Additional file 14: TFBS modules occuring in at least three of the seven promoter regions of the human 8q24.3 ZNF genes
Gene
ZNF7
ZNF7
ZNF7
ZNF7
ZNF7
ZNF7
ZNF7
ZNF7
ZNF7
ZNF16
ZNF16
ZNF16
ZNF34
ZNF34
ZNF250
ZNF250
ZNF250
ZNF250
ZNF250
ZNF250
ZNF250
ZNF251
ZNF251
ZNF251
ZNF251
ZNF251
ZNF251
ZNF251
ZNF251
ZNF251
ZNF251
ZNF252
ZNF252
ZNF252
ZNF252
ZNF252
ZNF252
ZNF252
ZNF252
ZNF517
ZNF517
ZNF517
ZNF517
ZNF517
ZNF517
ZNF517
TFBS module
EGRF_SP1F_01
ETSF_SP1F_03
SP1F_AP2F_01
EGRF_SP1F_01
EGRF_SP1F_01
KLFS_SP1F_01
IKRS_AP2F_01
SP1F_ETSF_04
ETSF_SP1F_03
ETSF_SP1F_05
SP1F_ETSF_01
ETSF_ETSF_02
ETSF_ETSF_06
EGRF_SP1F_01
ETSF_SP1F_04
ETSF_SP1F_03
EGRF_SP1F_01
SP1F_AP2F_01
SP1F_ETSF_01
NFKB_SP1F_04
EGRF_SP1F_01
IKRS_AP2F_01
ETSF_ETSF_04
SP1F_ETSF_01
ETSF_ETSF_02
EGRF_SP1F_01
NFKB_SP1F_04
EGRF_SP1F_01
KLFS_SP1F_01
ETSF_ETSF_04
ETSF_SP1F_05
SP1F_ETSF_01
IKRS_AP2F_01
ETSF_ETSF_02
ETSF_SP1F_05
ETSF_SP1F_03
ETSF_SP1F_03
KLFS_SP1F_01
EGRF_SP1F_01
ETSF_SP1F_04
SP1F_ETSF_01
IKRS_AP2F_01
NFKB_SP1F_02
EGRF_SP1F_01
SP1F_AP2F_01
ETSF_SP1F_04
1st TFBS
V$EGRF/EGR1.02
V$ETSF/PEA3.01
V$SP1F/GC.01
V$EGRF/EGR1.02
V$EGRF/EGR1.02
V$KLFS/KLF6.01
V$IKRS/IK2.01
V$SP1F/GC.01
V$ETSF/ELK1.02
V$ETSF/ELK1.02
V$SP1F/SP1.01
V$ETSF/ELK1.02
V$ETSF/PEA3.01
V$EGRF/EGR1.02
V$ETSF/SPI1_PU1.02
V$ETSF/PDEF.01
V$EGRF/EGR1.02
V$SP1F/SP1.01
V$SP1F/SP1.03
V$NFKB/NFKAPPAB.01
V$EGRF/EGR1.02
V$IKRS/IK2.01
V$ETSF/ELK1.02
V$SP1F/SP1.03
V$ETSF/ELK1.02
V$EGRF/EGR1.02
V$NFKB/NFKAPPAB50.01
V$EGRF/EGR1.02
V$KLFS/KKLF.01
V$ETSF/ETS1.01
V$ETSF/ELF2.01
V$SP1F/SP1.03
V$IKRS/IK2.01
V$ETSF/SPI1_PU1.02
V$ETSF/SPI1_PU1.02
V$ETSF/GABPB1.01
V$ETSF/CETS1P54.01
V$KLFS/GKLF.03
V$EGRF/EGR1.02
V$ETSF/CETS1P54.01
V$SP1F/SP1.02
V$IKRS/IK2.01
V$NFKB/CREL.01
V$EGRF/EGR1.02
V$SP1F/SP1.01
V$ETSF/SPI1_PU1.02
Start
262
301
322
325
353
364
390
471
521
491
504
507
154
578
53
411
433
438
452
468
484
69
460
447
460
505
515
566
572
640
693
223
384
480
480
604
613
617
625
146
161
203
354
483
488
489
End
278
321
336
341
369
380
402
485
541
511
518
527
174
594
73
431
449
452
466
480
500
81
480
461
480
521
527
582
588
660
713
237
396
500
500
624
633
633
641
166
175
215
366
499
502
509
Strand
(-)
(-)
(-)
(-)
(-)
(-)
(-)
(+)
(+)
(+)
(+)
