one may need to exercise caution with
respect to the “true” and “false” signals and cues received from others.
2.3. Supporting Evidence for Model Components
Factors A and N are consistent with the psychological literature on cognitive and emotional
resources that has been available for many years [36–39].
Factors M and S are analogous to “good” and “evil” in the philosophical sense. Behind these
characterizations, however, are external entities, albeit without tangible external manifestation, and
are still frequently accepted internally.
Alternatively, factor K has no explicit psychological nor philosophical bias. Nevertheless,
in everyday conversation, but without firm evidence, factor K is regarded like a person with a “good
heart” or like a “wicked person”. Indirect evidence suggests that collective psychological processes
characterizing the biopsychosocial model during active goal pursuit may indeed be instrumental in
influencing cardiovascular responses [40]. That is, the integrated mental engine has a connection to
the physical heart without clear evidence about the causal relationships.
2.4. Analytic Perspective of Component Interactions
The influence of a person’s internal milieu on his/her external environment can be sensed in terms
of his/her cognitive and emotional enhancement or block, which is reflected in his/her (a) human
behavior that acts as the mediating factor between the inner and outer layers; and (b) physiological
functioning throughput. As such, the good and the ill of the inner milieu of the person may be
represented in terms of the differential of negative/positive cognitive and emotional states in one of
three general outputs: (a) nonphysical blocker (NPB)—the ill of the internal milieu outweighs the good;
(b) nonphysical enhancer (NPE)—the good of the internal milieu outweighs the ill; and (c) nonphysical
indifferent (NPI)—the good of the internal milieu is balanced with the ill.
Figure 3a depicts an analytic perspective of the aforementioned states reflecting the resultant of
the interaction of factors A and N. The resultant may reside in one of four quadrants (left and right, top
and bottom; each quadrant consists of four zones). Four possible states are evident for such interaction,
namely: (a) preferred mode of operation in the presence of positive attributes of factors A and N
(A+,N+), that is, steady NPE (long-term zones in top-right quadrant in Figure 3a); (b) sub-optimal
mode of operation in the unsteady state of the negative zone (A−,N−), that is, unsteady NPB (top-right
zone in bottom-left quadrant in Figure 3a); (c) transient ((A−,N+); (A+,N−)), that is, transient NPE or
NPB (top-left and bottom-right quadrants), representing a changing state between steady and unsteady
states; and (d) balance between factors A and N (|A+| ~|N−|; |A−| ~|N+|), that is, NPI.
The positive mode of operation (that is, A+,N+) allows one to work in a steady state by being
more efficient and effective, and integrates the rational component of factor A and the positive impulse
of factor N. It should be noted that the short-term steady state zone could not be sustained for a long
period, with the person moving in and out of it to the long-term steady state operation. Alternatively,
the suboptimal mode of operation emanates from the union of “low” negative thinking of factor A and
the “low negative” state of factor N in the bottom-left quadrant of Figure 3a. The person in this zone is
Sustainability 2017, 9, 616
9 of 16
Sustainability 2017, 9, 616 9 of 16 “vulnerable”
to life and stress events and cannot sustain it for a long period of time. The person
is also
considered vulnerable in the remainder of this quadrant due to the impact of high A- or high N- and
time. The person is also considered vulnerable in the remainder of this quadrant due to the impact of may high A‐ or high N‐ and may be a threat for human health. be a threat for human health.
The The transient states for NPB or NPE are situated in the top‐left and bottom‐right quadrants in transient states for NPB or NPE are situated in the top-left and bottom-right quadrants in
Figure
3a.
