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#
Broad Spectrum UVA/UVB Sunscreen Lotion SPF 46
Formulation#RC-01-53
In-vivo SPF 46 (FDA protocol- 10 subjects)
In-vivo SPF 30 (without Synoxyl® HSS)
INCI name
Phase A1
Water
Disodium EDTA
Butylene Glycol
Trade Name/Supplier
% w/w
Water(demineralized)
Versene Na/Dow
Butylene Glycol/Ruger
Qs
0.10
2.00
Glycerine
Emery 916/BASF
2.00
Keltrol® CG-T/CP Kelko
Carbopol Ultez 21/Lubrizol
0.10
0.25
Finsolv TN/Finetex
Emulim 22/Gattefosse
Arlacel 165/Croda
Synoxyl® HSS/Sytheon
Eusolex HMS/EMD Chemicals
Eusolex OS/EMD Chemicals
Eusolex 9020/EMD Chemicals
Crodacol C-70/Croda
Performa V 6112/New Phase Technologies
Dow Corning 200,100 cst/Dow Corning
5.00
2.00
1.50
2.00
10.00
5.00
2.00
1.00
1.00
1.00
TEA 99%
0.20
Phase A2
Xanthan Gum
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Phase B
C12-15 Alkyl Benzoate
Tribehenin PEG -20 Esters
Glyceryl Stearate, PEG-100 Stearate
Trimethoxybenzylidene Pentanedione
Homosalate
Octyl Salicylate
Avobenzone
Cetyl Alcohol
C30+Olefin / Undecylenic Acid Copolymer
Dimethicone
Phase C
Triethanolamine
Phase D
Phenoxyethanol, Hexylene Glycol, Caprylyl Glycol
Lexgard HPO/Inolex
1.00
100.00
Total
Procedure:
Combine A-1; disperse A2 one by one in A1 while stirring and heat A to 75°C. Combine ingredients of phase B and
heat to 75 0C. Add phase B to A with good mixing. Homogenize mixture at moderate speed for 3-5 min while adding
phase C (adjust pH to 5.5-6.0). Cool batch to 40°C with propeller agitation until mixture is homogeneous. Add phase
D while continue mixing.
Notes:
• pH - 5.5-6.0
• Viscosity – 60,000- 80,000mPas (Brookfield RVT, Spindle C, 10 rpm) at 25°C
The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This
information is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is
any permission or recommendation to practice any invention covered by patent either expressed or implied.
!
"
Broad-spectrum UVA/UVB sunscreen spray SPF 45
Formulation#RC-01-80 A
In-vivo SPF 45 (FDA protocol- 5 subjects)
In-vivo SPF 30 (without Synoxyl® HSS)
INCI name
Phase A
Ethanol
VA/Butyl Maleate/Isobornyl Acrylate Copolymer
Phase B
Avobenzone
Trimethoxybenzylidene Pentanedione
Homosalate
Octyl Salicylate
Diisopropyl Adipate
Phase C
Trade Name/Supplier
% w/w
Ethanol
Advantage Plus/Ashland
42.00
2.00
Eusolex 9020/EMD
Synoxyl® HSS/Sytheon
Eusolex HMS/EMD
Eusolex OS/EMD
Dermol DIA/Alzo
2.00
2.00
10.00
5.00
10.00
Isodecyl Neopentanoate
Isosorbide Dicaprylate
Total
Ceraphyl SLK/Ashland
Synovea DOI/Sytheon
20.00
2.00
100.00
Procedure: Combine phase A; Pre-mix phase B and heat up to 75°C until is completely free of solids. Add
phase A and C to phase B while mixing.
______________________________________________________________________________________________
The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This information
is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is any
permission or recommendation to practice any invention covered by patent either expressed or implied
!
"
Broad Spectrum UVA/UVB Sunscreen Emulsion SPF 32
Formulation#RC-01-78
In Vivo SPF 32 (FDA protocol- 5 subjects)
INCI name
Phase A1
Water
Disodium EDTA
Glycerin
Butylene Glycol
Phase A2
Xanthan Gum
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Phase B
C12-15 Alkyl Benzoate
Tribehenin PEG-20 Esters
Glycerol stearate , PEG-100 stearate
Trimethoxybenzylidene Pentanedione
Homosalate
Octyl Salicylate
Avobenzone
Cetyl Alcohol
C30+Olefin / Undecylenic Acid Copolymer
Dimethicone
Phase C
Triethanolamine
Phase D
Phenoxyethanol, Hexylene Glycol, Caprylyl Glycol
Total
Trade Name/Supplier
% w/w
Water(demineralized)
Versene Na/Dow
Emery 916/BASF
Butylene Glycol/Ruger
Qs
0.10
2.00
2.00
Keltrol® CG-T/CP Kelko
Carbopol Ultez 21/Lubrizol
0.15
0.25
Finsolv TN/Finetex
Emulium 22/Gattefosse
Arlacel 165/Croda
Synoxyl® HSS/Sytheon
Eusolex HMS/EMD
Eusolex OS/EMD
Eusolex 9020/EMD
Crodacol C-70/Croda
Performa V 6112/New Phase
Technologies
Dow Corning 200,100 cst/Dow Corning
6.00
2.00
1.00
1.50
6.00
4.00
1.50
1.00
1.00
TEA 99%
0.15
Lexgard HPO/Inolex
1.00
100.00
1.00
Procedure:
Combine A-1; disperse A2 one by one in A1 while stirring and heat A to 75°C. Combine ingredients of phase B
and heat to 75 0C. Add phase B to A with good mixing. Homogenize mixture at moderate speed for 3-5 min while
adding phase C (adjust pH to 5.5-6.0). Cool batch to 40°C with propeller agitation until mixture is homogeneous.
