SAFETY DATA SHEET
Based upon Regulation (EC) No. 1907/2006, as amended by Regulation (EC) No. 453/2010
cadmium, metal, in massive state
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier:
Product name
Synonyms
Registration number REACH
Product type REACH
CAS number
EC index number
EC number
RTECS number
Molecular mass
Formula
: cadmium, metal, in massive state
: cadmium (non-pyrophoric); cadmium
: 01-2119489023-40-0013 (Nyrstar Budel BV)
: Substance/mono-constituent
: 7440-43-9
: 048-002-00-0
: 231-152-8
: EU9800000
: 112.41 g/mol
: Cd
1.2 Relevant identified uses of the substance or mixture and uses advised against:
1.2.1 Relevant identified uses
IU01 Cadmium metal production RLE (GESCd 0)
IU02 Cadmium metal production by pyrometallurgy (GESCd 0)
IU03 Storage of ingots-slabs in warehouses (GESCd 1)
IU04 Production of chemicals (pyro) (GESCd 3)
IU05 Production of chemicals (hydro) (GESCd 3)
IU06 Additive for production of inorganic catalysts (GESCd 2)
IU07 Melting, alloying and casting (GESCd 1)
IU08 Production of "targets" by (EB) PVD (GESCd 1)
IU09 Cadmium casting and rolling (GESCd 1, GESCd 6)
IU10 Wire and rods manufacturing (GESCd 1, GESCd 6)
IU11 Component for brazing products (GESCd 1, GESCd 6)
IU12 Component for soldering products (GESCd 1, GESCd 6)
IU13 Downstream use of Cadmium based brazing products (GESCd 8)
IU14 Downstream use of cadmium-based soldering products (GESCd 8)
IU15 Cadmium (alloyed) powder manufacturing (GESCd 2)
IU16 Powders for contact materials (GESCd 7)
IU17 Use of active powders for batteries (GESCd 7)
IU18 Use of fine powders for mechanical plating (GESCd 7)
IU19 Manufacturing of Cadmium containing-alloys (GESCd 1)
IU20 Use of cadmium containing Ag alloys (GESCd 6)
IU21 Electroplating (GESCd 1)
IU22 PVD / coating (GESCd 8)
For more detailed information regarding the Identified Uses and the associated Exposure Scenarios: see attached annex
1.2.2 Uses advised against
See heading 15.1: Reach Annex XVII - Restriction
1.3 Details of the supplier of the safety data sheet:
Supplier of the safety data sheet
Nyrstar Budel B.V. on behalf of Nyrstar Sales & Marketing A.G.
Hoofdstraat 1
6024 AA Budel-Dorplein
Tel: +32 14 44 96 80
Fax: +32 14 44 95 52
[email protected]
Manufacturer of the product
NYRSTAR Sales & Marketing AG
Tessinerplatz 7
CH-8002 Zürich
Tel: +41 44 745 81 00
Fax: +41 44 745 81 10
[email protected]
1.4 Emergency telephone number:
Reason for revision: 15.1
Revision number: 0101
Publication date: 2011-12-27
Date of revision: 2013-04-19
Product number: 51612
134-16274-381-en
Created by: Brandweerinformatiecentrum voor gevaarlijke stoffen vzw (BIG)
Technische Schoolstraat 43 A, B-2440 Geel
http://www.big.be
© BIG vzw
1 / 13
cadmium, metal, in massive state
24h/24h (Telephone advice: English, French, German, Dutch):
+32 14 58 45 45 (BIG)
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture:
2.1.1 Classification according to Regulation EC No 1272/2008
Classified as dangerous according to the criteria of Regulation (EC) No 1272/2008
Class
Carc.
Muta.
Repr.
Acute Tox.
STOT RE
STOT RE
Aquatic Acute
Aquatic Chronic
Category
category 1B
category 2
category 2
category 2
category 1
category 1
category 1
category 1
Hazard statements
H350: May cause cancer.
H341: Suspected of causing genetic defects.
H361fd: Suspected of damaging fertility. Suspected of damaging the unborn child.
H330: Fatal if inhaled.
H372: Causes damage to organs through prolonged or repeated exposure if inhaled.
H372: Causes damage to organs through prolonged or repeated exposure if swallowed.
H400: Very toxic to aquatic life.
H410: Very toxic to aquatic life with long lasting effects.
2.1.2 Classification according to Directive 67/548/EEC-1999/45/EC
Classified as dangerous in accordance with the criteria of Directive 67/548/EEC
Carc. Cat. 2; R45 - May cause cancer.
Muta. Cat. 3; R68 - Possible risk of irreversible effects.
Repr. Cat. 3; R62 - 63 - Possible risk of impaired fertility. Possible risk of harm to the unborn child.
T+; R26 - Very toxic by inhalation.
T; R25 - 48/23/25 - Toxic if swallowed. Toxic: danger of serious damage to health by prolonged exposure through inhalation and if swallowed.
N; R50-53 - Very toxic to aquatic organisms. May cause long-term adverse effects in the aquatic environment.
