Proteins relevant for
Neuroscience Research
Products currently
available from PeproTech:
Human Cytokines and Neurotrophins
Products
Catalogue#
Activin A.........................................120-14
Activin B.........................................120-15
Artemin...........................................450-17
BDNF..............................................450-02
b-NGF.............................................450-01
Cardiotrophin-1...............................300-32
CNTF...............................................450-13
CTGF...............................................120-19
EGF........................................... AF-100-15
FGF-acidic.......................................100-17
FGF-basic..................................... 100-18B
Fractalkine (CX3CL1) ......................300-31
GDNF.............................................450-10
GMF-b.............................................450-37
GRO-b (CXCL2)...............................300-39
HGF................................................100-39
I-309 (CCL1)....................................300-37
IFN-g...............................................300-02
IL-1a............................................ 200-01A
IL-1b............................................. 200-01B
IL-1RA........................................ 200-01RA
IL-2 ................................................200-02
sIL-2Ra......................................... 200-02R
IL-6 ................................................200-06
sIL-6Ra......................................... 200-06R
IL-8 (72 a.a.)................................ 200-08M
IL-8 (77 a.a.)....................................200-08
IL-10................................................200-10
IP-10 (CXCL10) ..............................300-12
MCP-1/MCAF (CCL2) .....................300-04
Midkine (MK) .................................450-16
MIP-1a (CCL3)................................300-08
MIP-1b (CCL4).................................300-09
Neuroserpin ...................................130-14
Neuritin........................................450-36D
Neurturin .......................................450-11
NNT-1/BCSF-3 . ..............................450-18
NT-3 ...............................................450-03
NT-4 ...............................................450-04
Continued
Neurobiology related research is devoted to understanding
the biological basis of the brain and nervous system.
Ultimately, this research could lead to a more complete
comprehension of the complex neural processes by which
we perceive, act, learn, and remember. The adjoining list
contains recombinant cytokine products that can act on
brain or nervous system cells.
Commonly used Cytokines in Neuroscience Research
Artemin
Synonyms: ART
Description: Artemin is a disulfide-linked homodimeric neurotrophic factor structurally
related to GDNF, Artemin, Neurturin and Persephin. These proteins belong
to the cysteine-knot superfamily of growth factors that assume stable dimeric
protein structures. Artemin, GDNF, Persephin and Neurturin all signal
through a multicomponent receptor system, composed of RET (receptor
tyrosine kinase) and one of the four GFRalpha (alpha1-alpha4) receptors.
Artemin prefers the receptor GFRalpha3-RET, but will use other receptors as
an alternative. Artemin supports the survival of all peripheral ganglia such
as sympathetic, neural crest and placodally derived sensory neurons, and
dompaminergic midbrain neurons. The functional human Artemin ligand
is a disulfide-linked homodimer, of two 12.0 kDa polypeptide monomers.
Each monomer contains seven conserved cysteine residues, one of which
is used for interchain disulfide bridging and the others are involved in
intramolecular ring formation known as the cysteine knot configuration.
Recombinant human Artemin is a 24.2 kDa, di-sulfide-linked homodimer
formed by two identical 113 amino acid subunits.
Continued
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18/3//2010
For more information about PeproTech products visit www.peprotech.com
Proteins relevant for Neuroscience Research continued
Human Cytokines
and Neurotrophins Continued
Commonly used Cytokines in Neuroscience Research continued
Products
Catalogue#
PEDF...............................................130-13
Persephin (PSP) . .............................450-12
Pleiotrophin.....................................450-15
Prolactin..........................................100-07
RANTES (CCL5) ..............................300-06
SDF-1a (CXCL12)......................... 300-28A
Slit2-N.............................................150-11
TGF-b1............................................100-21
TNF-a.......................................... 300-01A
TNF-b . ........................................ 300-01B
TNF-R1 ..........................................310-07
TWEAK ..........................................310-06
Synonyms: Brain Derived Neurotrophic Factor
Description:BDNF is a member of the NGF family of neurotrophic growth factors.