(-)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(-)
(+)
(-)
(+)
(+)
(-)
(-)
(-)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(+)
(-)
(-)
(-)
(+)
(+)
(+)
Sequence
CAGGGGCGGGGCGGGGC
GAGGGAGAGGAGGGCCCAGAG
AGGGGGCGGAGCCGC
CGGGCAGGGGGCGGAGC
GCGCCTGGGGGCGGGGT
AGGCGGGGCTGGCGCCT
GGGCGGGACCAGA
GGGAGGCGGGGCTGA
GGGCGGCCGGAAGTTTGCGGG
GGCGGGCCGGAATTCGGGGCG
TCGGGGCGGGACTTC
TGACCCCCGGAAGTCCCGCCC
GGCCCTAAGGAAGGGTGCGGT
CCCGGCGGGGGCGGGCG
CAGCAGCGGGAACCGCAAGGG
GCCCTCCAGGATTGGCGAACT
GGCTGTGGGGGCGGGAA
TGGGGGCGGGAACTG
GAGGGGCAGGAGCCC
CAGGGATTGGCGG
CGCAGACGGGGCGGGGC
AAAAGGGATTCAC
CGGGAACCGGAAGCCAGCCGC
TCCGGGCGGAACCGC
CGGGAACCGGAAGCCAGCCGC
CCCGCAGGGGGCGGGGA
GCGGGGAAGCCTG
CGGGGAGGGGGCGGGCT
CAGAGCCGGGGAGGGGG
GCCACCGAGGAAGCGCCGAGG
TCGGACCAGGAAGGAGCGCCA
GAAGGGCCGGGTCCA
AACCGGGAAGGAG
GGCAGGGCGGAAGTTCAGATT
GGCAGGGCGGAAGTTCAGATT
CCTGGTGCGGAGGTGCCGGAG
GAGGTGCCGGAGTGGCGCTGG
TGCCGGAGTGGCGCTGG
TGGCGCTGGGGCGGGCA
CCCTGGCCGGACGCCCCCGCT
GAAGGGCGGAGCGGG
GTTGGGGAGCACG
CTGGGGGGTTCCG
GTTTCCGGGGGCGGGGA
CGGGGGCGGGGAAGG
GGGGGCGGGGAAGGAACCGGA
Individual colors denote different module families
Start / End
Position within promoter region relative to first nucleotide of the sequence
strand orientation:
(+)
Sense strand with respect to transcript
(-)
Antisense strand with respect to transcript
Genomatix Matrix Family Library Version 8.1
Genomatix Module Library Version 5.2, Vertebrate Modules (June 2009)
Prediction by Genomatix ModelInspector 5.6.5
Core
Matrix
similarity similarity
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
0.907
0.836
0.965
0.924
0.903
0.932
0.919
0.930
0.980
0.961
0.976
0.977
0.930
0.969
0.912
0.888
0.987
0.973
0.897
0.810
0.909
0.928
0.987
0.901
0.987
0.919
0.809
0.966
0.950
0.963
0.941
0.885
0.947
0.991
0.991
0.812
0.817
0.892
0.879
0.924
0.938
0.906
0.942
0.886
0.997
0.956
2nd TFBS
V$SP1F/SP1.01
V$SP1F/SP1.03
V$AP2F/AP2.02
V$SP1F/GC.01
V$SP1F/SP1.01
V$SP1F/SP1.01
V$AP2F/AP2.02
V$ETSF/CETS1P54.01
V$SP1F/SP1.03
V$SP1F/GC.01
V$ETSF/ELK1.02
V$ETSF/ELK1.02
V$ETSF/SPI1_PU1.02
V$SP1F/SP1.01
V$SP1F/SP1.03
V$SP1F/SP1.01
V$SP1F/SP1.01
V$AP2F/AP2.02
V$ETSF/SPI1_PU1.02
V$SP1F/SP1.03
V$SP1F/SP1.01
V$AP2F/AP2.02
V$ETSF/SPI1_PU1.02
V$ETSF/ELK1.02
V$ETSF/SPI1_PU1.02
V$SP1F/SP1.01
V$SP1F/SP1.03
V$SP1F/SP1.01
