44.3.4
Page 1/8
Safety Data Sheet
acc. to OSHA HCS
Printing date 04/20/2017
Reviewed on 04/20/2017
1 Identification
· Product identifier
· Trade name: Caffeine Anhydrous
· Article number: 150114
· CAS Number:
58-08-2
· EC number:
200-362-1
· Molecular Formula C8 H10 N4 O2
· Molecular Weight 194.19
· Application of the substance / the mixture For Research Use Only
· Details of the supplier of the safety data sheet
· Manufacturer/Supplier:
MP Biomedicals, LLC
29525 Fountain Parkway
Solon, OH 44139
United States
www.mpbio.com
· Information department: Quality Control Department
· Emergency telephone number: CHEMTREC: 1-800-424-9300 (1-703-527-3887)
2 Hazard(s) identification
· Classification of the substance or mixture
GHS07
Acute Tox. 4 H302 Harmful if swallowed.
· Label elements
· GHS label elements The substance is classified and labeled according to the Globally Harmonized System (GHS).
· Hazard pictograms
GHS07
· Signal word Warning
· Hazard-determining components of labeling:
Caffeine Anhydrous
· Hazard statements
Harmful if swallowed.
· Precautionary statements
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
Rinse mouth.
Dispose of contents/container in accordance with local/regional/national/international regulations.
(Contd. on page 2)
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Safety Data Sheet
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Printing date 04/20/2017
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Trade name: Caffeine Anhydrous
(Contd. of page 1)
· Classification system:
· NFPA ratings (scale 0 - 4)
Health = 2
Fire = 1
Reactivity = 0
1
2
0
· HMIS-ratings (scale 0 - 4)
HEALTH
2
FIRE
1
REACTIVITY 0
Health = 2
Fire = 1
Reactivity = 0
· Other hazards
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.
3 Composition/information on ingredients
· Chemical characterization: Substances
· CAS No. Description
58-08-2 Caffeine Anhydrous
· Identification number(s)
· EC number: 200-362-1
4 First-aid measures
· Description of first aid measures
· After inhalation: Supply fresh air; consult doctor in case of complaints.
· After skin contact: Generally the product does not irritate the skin.
· After eye contact: Flush eyes with running water as a precaution.
· After swallowing:
Never give anything by mouth to an unconscious person. Rinse mouth with water. If symptoms persist consult a
Doctor.
· Information for doctor:
· Most important symptoms and effects, both acute and delayed No further relevant information available.
· Indication of any immediate medical attention and special treatment needed
No further relevant information available.
5 Fire-fighting measures
· Extinguishing media
· Suitable extinguishing agents: Use fire fighting measures that suit the environment.
· Special hazards arising from the substance or mixture No further relevant information available.
· Advice for firefighters
· Protective equipment: No special measures required.
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(Contd. on page 3)
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Safety Data Sheet
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Trade name: Caffeine Anhydrous
(Contd. of page 2)
6 Accidental release measures
· Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
· Environmental precautions: Do not allow to enter sewers/ surface or ground water.
· Methods and material for containment and cleaning up:
Pick up mechanically, dispose contaminated material as waste according to Section 13.
· Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
· Protective Action Criteria for Chemicals
· PAC-1:
Substance is not listed.
· PAC-2:
Substance is not listed.
· PAC-3:
Substance is not listed.
7 Handling and storage
· Handling:
· Precautions for safe handling
Avoid direct contect with skin. Use protective clothing including gloves, lab coat, face/eye protection.
· Information about protection against explosions and fires: No special requirements.
· Conditions for safe storage, including any incompatibilities
· Storage: 15-30 °C
· Requirements to be met by storerooms and receptacles: No special requirements.
· Further information about storage conditions:
· Specific end use(s) No further relevant information available.
8 Exposure controls/personal protection
· Additional information about design of technical systems: No further data; see Section 7.
· Control parameters
· Components with limit values that require monitoring at the workplace: Not required.
· Additional information: The lists that were valid during the creation were used as basis.
· Exposure controls
· Personal protective equipment:
· General protective and hygienic measures:
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
· Breathing equipment: Not required.
· Protection of hands:
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the
chemical mixture.
(Contd. on page 4)
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Trade name: Caffeine Anhydrous
(Contd. of page 3)
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
· Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and
varies from manufacturer to manufacturer.
· Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be
observed.
· Eye protection: Not required.
9 Physical and chemical properties
· Information on basic physical and chemical properties
· General Information
· Appearance:
Powder
Form:
White
Color:
Indeterminate
· Odor:
Not determined.
· Odor threshold:
· pH-value:
Not applicable.
· Change in condition
Boiling point/Boiling range:
Undetermined.
· Flash point:
Not applicable.
· Flammability (solid, gaseous):
Product is not flammable.
· Ignition temperature:
Decomposition temperature:
Not determined.
· Auto igniting:
Not determined.
· Danger of explosion:
See section 10
· Explosion limits:
Lower:
Upper:
Not Applicable
Not Applicable
· Vapor pressure:
Not applicable.
· Density:
· Relative density
· Vapor density
· Evaporation rate
Not Applicable
Not determined.
Not applicable.
Not applicable.
· Solubility in / Miscibility with
· Water at 16 °C (61 °F):
Not Determined
18.7 g/l
· Partition coefficient (n-octanol/water): Not determined.
· Viscosity:
Dynamic:
Kinematic:
Not applicable.
Not applicable.