As depicted in the figure, one can only be transiently located in one zone, and possible
Figure 3a. As depicted in the figure, one can only be transiently located in one zone, and possible shiftsshifts to neighboring zones may occur. To further clarify, factor S is capable, because of its one‐to‐
to neighboring zones may occur. To further clarify, factor S is capable, because of its one-to-many
many relationships, of additionally overcharging the negative intensity via a direct link to factor K, relationships,
of additionally overcharging the negative intensity via a direct link to factor K, hence
hence changing its state occasionally depending on the interaction of factors A and N (Figure 3b). An changing its state occasionally depending on the interaction of factors A and N (Figure 3b). An example
example would to instill a of
general state of intense “false” so as out
not the
to carry the final would
be to instill
a be general
state
intense
“false”
fear so
as notfear to carry
final out decision
decided
decision decided upon by factor K. Another example is to generate an intense “false” state of overjoy, upon by factor K. Another example is to generate an intense “false” state of overjoy, beyond the
beyond the normal, which may influence the occurrence of future good decisions. This may occur normal, which may influence the occurrence of future good decisions. This may occur when factor
when factor S observes that factor K is in a state of peace and tranquility; consequently it intends to S observes
that factor K is in a state of peace and tranquility; consequently it intends to change the
change the internal milieu via false excitement by shifting the state of affairs into a high positive‐
internal
milieu
viaand false
excitement
bycognitive shifting signal the state
affairs
into aturn highinto positive-energy
source
energy source a false, negative that ofcan eventually a high negative and aenergy source. false, negative cognitive signal that can eventually turn into a high negative energy source.
N+
A = N
High A‐
High N+
Low A‐
High N+
Low A+
High N+
High A+
High N+
Short Term
High A‐
low N+
Low A+
low N+
Low A‐
low N+
High A+
low N+
Long Term
A‐
High A‐
low N‐
Low A‐
low N‐
Low A+
low N‐
High A+
low N‐
Low A+
High N‐
High A+
High N‐
A+
Vulnerable
Suboptimal
High A‐
High N‐
Low A‐
High N‐
NPE
NPB
NPI
N‐
(a)
N+
A = N
A‐
A+
N‐
(b)
Figure 3. Analytic perspective of component interactions. (a) Interaction of factors A and N; (b) Figure 3. Analytic perspective of component interactions. (a) Interaction of factors A and N;
Influence of factor S on factor K (i.e., effect on state of factor K after the input of the resultant of factors (b) Influence
of factor S on factor K (i.e., effect on state of factor K after the input of the resultant
A and N). of factors A and N).
Sustainability 2017, 9, 616
10 of 16
It should be noted that a comparison of Figures 2 and 3 illustrates the versatility of the analytic
model. Each region of Figure 3 can be further divided into four smaller regions. This in turn provides
a more precise version of a system state. In the same way each smaller region can be divided into
four regions and so on. This division of the regions allows our model to be as discrete as needed for
any given system. For example, for slowly-changing systems, a very discrete model can represent the
system change in quantitative terms. Then if we know the timing of the change, we can immediately
obtain the time rate of change or “system velocity”. One can further observe that for passive systems,
the natural tendency is to move down and to the left. That is, without growth and/or positive
stimulation, the system will stagnate and move toward more negative configurations. Finally, with
successive discretization following the pattern of Figure 3, we can develop a system rating according
to position along and away from the lower left/upper right diagonal.
The aforementioned analytic formulation describing component interactions requires
information-gathering from social agents designed to capture the different states of factors A and N.
This can be implemented in a multitude of ways via surveys or through the creation of focus groups in
a social network environment. Surveys and focus groups are typically guided by scripts drawn from
typical scenarios, leading to real-world challenges impacting individuals in their daily lives.
For example, individuals with multiple chronic conditions are confronted with the utilization of
multiple medications thereby impacting their cognitive and emotional states and eventually resulting
in non-adherence to medications [41]. The goal here is to change the behavior of these individuals in
order to adhere to their medications to get well and eventually improve their physical, ecologic, and
economic well-being. Therefore, the survey or focus group mission ought to be focused on the issues
of interest to the members and the information gathering instrument should be designed in a way to
extract the modes of operation of factors A and N together with their interactions with factors S and
M with direct relevance to the situation at hand, as well as the inclusion of other any other factors
deemed to be of importance, such as A’ and N’ from other individuals. Accordingly one can design
smart logic to influence the persons in question.
It should be noted that one may be guided by analogy from the theory of stresses for different
types of engineered materials. Although we are dealing with the intangibles of the aforementioned
non-physical properties, we can however extract its projections on human behavior and action in
exposure to various life events and accordingly develop a specialized instrument designed to record
the challenges and opportunities to which humans are exposed. Accordingly, an algorithm can be built
with inputs from these surveys to determine the inner states of the person and develop smart logic to
better guide human actions to improve human, ecologic and economic well-being.
