International Journal of Gynecology and Obstetrics (2006) 94, 149 — 155 www.elsevier.com/locate/ijgo SPECIAL ARTICLE Misoprostol and active management of the third stage of labor N. Prata a,*, S. Hamza b,1, R. Gypson b,1, K. Nada b,1, F. Vahidnia a, M. Potts a a Bixby Program in Population, Family Planning and Maternal Health, School of Public Health, University of California, Berkeley, USA b John Snow Inc, Healthy Mother/Healthy Child, Maadi, Cairo, Egypt Received 22 December 2005; received in revised form 5 May 2006; accepted 25 May 2006 KEYWORDS Postpartum hemorrhage; Misoprostol; Active management of the third stage of labor Abstract Objective: To compare current practices for the active management of the third stage of labor (AMTSL) with the use of 600 Ag of oral misoprostol. Methods: An operations research study was designed to compare blood loss with current AMTSL practices and misoprostol use. Results: Women in the misoprostol group were less likely to bleed 500 ml or more (adjusted odds ratio, 0.30; 95% confidence interval, 0.16—0.56) compared with those in the current practices group. In the current practices group 73% women required interventions because of postpartum hemorrhage, compared with 11% in the misoprostol group. Conclusion: In situations where oxytocin and or ergometrine are not consistently and appropriately used during third stage of labor, misoprostol should be considered for inclusion in the AMTSL protocol. D 2006 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. 1. Introduction * Corresponding author. 314 Warren Hall, Berkeley, CA 947207360, USA. Tel.: +1 510 643 4284; fax: +1 510 643 8236. E-mail address: [email protected] (N. Prata). 1 At the time of the study the authors were working for The Healthy Mother Healthy Child Project; implemented by John Snow Inc. in Egypt under United States Agency for International Development (USAID) Contract No. 263-C-00-98-0041-00. In Egypt, although the maternal mortality ratio decreased from 174 to 84 per 100,000 live births between 1992—1993 and 2000, for a 52% reduction, the distribution of causes of death has not changed [1]. According to the National Maternal Mortality Study conducted in Egypt in 2000, postpartum hemorrhage (PPH) alone was responsible for 27% 0020-7292/$ - see front matter D 2006 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.ijgo.2006.05.027 150 of all maternal deaths, making it the leading contributor to maternal mortality in that country. Routine active management of the third stage of labor (AMTSL) has been recommended for vaginal deliveries in hospital settings [2,3]. It involves prophylactic administration of uterotonic agents before delivery of the placenta, early cord clamping and cutting, and controlled umbilical cord traction. Recommended uterotonics are oxytocin (10 IU administered intramuscularly or intravenously or an infusion of 20 IU intravenously) or ergometrine (0.2 mg intramuscularly or intravenously) [4]. In contrast, in expectant management of the third stage of labor, placental delivery is spontaneous or aided by gravity or nipple stimulation—without the use of uterotonics. In Egypt, the most recent essential obstetric care protocol for physicians, published by the Ministry of Health and Population, describes both active and expectant management of the third stage of labor [5]. For active management, the recommended uterotonic drug is oxytocin (5 IU) administered intramuscularly at the time of the delivery of the anterior shoulder. The protocol suggests that oral tablets of ergometrine have little effect on postpartum blood loss. Controlled cord traction, i.e., traction on the cord combined with upward counterpressure applied to the lower segment of the uterus, is recommended by the protocol to reduce blood loss and shorten the third stage of labor. However, the protocol does not encourage cord clamping immediately after delivery because of the perceived small effect on the incidence of PPH, and it may deprive the newborn of needed hemoglobin. Misoprostol, an E1 prostaglandin analogue, is a potent uterotonic agent whose usefulness is increasingly recognized in obstetric and gynecologic practice, including in the control of PPH [6—8]. Misoprostol can be administered orally, rectally, vaginally, or sublingually without syringes or intravenous equipment, and it is inexpensive, easy to store and stable at room temperature [9]. Studies comparing the results of prophylactic use of misoprostol for the reduction of blood loss