2.2 Label elements:
Labelling according to Regulation EC No 1272/2008 (CLP)
This substance/mixture, although classified dangerous, does not require a label because of the form in which it is placed on the market (Regulation (EC) No
1272/2008 Annex I chapter 1.3.4)
2.3 Other hazards:
SECTION 3: Composition/information on ingredients
3.1 Substances:
Name (REACH Registration No)
CAS No
EC No
cadmium (non-pyrophoric) (01-211948902340)
7440-43-9
231-152-8
Conc. (C)
99.99 %
Classification
Classification according to
Note
according to DSD/DPD CLP
Carc. Cat. 2; R45
Muta. Cat. 3; R68
Repr. Cat. 3; R62 - 63
T+; R26
T; R25 - 48/23/25
N; R50-53
Carc. 1B; H350
Muta. 2; H341
Repr. 2; H361fd
Acute Tox. 2; H330
STOT RE 1; H372
Aquatic Acute 1; H400
Aquatic Chronic 1; H410
(1)(2)(10)
Remark
Mono-constituent
(1) For R-phrases and H-statements in full: see heading 16
(2) Stof waarvoor binnen de Gemeenschap een blootstellingsgrens op de werkvloer geldt
(10) Subject to restrictions of Annex XVII of Regulation (EC) No. 1907/2006
3.2 Mixtures:
Not applicable
SECTION 4: First aid measures
4.1 Description of first aid measures:
General:
If you feel unwell, seek medical advice.
After inhalation:
After inhalation of fume: Remove the victim into fresh air. Respiratory problems: consult a doctor/medical service.
After skin contact:
Not applicable.
After eye contact:
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Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
2 / 13
cadmium, metal, in massive state
After contact with fume: Rinse with water. Take victim to a doctor/medical service if irritation persists.
After ingestion:
Not applicable.
4.2 Most important symptoms and effects, both acute and delayed:
4.2.1 Acute symptoms
After inhalation:
AFTER INHALATION OF FUME: Irritation of the nasal mucous membranes. Irritation of the respiratory tract. Coughing. Respiratory difficulties. Risk of lung
oedema. Possible inflammation of the respiratory tract. Lung tissue affection/degeneration. FOLLOWING SYMPTOMS MAY APPEAR LATER: Metal fume fever.
After skin contact:
Not applicable.
After eye contact:
After contact with fume: Irritation of the eye tissue.
After ingestion:
Not applicable.
4.2.2 Delayed symptoms
If applicable and available it will be listed below.
4.3 Indication of any immediate medical attention and special treatment needed:
If applicable and available it will be listed below.
SECTION 5: Firefighting measures
5.1 Extinguishing media:
5.1.1 Suitable extinguishing media:
EXTINGUISHING MEDIA FOR SURROUNDING FIRES: All extinguishing media allowed.
5.1.2 Unsuitable extinguishing media:
No unsuitable extinguishing media known.
5.2 Special hazards arising from the substance or mixture:
On burning: formation of metallic fumes (cadmium oxide). On heating (>160°C): formation of metallic fumes (cadmium oxide).
5.3 Advice for firefighters:
5.3.1 Instructions:
Dilute toxic gases with water spray.
5.3.2 Special protective equipment for fire-fighters:
Gloves. Protective clothing. Heat/fire exposure: compressed air/oxygen apparatus.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures:
No naked flames.
6.1.1 Protective equipment for non-emergency personnel
See heading 8.2
6.1.2 Protective equipment for emergency responders
Gloves. Protective clothing.
Suitable protective clothing
See heading 8.2
6.2 Environmental precautions:
No data available
6.3 Methods and material for containment and cleaning up:
Pick-up the material.
6.4 Reference to other sections:
See heading 13.
SECTION 7: Handling and storage
The information in this section is a general description. If applicable and available, exposure scenarios are attached in annex. Always use the relevant exposure
scenarios that correspond to your identified use.
7.1 Precautions for safe handling:
Avoid raising dust. Observe strict hygiene.
7.2 Conditions for safe storage, including any incompatibilities:
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
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cadmium, metal, in massive state
7.2.1 Safe storage requirements:
Store at ambient temperature. Meet the legal requirements.
7.2.2 Keep away from:
Heat sources, (strong) acids, oxidizing agents.
7.2.3 Suitable packaging material:
No data available
7.2.4 Non suitable packaging material:
No data available
7.3 Specific end use(s):
If applicable and available, exposure scenarios are attached in annex. See information supplied by the manufacturer.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters:
8.1.1 Occupational exposure
a) Occupational exposure limit values
If limit values are applicable and available these will be listed below.
The Netherlands
Cadmium (inhaleerbaar)
Time-weighted average exposure limit 8 h
0.005 mg/m³
Time-weighted average exposure limit 8 h
0.002 mg/m³
Time-weighted average exposure limit 8 h
0.01 mg/m³
USA (TLV-ACGIH)
Cadmium
Cadmium, compounds, as Cd
Cadmium
Time-weighted average exposure limit 8 h
Time-weighted average exposure limit 8 h
Time-weighted average exposure limit 8 h
0.01 mg/m³
0.01 mg/m³
0.002 mg/m³ (R)
Cadmium, compounds, as Cd
Time-weighted average exposure limit 8 h
0.002 mg/m³ (R)
France
Cadmium et composés, en Cd
Cadmium (oxyde de), en Cd
Time-weighted average exposure limit 8 h
Short time value
0.05 mg/m³
0.05 mg/m³
VL: Valeur non réglementaire indicative
VL: Valeur non réglementaire indicative
Time-weighted average exposure limit 8 h
Short time value
Time-weighted average exposure limit 8 h
0.025 mg/m³
0.05 mg/m³
0.025 mg/m³
Workplace exposure limit (EH40/2005)
Workplace exposure limit (EH40/2005)
Workplace exposure limit (EH40/2005)
Belgium
Cadmium et ses composés (particules
alvéolaires) (en Cd)
UK
Cadmium
Cadmium oxide fume (as Cd)
Private occupational exposure limit
value; inhalable
TLV - Adopted Value
TLV - Adopted Value
TLV - Adopted Value; (R): Respirable
fraction
TLV - Adopted Value; (R): Respirable
fraction
b) National biological limit values
If limit values are applicable and available these will be listed below.