3. Model Applications
3.1. Nonphysical Syndrome
A subset of NPB may be referred to as nonphysical syndrome (NPS), representing acute and
chronic maladaptive coping and traversing the interface into the physical domain (Figure 1b). It can
present itself in the form of pathologic conditions impacting human health under the general rubric of
maladaptive syndrome (MAS). It is hypothesized that the NPS phenomenon may lead to maladaptation
for not only the person, but also for other entities in the larger system as a consequence of the person’s
actions potentially impacting ecosystem health and the natural environments. For example, at the
individual level, a person may experience traumatic experiences during childhood, with the end
result being a feedback from the physical domain to the non-physical domain as shown in Figure 1a.
During the course of life events, the person may tune up or down his/her adaptive and maladaptive
responses and MAS may transpire as a general pathologic condition leading to different chronic and
acute conditions, with an end result of poorer health. In essence, MAS is a multi-system disease and
usually affects a number of physiologic systems, organs and tissues during its course [42].
Sustainability 2017, 9, 616
11 of 16
For further clarification,
Sustainability 2017, 9, 616 Figure 4 depicts the mapping of NPB and its elements from
the
11 of 16 non-physical domain into the maladaptive response and its constituents in the physical domain.
There is usually a time lag between the NPB and maladaptive response. In addition, the NPS (clinical
usually a time lag between the NPB and maladaptive response. In addition, the NPS (clinical phase phase of NPB) maps onto the MAS (clinical phase of maladaptive response). In addition, MAS may
of NPB) maps onto the MAS (clinical phase of maladaptive response). In addition, MAS may consist consist
both medically-explained
symptoms
and medically-unexplained
symptoms
[43]. Thus,
of both ofmedically‐explained symptoms and medically‐unexplained symptoms [43]. Thus, NPS NPS contributes
to theory the theory
of disease
in two
ways.
First,
NPScan canact acttogether togetherwith with the the genetic
contributes to the of disease in two ways. First, NPS genetic component as modifiers for the random stochastic processes of bodily diseases. Second, NPS may
component as modifiers for the random stochastic processes of bodily diseases. Second, NPS may contribute on its own, through non-random processes, as the main root cause of other bodily diseases. contribute on its own, through non‐random processes, as the main root cause of other bodily diseases. Non‐physicalBlock
Non‐physicalSyndrome
0
Time
T1
Medically
Unexplained
Symptoms
MedicallyExplained
Symptoms
MaladaptiveSyndrome
MaladaptiveResponse
Figure 4. Mapping of non‐physical block and syndrome into maladaptive response & syndrome. Figure 4. Mapping of non-physical block and syndrome into maladaptive response & syndrome.
3.2. Broadened Minds 3.2. Broadened Minds
The concept of NPE can be instrumental as an integral part of developing value‐added attributes The concept of NPE can be instrumental as an integral part of developing value-added attributes
for sustainable systems. It can be formulated in such tangible terms as the sustainability axiom of for sustainable systems. It can be formulated in such tangible terms as the sustainability axiom of
“Doing Good Is Good Business”. This axiom can be used to advance the sustainability of the larger “Doing
Good Is Good Business”. This axiom can be used to advance the sustainability of the larger
SEE complex adaptive system; consequently, it can be instituted as a device to prevent and mitigate SEE complex adaptive system; consequently, it can be instituted as a device to prevent and mitigate
the ills of system unsustainability. One must keep in mind that, although such an approach is the the ills of system unsustainability. One must keep in mind that, although such an approach is the
optimal path for sustainable systems, its time frame is intended for the longer term, making gains in optimal path for sustainable systems, its time frame is intended for the longer term, making gains in
incremental and sure ways, as opposed to non‐optimal approaches which may result in significant incremental and sure ways, as opposed to non-optimal approaches which may result in significant
gains in the short run, yet which may lead to long‐term disastrous outcomes. gains in the short run, yet which may lead to long-term disastrous outcomes. Within the context of this research, a “sustainability axiom” is a universal steady‐state actionable Within the context of this research, a “sustainability axiom” is a universal steady-state actionable
plan with the intent of satisfying the needs and wants of all SEE stakeholders during an agreed‐upon plan with the intent of satisfying the needs and wants of all SEE stakeholders during an agreed-upon
period of time, without creating conflicts and incompatibility among those needs and wants. “Doing period of time, without creating conflicts and incompatibility among those needs and wants. “Doing
Good and Not Doing Bad” Is “Good Business” is an example of one of the very few sustainability Good and Not Doing Bad” Is “Good Business” is an example of one of the very few sustainability
axioms available that may implement the spirit of the NPE. This axiom embodies a complex action axioms available that may implement the spirit of the NPE. This axiom embodies a complex action
plan into its meanings. plan into its meanings. 1.