· Solvent content:
Organic solvents:
VOC content:
0.0 %
0.0 g/l / 0.00 lb/gl
(Contd. on page 5)
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Safety Data Sheet
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Trade name: Caffeine Anhydrous
(Contd. of page 4)
· Other information
No further relevant information available.
10 Stability and reactivity
· Reactivity No further relevant information available.
· Chemical stability
· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
· Possibility of hazardous reactions No dangerous reactions known.
· Conditions to avoid No further relevant information available.
· Incompatible materials: No further relevant information available.
· Hazardous decomposition products: No dangerous decomposition products known.
11 Toxicological information
· Information on toxicological effects
· Acute toxicity:
· LD/LC50 values that are relevant for classification:
58-08-2 Caffeine Anhydrous
Oral
LD50
367.7 mg/kg (rat)
Dermal
LD50
2000 mg/kg (rat)
Inhalative LC50/4 h 4.94 mg/L (rat)
· Primary irritant effect:
· on the skin: No irritant effect.
· on the eye: Irritant and potentially harmful
· Sensitization: No sensitizing effects known.
· Additional toxicological information:
· Carcinogenic categories
· IARC (International Agency for Research on Cancer)
3
· NTP (National Toxicology Program)
Substance is not listed.
· OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
12 Ecological information
· Toxicity
· Aquatic toxicity: No further relevant information available.
· Persistence and degradability No further relevant information available.
· Behavior in environmental systems:
· Bioaccumulative potential No further relevant information available.
· Mobility in soil No further relevant information available.
· Additional ecological information:
· General notes:
Water hazard class 2 (Self-assessment): hazardous for water
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
(Contd. on page 6)
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Safety Data Sheet
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Trade name: Caffeine Anhydrous
(Contd. of page 5)
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.
· Other adverse effects No further relevant information available.
13 Disposal considerations
· Waste treatment methods
· Recommendation:
Can not be disposed together with household garbage. Do not allow product to reach sewage system.
· Uncleaned packagings:
· Recommendation: Discard must be made according to official regulations.
· Recommended cleansing agent: Water, if necessary with cleaning agents.
14 Transport information
· UN-Number
· DOT, ADR, IMDG, IATA
UN1544
· UN proper shipping name
· DOT
· ADR
· IMDG, IATA
Alkaloids, solid, n.o.s. (Caffeine Anhydrous)
1544 Alkaloids, solid, n.o.s. (Caffeine Anhydrous)
ALKALOIDS, SOLID, N.O.S. (Caffeine Anhydrous)
· Transport hazard class(es)
· DOT
· Class
· Label
6.1 Toxic substances
6.1
· ADR, IMDG, IATA
· Class
· Label
6.1 Toxic substances
6.1
· Packing group
· DOT, ADR, IMDG, IATA
III
· Environmental hazards:
Not applicable.
· Special precautions for user
· EMS Number:
· Stowage Category
Warning: Toxic substances
F-A,S-A
A
· Transport in bulk according to Annex II of
Not applicable.
MARPOL73/78 and the IBC Code
(Contd. on page 7)
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Safety Data Sheet
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Trade name: Caffeine Anhydrous
(Contd. of page 6)
· Transport/Additional information:
· DOT
· Quantity limitations
· ADR
· Excepted quantities (EQ)
· IMDG
· Limited quantities (LQ)
· Excepted quantities (EQ)
· UN "Model Regulation":
On passenger aircraft/rail: 100 kg
On cargo aircraft only: 200 kg
Code: E1
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 1000 g
5 kg
Code: E1
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 1000 g
UN 1544 ALKALOIDS, SOLID, N.O.S. (CAFFEINE ANHYDROUS),
6.1, III
15 Regulatory information
· Safety, health and environmental regulations/legislation specific for the substance or mixture
· Sara
· Section 355 (extremely hazardous substances):
Substance is not listed.
· Section 313 (Specific toxic chemical listings):
Substance is not listed.
· TSCA (Toxic Substances Control Act):
Substance is listed.
· Proposition 65
· Chemicals known to cause cancer:
Substance is not listed.
· Chemicals known to cause reproductive toxicity for females:
Substance is not listed.
· Chemicals known to cause reproductive toxicity for males:
Substance is not listed.
· Chemicals known to cause developmental toxicity:
Substance is not listed.
· Carcinogenic categories
· EPA (Environmental Protection Agency)
Substance is not listed.
· TLV (Threshold Limit Value established by ACGIH)
Substance is not listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
· GHS label elements The substance is classified and labeled according to the Globally Harmonized System (GHS).
(Contd. on page 8)
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Safety Data Sheet
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Printing date 04/20/2017
Reviewed on 04/20/2017
Trade name: Caffeine Anhydrous
(Contd. of page 7)
· Hazard pictograms
GHS07
· Signal word Warning
· Hazard-determining components of labeling:
Caffeine Anhydrous
· Hazard statements
Harmful if swallowed.
· Precautionary statements
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
Rinse mouth.
Dispose of contents/container in accordance with local/regional/national/international regulations.
· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for any
specific product features and shall not establish a legally valid contractual relationship.
· Department issuing SDS: Quality Control Dept.
· Date of preparation / last revision 04/20/2017 / · Abbreviations and acronyms:
ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International
Carriage of Dangerous Goods by Road)
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
ACGIH: American Conference of Governmental Industrial Hygienists
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic
vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Tox. 4: Acute toxicity – Category 4
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