Add phase D while continue mixing.
Notes:
• pH - 5.5-6.0
• Viscosity – 40,000- 60,000mPas (Brookfield RVT, Spindle C, 10 rpm) at 25°C
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!
"
Broad Spectrum UVA/UVB Sunscreen Lotion with ZnO
Formulation#RC-01-86A
In-vivo SPF 33 (FDA protocol - 5 subjects)
In-vivo SPF 21 (without Synoxyl® HSS)
INCI name
Phase A1
Water
Disodium EDTA
Butylene Glycol
Phase A2
Xanthan Gum
Phase B
Potassium Cetyl Phosphate
Oleth-10
Glyceryl Dibehenate, Tribehenin, Glyceryl Behenate
Stearyl/PPG-3 Myristyl Ether Dimer Dilinoleate
Dimethicone
Phase C
Ethyl Macademiate
Trimethoxybenzylidene Pentanedione
Zinc Oxide, Simmondsia Chinensis (Jojoba) Seed
Oil,Glyceryl Isostearate, Polyhydroxystearic Acid
Phase D
Polyacrylate 13,Polyisobutene,Polysorbate 20
Phase E
C8-22 Alkyl Acrylate/Methacrylic Acid Crosspolymer
Phase F
Phenoxyethanol, Hexylene Glycol, Caprylyl Glycol
Trade Name/Supplier
% w/w
Water(demineralized)
Versene Na/Dow
Butylene Glycol/Ruger
Qs
0.10
3.00
Keltrol® CG-T/CP Kelko
0.20
Amphisol K/DSM
Brij O10 /Croda
Compritol 888/Gattefosse
Liquiwax PolyIPL/Croda
Dow Corning 200,100 cst/Dow Corning
1.50
1.00
1.50
1.00
1.00
Floramac 10/Floratech
Synoxyl® HSS/Sytheon
5.00
1.50
ZinClear IM 50 JJ/Dow
20.00
(10% ZnO)
Sepiplus 400/Seppic
1.50
Intelimer 8600/Air Products
3.00
Lexgard HPO/Inolex
1.00
Total
100.00
Procedure:
Combine A-1; disperse A2 one by one in A1 while stirring and heat A to 75°C. Premix phase C separately and heat up to
750C until free of solids and add to phase C before emulsification. Combine ingredients of phase B and heat to 75 0C. Add
phase B to A with good mixing. Homogenize mixture at moderate speed for 3-5 min while adding phase D. Cool batch to
450C with propeller agitation until mixture is homogeneous. Add phase E &F while continue mixing.
Notes:
•
pH - 7.20-7.80
•
Viscosity – 30,000- 45,000mPas (Brookfield RVT, Spindle C, 10 rpm) at 25°C
The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This information
is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is any
permission or recommendation to practice any invention covered by patent either expressed or implied.
!
"
Broad Spectrum UVA/UVB Sunscreen Lotion SPF 50+(expected)
Formulation#RC-01-100
INCI name
Phase A1
Water
Disodium EDTA
Butylene Glycol
Trade Name/Supplier
% w/w
Water(demineralized)
Versene Na/Dow
Butylene Glycol/Ruger
Qs
0.10
2.00
Glycerine
Emery 916/BASF
2.00
Keltrol® CG-T/CP Kelko
Carbopol Ultez 21/Lubrizol
0.10
0.30
Finsolv TN/Finetex
Emulim 22/Gattefosse
Arlacel 165/Croda
Synoxyl® HSS/Sytheon
Eusolex HMS/EMD Chemicals
Eusolex OS/EMD Chemicals
Eusolex 9020/EMD Chemicals
5.00
2.00
1.50
2.50
15.00
5.00
2.50
Cetyl Alcohol
C30+Olefin / Undecylenic Acid Copolymer
Crodacol C-70/Croda
Performa V 6112/New Phase
Technologies
1.00
1.00
Dimethicone
Phase C
Triethanolamine
Phase D
Phenoxyethanol, Hexylene Glycol, Caprylyl Glycol
Dow Corning 200,100 cst/Dow Corning
1.00
TEA 99%
0.20
Phase A2
Xanthan Gum
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Phase B
C12-15 Alkyl Benzoate
Tribehenin PEG -20 Esters
Glyceryl Stearate, PEG-100 Stearate
Trimethoxybenzylidene Pentanedione
Homosalate
Octyl Salicylate
Avobenzone
Lexgard HPO/Inolex
1.00
100.00
Total
Procedure:
Combine A-1; disperse A2 one by one in A1 while stirring and heat A to 75°C. Combine ingredients of phase B and heat
to
75 0C. Add phase B to A with good mixing. Homogenize mixture at moderate speed for 3-5 min while adding phase C
(adjust pH to 5.5-6.0). Cool batch to 40°C with propeller agitation until mixture is homogeneous. Add phase D while
continue mixing.
Notes:
•
pH - 5.5-6.0
•
Viscosity – 60,000- 80,000mPas (Brookfield RVT, Spindle C, 10 rpm) at 25°C
________________________________________________________________________________________________
The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This information is
intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is any permission or
recommendation to practice any invention covered by patent either expressed or implied
!
"
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