“Doing Good” signifies the necessity of satisfying the needs and wants of all stakeholders without exception. As one can imagine, this axiom carries a long‐term time span into it (as opposed to short fixes). It is not designed to be a disruptive action. Indeed, the action plan will consist of an inventory of solutions designed to incrementally and steadily improve system Sustainability 2017, 9, 616
1.
2.
3.
12 of 16
“Doing Good” signifies the necessity of satisfying the needs and wants of all stakeholders without
exception. As one can imagine, this axiom carries a long-term time span into it (as opposed to
short fixes). It is not designed to be a disruptive action. Indeed, the action plan will consist of an
inventory of solutions designed to incrementally and steadily improve system performance for
all stakeholders at the same time. “Doing Good” enriches the SEE stakeholders by exploiting all
potential positive energy and attributes of the system in a way that activates the “Non-physical
Enhancers” for all social agents.
“Not Doing Bad” is the other side of the coin of “Doing Good”, with the intent of preventing
and filtering out bad and wicked actions from finding entry to the SEE system. It stipulates the
criticality of avoiding conflicts and incompatibility among the SEE constituents. This component
of the axiom is achieved via the control and minimization of the “Non-Physical Blockers” for all
social agents representing the SEE system.
Either “Doing Good” or “Not Doing Bad” is a necessary condition but neither is individually
sufficient on its own to induce the outcome of “Good Business”. Both components are necessary
and sufficient to produce the steady and incremental outcomes of “Good Business”. This is
essential both to activate and promote the system’s adaptive properties and to deactivate and
dampen the system’s maladaptive properties.
As an example, the above strategy may provide a balancing act for sustainable emerging
technologies such as engineered nanomaterials (ENMs) in the 21st Century, enabling a major
boost to global economic activities, while preserving and enriching human, ecologic and economic
well-being [19,44]. For ENMs to be sustainable across the SEE lifecycle trajectory, mental resources
should be directed towards higher and diminished states of NPE and NPB, respectively, together with
a balanced state of NPI, not impeding the harmonization of values among multiple stakeholders.
To illustrate this, it is common practice for venture capitalists in a start-up nanotechnology
company to put extreme pressure on its nano-scientists and engineers to quickly design and
manufacture ENM materials and nano-enabled products. This pressure, produced by the venture
capitalists, acts as a feedback loop for the mental resources of the nano-scientists and the engineers.
This tends to narrow the perspective of scientists and engineers, leading to system behavior and actions
with a focus on fewer stakeholders in the SEE system such as emphasizing human needs at the expense
of other biological species (e.g., nanomaterials may prove to be detrimental to other species along the
particle lifecycle trajectory). As a result, the perspective of other constituents is not taken into account.
This indicates that a broad, yet integrated, view is required whenever a product is manufactured for
human use—particularly a consumer product. Moreover, the design of the product must be consistent
with the SSE and its trajectory.
The NPE strategy is in line with the “broaden-and-build” theory of positive emotions which
advocates that positive emotions broaden an individual’s instantaneous thought-action reservoir
(that is, interest sparks the urge to explore); and that by broadening an individual’s thought-action
reservoir, positive emotions promote the discovery of novel and creative actions, which in turn build
the individual’s personal resources ranging from physical and intellectual to social and psychological
resources [45].