8.1.2 Sampling methods
Product name
Test
Cadmium
OSHA
Cadmium
NIOSH
Cadmium & Cpds (as Cd)
NIOSH
Cadmium (Cd)
NIOSH
Cadmium (Cd)
NIOSH
Cadmium (Elements on wipes)
NIOSH
Cadmium (Elements)
NIOSH
Cadmium (Elements, aqua regia ashing)
NIOSH
Cadmium (Elements, hot block/HCl/HNO3 digestion)
NIOSH
8.1.3 Applicable limit values when using the substance or mixture as intended
If limit values are applicable and available these will be listed below.
8.1.4 DNEL/PNEC values
DNEL - Workers
cadmium, metal, in massive state
Effect level (DNEL/DMEL)
Type
Number
ID 189
7048
7048
8005
8310
9102
7300
7301
7303
Value
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
Remark
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cadmium, metal, in massive state
DNEL
DNEL - General population
cadmium, metal, in massive state
Long-term local effects inhalation
Effect level (DNEL/DMEL)
Type
DNEL
Long-term systemic effects oral
PNEC
cadmium, metal, in massive state
Compartments
Value
Fresh water
0.19 µg/l
Marine water
1.14 µg/l
STP
20 µg/l
Fresh water sediment
1.8 mg/kg sediment dw
Marine water sediment
0.64 mg/kg
Soil
0.9 mg/kg soil dw
Oral
0.16 mg/kg food
8.1.5 Control banding
If applicable and available it will be listed below.
Value
1 mg/kg bw/day
Remark
Remark
8.2 Exposure controls:
The information in this section is a general description. If applicable and available, exposure scenarios are attached in annex. Always use the relevant exposure
scenarios that correspond to your identified use.
8.2.1 Appropriate engineering controls
Avoid raising dust.
8.2.2 Individual protection measures, such as personal protective equipment
Observe strict hygiene. Do not eat, drink or smoke during work.
a) Respiratory protection:
Not required for normal conditions of use. Dust production: dust mask with filter type P3. High dust production: self-contained breathing apparatus.
b) Hand protection:
Gloves.
- materials for protective clothing (good resistance)
Leather.
c) Eye protection:
In case of dust production: protective goggles.
d) Skin protection:
Protective clothing.
8.2.3 Environmental exposure controls:
See headings 6.2, 6.3 and 13
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties:
Physical form
Metal
Odour
Odourless
Odour threshold
Not applicable
Colour
Silvery
Particle size
Not applicable
Explosion limits
Not applicable
Flammability
Non-flammable
Log Kow
Not applicable
Dynamic viscosity
Not applicable
Kinematic viscosity
Not applicable
Melting point
321 °C
Boiling point
Not applicable
Flash point
Not applicable
Evaporation rate
Not applicable
Vapour pressure
Not relevant
Relative vapour density
Not applicable
Solubility
water ; 2.3 mg/l ; 20 °C
mineral acids ; soluble
Relative density
8.60 ; 20 °C
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
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cadmium, metal, in massive state
Decomposition temperature
No data available
Auto-ignition temperature
Not applicable
Explosive properties
No chemical group associated with explosive properties
Oxidising properties
No chemical group associated with oxidising properties
pH
Not applicable
Physical hazards
No physical hazard class
9.2 Other information:
Absolute density
8600 kg/m³ ; 20 °C
SECTION 10: Stability and reactivity
10.1 Reactivity:
No data available.
10.2 Chemical stability:
Stable under normal conditions.
10.3 Possibility of hazardous reactions:
No data available.
10.4 Conditions to avoid:
Avoid raising dust.
10.5 Incompatible materials:
(strong) acids, oxidizing agents.
10.6 Hazardous decomposition products:
Reacts with (some) acids: release of highly flammable gases/vapours (hydrogen). On heating (>160°C): formation of metallic fumes (cadmium oxide). On
burning: formation of metallic fumes (cadmium oxide).
SECTION 11: Toxicological information
11.1 Information on toxicological effects:
11.1.1 Test results
- Toxicokinetics: summary
Toxicokinetics (absorption, metabolism, distribution and elimination).
Uptake of cadmium can occur in humans via the inhalation of polluted air, the ingestion of contaminated food or drinking water and, to a minor extent,
through exposure of the skin to dusts or liquids contaminated by the element (JRC, 2008; SCOEL, 2009).
In occupational settings, mainly inhalation exposure occurs although the dermal route may also play a role when metal, powder or dust is handled or during
maintenance of machinery. Additional uptake is possible through food and tobacco (for example in workers who eat or smoke at the workplace).
For the general population, uptake of cadmium occurs principally via the ingestion of food or, to a lesser extent, of contaminated drinking water. In industrial
sites polluted by cadmium, inhalation of air and/or ingestion of soil or dusts may contribute to significant exposure. Tobacco is an important additional source
of cadmium uptake in smokers. Finally, the consumer could be exposed (skin, inhalation or oral) through the use of consumption products.