with conventional uterotonics have concluded that misoprostol had a positive effect [10—21]. Although some studies have found that conventional uterotonics were superior to misoprostol, none has rejected using misoprostol when injectable uterotonics are not available or cannot be properly used [22,23]. Moreover, the 2003 conference on underused technology to reduce maternal mortality organized by Parkway Academy of Technology and Health in Bellagio, Italy, called for a greater interest in the role of misoprostol in AMTSL [24]. N. Prata et al. A careful analysis of the management of the third stage of labor in an Egyptian teaching hospital showed that only 15% of the women received adequate AMTSL during the study period [25]. Staff shortages were given as the main explanation for the generally inappropriate management of deliveries, and that study’s findings are not unique. It is in these widespread circumstances that, given its ease of administration, misoprostol may have an advantage over conventional, intramuscularly or intravenously delivered uterotonics. An operations research study was conducted at three Egyptian hospitals to compare current AMTSL practices with the use of 600 Ag of oral misoprostol as the uterotonic agent. 2. Methods Menya University Hospital, Assiut University Hospital and Benha University Hospital were involved in the study over a period of 6 months. Together, these 3 hospitals employ 73 obstetricians, perform on average 700 deliveries per month, and have a maternal mortality ratio of 363 per 100,000 live births. According to hospital records, about 38% of maternal deaths are due to PPH and the incidence of PPH is about 5%. At each study site, the research period was divided into two phases, a pre-intervention phase that occupied the first 3 months and an intervention phase that lasted through the last 3 months of the study. During the pre-intervention phase, trained staff at the participating hospitals obtained informed consent from women admitted for delivery (inclusion criteria were anticipated vaginal delivery, gestational age N 36 weeks and ability to give informed consent) and collected blood for antepartum estimation of hemoglobin concentration. Women were excluded if they had bronchial asthma, other chronic disease (e.g., heart disease and/or diabetes), or any condition that could put them at higher risk for poor delivery outcomes if they participated in the study. After delivery and clamping of the umbilical cord, a calibrated drape was placed under the women’s buttocks for blood loss measurement. The calibrated drape remained in place for approximately 4 h following delivery, and blood loss was read cumulatively every 20 min. Antepartum, delivery and postpartum care were given to all women according to standard practices at the university hospitals. Postpartum hemoglobin concentration was assessed in women who needed to be hospitalized for more than 24 h because of PPH. Misoprostol and active management of the third stage of labor During the pre-intervention phase, apart from the use of the drape for blood loss collection, physicians continued to use the current AMTSL practices. In the intervention phase, all AMTSL procedures were still encouraged but the only uterotonic agent used prophylactically was misoprostol (600 Ag orally). The same data collection instrument was used at the three sites, and the data recording was done in stages (upon admission, soon after delivery, every 20 min after delivery for up to 4 h, and before discharge) by a physician trained as a clinical research officer. Data collected from each participant included sociodemographic characteristics, medical and obstetric history, assessment of blood loss every 20 min for the first 4 h after delivery, adverse effects of the intervention, any medication or other intervention received by the participant between admission and discharge, and condition of the newborn. The Egyptian ethics committee approved the study protocol, and the Healthy Mother Healthy Child Project, implemented in Egypt by John Snow Inc. under United States Agency for International Development (USAID) Contract No. 263-C-00-98-0041-00, was responsible for study implementation. The misoprostol used (Misotac; Sigma Co., Moubarak Industrial City, First Quarter Quesna, Egypt) was donated by Ventures Strategies for Health and Development. The database was developed using the Epi Info software system, version 2002 (available from the Centers for Disease Control and World