From the aforementioned discussion, one can deduce many corollaries that can assist in the
production of a detailed actionable action plan with the most appropriate outcomes for the SEE
system at hand. Currently, there is a gap in our knowledge with regard to the sustainability axioms
and their derived corollaries with the intent to enhance the sustainability of SEE systems and to
reduce vulnerabilities to sources of unsustainability. This area deserves future research with respect to
three issues: (a) assessment of existing frameworks geared towards the sustainability of SEE systems;
(b) deduction of sustainability axioms and their derived corollaries; and (c) demonstration of their
applicability to case studies across the different domains of SEE to draw the lessons learned as a guide
for further innovations within the sustainability sciences.
Sustainability 2017, 9, 616
13 of 16
4. Discussion and Concluding Remarks
Over the past several decades, there have been significant advances in science and technology
and related trans-disciplinary fields of knowledge. However, the constituents of the larger SEE
system are not achieving the expected improvements in different domains (e.g., human and ecologic
health) consistent with these advancements nor with the related cost increases. This paradox may be
understood in large part due to an absence of a model that adequately describes the root causes of
sustainability/unsustainability (both positive and negative) embodied in the intrinsic and intangible
nature of human and system behavior and action. Therefore, there are still gaps in knowledge that
have not been elucidated.
These issues may be explained by a number of parameters with origin in social, environmental,
technical, geographical, and political issues that result in unsustainable systems—systems that
cannot keep pace with their basic needs, let alone the higher needs of human populations and other
constituents of the larger SEE system. Other root causes may include, for example, a Western medicine
perspective that has traditionally compartmentalized its view of health by separating not only mental
from physical factors, but also by further segmenting individual people into “index diseases”, rather
than focusing on the whole person. This is due, in part, to the trend of medical “specialization”
that has occurred over the past 50 years or so, resulting in an inadequate and counterproductive
health-management approach.
It is our view that the above approach is going in a direction away from that of achieving optimum
human, ecologic and economic outcomes, by focusing too much on technology and specialization
as the answer for all ills. Therefore, this is limiting the ability to adequately improve the well-being
of human populations and ecosystems in a long-term fashion. The work presented in this paper is
foundational via its offerings of several thrusts aiming at enhancing and promoting the sustainability
of SEE systems.
First, the PFA model implies that human outcomes and actions, regardless of geo-political
circumstances, are determined by a number of influencers, including “non-physical”, physical and
social influencers, acting in a complex SOS to influence each person. Though the geo-socio-economic
influencers can vary, it is felt that the pathway(s) to how these influencers impact individual outcomes
and actions is universal for all mankind.
Second, an analytic formulation has been derived from the component interactions in the PFA
architecture that explains the phenomena of a non-physical blocker (i.e., a system behaving in a
negative mode), of an enhancer (i.e., a system behaving in a positive mode), and an indifferent
(or neutral system) that are responsible for the adaptation and maladaptation of social agents, and
accordingly for the sustainability and unsustainability of SEE systems. As pointed out, additional
research is warranted to build instruments for information-gathering purposes from social agents and
algorithms designed to capture the inner states of NPB, NPE and NPI with proxies from projections
on human behavior, actions and outcomes. It should be kept in mind that the linguistic analytics
presented in Figure 3a should not be construed as a linear system when projected at the digital level.
Rather, it is a non-linear system with the linguistic processing as a device intended to manage the
complexities of non-linear relationships at the digital level.
Third, examples were presented to illustrate the model applications at the individual level, such as
non-physical and maladaptive syndromes. It has been hypothesized that NPB can contribute to the
theory of diseases in two ways: (a) as a modifier for bodily medical conditions; and (b) as a root cause
for non-random bodily disease processes. This line of work requires additional research with the
exploratory intent of determining how to alter these responses with appropriate intervention strategies
to improve human well-being. It is maintained that these interventions can divert an individual from,
for example, poor health to good health if the imbalance of influencing factors leading to the negative
patterns of MAS can be recognized in time early enough to impact its progression. Another important
application is the utilization of the NPE phenomenon in the creation of value-added benefits for
emerging technologies (e.g., ENMs) for all stakeholders of the larger SEE system. This step is essential
Sustainability 2017, 9, 616
14 of 16
at the predesign stage to ensure that adequate measures have been put in place to avoid disastrous
consequences of large-scale technological artifacts. In such situations, a sociotechnical approach is
required with customization for the application at hand.