Absorption: Gastrointestinal absorption of cadmium is usually less than 5% but varies with the form of cadmium present, the composition of the diet, age and
the individual iron status. High gastrointestinal absorption rates (up to 20%) have been observed for example in women with lowered iron stores (serum
ferritin <20 μg/L) (Sasser and Jarboe, 1977; Weigel et al., 1984; JRC, 2007). Cadmium is absorbed by the respiratory route at rates varying between 2 and 50%
depending on the cadmium compound involved (water soluble or insoluble), the size of the particles (dusts or fumes), the deposition pattern in the
respiratory tract and the ventilation rate. Values of 10 to 30% for dusts and 25-50% for fumes are cited in the EU Summary Risk Assessment Report (RAR) (JRC,
2007) and various publications (Boisset et al., 1978; Glaser et al., 1986; Oberdörster et al., 1979; Oberdörster and Cox, 1989; Oberdörster, 1992; Dill et al.,
1994; Hadley et al., 1980). The results from studies in mouse, rat, rabbit and in vitro human skin models suggest that, although cadmium may penetrate
through skin, absorption of soluble and less soluble compounds is generally lower than 1% (Kimura and Otaki, 1972; Lansdown and Sampson, 1996; Wester et
al., 1992; JRC, 2008).
Distribution: Following absorption, the biodisposition of cadmium (Cd2+) is assumed to be independent of the chemical form to which exposure occured (JRC,
2007). Cadmium is a cumulative toxicant. It is transported from its absorption site (lungs or gut) to the liver, where it induces the synthesis of metallothionein
which sequestrates cadmium. The cadmium-metallothionein complex is then slowly released from the liver and transported in the blood to the kidneys,
filtrated through the glomerulus and reabsorbed in the proximal tubule where it may dissociate intracellularly (Chan and Cherian, 1993). There, free cadmium
again induces the synthesis of metallothionein, which protects against cellular toxicity until saturation.
In non-occupationally exposed individuals, cadmium concentrations in kidney is generally between 10 and 50 mg/kg wet weight, with smokers showing 2 to 5fold higher values than non-smokers (Nilsson et al., 1995). After long-term low level exposure, approximately half the cadmium body burden is stored in the
liver and kidneys, one third being in the kidney where the major part is located in the cortex (Kjellström et al., 1979). The kidney:liver concentration ratio
decreases with the intensity of exposure and is, for instance, lower in occupationally exposed workers (7 to 8-fold ratio) (Ellis et al., 1981; Roels et al., 1981)
than in the general population (10 to 30-fold ratio) (Elinder et al., 1985). The distribution of cadmium in the kidney is important as this organ is one of the
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Product number: 51612
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cadmium, metal, in massive state
critical targets after long-term exposure.
In blood, most cadmium is localised in erythrocytes (90%) and values measured in adult subjects with no occupational exposure are generally lower than 1
μg/L in non-smokers. Blood cadmium (Cd-B) values are 2 to 5-fold higher in smokers than in non-smokers (Staessen et al., 1990; Järup et al., 1998; Ollson,
2002). In the absence of occupational exposure, the mean urinary cadmium concentration (Cd-U) is generally below 1 to 2 μg/g creatinine in adults. While CdB is influenced by both recent exposure and cadmium body burden, Cd-U is mainly related to the body burden (Lauwerys and Hoet, 2001). Smokers excrete
more cadmium than non-smokers and their Cd-U is on average 1.5-fold higher than for non-smokers.
The placenta provides a relative barrier, protecting the foetus against cadmium exposure. Cadmium can cross the placenta but at a low rate (Trottier et al.,
2002; Lauwerys et al., 1978; Lagerkvist et al., 1992).
Metabolism: Cadmium is not known to undergo any direct metabolic conversion such as oxidation, reduction or alkylation. The cadmium (Cd2+) ion does bind
to anionic groups (especially sulfhydryl groups) in proteins and other molecules (Nordberg et al., 1985). Plasma cadmium circulates primarily bound to
metallothionein and albumin (Foulkes and Blanck, 1990; Roberts and Clark, 1988).
Excretion: Absorbed cadmium is excreted very slowly, with urinary and fecal pathways being approximately equal in quantity (< 0.02% of the total body
burden per day) (Kjellström et al., 1985). It accumulates over many years, mainly in the renal cortex and to a smaller extent in the liver and lung. The biologic
half-life of cadmium has been estimated to be between 10 to 30 years in kidney and 4.7 to 9.7 years in liver (Ellis et al., 1985). The half-life in both organs is
markedly reduced with the onset of renal toxicity when tubule loss of cadmium is accelerated. The total cadmium body burden reaches about 30 mg by the
age of 30.
Biomonitoring: Biomonitoring methods for either Cd-B or Cd-U are often used rather than airborne measurements because they integrate all possible sources
of occupational and environmental exposures (e.g. digestive exposure at the workplace, tobacco smoking and diet). In addition, since cadmium is a cumulative
toxicant, a measure of the body burden (i.e. Cd-U) is the most appropriate exposure parameter for conducting risk assessments. In workers with substantial
cadmium exposure (i.e. Cd-U > 3 μg/g creatinine), 30 years exposure to 50 μg/m³ of cadmium would lead to a Cd-U of 3 μg/g creatinine (SCOEL, 2009).
Acute toxicity
cadmium, metal, in massive state
Route of
Parameter
exposure
Oral
LC50
Oral
LC50
Dermal
Inhalation
(aerosol)
Conclusion
Fatal if inhaled.