Health Organization), and statistical analysis was performed using the Stata Statistical Software, release 8.0 (College Station, Tex, USA). Descriptive statistics were reported and the main outcomes estimated and compared between the two study phases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the main study outcomes. Adjusted ORs were estimated using a logistic regression model and corresponding P values (two-sided maximum likelihood test). Mean blood loss at 20, 40, 60, 80, 100 and 120 min) and 95% CIs were estimated and compared between study phases. Participants who were enrolled but then had a cesarean section or an instrumentassisted delivery were excluded from the final comparison analysis. 3. Results A total of 2532 women were enrolled in the study, 53% of whom during the pre-intervention phase. The participants’ sociodemographic as well as pregnancy and medical history characteristics are 151 Table 1 Selected sociodemographic characteristics and delivery history of women enrolled in the study Characteristic Pre-intervention Intervention Total 1343 (53%) 1189 (47%) (%) Mean age in 24.8 (5.2) 25.2 (5.2) years (S.D.) Parity (%) 0 36.1 34.6 1 29.7 26.0 2 18.3 19.9 3 8.5 8.5 4+ 7.4 11.0 Education (%) Illiterate 44.5 46.7 Literate 55.5 53.3 Ante partum Hgba (g/dl) (%) b11 25.0 18.9 z11 75.0 81.1 Antenatal care visits (%) None 38.1 37.5 One or more 61.9 62.5 Integrity of membranes (%) Intact 76.0 72.3 Ruptured 24.0 27.7 Time from admission to birth (h) (%) b1 23.0 29.6 1—2.9 29.2 27.4 3—4.9 27.7 25.8 5+ 20.1 17.1 25.0 (5.2) 35.4 27.9 19.1 8.5 9.2 45.5 54.5 22.4 77.6 37.8 62.2 74.3 25.1 26.1 28.3 26.8 18.7 a Hemoglobin measured to 1807 patients only, 57% during pre-intervention phase. shown in Table 1. A majority of women (69%) were aged between 20 and 29 years, with no significant difference between the study phases, and 46% were illiterate, with similar distributions in the preintervention (45%) and intervention (47%) phases. Furthermore, the participants’ parity was similar in the two study phases. The pregnancy and medical histories taken upon admission showed the similarity of the study populations in the two phases. Most women had at least one antenatal visit. Hemoglobin levels were assessed for only 1807 women, 57% of whom from the pre-intervention phase. Less than 1% of women in either study phase had experienced previous PPH and retained placenta (data not shown). The pre-intervention phase consisted in collecting information from current practices in the management of the third stage of labor. During this phase, 7% of the participants received no uterotonic agent, and the remaining 93% received either oxytocin or ergometrine (Table 2). Of those receiving oxytocin (n = 609), about 35% received 5 IU and the remaining received 10 IU or more. Of those receiving ergometrine (n = 621), about half re- 152 N. Prata et al. Table 2 History of third stage of labor among women with vaginal deliveries Pre-intervention Early cord clamping Cord traction Uterine stage Use of uteronics None Oxytocin or ergometrine Misoprostol Intervention 1326 (53%) 1180 (47%) 96.9 98.4 97.2 99.2 99.4 99.1 7.2 92.8 n/a n/a n/a 100.0 ceived 0.4 mg and the remaining received 0.2 mg. The route of administration for ergometrine was intramuscular; for oxytocin, it was intramuscular for those receiving 5 IU and intravenous for those receiving 10 IU or more. During the intervention phase, all participants received 600 Ag of misoprostol orally. Unlike the administration of uterotonics, which was not universal, uterine massage, cord traction and early cord clamping were performed in almost all cases regardless of the study phase. The cumulative mean blood loss during each study phase and respective 95% CIs around the mean are presented in Fig. 1. On average, women enrolled during the intervention phase and receiving misoprostol as part of AMTSL lost less blood than those enrolled during the pre-intervention phase. Fig. 1 also shows that, for each time point after delivery, the mean blood loss was significantly lower in the intervention (misoprostol) than in the pre-intervention (current AMTSL practices) phase. Statistically significant differences were observed between the pre-intervention and the intervention groups regarding the amount of blood loss at the two most important cut-off points for Figure 1 vaginal bleeding after delivery (Table 3). Results show that, when the blood loss was 500 ml or greater, women in the misoprostol group were less likely to incur