In conclusion, a narrow consideration of what influences human outcomes and actions with a sole
focus on technology will result in non-sustainable systems with negative outcomes impacting human
populations and constituents of the larger SEE system. The model of “SOS” for human outcomes
and actions, acknowledging both physical and non-physical influencers, can serve as a roadmap for
defining and executing interventions that can induce positive change and minimize negative behavior
for all stakeholders of society’s many systems.
Acknowledgments: The work presented herein was based on the authors’ initiatives and was not subject to
external funding.
Author Contributions: A. Genaidy and R. Huston were responsible for conceiving the initial structural entities of
the model and were validated by D. Dionysiou and W. Karwowski. The four authors contributed to all parts of
the manuscript.
Conflicts of Interest: The authors declare no conflict of interest.
Abbreviations
Acronyms
ENM
Engineered nanomaterials
MAS
Maladaptive syndrome
MMP
Multimorbid patient
NPB
Nonphysical blocker
NPE
Nonphysical enhancer
NPI
Nonphysical indifferent (an intermediary of NPB and NPE)
NPS
Nonphysical syndrome
PFA
Person focused architecture
SEE
society, environment, economy
Major Factors
A
Rational, reasonable and logical factor
N
Energy producing factor
K
Decision making factor, based upon input from all other factors
M
Positive influencing factor (Compare with factor S)
S
Negatively influencing factor (Compare with factor M)
References
1.
2.
3.
4.
5.
6.
7.
8.
Fiksel, T.; Graedel, A.D.; Hecht, D.; Rejeski, D.; Sayer, G.S.; Senge, P.M.; Swackhamer, D.L.; Theis, L.T. EPA
at 40: Bringing Environmental Protection into the 21st Century. Environ. Sci. Technol. 2009, 43, 8716–8720.
[CrossRef] [PubMed]
Williams, P.R.D.; Dotson, G.S.; Maier, A. Cumulative Risk Assessment (CRA): Transforming the Way We
Assess Health Risks. Environ. Sci. Technol. 2012, 46, 10868–10874. [CrossRef] [PubMed]
Depledge, M.H.; Stone, R.J.; Bird, W.J. Can Natural and Virtual Environments Be Used to Promote Improved
Human Health and Wellbeing? Environ. Sci. Technol. 2011, 45, 4660–4665. [CrossRef] [PubMed]
Simon, H.A. A Behavioral Model of Rational Choice. Q. J. Econ. 1995, 69, 99–118. [CrossRef]
Simon, H.A. Rational Choice and the Structure of the Environment. Psychol. Rev. 1956, 63, 129–138. [CrossRef]
[PubMed]
Simon, H.A. Motivational and Emotional Controls of Cognition. Psychol. Rev. 1967, 74, 29–39. [CrossRef]
[PubMed]
Barabasi, A.L. The Origin of Bursts and Heavy Tails in Human Dynamics. Nature 2005, 435, 207–211.
[CrossRef] [PubMed]
Karwowski, W. A Review of Human Factors Challenges of Complex Adaptive Systems Discovering and
Understanding Chaos in Human Performance. Hum. Factors 2012, 54, 983–995. [CrossRef] [PubMed]
Sustainability 2017, 9, 616
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
15 of 16
Pentland, A.; Liu, A. Modeling and Prediction of Human Behavior. Neural Comput. 1999, 11, 229–242.
[CrossRef] [PubMed]
Bonabeau, E. Agent-Based Modeling: Methods and Techniques for Simulating Human Systems. Proc. Natl.
Acad. Sci. USA 2002, 99, 7280–7287. [CrossRef] [PubMed]
Homer, J.B.; Hirsch, G.B. System Dynamics Modeling for Public Health: Background and Opportunities.
