The Marie Curie Research Training Network
CARBIO: Multifunctional Carbon Nanotubes
for Biomedical Applications
Rüdiger Klingeler
Leibniz Institute for Solid State and Materials Research IFW Dresden
and
Marie Curie Research Training Network
Multifunctional Carbon Nanotubes for Biomedical Applications (CARBIO)
(Physics, Chemistry, Biology, Biophysics, Biochemistry, Medicine, Medical Engeneering)
(~45 staff scientists + 17 fellows)
www.CARBIO.eu
The Marie Curie Research Training Network
CARBIO: Multifunctional Carbon Nanotubes
for Biomedical Applications
• How is the Network designed?
• Management Structure
• Training and Education of students
• Criteria of Recruitment
Concept: Carbon wrapped magnetic
probes for biological systems
Aim: Training of early stage researchers on the paradigmatic
example of an state-of-the-art scientific problem in order to
generate excellent scientists.
Therapeutic
Temperature
sensor
Antibody
Ferromagnet
Functional
groups
Scientific concept: Apply carbon wrapped nanoscaled
magnetic probes in order to manipulate (move, heat) and
locate magnets in tissue, i.e. for diagnosis and therapy on the
cellular level, with a focus on anti cancer treatment.
The CARBIO Network
Chemistry
Biochemistry
Biology
Biochemistry,
Biophysics
Immunochemistry
Toxicology
Physics, Medicine
Med. Engineering
The CARBIO Network
12 Research Tasks (13 PhD students, 4 PostDocs)
Open: 3 PhD, 3 PostDocs
WP 1
Synthesis and filling of single- and doublewalled CNT
Synthesis
Synthesis and filling of multi-walled CNT
Exohedral functionalisation
Functionalisation of RNA-wrapped CNT for RNAi biodelivery
WP 2
Interactions of CNT with the immune system: characterisation
and modification of interactions by derivatisation.
Biocompatibility
Biocompatibility studies
and bioactivity
RT 6
Binding of functionalized CNT to cells and delivery into the
cell: A microscopic view
WP 3
RT 7
Non-invasive intracellular sensors and markers: NMR studies
Imaging and
RT 8
Imaging FM CNT: spatially resolved SQUID studies
Sensoring
RT 9
Imaging CNT: micro-MRI and NMR studies
WP 4 HyperRT 10 Magnetically filled CNT as intracellular probes for heating
thermia/
RT 11 Delivery of RNA-wrapped CNT to kill cancer cells
medical studies
RT 12 Medical studies using MWNT for tumour therapy
RT 1
RT 2
RT 3
RT 4
RT 5
The CARBIO Network
Dr. R. Klingeler, Dr. S. Hampel, D. Haase, Ch. Müller, Dr. A. Leonhardt,
Dr. M. Ritschel, Dr. T. Gemming, Dr. A. Vyalykh, Prof. B. Büchner
Leibniz Institute for Solid State and Materials Research IFW Dresden
Dr. A. Meye, D. Kunze, Dr. S. Füssel, Dr. K. Krämer,
Prof. M.P. Wirth, U Hospital TU Dresden
Prof. E. Flahaut, UPS Toulouse
Dr. E. Borowiak-Palen, U Szechin
Prof. R.B. Sim, U Oxford
Dr. F. Kienberger, U Linz
Prof. J. McFadden, Dr. H. Coley, Prof. R. Silva, U Surrey
Dr. B. ten Haken, Dr. A.H. Velders, U Twente
(for more information cf. www.CARBIO.eu)
Dr. S. Achten, Boehringer Ingelheim Foundation
Dr. A. Jordan, CEO MagForce GmbH
Dr. F. Rossi, EU Health Research Centre Ispra
Prof. H. Sturm, Ethics, U St. Augustin
The CARBIO structure
Advisory Board
Dr. Achten, Dr. Jordan, Dr. Rossi
EU
Project Management Commitee
(all 8 project leaders)
IFW EU
office
Partner
Admin.
IFW
Finance
Dep.
Public
Relations
Coordinator
Recruitment
Communication
Gender
aspects
Education
Industry
IPR
Kienberger
ten Haken
BorowiakPalen
Sim, Meye,
Krämer
McFadden
Flahaut
Intra-RTN
Commun.
Scientific
training
Training/
Biannual
meetings
Additional
Skills
12 RT
Society
Fellows
Associated
Industrial
Partners:
Intel, MagForce,
Sanofi Pasteur,
Nanoscan
Scientific
Objectives
4 WP
4 WP
ESR respresentative
4 WP
Leaders
Who can be recruited? Thumb rules
• 70% EU or associated states members, > 40% female
(CARBIO: >90% EU citicens, ~60% female)
• Transnational mobility!
- not from contractor country
- not worked in a country for >12 months in last 3 years
Criteria:
• Clear and well written application! What do you apply for?
• Does the field of your graduation fits to the PhD topic?
• Quality of education, very good marks
• Invited talk!!!
• Motivation, ability to communicate
Remark: Salary ~ double compared to non-MC fellows.
Training and Education
• PhD thesis in a emerging area and training in cutting edge
(world leading) experimental techniques
• Local training: Lectures, additional skills, experimental
• Network wide training
- Biannual meetings with talks or poster sessions
- Winter workshops: Practical (in-vivo AFM, cell cultures,..)
- Summer school: Ethics, Scientific writing (e.g. June 2007)
- International conferences
- Secondments (mandatory!)
- ...
IFW
IFW
CIR
SUT
SUR
CIR
X
SUT
X
X
SUR
X
X
UOX IFB
X
X
X
X
X
UT
X
X
X
X
TUD
X
X
X
Marie Curie: www
http://cordis.europa.eu/mc-opportunities/