Fall 2016
Cell Biology PCB 3023 University of South Florida Sarasota-­Manatee Instructor: Dr. Christelle Bouchard Office Hours: Tuesday 3:30-­4:30 am E-­Mail: use Canvas to communicate with me Thursday 3:30-­4:30 am Office: B314 Telephone: 941-­359-­4370 Class time: Tuesdays and Thursdays 2:00 p.m.-­3:15 p.m. in B226 PREREQUISITES: BSC 2010 or BSC 1010C & BSC 2010L Minimum Grade: C-­ or BSC 1010L & CHM 1045 or CHM 1045C or CHM 2045 or CHM 2045C, & CHM 1046 or CHM 1046C or CHM 2046 or CHM 2046C (These courses must be completed with a grade of C-­ or better.) COURSE TEXTBOOK: Becker’s World of the Cell. J. Hardin & Gregory Bertoni. 9th edition. Pearson. COURSE DESCRIPTION: Cell Biology is the study of living properties of cells and encompasses a broad area of the life sciences that includes cellular physiology and life cycle, organelle structure and function, and biomolecular structure and function. COURSE OBJECTIVES: The main objective of this course is to learn essential concepts about the Cell. This course teaches a broad knowledge of both prokaryotic and eukaryotic cells. Students will study the structure and function of eukaryotic cells, and explore how such cells regulate their biological processes. Topics include macromolecules, anatomy of the cell, enzymology, membrane structure and transport, receptors and signal transduction, DNA repair and recombination, as well as the structure of the genetic materials and gene expression. COURSE STUDENT LEARNING OUTCOMES: 1. Students will demonstrate an understanding that life begins with cells, and that there is a diversity and commonality of cells. 2. Students will demonstrate an understanding of chemical foundations of atomic and molecular interactions, as well as the chemical building blocks of cells. Fall 2016
3. Students will demonstrate an understanding of protein structure and function as it relates to enzymatic activity and methods of protein purification. 4. Students will demonstrate an understanding of basic molecular genetic mechanisms including the structure of nucleic acids, transcription of protein-­coding genes, formation of mRNA, the roles of RNA in translation, and the steps of DNA replication. Current topics in molecular biotechnology will be considered—including gene splicing, plasmid construction, transformation of bacteria, PCR, and other applications of DNA cloning. 5. Students will demonstrate an understanding of eukaryotic biomembranes and cell architecture, including the structure and function of organelles and how they can be specifically isolated and targeted for analysis. 6. Students will demonstrate an understanding of eukaryotic cell signaling through cell-­
surface receptors, signal transduction pathways, and the integration of theses signals as they effect cell fate. REQUIRED CLASS MATERIALS: Text: Becker’s World of the Cell, a laptop, and access to Canvas website CANVAS USE: PCB 3023 uses the CANVAS Course Management system, for course communications, to distribute course information, and for grading. You can log into CANVAS with your USF net ID and password GRADING, EVALUATION AND ATTENDANCE POLICIES: The course will consist of 300 total points. The grade is based on 4 exams (50 points each-­ lowest grade will be dropped), 4 quizzes (60 total points) and 2 assignments (40 total points). Final grades: Your letter grade will be based on your total percent score A+=97-­100%;; A=93-­96%;; A-­=90-­92%;; B+=87-­89%;; B=83-­86%;; B-­=80-­83%;; C+=77-­79%;; C=73-­76%;; C-­=70-­72%;; D+=67-­69%;; D=63-­66%;; D-­=60-­62%;; F=<59%. Attendance: You are expected to arrive on time and leave when class is dismissed. Missing any class puts you at a disadvantage because you miss valuable information. If you miss a class meeting for any reason, you will be held responsible for all material covered and announcements made in your absence. It will be your responsibility to consult with students in the class concerning what you missed. Fall 2016
Week/session August 23-­25 Aug. 30-­ Sept. 1 (assignment 1 due) September 6-­8 Weekly Topics* CH. 1: The diversity of Cells – Microscopy (assignment 1) CH. 2 : The chemistry of the cell: Importance of carbon, water, membranes, synthesis by polymerization and self-­assembly. CH. 3: Macromolecules of the cell: Chemistry of proteins, nucleic acids, polysaccharides and lipids. (Quiz 1) September 13-­15 CH. 4: Cells and Organelles: Properties of prokaryotic and eukaryotic cells. Characteristics of viruses, viroids and prions. September 20-­22 CH. 6: Enzymes: the catalysis of life. Importance of activation energy, enzyme kinetics and enzyme regulation. September 27-­29 EXAM 1 CH 16 (18). The structural basis of cellular information: The DNA structure, organization of DNA in genomes and how DNA is packaged in the cells. Extrachromosomique DNA. The structure and functions of nuclear membrane, nuclear matrix, nuclear lamina and nucleolus. October 4-­6 CH. 16 (18) Continue. CH. 18/19 (21/22) Gene expression October 11-­13 CH. 7: Membranes. CH. 7/8: Membranes. Transport