Am. J. Public Health 2006, 96, 452–458. [CrossRef] [PubMed]
Janssen, M.A.; Walker, B.H.; Langridge, J.; Abel, N. An Adaptive Agent Model for Analyzing Co-evolution
of Management and Policies in a Complex Rangeland System. Ecol. Model. 2000, 131, 249–268. [CrossRef]
Jager, W.; Janssen, M.A.; de Vries, H.J.M.; de Greef, J.; Vlek, C.A.J. Behavior in Commons Dilemmas: Homo
Economicus and Homo Psychologicus in an Ecological-Economic Model. Ecol. Econ. 2000, 35, 357–379.
[CrossRef]
Bagozzi, R.P. Alternative Perspectives in Philosophy of Mind and Their Relationship to Structural Equation
Models in Psychology. Psychol. Inq. 2011, 22, 88–99. [CrossRef]
Kusmartsev, F.V.; Kurten, K.E. Physics of the Mind: Opinion Dynamics and Decision Making Processes
Based on a Binary Network Model. Int. J. Mod. Phys. B 2008, 22, 4482–4494. [CrossRef]
Pojola, C.; Stanculete, M.F. Biopsychosocial approach of gastrointestinal disorders. Clujul Med. 2014, 87,
95–97.
Kerr, C. Translating “Mind-In-Body”: Two Models of Patient Experience Underlying a Randomized
Controlled Trial of Qigong. Cult. Med. Psychiatry 2002, 26, 419–447. [CrossRef] [PubMed]
Iyer, I.; Albert, P.B.; Devi, S.M.A.; Devi, S.M.A.; Rakkiappan, C.N.; Mohanan, M.; Maharaj, D.O. The Science
of Manifestations by God and Divinity leading to Inspiration and Persistence as Holy Books or Holy Sites or
Evolved/Systematic Holy Ways of Life—A consequence of the Evolution of the Mind and the Heart inspired
by Consciousness fields as explained in the New Consciousness model which scientifically converges Science
and Spirituality with converged scientific and spiritual insights into the aspects of God, Soul, Karma, Birth
and Re-birth, Machine Consciousness and Awareness, Plants, Animals, All Life, Natural and non-Natural
forms and Convergence of Religious Teachings. Int. J. BioSci. Technol. 2013, 6, 37–73.
Tolaymat, T.; El Badawy, A.; Sequeira, R.; Genaidy, A. A System-of-Systems Approach as a Broad and
Integrated Paradigm for Sustainable Engineered Nanomaterials. Sci. Total Environ. 2015, 511, 595–607.
[CrossRef] [PubMed]
Shilling, C.; Mellor, P.A. Embodiment, Structuration Theory and Modernity: Mind/Body Dualism and the
Repression of Sensuality. Body Soc. 1996, 2, 1–15. [CrossRef]
Sperry, R.W. Mind-Brain Interaction: Mentalism, Yes; Dualism, No. Neuroscience 1980, 5, 195–206. [CrossRef]
Borrell-Carrio, F.; Suchman, A.L.; Epstein, R.M. The Biopsychosocial Model 25 Years Later: Principles,
Practice and Scientific Enquiry. Ann. Fam. Med. 2004, 2, 576–582. [CrossRef] [PubMed]
Alonso, Y. The Biopsychosocial Model in Medical Research: The Evolution of the Health Concept over the
Last Two Decades. Patient Educ. Couns. 2004, 53, 239–244. [CrossRef]
Engel, G.L. The Need for a New Medical Model: A Challenge for Biomedicine. Science 1977, 196, 129–136.
[CrossRef] [PubMed]
Brown, T.M. Cartesian Dualism and Psychosomatics. Psychosomatics 1989, 30, 322–331. [CrossRef]
Engel, G.L. How Much Longer Must Medicine’s Science Be Bound by a Seventeenth Century World View?
Psychother. Psychosom. 1992, 57, 3–16. [CrossRef] [PubMed]
Wade, D.T.; Halligan, P.W. Do Biomedical Models of Illness Make for Good Healthcare Systems? Br. Med. J.
2004, 329, 1398–1401. [CrossRef] [PubMed]
Wade, D. Complexity, Case-Mix and Rehabilitation: The Importance of a Holistic Model of Illness.