V$SP1F/SP1.01
V$ETSF/ELF2.01
V$SP1F/SP1.03
V$ETSF/SPI1_PU1.02
V$AP2F/AP2.02
V$ETSF/ELK1.02
V$SP1F/SP1.03
V$SP1F/SP1.01
V$SP1F/SP1.03
V$SP1F/SP1.01
V$SP1F/SP1.01
V$SP1F/SP1.03
V$ETSF/ETS1.01
V$AP2F/AP2.02
V$SP1F/TIEG.01
V$SP1F/SP1.01
V$AP2F/AP2.02
V$SP1F/SP1.01
Start
259
281
297
322
350
350
410
451
542
487
491
491
165
583
145
438
438
460
438
494
489
44
511
432
446
510
540
563
563
693
682
214
360
498
476
630
634
630
630
230
164
225
352
488
507
580
End
273
295
311
336
364
364
424
471
556
501
511
511
185
597
159
452
452
474
458
508
503
58
531
452
466
524
554
577
577
713
696
234
374
518
490
644
648
644
644
244
184
239
366
502
521
594
Strand
Sequence
(-)
(-)
(-)
(-)
(-)
(-)
(-)
(-)
(+)
(+)
(+)
(+)
(-)
(+)
(+)
(+)
(+)
(+)
(+)
(-)
(+)
(+)
(+)
(+)
(+)
(+)
(-)
(-)
(-)
(+)
(+)
(+)
(+)
(-)
(+)
(+)
(+)
(+)
(+)
(+)
(-)
(-)
(-)
(+)
(+)
(+)
GCGGGGCGGGGCCGG
AGTGGGCGGTGCCTG
AGGGCCCAGAGCCCG
AGGGGGCGGAGCCGC
TGGGGGCGGGGTACA
TGGGGGCGGGGTACA
GGGGCCCGAGGGACA
CAGGCTCCGGAGAAGGGGTGG
GCGGGGCGGACGCGG
GAGCGGCGGGCCGGA
GGCGGGCCGGAATTCGGGGCG
GGCGGGCCGGAATTCGGGGCG
GAGAAACGGGAACCGCACCCT
CGGGGGCGGGCGCGC
GCGGGGCCGGCAGGG
TGGGGGCGGGAACTG
TGGGGGCGGGAACTG
GGAGCCCCCAGGGAT
TGGGGGCGGGAACTGAGGGGC
AAAGGGCTGCCCCGC
ACGGGGCGGGGCAGC
CTGGCCTCTGGGACT
GGGGGCGGGGAAGCCTGCGTG
GCGGCCCCGGAAGAATCCGGG
ATCCGGGCGGAACCGCGGCTG
AGGGGGCGGGGAAGC
GGCGGGCCGGGCCGA
AGGGGGCGGGCTAGG
AGGGGGCGGGCTAGG
TCGGACCAGGAAGGAGCGCCA
GTGGGGCAGTGTCGG
CTAGGTGAGGAAGGGCCGGGT
TCCGCCAAGGGCTGG
CCTGGGCCGGAAATGCCTAAT
GAAGGGCAGGGCGGA
CTGGGGCGGGCAGGG
GGCGGGCAGGGGCGG
CTGGGGCGGGCAGGG
CTGGGGCGGGCAGGG
CGGGGGCAGAGAGTG
GACCCGCAGGAAGGGCGGAGC
TCTGCCCCCGGGTGG
CTGGGGGGTTCCGGG
CGGGGGCGGGGAAGG
GGAGCCTGAGAGCCG
GCGGGGCGGGGACTG
Core
Matrix
similarity similarity
1.000
1.000
0.905
1.000
1.000
1.000
0.905
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
0.905
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
0.823
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
0.905
1.000
1.000
1.000
1.000
1.000
0.932
0.795
0.965
0.997
0.997
0.910
0.843
0.924
0.835
0.961
0.961
0.918
0.976
0.885
0.973
0.973
0.808
0.941
0.828
1.000
0.894
0.956
0.948
0.946
0.997
0.903
0.977
0.977
0.941
0.872
0.958
0.866
0.984
0.896
0.955
0.900
0.955
0.955
0.883
0.967
0.894
0.728
0.997
0.793
0.997