across membranes: Overcoming the permeability barrier. Differences between simple diffusion, facilitated diffusion and active transport. (Quiz 2) October 18-­20 CH. 8 continue. October 25-­27** EXAM 2 CH. 22 (13): Signal transduction Mechanisms: How neurons transmit signals throughout the body. November 1-­3 CH. 23 (14). Signal transduction mechanisms: Understanding messenger molecules and receptors. Importance of G-­proteins, protein kinases and growth factors in the cell. (assignment 2) (Quiz 3) November 8-­10 CH. 13: Cytoskeletal systems (assignment 2 due) November 15-­17 EXAM 3 CH 14: Cellular Movement November 22 CH. 14 continue Nov. 29 CH. 26 Cancer Cell (Quiz 4) Week of December 5 EXAM 4 *Schedule is tentative and subject to change. However, the schedule for exams will not be modified. ** October 29th: Last day to drop with a “W”;; no refund & no academic penalty for Fall 2016. Reading Assignments and Reading Guides. Readings provide an introduction to the subjects we
cover in this course. You are expected to read all of the assigned readings for this course including the
entire chapters of the textbook that correspond with topics we cover each week.
Fall 2016
Note: It would be to your advantage to exchange phone numbers and/or email addresses with a couple
of your classmates in order to get notes and/or additional assignments if you miss class.
Computer and Technology use in class: Computer use in class, especially off-task computer use,
can be a distraction to other students. Technology may be utilized to support coursework activities.
While in class, you will use technology only for purposes related to this course. You are expected
to be considerate of the instructor and other students while using technology. It is easy for
technology to become a distraction to you and to those around you. Inappropriate uses will be
noted and may affect your final grade.
Appropriate Uses
• Taking notes.
• Following along with presentations, demonstrations, and other whole class activities.
• Engaging in assigned classroom tasks.
• Delivering classroom presentations or other assigned tasks.
• Facilitating discussions that require laptop/technology use.
Inappropriate Uses
• Displaying materials on screen which may be distracting or offensive to others.
• Instant messaging, e-mailing, surfing the Internet, playing games, writing papers, doing
homework, etc.
• Keyboarding
• Talking on cell phone, text messaging, using pagers, or using other similar devices.
• Allowing distracting audio from any device.
Audio and Video-Recordings
• Recording of class via tape recorder, cell phone, or other recording devices is strictly
prohibited without the express written permission of the instructor.
• Non-permission to sell class notes, materials, recordings: Students are not permitted
to sell notes, materials, tests, recordings, or any other items related to this course.
PREPARATION FOR EXAMS or ASSESSMENTS: All exams are to be completed at the scheduled time. No make-­up periods are scheduled. Students with a documented reason for missing a course test, which is confirmed by supporting documentation (e.g., a doctor’s letter) may request accommodation from the course instructor. The final session exam will only be given on the assigned day. Please contact me in advance if you will not be able to take an exam at the scheduled time. All exams will be based on material presented in class activities, lectures, discussion, and required readings. The exams may be comprised of multiple choice, short answer, extended response and/or essay questions. Test Format – Any combination of Matching, Multiple Choice, Short Answer, Extended Response, and Essay. Recommendation: READ ALL designated MATERIAL. Exams may include materials Fall 2016
from lectures, quizzes and assignments. You are expected to read the materials, as assigned, and understand the content. If you do not understand the content, it is your responsibility to ask questions. PLAGIARISM PREVENTION The University of South Florida has an account with an automated plagiarism detection service which allows student assignments be checked for plagiarism. I reserve the right to ask students to submit their assignments to Turnitin through Canvas. Assignments are compared automatically with a database of journal articles, web articles, and previously submitted papers. The instructor receives a report showing exactly how a student’s paper was plagiarized. PLEASE REMOVE YOUR NAME FROM THE BODY OF YOUR PAPER AND REPLACE IT WITH YOUR USF ID#. ALSO REMOVE YOUR NAME FROM THE FILE NAME AND REPLACE IT WITH YOUR USF ID# (e.g., “U12345678 Essay 1.docx”) BEFORE SUBMITTING IT TO TURNITIN. Pursuant to the provisions of the Family Educational Rights and Privacy Act (FERPA), students are requested to maintain confidentiality as a way to keep their personal contact information (i.e. name, address, telephone) from being disclosed to vendors or other outside agencies. By your submission, you are also agreeing to release your original work for review for academic