Method
Value
Exposure time
2330 mg/kg bw
89 mg/kg bw
LC50
0.056 mg/l
Species
Gender
Rat
Mouse
4 week(s)
Rat
Male/female
Value
determination
Experimental value
Experimental value
Not relevant,
expert judgement
Read-across
Corrosion/irritation
cadmium, metal, in massive state
Route of exposure Result
Eye
Method
Exposure time
Time point
Species
Skin
Inhalation
Value determination
Not determined,
exemption according
to REACH
Not determined,
exemption according
to REACH
Not determined,
exemption according
to REACH
Conclusion
Not classified as irritating to the skin
Not classified as irritating to the eyes
Respiratory or skin sensitisation
cadmium, metal, in massive state
Route of exposure Result
Method
Exposure time
Observation time Species
point
Gender
Skin
Inhalation
Value
determination
Not determined,
exemption
according to
REACH
Not determined,
exemption
according to
REACH
Conclusion
Not sensitizing for inhalation
Not sensitizing for skin
Specific target organ toxicity
Reason for revision: 15.1
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Product number: 51612
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cadmium, metal, in massive state
cadmium, metal, in massive state
Route of
Parameter
exposure
Oral
NOAEL
Oral
NOAEL
Method
Value
Organ
Effect
3 mg/kg
bw/day
0.12 mg/kg
bw/day
Equivalent to 0.022 mg/m³ Lungs
OECD 413
0.013 mg/m³
Exposure time
Species
3 month(s)
Rat
462 week(s)
Monkey
Inhalation
LOAEL
Overall effects 6 h
(aerosol)
Inhalation
NOAEL
6h
(aerosol)
Conclusion
Causes damage to organs through prolonged or repeated exposure if inhaled.
Causes damage to organs through prolonged or repeated exposure if swallowed.
Gender
Value
determination
Male/femal Read-across
e
Male
Read-across
Mouse
Male/femal Read-across
e
Male
Read-across
Hamster
Mutagenicity (in vitro)
cadmium, metal, in massive state
Result
Method
Negative
Equivalent to OECD 471
Positive
Equivalent to OECD 473
Test substrate
Bacteria (S.typhimurium)
Effect
Value determination
Read-across
Read-across
Mutagenicity (in vivo)
cadmium, metal, in massive state
Result
Method
Exposure time
Limited positive test Human observation
result
study
Test substrate
Gender
Male/female
Organ
Value determination
Experimental value
Carcinogenicity
cadmium, metal, in massive state
Route of
Parameter Method
exposure
Inhalation
LOAEL
(aerosol)
Dermal
Oral
LOAEL
Value
Exposure time Species
Gender
0.03 mg/m³
< 18 month(s)
Male/female
Value
Organ
determination
Read-across
Lungs
Male
Not relevant,
expert
judgement
Read-across
3.5 mg/kg
bw/day
77 week(s)
Rat
Rat
Prostate
Effect
Tumor
formation
Benign tumor
formation
Reproductive toxicity
cadmium, metal, in massive state
Parameter
Method
Developmental toxicity NOAEL
OECD 414
NOAEL
OECD 414
Effects on fertility
NOAEL (P)
LOAEL
NOAEL (F1)
LOAEL
Value
Exposure
time
0.05 mg/m³ 4 - 17 days
air
(gestation,
daily)
0.5 mg/m³ 4 - 19 days
air
(gestation,
daily)
1 mg/kg
13 week(s)
bw/day
10 mg/kg 13 weeks
bw/day
(daily, 5
days/week)
1 mg/kg
13 weeks
bw/day
(daily, 5
days/week)
10 mg/kg 13 weeks
bw/day
(daily, 5
days/week)
Species
Gender
Effect
Organ
Value
determination
Read-across
Mouse
Female
No effect
Rat
Female
Rat
Female
Reduced
foetal
bodyweights
No effect
Rat
Female
Read-across
Rat
Male/female No effect
Read-across
Rat
Male/female Weight
reduction
Read-across
Read-across
Read-across
Conclusion CMR
Suspected of causing genetic defects.
May cause cancer.
Suspected of damaging fertility. Suspected of damaging the unborn child.
Reason for revision: 15.1
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Product number: 51612
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cadmium, metal, in massive state
Toxicity other effects
cadmium, metal, in massive state
No (test)data available
Chronic effects from short and long-term exposure
cadmium, metal, in massive state
ON CONTINUOUS/REPEATED EXPOSURE/CONTACT: Change in the haemogramme/blood composition. Change in urine output.
SECTION 12: Ecological information
12.1 Toxicity:
cadmium, metal, in massive state
Parameter
Method
Value
Duration
Acute toxicity fishes
LC50
Other
0.748 mg/l
96 h
Acute toxicity invertebrates
LC50
ASTM E72980
OECD 201
0.036 mg/l
48 h
Daphnia magna
0.070 mg/l
72 h
Pseudokirchnerie Static system Fresh water
lla subcapitata
NOEC
Other
0.063 mg/l
5 day(s)
Ulva sp.