PPH (adjusted OR, 0.30; 95% CI, 0.16—0.56). The difference between the two groups was even more pronounced for severe PPH (adjusted OR, 0.12; 95% CI, 0.02—0.93). Additional uterotonic agents were given to 73% of the women who experienced PPH in the preintervention phase, compared with only 11% in the intervention group. Of the main potentially adverse effects measured 20 min after delivery, women in the intervention group were consistently more likely to develop high temperature (z 37 8C), shivering, nausea and vomiting (Table 3). The mean temperature of the participants was 37.1 8C in the pre-intervention group and 37.3 8C in the intervention group, and less than 1% of the participants needed to be treated for pyrexia. Although nausea and vomiting affected only a small number of participants, the number was significantly higher in the intervention group. A separate analysis that excluded the women who did not receive uterotonics in the pre-intervention phase was performed for the main study outcomes and a slightly but significantly lower adjusted OR was found (0.36 vs. 0.30). The same was found regarding the need for additional interventions. Without the women who did not receive uterotonics, the adjusted OR for a blood loss of 1000 ml or greater was insignificant. 4. Discussion This study was intended to provide information for the review and possible revision of the current Ministry of Health and Population policy in Egypt on the management of the third stage of labor. It can Cumulative mean blood loss and 95% confidence intervals according to study period (vaginal deliveries). Misoprostol and active management of the third stage of labor Table 3 153 Primary and secondary study outcomes among women with vaginal deliveries Blood loss Z 500 ml Blood loss Z 1000 ml Additional interventions Among those PPH Among study participants Main side effects Temp. N 37 8C Shivering Nausea Vomiting Crude OR (95% CI) Adjusted ORa (95% CI) (1.6%) (0.1%) 0.28* (0.17 to 0.47) 0.10** (0.01 to 0.79) 0.30* (0.16 to 0.56) 0.12** (0.02 to 0.93) 2/19 2/1178 (10.5%) (0.2%) 1.04** (0.01 to 0.27) 0.04** (0.01 to 0.17) 0.02** (0.00 to 0.19) 0.03** (0.00 to 0.19) 280/1178 253/1119 73/1119 39/1115 (23.0%) (22.6%) (6.5%) (3.5%) 2.80* 4.50* 2.90* 2.70** 1.63** 4.03* 3.74* 3.36* Pre-intervention (current practice) Intervention (misoprostol) n (%) n (%) 73/1324 11/1324 (5.5%) (0.8%) 19/1178 1/1178 53/73 53/1324 (72.6%) (4.0%) 169/1324 79/1297 30/1295 17/1295 (12.7%) (6.1%) (2.3%) (2.3%) (2.16 (3.45 (1.90 (1.50 to to to to 3.53) 5.89) 4.50) 4.80) (1.20.to 2.20) (2.93 to 5.55) (2.33 to 6.00) (1.81 to 6.22) *p b 0.05; **Fisher’s exact test. a Adjusted for parity, integrity of membranes, antenatal Hgb and time from admission to birth. Additional interventions among those with PPH are adjusted for parity, integrity of membranes and time from admission to birth. also help inform policy makers on the feasibility of using misoprostol in AMTSL, especially in resourcepoor settings where other uterotonics are unavailable or wherever AMTSL is not practiced. In recent years, an increasing body of literature has shown the importance of using uterotonics in AMTSL, and many international organizations, including FIGO, recommend that uterotonics be used in all deliveries to decrease PPH-associated morbidity and mortality. In Egypt, despite the success achieved in overall reduction of maternal mortality in the last decade, PPH continues to be the single most important cause of maternal mortality. The study sites chosen for this operations research study are university hospitals similar in availability of staff, client volume and maternal and neonatal outcomes, with similar experience conducting operations research study in the labor ward. The study was designed as a quasi experiment, where the study factor was assessed and compared between two groups without the use of randomization. These types of studies have limitations. They do not test for the efficacy of a therapeutic or prevention measure; they can introduce bias due to greater attention from the care provider during the intervention phase; and the lack of randomization can introduce distortions in the results. However, the efficacy of misoprostol has been well established in other studies, some of them reviewed in the present article, and the superiority of conventional uterotonics is not being questioned in this study. The major contribution of this type of design, as in the present study, is to evaluate the effectiveness of