Clin. Rehabil. 2011, 25, 387–395. [CrossRef] [PubMed]
Greene, R.A.; Dasso, E.; Ho, S.; Frank, J.; Scandrett, G.; Genaidy, A.M. Patterns and Expenditures of
Multi-morbidity in an Insured Working Population in the United States: Insights for a Sustainable Health
Care System and Building Healthier Lives. Popul. Health Manag. 2013, 16, 381–389. [CrossRef] [PubMed]
Greene, R.A.; Dasso, E.; Ho, S.; Genaidy, A.M. A Person-Focused Model of Care for the Twenty-First Century:
A System-of-Systems Perspective. Popul. Health Manag. 2014, 17, 166–671. [CrossRef] [PubMed]
Genaidy, A.; Karwowski, W.; Shoaf, C. The Fundamentals of Work System Compatibility Theory:
An Integrated Approach to Optimize Human Performance at Work. Theor. Issues Ergon. Sci. 2002, 3,
346–368. [CrossRef]
Sustainability 2017, 9, 616
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
16 of 16
Genaidy, A.; Salem, O.; Karwowski, W.; Paez, O.; Tuncel, S. The Work Compatibility Improvement
Framework: An Integrated Perspective of the Human-At-Work System. Ergonomics 2007, 50, 3–25. [CrossRef]
[PubMed]
Boardman, J.; Sauser, B. System of Systems—The meaning of of. In Proceedings of the IEEE International
Conference on System of Systems Engineering, Los Angeles, CA, USA, 24–26 April 2006; pp. 118–123.
Gorod, A.; Sauser, B.; Boardman, J. System-of-Systems Engineering Management: A Review of Modern
History and a Path Forward. IEEE Syst. J. 2008, 2, 484–499. [CrossRef]
DiMario, M.J.; Boardman, J.T.; Sauser, B.J. System of Systems Collaborative Formation. IEEE Syst. J. 2009, 3,
360–368. [CrossRef]
Dember, W.N.; Jenkins, J.J.; Teyler, T.J. The Group: Social Roles and Social Impact. In General Psychology,
2nd ed.; Wm. C. Brown: Dubuque, IA, USA, 1984; Chapter 18; pp. 731–739.
Dember, W.N.; Jenkins, J.J.; Teyler, T.J. The Group: Social Interaction. In General Psychology, 2nd ed.; Wm. C.
Brown: Dubuque, IA, USA, 1984; Chapter 19; pp. 761–797.
Cohen, A. Heat, Stress, and Workload in an Era of Workplace Change, Ergonomics and Human Factors; Mark, L.S.,
Warm, J.S., Huston, R.L., Eds.; Springer: New York, NY, USA, 1987; pp. 155–169.
Hancock, P.A. Arousal theory, stress and performance: Problems of incorporating energetic aspects of
behavior into human-machine systems function. In Ergonomics and Human Factors; Mark, L.S., Warm, J.S.,
Huston, R.L., Eds.; Springer: New York, NY, USA, 1987; pp. 170–179.
Seery, M.D. The Biopsychosocial Model of Challenge and Threat: Using the Heart to Measure the Mind.
Soc. Personal. Psychol. Compass 2013, 7, 637–653. [CrossRef]
Starfield, B. Is patient care the same as person-focused care? Perm. J. 2011, 15, 63–69. [CrossRef] [PubMed]
Jakovljevic, M.; Ostojic, L. Comorbidity and Multimorbidity in Medicine Today: Challenges and
Opportunities for Bringing Separated Branches of Medicine Closer to Each Other. Psychiatra Danub. 2013, 25,
18–28.
Burton, C. (Ed.) ABC of Medically Unexplained Symptoms; Wiley-Blackwell: Oxford, UK, 2013.
Organization for Economic Co-operation and Development (OECD). Important Issues on Risk Assessment of
Manufactured Nanomaterials; OECD: Paris, France, 2012.
Fredrickson, B.L. The role of positive emotions in positive psychology: The broaden-and-build theory of
positive emotions. Am. Psychol. 2001, 56, 218. [CrossRef] [PubMed]
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).