Static system Salt water
Long-term toxicity fish
NOEC
Other
0.012 mg/l
84 day(s)
Long-term toxicity aquatic
invertebrates
NOEC
Compareble 0.0006 mg/l
to UBA
21 day(s)
Oncorhynchus
mykiss
Daphnia magna
Flow-through Fresh water
system
Semi-static Fresh water
NOEC
Other
0.002 mg/l
33 day(s)
Americamysis
bahia
Flow-through Salt water
system
NOEC
OECD 209
0.2 mg/l
3h
Bacteria
Static system Fresh water
Toxicity algae and other aquatic EC50
plants
Toxicity aquatic microorganisms
Toxicity soil macro-organisms
Toxicity terrestrial plants
Toxicity birds
Parameter
NOEC
NOEC
NOEC
NOEC
NOEC
NOEC
NOEC
Method
Other
Other
Not further
determined
Not further
determined
Species
Fresh/salt
water
Carassius auratus Flow-through Fresh water
system
Value
150 mg/kg soil dw
10 mg/kg soil dw
6.25 mg/kg soil dw
25 mg/kg soil dw
Duration
84 day(s)
21 day(s)
10 day(s)
10 day(s)
3.12 mg/kg soil dw
10 mg/kg
10 day(s)
84 day(s)
38 mg/kg
42 day(s)
Test design
Value determination
Static system Fresh water
Read-across;
Nominal
concentration
Read-across; Lethal
Experimental value;
Growth rate
Read-across;
Reproduction
Read-across; Lethal
Read-across;
Reproduction
Read-across;
Growth
Experimental value
Species
Lumbricus rubellus
Eisenia sp.
Avena sativa
Brassica campestris
var. chinensis
Lactuca sativa
Anas platyrhynchas
Value determination
Read-across
Read-across
Experimental value
Experimental value
Coturnix coturnix
japonica
Weight of evidence
Experimental value
Weight of evidence
Conclusion
Highly toxic to fishes
Very toxic to invertebrates (Daphnia)
Highly toxic to algae
Inhibition of activated sludge
Ecotoxicity is only applicable when components are released
12.2 Persistence and degradability:
cadmium, metal, in massive state
Biodegradation water
Method
Not applicable (inorganic)
Biodegradation soil
Method
Not applicable (inorganic)
Value
Duration
Value determination
Value
Duration
Value determination
Conclusion
Biodegradability: not applicable
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
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cadmium, metal, in massive state
12.3 Bioaccumulative potential:
cadmium, metal, in massive state
BCF fishes
Parameter
BCF
Method
Log Kow
Method
Value
5 - 1385
Remark
Not applicable
Duration
92 day(s)
Species
Salmo salar
Value
Value determination
Read-across
Temperature
Value determination
Conclusion
No straightforward conclusion can be drawn based upon the available numerical values
12.4 Mobility in soil:
12.5 Results of PBT and vPvB assessment:
Due to insufficient data no statement can be made whether the substance fulfils the criteria of PBT and vPvB according to Annex XIII of Regulation (EC)
No 1907/2006.
12.6 Other adverse effects:
cadmium, metal, in massive state
Ozone-depleting potential (ODP)
Not classified as dangerous for the ozone layer (Regulation (EC) No. 1272/2008 and 1005/2009)
SECTION 13: Disposal considerations
The information in this section is a general description. If applicable and available, exposure scenarios are attached in annex. Always use the relevant exposure
scenarios that correspond to your identified use.
13.1 Waste treatment methods:
13.1.1 Provisions relating to waste
Waste material code (Directive 2008/98/EC, decision 2000/0532/EC).
06 04 05* (wastes containing other heavy metals).
12 01 03 (non-ferrous metal filings and turnings). Depending on branch of industry and production process, also other EURAL codes may be applicable.
Hazardous waste according to Directive 2008/98/EC.
13.1.2 Disposal methods
Recycle/reuse. Remove waste in accordance with local and/or national regulations. Hazardous waste shall not be mixed together with other waste. Different
types of hazardous waste shall not be mixed together if this may entail a risk of pollution or create problems for the further management of the waste.
Hazardous waste shall be managed responsibly. All entities that store, transport or handle hazardous waste shall take the necessary measures to prevent
risks of pollution or damage to people or animals. Do not discharge into surface water (2000/60/EC, Council decision 2455/2001/EC, O.J. L331 of
15/12/2001).
13.1.3 Packaging/Container
Waste material code packaging (Directive 2008/98/EC).
15 01 10* (packaging containing residues of or contaminated by dangerous substances).
SECTION 14: Transport information
Road (ADR)
14.1 UN number:
Transport
14.2 UN proper shipping name:
14.3 Transport hazard class(es):
Hazard identification number
Class
Classification code
14.4 Packing group:
Packing group
Labels
14.5 Environmental hazards:
Environmentally hazardous substance mark
14.6 Special precautions for user:
Special provisions
Limited quantities
Not subject
no
Rail (RID)
14.1 UN number:
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
10 / 13
cadmium, metal, in massive state
Transport
14.2 UN proper shipping name:
14.3 Transport hazard class(es):
Hazard identification number
Class
Classification code
14.4 Packing group:
Packing group
Labels
14.5 Environmental hazards:
Environmentally hazardous substance mark
14.6 Special precautions for user:
Special provisions
Limited quantities
Not subject
no
Inland waterways (ADN)
14.1 UN number:
Transport
14.2 UN proper shipping name:
14.3 Transport hazard class(es):
Class
Classification code
14.4 Packing group:
Packing group
Labels
14.5 Environmental hazards:
Environmentally hazardous substance mark
14.6 Special precautions for user:
Special provisions
Limited quantities
Not subject
no
Sea (IMDG)
14.1 UN number:
Transport
Not subject
14.2 UN proper shipping name:
14.3 Transport hazard class(es):
Class
14.4 Packing group:
Packing group
Labels
14.5 Environmental hazards:
Marine pollutant
Environmentally hazardous substance mark
no
14.6 Special precautions for user:
Special provisions
Limited quantities
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code:
Annex II of MARPOL 73/78
Air (ICAO-TI/IATA-DGR)
14.1 UN number:
Transport
14.2 UN proper shipping name:
14.3 Transport hazard class(es):
Class
14.4 Packing group:
Packing group
Labels
14.5 Environmental hazards:
Environmentally hazardous substance mark
14.6 Special precautions for user:
Special provisions
Not subject
no
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
11 / 13
cadmium, metal, in massive state
Passenger and cargo transport: limited quantities: maximum net quantity
per packaging
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture:
European legislation:
REACH Annex XVII - Restriction
Subject to restrictions of Annex XVII of Regulation (EC) No. 1907/2006: restrictions on the manufacture, placing on the market and use of certain
dangerous substances, mixtures and articles.
