List of Publications 1. 2. 3. 4. 5. 6. 7. 8. Single bacteriocin typing scheme for the Vibrio group of organism. Smita Mitra. T.S.Balganesh, Sujata G Dastidar and A.N.Chakraborty. Infection and Immunity 30 74‐77 (1980). Transfer of polymixim resistance from Bacillus polymyxa: Transformation of Gram positive and Gram negative bacteria. Minakshi Sen, T.S.Balganesh, Sujata G Dastidar and A.N.Chakrabarty. Indian Journal of Experimental Biology 18 1256‐1259 (1980). Transfer of R plasmids from Staphylococcus aureus to Escherichia coli and Vibrio cholerae. Chakrabarty, A.N., Minakshi Sen, T.S.Balganesh, and Sujata G Dastidar. Indian Journal of Experimental Biology 19,511‐515 (1981). Recognition of 2‐keto‐3‐deoxyoctonate in bacterial cells and lipopolysaccharides by sialic acid binding lectin from the horse shoe crab Carcinoscorpius rotunda cauda. D.Thambi Dorai, Subita‐Sanyal, S.Mohan, B.K.Bachhawat and T.S.Balganesh. Biochem. Biophys. Res.Commun. 154,141‐147 (1982). LPS recognition by sialic acid binding lectin from horse shoe crab. Sabita Sanyal, T.S.Balganesh, S.Mohan, B.K.Bachhawat and T.S.Balganesh. FEMS Microbiology Lett. 1982. Enterotoxin production, DNA repair and Alkaline phosphates of Vibrio cholerae before and after animal passage. Nirmal K Roy, Gautam Das, T.S.Balganesh, S.N.Dey, R.K.Ghosh, and Jyotirmoy Das. J Gen.Microbiol. 128, 1927‐1932 (1982). Plasmid vector for cloning in Streptococcus pneumoniae and strategies for enrichment of recombinant plasmids. T.S.Balganesh and Sanford A Lacks. Gene 29,221‐230 (1984). Heteroduplex DNA mismatch repair system of Streptococcus pneumoniae: cloning and expression of the hex‐A gene. T.S.Balganesh and Sanford A Lacks. J. Bact.162,979‐984 (1985). 9. 10. Nucleotide sequence, of the DpnII DNA methylase gene of Streptococcus pneumoniae and its relationship to the dam gene of Escherichia coli. Bruno M Mannerelli, T.S.Balganesh, Bill Greenberg, Sylvia S Springhorn and Sanford A Lacks. Proc.Natl.Acad.Sci (USA) 8,4468‐4472 (1985). Organisation of multispecific DNA methyltransferases encoded by temperate Bacillus subtilis phages. Behrens,B., Noyer‐Weidner,M., Pawlek,B., Lauster,R., Balganesh,T.S. and T.A.Trautner. EMBO J 6,1137‐
1142 (1987). 11. Construction and use of chimeric SPR/ 3T DNA methyltransferases in the definition of sequence recognising enzyme regions. Balganesh,T.S., Reiners,l., Lauster,R., Noyer‐Weidner,M., Wilke,K. and Trautner,T.A. EMBO J 6, 3543‐3549 (1987). 12 Chimeric multispecific DNA methyltransferases with novel combinations of target recognition. Trautner,T.A., Balganesh,T.S. and Pawlek,B. Nucleic Acid Res. 39,6649‐6655 (1988). 13. Organisation of target recognising domains in the multispecific DNA (cytos'me‐5) methyltransferases of Bacillus subtilis. T.A.Trautner, Balganesh,T.S., Wilke,K., Noyer‐Weidner,M., Rauhut,E., Lauster,R., Behrens,B. and Pawlek,B. Gene 74,267‐268 (1988). 14. Cloning and hyperexpression of a gene encoding the heat‐stable toxin of Escherichia coli. P.Dwarkanath, Sandhya S. Vishweshvariah, Y.V.B.K.Subramianiam. G.Shanthi. H.M.Jagannatha and T.S.Balganesh. Gene 81,219‐226 (1989). 