HERNÁN R. BONOMI, PhD
Age: 35
Residence: Buenos Aires, Argentina.
Work address: Av. Patricias Argentinas 435 - Buenos Aires, Argentina. C1405BWE.
Work phone: (54+11) 5238-7500 ext. 2304
e-mail: [email protected]
CURRENT POSITION
CONICET Fellow assistant researcher, Immunology and Molecular Microbiology laboratory, Fundación Instituto Leloir-IIBBA-CONICET,
Buenos Aires, Argentina.
EDUCATION
2010
2005
Doctor of Science (PhD) in the area of Biological Chemistry, Buenos Aires University (UBA), Biological Chemistry Department,
FCEyN, (2010)
Licentiate in Biological Sciences. Honor diploma. UBA, FCEyN (2005)
PEER-REVIEWED PUBLISHED ARTICLES
9.
Crystallographic and kinetic study on riboflavin synthase from Brucella abortus, a chemotherapeutic target with an
enhanced intrinsic flexibility
Serer I, Bonomi HR, Guimarães BG, Rossi RC, Goldbaum FA, Klinke S
Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1419-34. PMID: 24816110
8.
Identification of a functional member of a novel family of bacterial flavin transporters in Rhizobium leguminosarum
García-Angulo V*, Bonomi HR*, Posadas DM, Serer MI, Torres AG, Zorreguieta A, Goldbaum FA
J Bacteriol. 2013 Oct;195(20):4611-9. PMID: 23935051
7.
Light regulates attachment, exopolysaccharide production and nodulation in Rhizobium leguminosarum through a LOVhistidine kinase photoreceptor
Bonomi HR*, Posadas DM*, Paris G*, Carrica MC, Frederickson M, Pietrasanta L, Bogomolni RA, Zorreguieta A, Goldbaum FA
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12135-40. PMID: 22773814
6.
The β-scaffold of the LOV domain of the Brucella light-activated histidine kinase is a key element for signal transduction
Rinaldi J, Gallo M, Klinke S, Paris G, Bonomi HR, Bogomolni RA, Cicero DO, Goldbaum FA
J Mol Biol. 2012 June; 420(1–2):112–27. PubMed PMID: 22504229
5.
BmaC, a novel autotransporter of Brucella suis, is involved in bacterial adhesion to host cells
Posadas DM, Ruiz-Ranwez V, Bonomi HR, Martín FA, Zorreguieta A
Cell Microbiol. 2012 Jun;14(6):965-82. PMID: 22321605
4.
Sensing the dissociation of a polymeric enzyme by means of an engineered intrinsic probe
Ainciart N, Zylberman V, Craig PO, Nygaard D, Bonomi HR, Cauerhff AA, Goldbaum FA
Proteins. 2011 Apr;79(4):1079-88. PMID: 21246631.
3.
The Xanthomonas axonopodis pv. citri flagellum is required for mature biofilm and canker development
Malamud F, Torres PS, Roeschlin R, Rigano LA, Enrique R, Bonomi HR, Castagnaro AP, Marano MR, Vojnov AA
Microbiology. 2011 Mar;157(Pt 3):819-29. PMID: 21109564
2.
An atypical riboflavin pathway is essential for Brucella abortus virulence
Bonomi HR*, Marchesini MI*, Klinke S, Ugalde JE, Zylberman V, Ugalde RA, Comerci DJ, Goldbaum FA
PLoS One. 2010 Feb 25;5(2):e9435. PMID: 20195542
1.
Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales
Klinke S, Zylberman V, Bonomi HR, Haase I, Guimarães BG, Braden BC, Bacher A, Fischer M, Goldbaum FA
J Mol Biol. 2007 Oct 26;373(3):664-80. PMID: 17854827
*authors contributed equally to these works
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PROTEIN DATA BANK DEPOSITIONS
RCSB Protein Data Bank: 2F59, 2I0F, 2O6H y 2OBX
CONFERENCES, SYMPOSIUMS & MEETINGS
2006 – present
2003 – present
11 international oral and poster presentations
12 national oral and poster presentations
HUMAN RESOURCES
2014 – present
2013 – present
Licentiate thesis director. Student: Santiago Sosa. Biological Sciences, FCEyN, UBA
Doctoral thesis co-director. Student: Lic. Dario Balcazar, Biological Chemistry Department, FCEyN, UBA
FACULTY
2004-2005.
2004
Undergraduate assistant. UBA, FCEyN, Biological Chemistry department.
Undergraduate assistant, UBA, FCEyN, Physiology, Molecular and Cellular Biology department.
SCHOLLARSHIPS
2011
2009
2006
2005
Postdoctoral: Biochemistry. CONICET
Postgraduate Type II: Biochemistry. CONICET
Postgraduate Type II: Biochemistry. CONICET
Postgraduate. ANCYPT (FONCyT PICT #8365)
EXAMINER ACTIVITIES
2013
2013
Licentiate thesis. Major: Biological Sciences. Student: Jeremias Barclay
FONCyT. MINCyT / ANCyT PICT-2013 projects
EXTERNAL JOURNAL REVIEWER
2013 - present
2013 - present
Journal of Bacteriology
Molecular Microb Plant Interactions
COMPLEMENTARIES
2013
OVERGRAD BEST MODEL AWARD, Buenos Aires Team. International Genetically Engineered Machine (iGEM)
competition. Massachusetts , Institute of Technology, Massachusetts, USA
SUPPORTED BY AND CO-LEAD IN THE FOLLOWING GRANTS
2011-2016
“Light sensing by a LOV histidine-kinase activates a general stress response system in Brucella”
MINCyT / ANCyT(#2672), from 5/10/2012 to 5/10/2016. U$D 240.000
2011-2012
“The light-dependant virulence pathway in Brucella and other Rhizobiales”
MINCyT / ANCyT (#1729), from: 08/2011 to 07/2012. U$D 67.000
2008-2009
“The light-dependant virulence pathway in Brucella and other Rhizobiales”
MINCyT / ANCyT (#PME-2006-02191), from 02/2008 to 12/2009. U$D 30.000
2007-2011
“Metabolism of flavins and oxygen sensing as Brucella virulence factors”
Howard Hughes Medical Institute from 01/2007 to 12/2011. U$S 487.500
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