· cadmium (non-pyrophoric)
Designation of the substance, of the group of
substances or of the mixture
Conditions of restriction
Cadmium
For the purpose of this entry, the codes and chapters indicated in square brackets are the
codes and chapters of the tariff and statistical nomenclature of Common Customs Tariff as
established by Council Regulation (EEC) No 2658/87 (OJ L 256, 7.9.1987, p. 42).1. Shall not be
used in mixtures and articles produced from synthetic organic polymers (hereafter referred
to as plastic material) such as: — polymers or copolymers of vinyl chloride (PVC) [3904 10]
[3904 21] — polyurethane (PUR) [3909 50] — low-density polyethylene (LDPE), with the
exception of low-density polyethylene used for the production of coloured masterbatch
[3901 10] — cellulose acetate (CA) [3912 11] — cellulose acetate butyrate (CAB) [3912 11] —
epoxy resins [3907 30] — melamine-formaldehyde (MF) resins [3909 20] — ureaformaldehyde (UF) resins [3909 10] — unsaturated polyesters (UP) [3907 91] — polyethylene
terephthalate (PET) [3907 60] — polybutylene terephthalate (PBT) — transparent/generalpurpose polystyrene [3903 11] — acrylonitrile methylmethacrylate (AMMA) — cross-linked
polyethylene (VPE) — high-impact polystyrene — polypropylene (PP) [3902 10] — highdensity polyethylene (HDPE) [3901 20] — acrylonitrile butadiene styrene (ABS) [3903 30] —
poly(methyl methacrylate) (PMMA) [3906 10].
Mixtures and articles produced from plastic material shall not be placed on the market if the
concentration of cadmium (expressed as Cd metal) is equal to or greater than 0,01 % by
weight of the plastic material.
By way of derogation, the second subparagraph shall not apply to articles placed on the
market before 10 December 2011.
The first and second subparagraphs apply without prejudice to Council Directive 94/62/EC
(OJ L 365, 31.12.1994, p. 10) and acts adopted on its basis.By 19 November 2012, in
accordance with Article 69, the Commission shall ask the European Chemicals Agency to
prepare a dossier conforming to the requirements of Annex XV in order to assess whether
the use of cadmium and its compounds in plastic material, other than that listed in
subparagraph 1, should be restricted.2. Shall not be used in paints [3208] [3209]. For paints
with a zinc content exceeding 10 % by weight of the paint, the concentration of cadmium
(expressed as Cd metal) shall not be equal to or greater than 0,1 % by weight. Painted
articles shall not be placed on the market if the concentration of cadmium (expressed as Cd
metal) is equal to or greater than 0,1 % by weight of the paint on the painted article.3. By
way of derogation, paragraphs 1 and 2 shall not apply to articles coloured with mixtures
containing cadmium for safety reasons.4. By way of derogation, paragraph 1, second
subparagraph shall not apply to: — mixtures produced from PVC waste, hereinafter referred
to as “recovered PVC”, — mixtures and articles containing recovered PVC if their
concentration of cadmium (expressed as Cd metal) does not exceed 0,1 % by weight of the
plastic material in the following rigid PVC applications: (a) profiles and rigid sheets for
building applications; (b) doors, windows, shutters, walls, blinds, fences, and roof gutters; (c)
decks and terraces; (d) cable ducts; (e) pipes for non-drinking water if the recovered PVC is
used in the middle layer of a multilayer pipe and is entirely covered with a layer of newly
produced PVC in compliance with paragraph 1 above. Suppliers shall ensure, before the
placing on the market of mixtures and articles containing recovered PVC for the first time,
that these are visibly, legibly and indelibly marked as follows: “Contains recovered PVC” or
with the following pictogram:Pictogram PVCIn accordance with Article 69 of this Regulation,
the derogation granted in paragraph 4 will be reviewed, in particular with a view to reducing
the limit value for cadmium and to reassess the derogation for the applications listed in
points (a) to (e), by 31 December 2017.5. For the purpose of this entry, “cadmium plating”
means any deposit or coating of metallic cadmium on a metallic surface. Shall not be used for
cadmium plating metallic articles or components of the articles used in the following
sectors/applications: (a) equipment and machinery for: — food production [8210] [8417 20]
[8419 81] [8421 11] [8421 22] [8422] [8435] [8437] [8438] [8476 11] — agriculture [8419 31]
[8424 81] [8432] [8433] [8434] [8436] — cooling and freezing [8418] — printing and bookbinding [8440] [8442] [8443] (b) equipment and machinery for the production of: —
household goods [7321] [8421 12] [8450] [8509] [8516] — furniture [8465] [8466] [9401]
[9402] [9403] [9404] — sanitary ware [7324] — central heating and air conditioning plant
[7322] [8403] [8404] [8415] In any case, whatever their use or intended final purpose, the
placing on the market of cadmium-plated articles or components of such articles used in the
sectors/applications listed in points (a) and (b) above and of articles manufactured in the
sectors listed in point (b) above is prohibited.6. The provisions referred to in paragraph 5
shall also be applicable to cadmium-plated articles or components of such articles when used
in the sectors/applications listed in points (a) and (b) below and to articles manufactured in
the sectors listed in (b) below: (a) equipment and machinery for the production of: — paper
and board [8419 32] [8439] [8441] textiles and clothing [8444] [8445] [8447] [8448] [8449]
[8451] [8452] (b) equipment and machinery for the production of: — industrial handling
equipment and machinery [8425] [8426] [8427] [8428] [8429] [8430] [8431] — road and
agricultural vehicles [chapter 87] — rolling stock [chapter 86] — vessels [chapter 89]7.
