Anti-MME monoclonal antibody, clone FQS6015
Cat.No: DCABH-1824
Lot. No. (See product label)
PRODUCT INFORMATION
Product Overview
Rabbit monoclonal to CD10
Antigen Description
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by
cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved
in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin
preelastic and elastic fibers.
Immunogen
A recombinant protein fragment corresponding to residues in Human CD10.
Isotype
IgG
Source/Host
Rabbit
Species Reactivity
Rat, Human
Clone
FQS6015
Purity
Tissue culture supernatant
Conjugate
Unconjugated
Applications
Blocking, WB, IP, IHC-P
Positive Control
WB: LnCaP, Ramos, Jurkat and Human fetal kidney lysates IHC-P: Human diffuse large B-cell
lymphoma, kidney and tonsil tissues
Format
Liquid
Size
100 μl
Buffer
pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Storage
Store at -20°C. Stable for 12 months at -20°C
Antigen Gene Information
Gene Name
MME membrane metallo-endopeptidase [ Homo sapiens ]
Official Symbol
MME
Synonyms
MME; membrane metallo-endopeptidase; neprilysin; CALLA; CD10; enkephalinase; NEP; neutral
endopeptidase; atriopeptidase; skin fibroblast elastase; neutral endopeptidase 24.11; membrane
metallo-endopeptidase variant 1; membrane metallo-endopeptidase varian
Entrez Gene ID
4311
mRNA Refseq
NM_000902
Protein Refseq
NP_000893
MIM
120520
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
1
UniProt ID
P08473
Chromosome Location 3q25.2
Pathway
Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved
biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and
absorption, conserved biosystem; Renin-angiotensin system, organism-specific biosystem;
Function
endopeptidase activity; endopeptidase activity; metal ion binding; metalloendopeptidase activity;
metalloendopeptidase activity; peptidase activity; peptide binding; protein binding; zinc ion binding;
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
2