purposes to Turnitin. USFSM AND USF SYSTEM POLICIES Policies are available in the USFSM Catalog and at regulationspolicies.usf.edu . A. Academic Dishonesty: The University considers any form of plagiarism or cheating on exams, projects, or papers to be unacceptable behavior. Please review the USF System Regulation USF3.027 Academic Integrity of Students and the USF System Regulation USF6.0021 Student Code of Conduct. B. Academic Disruption: The University does not tolerate behavior that disrupts the learning process. Please review USF System Regulation USF3.025 Disruption of Academic Policy. C. Contingency Plans: In the event of an emergency, it may be necessary for USFSM to suspend normal operations. During this time, USFSM may opt to continue delivery of instruction through methods that include but are not limited to: Canvas, online conferencing/collaboration tools, email messaging, and/or an alternate schedule. It is the responsibility of the student to monitor Canvas for each of their classes for course specific communication, as well as the USFSM website, their student email account, and MoBull messages for important general information. The USF hotline at 1 (800) 992-­‐‑4231 is updated with pre-­‐‑recorded information during an emergency. See the Campus Police Website for further information. Fall 2016
D. Disabilities Accommodation: Students are responsible for registering with the Office of Students with Disabilities Services (SDS) in order to receive academic accommodations. Reasonable notice must be given to the SDS office (typically 5 working days) for accommodations to be arranged. It is the responsibility of the student to provide each instructor with a copy of the official Memo of Accommodation. Contact Information: Disability Coordinator, 941-­‐‑359-­‐‑4714, [email protected], http://usfsm.edu/disability-­‐‑services/ E. Fire Alarm Instructions: At the beginning of each semester please note the emergency exit maps posted in each classroom. These signs are marked with the primary evacuation route (red) and secondary evacuation route (orange) in case the building needs to be evacuated. See Emergency Evacuation Procedures. F. Religious Observances: USFSM recognizes the right of students and faculty to observe major religious holidays. Students who anticipate the necessity of being absent from class for a major religious observance must provide notice of the date(s) to the instructor, in writing, by the second week of classes. Instructors canceling class for a religious observance should have this stated in the syllabus with an appropriate alternative assignment. G. Protection of Students Against Discrimination and Harassment: 1. Sexual Misconduct/Sexual Harassment Reporting: USFSM is committed to providing an environment free from sex discrimination, including sexual harassment and sexual violence (USF System Policy 0-­‐‑004). 2. Other Types of Discrimination and Harassment: USFSM also is committed to
providing an environment free from discrimination and harassment based on race,
color, marital status, sex, religion, national origin, disability, age, genetic
information, sexual orientation, gender identity and expression, or veteran status
(USF System Policy 0-007).
The Counseling and Wellness Center is a confidential resource where you can talk about incidents
of discrimination and harassment, including sexual harassment, gender-based crimes, sexual
assault, stalking, and domestic/relationship violence. This confidential resource can help you
without having to report your situation to either the Office of Student Rights and Responsibilities
(OSSR) or the Office of Diversity, Inclusion, and Equal Opportunity (DIEO), unless you request that
they make a report.
Please be aware that in compliance with Title IX and under the USF System Policy, educators
must report incidents of discrimination and harassment, including sexual harassment, gender-based
crimes, sexual assault, stalking, and domestic/relationship violence. If a student discloses any of
these situations in class, in papers, or to a faculty member personally, he or she is required to report
it to OSSR or DIEO for investigation. Students who are victims or who have knowledge of such
discrimination or harassment are encouraged to report it to either OSSR or D I E O . The Deputy
Coordinator for USFSM is Allison Dinsmore, Coordinator of Disability Services & Student
Advocacy, 941-359-4714 or [email protected].
Fall 2016
Campus Resources:
Counseling Center and Wellness Center 941-487-4254
Victim Advocate (24/7) 941-504-8599
List of off-campus resources:
HOPE Family Services: 941-755-6805
Safe Place & Rape Crisis Center (SPARCC) – Sarasota: 941-365-1976
First Call for Help- Manatee & Sarasota: 941-366-5025
Centerstone: 941-782-4800; 24-hr Hotline 941-708-6059
H. Web Portal Information: Every newly enrolled USF student receives an official USF e-­‐‑mail account. Students receive official USF correspondence and Canvas course information via that address. The web portal is accessed at http://my.usf.edu.