Anti-SDC1 polyclonal antibody [Biotin]
Cat.No: DPABY-547
Lot. No. (See product label)
PRODUCT INFORMATION
Antigen Description
Syndecans are type 1 transmembrane proteoglycans that constitute the major physiological form of
heparan sulfate (HS) on the cell surface. The four vertebrate syndecans, Syndecan-1 through -4, have
similar short cytoplasmic domains and extracellular portions that diverge, except for HS attachment
sites. Structurally diverse side chains add considerably to the size of the core proteins and serve as
binding sites for growth factors, cytokines, and extracellular matrix proteins. Syndecans are present as
homodimers or multimers, and are often expressed in developmental and cell type-specific patterns.
They have many biological roles including regulating cell growth, differentiation, and adhesion.
Specificity
Detects humanSyndecan-1/CD138 in ELISAs and Western blots. In sandwich ELISAs, less than 0.3%
cross-reactivity with recombinant human (rh) Syndecan-2, rhSyndecan-3, rhSyndecan-4,and
recombinant mouse Syndecan-1 is observed.
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Syndecan-1/CD138. Gln18-Glu251
Accession Number NP_002988
Isotype
IgG
Source/Host
Goat
Species Reactivity
Human
Purification
Antigen Affinity-purified
Conjugate
Biotin
Applications
Western Blot, Immunohistochemistry, ELISA Detection (Matched Pair)
Procedure
Matched Antibody Pairs
Format
Liquid
Size
50 μg
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Antigen Gene Information
Gene Name
SDC1 syndecan 1 [ Homo sapiens (human) ]
Official Symbol
SDC1
Synonyms
SDC1; syndecan 1; SDC; CD138; SYND1; syndecan; syndecan-1; CD138 antigen; syndecan
proteoglycan 1; heparan sulfate proteoglycan fibroblast growth factor receptor;
Entrez Gene ID
6382
mRNA Refseq
NM_001006946
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
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Protein Refseq
NP_001006947
MIM
186355
UniProt ID
P18827
Chromosome Location 2p24.1
Pathway
A tetrasaccharide linker sequence is required for GAG synthesis; Arf6 trafficking events; Cell adhesion
molecules (CAMs); Chondroitin sulfate/dermatan sulfate metabolism; Chylomicron-mediated lipid
transport; Disease; Diseases associated with visual trans
Function
cytoskeletal protein binding; glycoprotein binding; protein C-terminus binding; protein binding;
Creative Diagnostics. All rights reserved
45-1 Ramsey Road Shirley, NY 11967, USA
Tel: 1-631-624-4882 Fax: 1-631-938-8221
E-mail: [email protected]
www.creative-diagnostics.com
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