a planned intervention and suggest program and policy changes in response to this evaluation. Results from this study demonstrate that in a busy hospital misoprostol can offer the optimum care at delivery. These findings are in contrast to those reported by Gulmezoglu et al. [22]. Theirs was a randomized controlled experiment (oxytocin vs. misoprostol), whereas the present study simply standardized the btreatment effectQ with misoprostol while maintaining real-life labor ward conditions. The main goal of this operations research study was not to assess the efficacy of uterotonics, but to assess the effectiveness of implementing a standardized, easy to manage intervention during the third stage of labor. The similarity in the participants’ characteristics in the pre-intervention and intervention phases is reassuring, and the women enrolled in both study periods would have had a similar likelihood of experiencing PPH. This study’s findings about the quality of management of the third stage of labor, particularly during the pre-intervention phase, are in agreement with what was found by Cherine et al. [25]. Day-to-day practice in delivery rooms can be inconsistent, especially when uterotonics are used. Dosages are not standardized and in some cases uterotonics are not used. Regarding blood loss, the observed differences were unexpectedly great, which suggests that careful attention should be paid to the chemical stability of ergometrine and oxytocin. Available studies on delivery-related blood loss do not address this issue and the present study cannot address it. Moreover, the great variation in doses and routes of administration of uterotonics could have affected what constitutes AMTSL. The difference in the mean blood loss 20 min after delivery is also surprising, given that the intramuscular and intravenous routes are expected to cause contractions earlier than the oral route, and therefore to result in less blood loss. However, it is difficult to assess how different the present study population may be from other 154 study populations. To date, there are no available published results of blood loss in the first 20 min after prophylactic use of uterotonics. Studies tend to report total blood loss using cut-off points (i.e., 500, 750 and 1000 ml). There exists a possibility of bias among health care providers, who might have paid greater attention in the intervention phase, but it cannot be the only reason for the differences between the two groups. Other components of active management (uterine massage, cord traction and early clamping) were almost universally administered and not significantly different between the two study phases. Furthermore, the analysis of the study population without the women who did not receive uterotonics showed significant differences between the two groups, and these differences were in favor of the intervention. There was no significant difference when severe blood loss (z 1000 ml) only was considered, but this can be attributed to the fact that severe PPH occurred in less than 1% of the participants. It is clear from the results that 600 Ag of oral misoprostol can reduce total blood loss after delivery. The advantage of using misoprostol is its easy administration, and also the fact that only one drug regimen is used. The downside of this potent uterotonic is that women taking misoprostol are at higher risk for a higher temperature, shivering, nausea and vomiting. However, none of these effects are life-threatening; a very small proportion of women require treatment to alleviate them; and these effects can be easily managed by delivery room staff. In summary, the benefits from a substantial decrease in the number of women that will develop PPH and in need of additional uterotonics, outweigh the risks of side effects associated with misoprostol. In conclusion, misoprostol is a proven, potent uterotonic agent. In situations where oxytocin and or ergometrine are not consistently and appropriately used for active management of the third stage of labor for various reasons (i.e. drug shortage, shortage of staff to administer i.v./i.m., storage and or refrigeration problems, high caseload, etc.), misoprostol should be considered for inclusion in the protocol for AMTSL. N. Prata et al. [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] References [1] Campbell O, Gipson R, Issa AH, Matta N, El Deeb B, El Mohandes A, et al. National maternal mortality ratio in Egypt halved between 1992—93 and 2000. Bull World