Murine Cytokines and Neurotrophins
b-NGF.............................................450-34
Cardiotrophin-1...............................250-25
EGF ................................................315-09
FGF-acidic.................................... 450-33A
GDNF.............................................450-44
IFN-g ..............................................315-05
IL-1a ........................................... 211-11A
IL-1b ........................................... 211-11B
IL-2 ................................................212-12
IL-6 ................................................216-16
IL-10................................................210-10
IP-10 (CXCL10)................................250-16
JE/MCP-1 (CCL2) ............................250-10
MIP-1a (CCL3)................................250-09
MIP-1b (CCL4).................................250-32
Persephin........................................450-35
Prolactin..........................................315-16
RANTES (CCL5)...............................250-07
SDF-1a (CXCL12)......................... 250-20A
TNF-a.......................................... 315-01A
BDNF
Like other members of this family, BDNF supports neuron proliferation
and survival. BDNF can bind to a low affinity cell surface receptor called
LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4.
However, BDNF mediates its neurotrophic properties by signaling through
a high affinity cell surface receptor called gp145/trkB. BDNF is expressed
as the C-terminal portion of a 247 amino acid polypeptide precursor, which
also contains a signal sequence of 18 amino acid residue and a propeptide
of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa
homodimer of two 119 amino acid subunits linked by strong non-covalent
interactions. Human and Mouse BDNF sequences are identical.
b-NGF
Synonyms: NGF-beta
Description:b-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-
4. These proteins belong to the cysteine-knot family of growth factors that
assume stable dimeric structures. b-NGF is a potent neurotrophic factor
that signals through its receptor b-NGFR, and plays a crucial role in the
development and preservation of the sensory and sympathetic nervous
systems. b-NGF also acts as a growth and differentiation factor for B
lymphocytes and enhances B-cell survival. The functional form of human
b-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa
polypeptide monomers (238 total amino acid residues). The three disulfide
bonds are required for biological activity.
GDNF
Synonyms: Glial-Derived Neurotrophic Factor, ATF-1
Description:GDNF is a disulfide-linked homodimeric neurotrophic factor structurally
related to Artemin, Neurturin and Persephin. These proteins belong to the
cysteine-knot superfamily of growth factors that assume stable dimeric
protein structures. GDNF signals through a multicomponent receptor
system, composed of a RET and one of the four GFRalpha (alpha1-alpha4)
receptors. GDNF specifically promotes dopamine uptake and survival
and morphological differentiation of midbrain neurons. Using Parkinson’s
disease mouse model, GDNF has been shown to improve conditions such
as bradykinesia, rigidity, and postural instability. The functional human
GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide
chains called monomers. Each monomer contains seven conserved cysteine
residues, one of which (Cys 101) is used for inter-chain disulfide bridging
and the others are involved in intramolecular ring formation known as the
cysteine knot configuration.
Rat Cytokines and Neurotrophins
CNTF .............................................450-50
EGF ................................................400-25
GDNF.............................................450-51
IFN-g ..............................................400-20
IL-1a ........................................... 400-01A
IL-1b ........................................... 400-01B
IL-2..................................................400-02
IL-6 ................................................400-06
IP-10 (CXCL10)................................400-33
MCP-1 (CCL2).................................400-12
MIP-1a (CCL3)................................400-15
MIP-1b (CCL4) . ..............................400-09
RANTES (CCL5)...............................400-13
SDF-1a (CXCL12)......................... 400-32A
TNF-a ............................................400-14
Animal-Free Neurotrophic Factors
BDNF........................................ AF-450-02
Antibodies and ELISA Kits
are available for most products.
NT-3
Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve growth factor-2, NGF-2,
HGNF
Description:NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-
4. These proteins belong to the cysteine-knot family of growth factors that
assume stable dimeric structures. NT-3 is expressed by neurons of the central
nervous systems and can signal through the trk receptors. NT-3 promotes
the growth and survival of nerve and glial cells. The amino acid sequences
of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a
noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers
(240 total amino acid residues). Human and Mouse NT-3 sequences are
identical.