However, the restrictions in paragraphs 5 and 6 shall not apply to: — articles and
components of the articles used in the aeronautical, aerospace, mining, offshore and nuclear
sectors whose applications require high safety standards and in safety devices in road and
agricultural vehicles, rolling stock and vessels, — electrical contacts in any sector
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
12 / 13
cadmium, metal, in massive state
of use, where that is necessary to ensure the reliability required of the apparatus on which
they are installed.‘8. Shall not be used in brazing fillers in concentration equal to or greater
than 0,01 % by weight. Brazing fillers shall not be placed on the market if the concentration
of cadmium (expressed as Cd metal) is equal to or greater than 0,01 % by weight. For the
purpose of this paragraph brazing shall mean a joining technique using alloys and undertaken
at temperatures above 450 °C.9. By way of derogation, paragraph 8 shall not apply to brazing
fillers used in defence and aerospace applications and to brazing fillers used for safety
reasons.10. Shall not be used or placed on the market if the concentration is equal to or
greater than 0,01 % by weight of the metal in: (i) metal beads and other metal components
for jewellery making; (ii) metal parts of jewellery and imitation jewellery articles and hair
accessories, including: — bracelets, necklaces and rings, — piercing jewellery, — wristwatches and wrist-wear, — brooches and cufflinks.11. By way of derogation, paragraph 10
shall not apply to articles placed on the market before 10 December 2011 and jewellery
more than 50 years old on 10 December 2011
Volatile organic compounds (VOC)
Not applicable
15.2 Chemical safety assessment:
A chemical safety assessment has been performed.
SECTION 16: Other information
Labelling according to Directive 67/548/EEC-1999/45/EC (DSD/DPD)
This metal, although classified dangerous, does not require a label because of the form in which it is placed on the market (directive 2001/59/EC, annex 6
chapter 8.3)
Full text of any R-phrases referred to under headings 2 and 3:
R25 Toxic if swallowed
R26 Very toxic by inhalation
R45 May cause cancer
R48/23/25 Toxic: danger of serious damage to health by prolonged exposure through inhalation and if swallowed
R50 Very toxic to aquatic organisms
R53 May cause long-term adverse effects in the aquatic environment
R62 Possible risk of impaired fertility
R63 Possible risk of harm to the unborn child
R68 Possible risk of irreversible effects
Full text of any H-statements referred to under headings 2 and 3:
H330 Fatal if inhaled.
H341 Suspected of causing genetic defects.
H350 May cause cancer.
H361fd Suspected of damaging fertility. Suspected of damaging the unborn child.
H372 Causes damage to organs through prolonged or repeated exposure if inhaled.
H372 Causes damage to organs through prolonged or repeated exposure if swallowed.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
(*) = INTERNAL CLASSIFICATION BY BIG
PBT-substances = persistent, bioaccumulative and toxic substances
DSD
Dangerous Substance Directive
DPD
Dangerous Preparation Directive
CLP (EU-GHS) Classification, labelling and packaging (Globally Harmonised System in Europe)
The informa on in this safety data sheet is based on data and samples provided to BIG. The sheet was wri en to the best of our ability and
according to the state of knowledge at that me. The safety data sheet only cons tutes a guideline for the safe handling, use, consump on,
storage, transport and disposal of the substances/prepara ons/mixtures men oned under point 1. New safety data sheets are wri en from
me to me. Only the most recent versions may be used. Old versions must be destroyed. Unless indicated otherwise word for word on the
safety data sheet, the informa on does not apply to substances/prepara ons/mixtures in purer form, mixed with other substances or in
processes. The safety data sheet offers no quality specifica on for the substances/prepara ons/mixtures in ques on. Compliance with the
instruc ons in this safety data sheet does not release the user from the obliga on to take all m easures dictated by com m on sense,
regula ons and recommenda ons or which are necessary and/or useful based on the real applicable circum stances. BIG does not guarantee
the accuracy or exhaus veness of the informa on provided and cannot be held liable for any changes by third par es. This safety data sheet
is only to be used within the European Union, Switzerland, Iceland, Norway and Liechtenstein. Any use outside of this area is at your own
risk. Use of this safety data sheet is subject to the licence and liability lim i ng condi ons as stated in your BIG licence agreem ent or when
this is failing the general condi ons of BIG. All intellectual property rights to this sheet are the property of BIG and its distribu on and
reproduc on are limited. Consult the men oned agreement/condi ons for details.
Reason for revision: 15.1
Publication date: 2011-12-27
Date of revision: 2013-04-19
Revision number: 0101
Product number: 51612
13 / 13