Health Organ 2005;83(6):462 – 71. [2] Rogers J, Wood J, McCandlish R, Ayers S, Truesdale A, Elbourne D. Active versus expectant management of third [19] stage of labour: the Hinchingbrooke randomised controlled trial. Lancet 1998;351(9104):693 – 9. Prendiville WJ, Elbourne D, McDonald S. Active versus expectant management in the third stage of labour. Cochrane Database Syst Rev 2000;3:CD000007. World Health Organization, Department of Reproductive Health and Research, Family and Community Health. Integrated Management of Pregnancy and Childbirth. Pregnancy, childbirth, postpartum and newborn care: a guide for essential practice. Geneva, Switzerland7 WHO; 2003. Ministry of Health and Population. Essential obstetric care: protocol for physicians. Cairo, Arab Republic of Egypt7 MOHP; 2001. Walder J. Misoprostol: preventing postpartum haemorrhage. Mod Midwife 1997;7(9):3 – 7. El-Refaey H, O’Brien P, Morafa W, Walder J, Rodeck C. Use of oral misoprostol in the prevention of postpartum haemorrhage. Br J Obstet Gynaecol 1997;104(3):336 – 339. Blanchard K, Clark S, Winikoff B, Gaines G, Kabani G, Shannon C. Misoprostol for women’s health: a review. Obstet Gynecol 2002;99(2):316 – 332. Hofmeyr GJ, Walraven G, Gulmezoglu AM, Maholwana B, Alfirevic Z, Villar J. Misoprostol to treat postpartum haemorrhage: a systematic review. Br J Obstet Gynaecol 2005;112(5):547 – 553. Gerstenfeld TS, Wing DA. Rectal misoprostol versus intravenous oxytocin for the prevention of postpartum hemorrhage after vaginal delivery. Am J Obstet Gynecol 2001;185(4):878 – 882. Kundodyiwa TW, Majoko F, Rusakaniko S. Misoprostol versus oxytocin in the third stage of labor. Int J Gynecol Obstet 2001;75(3):235 – 241. Bugalho A, Daniel A, Faundes A, Cunha M. Misoprostol for prevention of postpartum hemorrhage. Int J Gynecol Obstet 2001;73(1):1 – 6. Surbek DV, Fehr PM, Hosli I, Holzgreve W. Oral misoprostol for third stage of labor: a randomized placebo-controlled trial. Obstet Gynecol 1999;94(2):255 – 258. Hofmeyr GJ, Nikodem VC, de Jager M, Gelbart BR. A randomised placebo controlled trial of oral misoprostol in the third stage of labour. Br J Obstet Gynaecol 1998;105(9):971 – 975. Oboro VO, Tabowei TO. A randomised controlled trial of misoprostol versus oxytocin in the active management of the third stage of labour. J Obstet Gynaecol 2003;23(1): 13 – 6. Walraven G, Dampha Y, Bittaye B, Sowe M, Hofmeyr J. Misoprostol in the treatment of postpartum haemorrhage in addition to routine management: a placebo randomised controlled trial. Br J Obstet Gynaecol 2004;111(9): 1014 – 7. Vimala N, Mittal S, Kumar S, Dadhwal V, Mehta S. Sublingual misoprostol versus methylergometrine for active management of the third stage of labor. Int J Gynaecol Obstet 2004;87(1):1 – 5. El-Refaey H, Nooh R, O’Brien P, Abdalla M, Geary M, Walder J, et al. The misoprostol third stage of labour study: a randomised controlled comparison between orally administered misoprostol and standard management. Br J Obstet Gynaecol 2000;107(9):1104 – 10. Walley RL, Wilson JB, Crane JM, Matthews K, Sawyer E, Hutchens D. A double-blind placebo controlled randomised trial of misoprostol and oxytocin in the management of the third stage of labour. Br J Obstet Gynaecol 2000; 107(9):1111 – 5. Misoprostol and active management of the third stage of labor [20] Caliskan E, Dilbaz B, Meydanli MM, Ozturk N, Narin MA, Haberal A. Oral misoprostol for the third stage of labor: a randomized controlled trial. Obstet Gynecol 2003; 101(5):921 – 8. [21] Ng PS, Chan AS, Sin WK, Tang LC, Cheung KB, Yuen PM. A multicentre randomized controlled trial of oral misoprostol and i.m. syntometrine in the management of the third stage of labour. Hum Reprod 2001;16(1):31 – 5. [22] Gulmezoglu AM, Villar J, Ngoc NT, Piaggio G, Carroli G, Adetoro L, et al. WHO multicentre randomised trial of misoprostol in the management of the third stage of labour. Lancet 2001;358(9283):689 – 95. 155 [23] Villar J, Gulmezoglu AM, Hofmeyr GJ, Forna F. Systematic review of randomized controlled trials of misoprostol to prevent postpartum hemorrhage. Obstet Gynecol 2002; 100(6):1301 – 12. [24] Tsu VD, Shane B. New and underutilized technologies to reduce maternal mortality: call to action from a Bellagio workshop. Int J Gynaecol Obstet 2004;85(suppl 1): S83 – 93. [25] Cherine M, Khalil K, Hassanein N, Sholkamy H, Breebaart M, Elnoury A. Management of the third stage of labor in an Egyptian teaching hospital. Int J Gynaecol Obstet 2004;87(1):54 – 8.
© Copyright 2026 Paperzz