15. Identification of carbohydrate structures as receptors for localised adherent enteropathogenic Escherichia coli. H.M.Jagannatha, Umender K Sharma, Tara Ramseshan, A.Surolia and T.S.Balganesh. Microbial Pathogenesis 12,209‐218 (1991). 16. Interaction of heat‐stable enterotoxins with human colonic (T‐84) cells: modulation of the activation of guyanylyl cyclase. Sandhya S Vishweshvariah, G.Shanthi, and T.S.Balganesh. Microbial Pathogenesis 12,209‐218 (1992). 17. Deletion analysis of the essentiality of penicillin binding proteins 1A, 2B and 2X of Streptococcus pneumoniae. Christopher A Yuell, Umendar K Sharma, Christopher G Dowson, Christine Town, Tanjore S Balganesh and Brian G Spratt. FEMS Microbiology Lett. 106,171‐1 76 (1993). 18. Expression and characterisation for the pon A (ORF 1) gene of Haemophilus influenzae: complementation in a heterologous system. Umendar K Sharma, P.Dwarkanath, Nabanita Bannerjee, C.Town, and T.S.Balganesh. J.Bact. 177,6745‐6750 (1996). 19. Study of Interaction between Bacteriophage T4 AsiA and E.coli 70 using Yeast Two Hybrid System: Neutralistion of AsiA Toxicity of E.coli Cells by Co‐expressing a Truncated 70 Fragment. Umender K. Sharma, Sudha Ravishankar, Radha Krishan Shandil, P.V.K. Praveen and T. S. Balganesh J. Bact. 181, 5855‐ 5859 ( 1999). 20. Novel Scintillation proximity assay for measuring membrane‐associated steps of peptidoglycan synthesis in Escherichia coli. A novel SPA based assay to detect cell wall inhibitors. Chandrakala, B, Elias, B.C., Mehra, U., Umapathy, N.S., Dwarakanath, P, Balganesh, T.S. and deSousa,S.M. Agents and Chemotherapy, 45, 768 – 775 (2001). 21. Mutational analysis of bacteriophage T4 AsiA: involvement of N‐ and C‐ terminal regions in binding of sigma(70) of Escherichia coli in vivo. Sharma, U.K., Praveen, P.K., and Balganesh, T.S. J.Bact., 295, 125‐134 (2002). 22. Drug discovery for tuberculosis: Bottlenecks and path forward. Balganesh, T.S., Balasubramanian, V. and Anand Kumar, S. Current Science 86, 167 176 (2004). 23. Molecular approaches target discovery:‐ evaluating targets for anti‐ tuberculosis drug discovery. Balganesh, T.S. and Furr, B. J. Infect.Disord. Drug Targets. 7,120‐126 (2007) 24. A changing paradigm of tuberculosis drug development. Tanjore S Balganesh, Pedro M. Alzari and Stewart T. Cole. Trends Pharmacol Sci. 2008 ;29(11):576‐81 25. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint‐Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST. Science. 2009 May 8;324(5928):801‐4. Patent 1.
2.
3.
4.
5.
6.
U.S. Patent 4,729,954. “Vector for cloning in Gram positive bacteria”, T.S. Balganesh and Sanford A Lacks UK patent application “Secretion vector”, G. Das, Balganesh, T.S. and S.S. Vishweshvariah. GB 2 240 1064 UK patent application “Novel polypeptides”, Balganesh, T.S. and Christine Town. GB 2 290 792. EPO application No. P9503247‐0 “RNA polymerase inhibitors” M.Balganesh, T.S. Balganesh, Umender K. Sharma. R 1765‐1 “RNA polymerase assay” T.S. Balganesh, Umender K. Sharma, Vasanthi Ramachandran. PCT‐ WO 2004/087943 AI . Method for targeting intracellular pathogens. Balganesh, Tanjore SoundaraRajan., Datta, Santanu., Ghosh, Indira.